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Experimental and Therapeutic Medicine
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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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October-2022 Volume 24 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

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Circular RNA PVT1 promotes progression of thyroid cancer by competitively binding miR‑384

  • Authors:
    • Tebo Hua
    • Yong Luo
  • View Affiliations / Copyright

    Affiliations: Department of Thyroid Breast Surgery, Ningbo Medical Centre Lihuili Hospital, Ningbo, Zhejiang 315040, P.R. China
    Copyright: © Hua et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 629
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    Published online on: August 19, 2022
       https://doi.org/10.3892/etm.2022.11566
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Abstract

Plasmacytoma variant translocation 1 circular RNA (circPVT1) is involved in the initiation and development of several types of cancer. However, the underlying molecular role of circPVT1 in tumorigenesis of thyroid cancer remains to be elucidated. In the present study, relative expression of circPVT1 was markedly upregulated in thyroid cancer compared with adjacent normal tissue. circPVT1 expression was associated with clinical stage and lymph node metastasis. Furthermore, Cell Counting Kit‑8, colony formation and Transwell chamber assays demonstrated that knockdown of circPVT1 decreased proliferation, migration and invasion of thyroid cancer cells in vitro. Moreover, circPVT1 directly interacted with microRNA (miR)‑384, as shown by bioinformatics prediction and dual luciferase and RNA pull‑down assay. miR‑384 inhibition partially reversed the circPVT1 knockdown‑mediated inhibitory effect on proliferation, migration and invasion of thyroid cancer cells. In summary, these findings demonstrated that circPVT1 may be a potential therapeutic target for thyroid cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Hua T and Luo Y: Circular RNA PVT1 promotes progression of thyroid cancer by competitively binding miR‑384. Exp Ther Med 24: 629, 2022.
APA
Hua, T., & Luo, Y. (2022). Circular RNA PVT1 promotes progression of thyroid cancer by competitively binding miR‑384. Experimental and Therapeutic Medicine, 24, 629. https://doi.org/10.3892/etm.2022.11566
MLA
Hua, T., Luo, Y."Circular RNA PVT1 promotes progression of thyroid cancer by competitively binding miR‑384". Experimental and Therapeutic Medicine 24.4 (2022): 629.
Chicago
Hua, T., Luo, Y."Circular RNA PVT1 promotes progression of thyroid cancer by competitively binding miR‑384". Experimental and Therapeutic Medicine 24, no. 4 (2022): 629. https://doi.org/10.3892/etm.2022.11566
Copy and paste a formatted citation
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Spandidos Publications style
Hua T and Luo Y: Circular RNA PVT1 promotes progression of thyroid cancer by competitively binding miR‑384. Exp Ther Med 24: 629, 2022.
APA
Hua, T., & Luo, Y. (2022). Circular RNA PVT1 promotes progression of thyroid cancer by competitively binding miR‑384. Experimental and Therapeutic Medicine, 24, 629. https://doi.org/10.3892/etm.2022.11566
MLA
Hua, T., Luo, Y."Circular RNA PVT1 promotes progression of thyroid cancer by competitively binding miR‑384". Experimental and Therapeutic Medicine 24.4 (2022): 629.
Chicago
Hua, T., Luo, Y."Circular RNA PVT1 promotes progression of thyroid cancer by competitively binding miR‑384". Experimental and Therapeutic Medicine 24, no. 4 (2022): 629. https://doi.org/10.3892/etm.2022.11566
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