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Recombinant human soluble thrombomodulin and danaparoid combination anticoagulant therapy for disseminated intravascular coagulation in a child with streptococcal toxic shock syndrome: A case report

  • Authors:
    • Yutaka Kato
    • Hiroshi Kawaguchi
    • Shinichiro Iwataki
    • Hirotaka Kihara
    • Satoshi Okada
  • View Affiliations / Copyright

    Affiliations: Department of Pediatrics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima 734‑8551, Japan, Department of Pediatrics, Japan Agricultural Cooperatives Onomichi General Hospital, Onomichi, Hiroshima 722‑8508, Japan
    Copyright: © Kato et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 714
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    Published online on: October 7, 2022
       https://doi.org/10.3892/etm.2022.11650
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Abstract

Disseminated intravascular coagulation (DIC) is a common and morbid complication of streptococcal toxic shock syndrome (STSS). Because DIC with STSS progresses rapidly, prompt and proper care is critical. The present report describes the case of a 10‑year‑old boy who survived STSS with DIC without sequelae after treatment with combination anticoagulant therapy of recombinant human soluble thrombomodulin (rhTM) and danaparoid. RhTM and antithrombin‑III were administered on day 1. RhTM administration was continued. Despite this, on day 2, his general condition remained poor, his fever persisted and his DIC score increased from an initial 5 points upon admission to 9 points. Therefore, danaparoid was additionally administered from day 2 onwards. The patient recovered without serious complications. Combination anticoagulant therapy of rhTM and danaparoid for DIC in a child with STSS was effective and safe. Therefore, this combination therapy could be used as an option for managing high‑risk, rapidly progressing disease states, which predispose to morbid sequelae and death, such as DIC with STSS. RhTM and danaparoid therapy may reduce the risk of serious complications, such as organ failure, and improve the prognosis not only in STSS but also in other conditions with infection and DIC concurrence, such as sepsis.
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Copy and paste a formatted citation
Spandidos Publications style
Kato Y, Kawaguchi H, Iwataki S, Kihara H and Okada S: Recombinant human soluble thrombomodulin and danaparoid combination anticoagulant therapy for disseminated intravascular coagulation in a child with streptococcal toxic shock syndrome: A case report. Exp Ther Med 24: 714, 2022.
APA
Kato, Y., Kawaguchi, H., Iwataki, S., Kihara, H., & Okada, S. (2022). Recombinant human soluble thrombomodulin and danaparoid combination anticoagulant therapy for disseminated intravascular coagulation in a child with streptococcal toxic shock syndrome: A case report. Experimental and Therapeutic Medicine, 24, 714. https://doi.org/10.3892/etm.2022.11650
MLA
Kato, Y., Kawaguchi, H., Iwataki, S., Kihara, H., Okada, S."Recombinant human soluble thrombomodulin and danaparoid combination anticoagulant therapy for disseminated intravascular coagulation in a child with streptococcal toxic shock syndrome: A case report". Experimental and Therapeutic Medicine 24.6 (2022): 714.
Chicago
Kato, Y., Kawaguchi, H., Iwataki, S., Kihara, H., Okada, S."Recombinant human soluble thrombomodulin and danaparoid combination anticoagulant therapy for disseminated intravascular coagulation in a child with streptococcal toxic shock syndrome: A case report". Experimental and Therapeutic Medicine 24, no. 6 (2022): 714. https://doi.org/10.3892/etm.2022.11650
Copy and paste a formatted citation
x
Spandidos Publications style
Kato Y, Kawaguchi H, Iwataki S, Kihara H and Okada S: Recombinant human soluble thrombomodulin and danaparoid combination anticoagulant therapy for disseminated intravascular coagulation in a child with streptococcal toxic shock syndrome: A case report. Exp Ther Med 24: 714, 2022.
APA
Kato, Y., Kawaguchi, H., Iwataki, S., Kihara, H., & Okada, S. (2022). Recombinant human soluble thrombomodulin and danaparoid combination anticoagulant therapy for disseminated intravascular coagulation in a child with streptococcal toxic shock syndrome: A case report. Experimental and Therapeutic Medicine, 24, 714. https://doi.org/10.3892/etm.2022.11650
MLA
Kato, Y., Kawaguchi, H., Iwataki, S., Kihara, H., Okada, S."Recombinant human soluble thrombomodulin and danaparoid combination anticoagulant therapy for disseminated intravascular coagulation in a child with streptococcal toxic shock syndrome: A case report". Experimental and Therapeutic Medicine 24.6 (2022): 714.
Chicago
Kato, Y., Kawaguchi, H., Iwataki, S., Kihara, H., Okada, S."Recombinant human soluble thrombomodulin and danaparoid combination anticoagulant therapy for disseminated intravascular coagulation in a child with streptococcal toxic shock syndrome: A case report". Experimental and Therapeutic Medicine 24, no. 6 (2022): 714. https://doi.org/10.3892/etm.2022.11650
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