Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
December-2022 Volume 24 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2022 Volume 24 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Vitamin C inhibits apoptosis in THP‑1 cells in response to incubation with Mycobacterium tuberculosis

  • Authors:
    • Fuyang Song
    • Yiming Wu
    • Xue Lin
    • Di Xue
    • Yujiong Wang
  • View Affiliations / Copyright

    Affiliations: Key Laboratory of The Ministry of Education for Conservation and Utilization of Special Biological Resources in The West, Ningxia University, Yinchuan, Ningxia Hui Autonomous Region 750021, P.R. China, Institute of Medical Sciences, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750004, P.R. China
    Copyright: © Song et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 717
    |
    Published online on: October 11, 2022
       https://doi.org/10.3892/etm.2022.11653
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Tuberculosis (TB) is a chronic and fatal zoonotic infectious disease caused by Mycobacterium tuberculosis (M. tb) infection. The THP‑1 cell line is a cell model for studying the function, mechanism and signaling pathways of macrophages; macrophages are the primary host cells of M. tb. Macrophages are important for the progression of tuberculosis, as they affect the release of various inflammatory cytokines, including IL‑1β, IL‑6 and TNF‑α. Vitamin C is a trace element for the human body. Its biological efficacy depends on its redox abilities and its role as a cofactor in several enzymatic reactions. However, whether vitamin C can protect THP‑1 cells from M. tb infection has not yet been reported. The present study aimed to further investigate the effects of vitamin C on M. tb infection‑induced THP‑1 cell injury and its mechanism. In the present study, MTT assay, reverse transcription‑quantitative PCR, EdU cell proliferation assay, western blotting, immunohistochemistry, flow cytometry and TUNEL staining assays were used to assess the cell viability, inflammation and apoptotic levels of THP‑1 cells induced by M. tb following vitamin C treatment. The effect of vitamin C on M. tb infection was also assessed using Balb/c mice; pulmonary injury was assessed by H&E staining of the lung tissue. The results demonstrated that vitamin C markedly attenuated cellular damage caused by M. tb infection. The results demonstrated that vitamin C reduced the expression of M. tb‑induced apoptosis‑related proteins (Cleaved‑caspase‑9, Cleaved‑caspase‑3, Bcl‑2, Cyt‑c) and inflammatory factors (IL‑1β, IL‑6, NLRP3, TNF‑α, IL‑8, NF‑κB) in THP‑1 cells and reduced apoptosis. Overall, these results suggested that vitamin C may reduce lung damage caused by M. tb infection.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Liu H, Zhu T, Li Q, Xiong X, Wang J, Zhu X, Zhou X, Zhang L, Zhu Y, Peng Y, et al: TRIM25 upregulation by Mycobacterium tuberculosis infection promotes intracellular survival of M. tb in RAW264.7 cells. Microb Pathog. 148(104456)2020.PubMed/NCBI View Article : Google Scholar

2 

Rajaram MV, Ni B, Dodd CE and Schlesinger LS: Macrophage immunoregulatory pathways in tuberculosis. Semin Immunol. 26:471–485. 2014.PubMed/NCBI View Article : Google Scholar

3 

Zhang H, Lu Q, Zhang J, Qu W, Xie S, Huang L, Yuan Z and Pan Y: Discovery of novel nitrogenous heterocyclic-containing quinoxaline-1,4-di-N-oxides as potent activator of autophagy in M. tb-infected macrophages. Eur J Med Chem. 223(113657)2021.PubMed/NCBI View Article : Google Scholar

4 

Qin Z: The use of THP-1 cells as a model for mimicking the function and regulation of monocytes and macrophages in the vasculature. Atherosclerosis. 221:2–11. 2012.PubMed/NCBI View Article : Google Scholar

5 

Ali S, Ehtram A, Arora N, Manjunath P, Roy D, Ehtesham NZ and Hasnain SE: The M. tuberculosis Rv1523 methyltransferase promotes drug resistance through methylation-mediated cell wall remodeling and modulates macrophages immune responses. Front Cell Infect Microbiol. 11(622487)2021.PubMed/NCBI View Article : Google Scholar

6 

Dallenga T, Repnik U, Corleis B, Eich J, Reimer R, Griffiths GW and Schaible UE: M, M. tuberculosis-induced necrosis of infected neutrophils promotes bacterial growth following phagocytosis by macrophages. Cell Host Microbe. 22:519–530.e3. 2017.PubMed/NCBI View Article : Google Scholar

7 

Yang H, Chen J, Chen Y, Jiang Y, Ge B and Hong L: Sirtuin inhibits M. tuberculosis-induced apoptosis in macrophage through glycogen synthase kinase-3β. Arch Biochem Biophys. 694(108612)2020.PubMed/NCBI View Article : Google Scholar

8 

Fol M, Druszczynska M, Wlodarczyk M, Ograczyk E and Rudnicka W: Immune response gene polymorphisms in tuberculosis. Acta Biochim Pol. 62:633–640. 2015.PubMed/NCBI View Article : Google Scholar

9 

Adikesavalu H, Gopalaswamy R, Kumar A, Ranganathan UD and Shanmugam S: Autophagy induction as a host-directed therapeutic strategy against Mycobacterium tuberculosis infection. Medicina (Kaunas). 57(522)2021.PubMed/NCBI View Article : Google Scholar

10 

Kuhn SO, Meissner K, Mayes LM and Bartels K: Vitamin C in sepsis. Curr Opin Anaesthesiol. 31:55–60. 2018.PubMed/NCBI View Article : Google Scholar

11 

Aumailley L and Lebel M: The impact of vitamin C on different system models of Werner syndrome. Antioxid Redox Signal. 34:856–874. 2021.PubMed/NCBI View Article : Google Scholar

12 

van Gorkom GNY, Lookermans EL, Van Elssen CHMJ and Bos GMJ: The effect of vitamin C (ascorbic acid) in the treatment of patients with cancer: A systematic review. Nutrients. 11(977)2019.PubMed/NCBI View Article : Google Scholar

13 

Varghese GM, Turaka VP, Janardhanan J, Yadav S, Lakshmi KM, S VT and Cherayil B: Serum siderocalin levels in patients with tuberculosis and HIV infection. Int J Infect Dis. 85:132–134. 2019.PubMed/NCBI View Article : Google Scholar

14 

Chanput W, Mes JJ and Wichers HJ: THP-1 cell line: An in vitro cell model for immune modulation approach. Int Immunopharmacol. 23:37–45. 2014.PubMed/NCBI View Article : Google Scholar

15 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

16 

Wu H, Zhang M, Li W, Zhu S and Zhang D: Stachydrine attenuates IL-1β-induced inflammatory response in osteoarthritis chondrocytes through the NF-κB signaling pathway. Chem Biol Interact. 326(109136)2020.PubMed/NCBI View Article : Google Scholar

17 

Wawrocki S and Druszczynska M: Inflammasomes in Mycobacterium tuberculosis-driven immunity. Can J Infect Dis Med Microbiol. 2017(2309478)2017.PubMed/NCBI View Article : Google Scholar

18 

Silva DR, Menegotto DM, Schulz LF, Gazzana MB and Dalcin Pde T: Factors associated with mortality in hospitalized patients with newly diagnosed tuberculosis. Lung. 188:33–41. 2010.PubMed/NCBI View Article : Google Scholar

19 

Connor SR: Palliative care for tuberculosis. J Pain Symptom Manage. 55:S178–S180. 2018.PubMed/NCBI View Article : Google Scholar

20 

Carr AC and Maggini S: Vitamin C and immune function. Nutrients. 9(1211)2017.PubMed/NCBI View Article : Google Scholar

21 

Ang A, Pullar JM, Currie MJ and Vissers MCM: Vitamin C and immune cell function in inflammation and cancer. Biochem Soc Trans. 46:1147–1159. 2018.PubMed/NCBI View Article : Google Scholar

22 

Ferrada L, Barahona MJ, Salazar K, Vandenabeele P and Nualart F: Vitamin C controls neuronal necroptosis under oxidative stress. Redox Biol. 29(101408)2020.PubMed/NCBI View Article : Google Scholar

23 

Carr AC, Spencer E, Dixon L and Chambers ST: Patients with community acquired pneumonia exhibit depleted vitamin C status and elevated oxidative stress. Nutrients. 12(1318)2020.PubMed/NCBI View Article : Google Scholar

24 

Herb M and Schramm M: Functions of ROS in macrophages and antimicrobial immunity. Antioxidants (Basel). 10(313)2021.PubMed/NCBI View Article : Google Scholar

25 

Fu C, Chen J, Lu J, Yi L, Tong X, Kang L, Pei S, Ouyang Y, Jiang L, Ding Y, et al: Roles of inflammation factors in melanogenesis (review). Mol Med Rep. 21:1421–1430. 2020.PubMed/NCBI View Article : Google Scholar

26 

Alfaro C, Sanmamed MF, Rodríguez-Ruiz ME, Teijeira Á, Oñate C, González Á, Ponz M, Schalper KA, Pérez-Gracia JL and Melero I: Interleukin-8 in cancer pathogenesis, treatment and follow-up. Cancer Treat Rev. 60:24–31. 2017.PubMed/NCBI View Article : Google Scholar

27 

Kim YG, Kim SM, Kim KP, Lee SH and Moon JY: The role of inflammasome-dependent and inflammasome-independent NLRP3 in the kidney. Cells. 8(1389)2019.PubMed/NCBI View Article : Google Scholar

28 

Tanaka T, Narazaki M and Kishimoto T: IL-6 in inflammation, immunity, and disease. Cold Spring Harb Perspect Biol. 6(a016295)2014.PubMed/NCBI View Article : Google Scholar

29 

Shao BZ, Xu ZQ, Han BZ, Su DF and Liu C: NLRP3 inflammasome and its inhibitors: A review. Front Pharmacol. 6(262)2015.PubMed/NCBI View Article : Google Scholar

30 

Wang Y, Liu X, Shi H, Yu Y, Yu Y, Li M and Chen R: NLRP3 inflammasome, an immune-inflammatory target in pathogenesis and treatment of cardiovascular diseases. Clin Transl Med. 10:91–106. 2020.PubMed/NCBI View Article : Google Scholar

31 

Cui L, Bu W, Song J, Feng L, Xu T, Liu D, Ding W, Wang J, Li C, Ma B, et al: Apoptosis induction by alantolactone in breast cancer MDA-MB-231 cells through reactive oxygen species-mediated mitochondrion-dependent pathway. Arch Pharm Res. 41:299–313. 2018.PubMed/NCBI View Article : Google Scholar

32 

Prasad S, Gupta SC and Tyagi AK: Reactive oxygen species (ROS) and cancer: Role of antioxidative nutraceuticals. Cancer Lett. 387:95–105. 2017.PubMed/NCBI View Article : Google Scholar

33 

Lv X, Zhou X, Yan J, Jiang J and Jiang H: Propofol inhibits LPS-induced apoptosis in lung epithelial cell line, BEAS-2B. Biomed Pharmacother. 87:180–187. 2017.PubMed/NCBI View Article : Google Scholar

34 

Wang H, Zhu J, Jiang L, Shan B, Xiao P, Ai J, Li N, Qi F and Niu S: Mechanism of Heshouwuyin inhibiting the Cyt c/Apaf-1/Caspase-9/Caspase-3 pathway in spermatogenic cell apoptosis. BMC Complement Med Ther. 20(180)2020.PubMed/NCBI View Article : Google Scholar

35 

An HK, Chung KM, Park H, Hong J, Gim JE, Choi H, Lee YW, Choi J, Mun JY and Yu SW: CASP9 (caspase 9) is essential for autophagosome maturation through regulation of mitochondrial homeostasis. Autophagy. 16:1598–1617. 2020.PubMed/NCBI View Article : Google Scholar

36 

D'Amelio M, Cavallucci V and Cecconi F: Neuronal caspase-3 signaling: not only cell death. Cell Death Differ. 17:1104–1114. 2010.PubMed/NCBI View Article : Google Scholar

37 

Wall DM and McCormick BA: Bacterial secreted effectors and caspase-3 interactions. Cell Microbiol. 16:1746–1756. 2014.PubMed/NCBI View Article : Google Scholar

38 

Tawa P, Hell K, Giroux A, Grimm E, Han Y, Nicholson DW and Xanthoudakis S: Catalytic activity of caspase-3 is required for its degradation: stabilization of the active complex by synthetic inhibitors. Cell Death Differ. 11:439–447. 2004.PubMed/NCBI View Article : Google Scholar

39 

Ebrahim AS, Sabbagh H, Liddane A, Raufi A, Kandouz M and Al-Katib A: Hematologic malignancies: Newer strategies to counter the BCL-2 protein. J Cancer Res Clin Oncol. 142:2013–2022. 2016.PubMed/NCBI View Article : Google Scholar

40 

Pattingre S and Levine B: Bcl-2 inhibition of autophagy: A new route to cancer? Cancer Res. 66:2885–2888. 2006.PubMed/NCBI View Article : Google Scholar

41 

Willis S, Day CL, Hinds MG and Huang DC: The Bcl-2-regulated apoptotic pathway. J Cell Sci. 116:4053–4056. 2003.PubMed/NCBI View Article : Google Scholar

42 

Huang Y, Xu W and Zhou R: NLRP3 inflammasome activation and cell death. Cell Mol Immunol. 18:2114–2127. 2021.PubMed/NCBI View Article : Google Scholar

43 

Shakeri R, Kheirollahi A and Davoodi J: Apaf-1: Regulation and function in cell death. Biochimie. 135:111–125. 2017.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Song F, Wu Y, Lin X, Xue D and Wang Y: Vitamin C inhibits apoptosis in THP‑1 cells in response to incubation with <em>Mycobacterium tuberculosis</em>. Exp Ther Med 24: 717, 2022.
APA
Song, F., Wu, Y., Lin, X., Xue, D., & Wang, Y. (2022). Vitamin C inhibits apoptosis in THP‑1 cells in response to incubation with <em>Mycobacterium tuberculosis</em>. Experimental and Therapeutic Medicine, 24, 717. https://doi.org/10.3892/etm.2022.11653
MLA
Song, F., Wu, Y., Lin, X., Xue, D., Wang, Y."Vitamin C inhibits apoptosis in THP‑1 cells in response to incubation with <em>Mycobacterium tuberculosis</em>". Experimental and Therapeutic Medicine 24.6 (2022): 717.
Chicago
Song, F., Wu, Y., Lin, X., Xue, D., Wang, Y."Vitamin C inhibits apoptosis in THP‑1 cells in response to incubation with <em>Mycobacterium tuberculosis</em>". Experimental and Therapeutic Medicine 24, no. 6 (2022): 717. https://doi.org/10.3892/etm.2022.11653
Copy and paste a formatted citation
x
Spandidos Publications style
Song F, Wu Y, Lin X, Xue D and Wang Y: Vitamin C inhibits apoptosis in THP‑1 cells in response to incubation with <em>Mycobacterium tuberculosis</em>. Exp Ther Med 24: 717, 2022.
APA
Song, F., Wu, Y., Lin, X., Xue, D., & Wang, Y. (2022). Vitamin C inhibits apoptosis in THP‑1 cells in response to incubation with <em>Mycobacterium tuberculosis</em>. Experimental and Therapeutic Medicine, 24, 717. https://doi.org/10.3892/etm.2022.11653
MLA
Song, F., Wu, Y., Lin, X., Xue, D., Wang, Y."Vitamin C inhibits apoptosis in THP‑1 cells in response to incubation with <em>Mycobacterium tuberculosis</em>". Experimental and Therapeutic Medicine 24.6 (2022): 717.
Chicago
Song, F., Wu, Y., Lin, X., Xue, D., Wang, Y."Vitamin C inhibits apoptosis in THP‑1 cells in response to incubation with <em>Mycobacterium tuberculosis</em>". Experimental and Therapeutic Medicine 24, no. 6 (2022): 717. https://doi.org/10.3892/etm.2022.11653
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team