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A pan‑cancer analysis of RCC2 and its interaction with HMGA2 protein in an in vitro model of colorectal cancer cells

  • Authors:
    • Guiyuan Gu
    • Yuhong Wang
    • Yucheng Shen
    • Yan Ma
    • Hongli Yang
    • Shan Huang
    • Lin Hu
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, The Affiliated Hai'an Hospital of Nantong University, Nantong, Jiangsu 226601, P.R. China, Department of Pathology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215000, P.R. China, Department of Oncology, The Affiliated Hai'an Hospital of Nantong University, Nantong, Jiangsu 226601, P.R. China, Institutes of Biology and Medical Sciences, Soochow University, Suzhou, Jiangsu 215000, P.R. China
    Copyright: © Gu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 725
    |
    Published online on: October 20, 2022
       https://doi.org/10.3892/etm.2022.11661
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Abstract

Regulator of chromosome condensation 2 (RCC2) is highly involved in the development of tumor malignancies. The underlying mechanisms remain to be elucidated. The present study aimed to explore the role of RCC2 in the development of tumor malignancies and explore the underlying mechanisms in colorectal cancer (CRC). RCC2 expression and survival analysis were performed in human pan‑cancer. The results of searching its mRNA expression in The Cancer Genome Atlas (TCGA) database showed that RCC2 was highly expressed in different types of cancer. High RCC2 expression levels were significantly correlated with poor survival outcomes by the Kaplan‑Meier analysis in the TCGA database. Immunohistochemistry revealed that RCC2 was higher expressed in 36 CRC tissues than in adjacent normal tissues. Co‑immunoprecipitation revealed that RCC2 bound to high mobility group A2 (HMGA2). Ectopic expression of RCC2 promoted cell proliferation, migration and invasion, whereas knockdown of HMGA2 exerted the opposite effects. Collectively, the data provided a novel biomarker of RCC2 in various types of cancer. High RCC2 expression levels were correlated with poor prognosis in different types of cancer. In addition, RCC2 may combine with HMGA2 to promote CRC malignancy.
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Copy and paste a formatted citation
Spandidos Publications style
Gu G, Wang Y, Shen Y, Ma Y, Yang H, Huang S and Hu L: A pan‑cancer analysis of RCC2 and its interaction with HMGA2 protein in an <em>in vitro</em> model of colorectal cancer cells. Exp Ther Med 24: 725, 2022.
APA
Gu, G., Wang, Y., Shen, Y., Ma, Y., Yang, H., Huang, S., & Hu, L. (2022). A pan‑cancer analysis of RCC2 and its interaction with HMGA2 protein in an <em>in vitro</em> model of colorectal cancer cells. Experimental and Therapeutic Medicine, 24, 725. https://doi.org/10.3892/etm.2022.11661
MLA
Gu, G., Wang, Y., Shen, Y., Ma, Y., Yang, H., Huang, S., Hu, L."A pan‑cancer analysis of RCC2 and its interaction with HMGA2 protein in an <em>in vitro</em> model of colorectal cancer cells". Experimental and Therapeutic Medicine 24.6 (2022): 725.
Chicago
Gu, G., Wang, Y., Shen, Y., Ma, Y., Yang, H., Huang, S., Hu, L."A pan‑cancer analysis of RCC2 and its interaction with HMGA2 protein in an <em>in vitro</em> model of colorectal cancer cells". Experimental and Therapeutic Medicine 24, no. 6 (2022): 725. https://doi.org/10.3892/etm.2022.11661
Copy and paste a formatted citation
x
Spandidos Publications style
Gu G, Wang Y, Shen Y, Ma Y, Yang H, Huang S and Hu L: A pan‑cancer analysis of RCC2 and its interaction with HMGA2 protein in an <em>in vitro</em> model of colorectal cancer cells. Exp Ther Med 24: 725, 2022.
APA
Gu, G., Wang, Y., Shen, Y., Ma, Y., Yang, H., Huang, S., & Hu, L. (2022). A pan‑cancer analysis of RCC2 and its interaction with HMGA2 protein in an <em>in vitro</em> model of colorectal cancer cells. Experimental and Therapeutic Medicine, 24, 725. https://doi.org/10.3892/etm.2022.11661
MLA
Gu, G., Wang, Y., Shen, Y., Ma, Y., Yang, H., Huang, S., Hu, L."A pan‑cancer analysis of RCC2 and its interaction with HMGA2 protein in an <em>in vitro</em> model of colorectal cancer cells". Experimental and Therapeutic Medicine 24.6 (2022): 725.
Chicago
Gu, G., Wang, Y., Shen, Y., Ma, Y., Yang, H., Huang, S., Hu, L."A pan‑cancer analysis of RCC2 and its interaction with HMGA2 protein in an <em>in vitro</em> model of colorectal cancer cells". Experimental and Therapeutic Medicine 24, no. 6 (2022): 725. https://doi.org/10.3892/etm.2022.11661
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