Open Access

Frequency of HLA‑G UTR‑1/UTR‑3/UTR‑7 in women with unexplained recurrent spontaneous abortion

  • Authors:
    • Wei Bai
    • Zhi Lin
    • Jin Ye
    • Linshuang Zhou
    • Jingqiao Xi
    • Wenpin Cai
  • View Affiliations

  • Published online on: October 24, 2022     https://doi.org/10.3892/etm.2022.11665
  • Article Number: 729
  • Copyright: © Bai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Human leukocyte antigen (HLA)‑G is an important molecule that maintains maternal‑fetal interface tolerance and plays a vital role in a healthy pregnancy. Single‑nucleotide polymorphisms in the 3'‑untranslated regions (UTR) of the HLA‑G gene may differ in women with unexplained recurrent spontaneous abortion (URSA). The present study involved the isolation of genome DNA from peripheral blood leukocytes, Sanger sequencing and analysis of the polymorphism sites in the 3'UTR of the HLA‑G gene based on polymerase chain reaction. In total, 261 DNA samples from cases of URSA (n=133), including primary URSA (n=83) and secondary URSA (n=50), and controls (n=128) were evaluated. The present data showed that +3010CC genotype carriers exhibited a higher risk of URSA, while +3187GG genotype carriers exhibited a lower risk. Secondary URSA patients carrying +3010C had a higher risk of URSA, while +3187G carriers exhibited a lower risk of URSA. UTR‑1 haplotype carriers may be associated with a reduced risk of primary and secondary URSA. Notably, UTR‑3 and UTR‑7 could increase the risk of primary and secondary URSA, respectively. The present results showed that HLA‑G 3'UTR polymorphisms and haplotypes may be involved in URSA development and be a predictor of pregnancy outcome.
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December-2022
Volume 24 Issue 6

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Spandidos Publications style
Bai W, Lin Z, Ye J, Zhou L, Xi J and Cai W: Frequency of HLA‑G UTR‑1/UTR‑3/UTR‑7 in women with unexplained recurrent spontaneous abortion. Exp Ther Med 24: 729, 2022
APA
Bai, W., Lin, Z., Ye, J., Zhou, L., Xi, J., & Cai, W. (2022). Frequency of HLA‑G UTR‑1/UTR‑3/UTR‑7 in women with unexplained recurrent spontaneous abortion. Experimental and Therapeutic Medicine, 24, 729. https://doi.org/10.3892/etm.2022.11665
MLA
Bai, W., Lin, Z., Ye, J., Zhou, L., Xi, J., Cai, W."Frequency of HLA‑G UTR‑1/UTR‑3/UTR‑7 in women with unexplained recurrent spontaneous abortion". Experimental and Therapeutic Medicine 24.6 (2022): 729.
Chicago
Bai, W., Lin, Z., Ye, J., Zhou, L., Xi, J., Cai, W."Frequency of HLA‑G UTR‑1/UTR‑3/UTR‑7 in women with unexplained recurrent spontaneous abortion". Experimental and Therapeutic Medicine 24, no. 6 (2022): 729. https://doi.org/10.3892/etm.2022.11665