|
1
|
Wang Y and Kou J: Research progress of
oxLDL in atherosclerotic thrombosis. Chin J Cardiovasc Rehabil Med.
30:344–347. 2021.
|
|
2
|
Trpkovic A, Resanovic I, Stanimirovic J,
Radak D, Mousa SA, Cenic-Milosevic D, Jevremovic D and Isenovic ER:
Oxidized low-density lipoprotein as a biomarker of cardiovascular
diseases. Crit Rev Clin Lab Sci. 52:70–85. 2015.PubMed/NCBI View Article : Google Scholar
|
|
3
|
Wojakowski W and Gminski J: Soluble
ICAM-1, VCAM-1 and E-selectin in children from families with high
risk of atherosclerosis. Int J Mol Med. 7:181–185. 2001.PubMed/NCBI View Article : Google Scholar
|
|
4
|
Davies MJ, Gordon JL, Gearing AJ, Pigott
R, Woolf N, Katz D and Kyriakopoulos A: The expression of the
adhesion molecules ICAM-1, VCAM-1, PECAM, and E-selectin in human
atherosclerosis. J Pathol. 171:223–229. 1993.PubMed/NCBI View Article : Google Scholar
|
|
5
|
Zhong XJ, Chen TW, Chen YH, Chen FH,
Zhou-Xue LI, Liu LL, Liu MQ and Huang QR: Effects of ox-LDL on the
proaggregation and proadhesion-related molecules expression of
vascular endothelial cells. Chin J Arterioscler. 9(e89877)2014.
|
|
6
|
Sen-Banerjee S, Mir S, Lin Z, Hamik A,
Atkins GB, Das H, Banerjee P, Kumar A and Jain MK: Kruppel-like
factor 2 as a novel mediator of statin effects in endothelial
cells. Circulation. 112:720–726. 2005.PubMed/NCBI View Article : Google Scholar
|
|
7
|
Chandrasekar B, Mummidi S, Mahimainathan
L, Patel DN, Bailey SR, Imam SZ, Greene WC and Valente AJ:
Interleukin-18-induced human coronary artery smooth muscle cell
migration is dependent on NF-kappaB- and AP-1-mediated matrix
metalloproteinase-9 expression and is inhibited by atorvastatin. J
Biol Chem. 281:15099–15109. 2006.PubMed/NCBI View Article : Google Scholar
|
|
8
|
Takemoto M and Liao JK: Pleiotropic
effects of 3-hydroxy-3-methylglutaryl coenzyme a reductase
inhibitors. Arterioscler Thromb Vasc Biol. 21:1712–1719.
2001.PubMed/NCBI View Article : Google Scholar
|
|
9
|
Wu Z and Wang S: Role of kruppel-like
transcription factors in adipogenesis. Dev Biol. 373:235–243.
2013.PubMed/NCBI View Article : Google Scholar
|
|
10
|
Atkins GB, Wang Y, Mahabeleshwar GH, Shi
H, Gao H, Kawanami D, Natesan V, Lin Z, Simon DI and Jain MK:
Hemizygous deficiency of Krüppel-like factor 2 augments
experimental atherosclerosis. Circ Res. 103:690–693.
2008.PubMed/NCBI View Article : Google Scholar
|
|
11
|
Novodvorsky P and Chico TJ: The role of
the transcription factor KLF2 in vascular development and disease.
Prog Mol Biol Transl Sci. 124:155–188. 2014.PubMed/NCBI View Article : Google Scholar
|
|
12
|
Parmar KM, Larman HB, Dai G, Zhang Y, Wang
ET, Moorthy SN, Kratz JR, Lin Z, Jain MK, Gimbrone MA Jr and
García-Cardeña G: Integration of flow-dependent endothelial
phenotypes by Kruppel-like factor 2. J Clin Invest. 116:49–58.
2006.PubMed/NCBI View
Article : Google Scholar
|
|
13
|
Das H, Kumar A, Lin Z, Patino WD, Hwang
PM, Feinberg MW, Majumder PK and Jain MK: Kruppel-like factor 2
(KLF2) regulates proinflammatory activation of monocytes. Proc Natl
Acad Sci USA. 103:6653–6658. 2006.PubMed/NCBI View Article : Google Scholar
|
|
14
|
Mahabeleshwar GH, Kawanami D, Sharma N,
Takami Y, Zhou G, Shi H, Nayak L, Jeyaraj D, Grealy R, White M, et
al: The myeloid transcription factor KLF2 regulates the host
response to polymicrobial infection and endotoxic shock. Immunity.
34:715–728. 2011.PubMed/NCBI View Article : Google Scholar
|
|
15
|
Lingrel JB, Pilcher-Roberts R, Basford JE,
Manoharan P, Neumann J, Konaniah ES, Srinivasan R, Bogdanov VY and
Hui DY: Myeloid-specific Krüppel-like factor 2 inactivation
increases macrophage and neutrophil adhesion and promotes
atherosclerosis. Circ Res. 110:1294–1302. 2012.PubMed/NCBI View Article : Google Scholar
|
|
16
|
Frostegård J: Immunity, atherosclerosis
and cardiovascular disease. BMC Med. 11(117)2013.PubMed/NCBI View Article : Google Scholar
|
|
17
|
Summerhill VI, Grechko AV, Yet SF, Sobenin
IA and Orekhov AN: The atherogenic role of circulating modified
lipids in atherosclerosis. Int J Mol Sci. 20(3561)2019.PubMed/NCBI View Article : Google Scholar
|
|
18
|
Salmon M, Spinosa M, Zehner ZE, Upchurch
GR and Ailawadi G: Klf4, Klf2, and Zfp148 activate
autophagy-related genes in smooth muscle cells during aortic
aneurysm formation. Physiol Rep. 7(e14058)2019.PubMed/NCBI View Article : Google Scholar
|
|
19
|
Guixé-Muntet S, de Mesquita FC, Vila S,
Hernández-Gea V, Peralta C, García-Pagán JC, Bosch J and
Gracia-Sancho J: Cross-talk between autophagy and KLF2 determines
endothelial cell phenotype and microvascular function in acute
liver injury. J Hepatol. 66:86–94. 2017.PubMed/NCBI View Article : Google Scholar
|
|
20
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(-Delta Delta C(T)) method. Methods. 25:402–408.
2001.PubMed/NCBI View Article : Google Scholar
|
|
21
|
Hu YW, Wang Q, Ma X, Li XX, Liu XH, Xiao
J, Liao DF, Xiang J and Tang CK: TGF-beta1 up-regulates expression
of ABCA1, ABCG1 and SR-BI through liver X receptor alpha signaling
pathway in THP-1 macrophage-derived foam cells. J Atheroscler
Thromb. 17:493–502. 2010.PubMed/NCBI View
Article : Google Scholar
|
|
22
|
Jain MK, Sangwung P and Hamik A:
Regulation of an inflammatory disease: Krüppel-like factors and
atherosclerosis. Arterioscler Thromb Vasc Biol. 34:499–508.
2014.PubMed/NCBI View Article : Google Scholar
|
|
23
|
Huang RT, Wu D, Meliton A, Oh MJ, Krause
M, Lloyd JA, Nigdelioglu R, Hamanaka RB, Jain MK, Birukova A, et
al: Experimental lung injury reduces Krüppel-like factor 2 to
increase endothelial permeability via regulation of RAPGEF3-Rac1
signaling. Am J Respir Crit Care Med. 195:639–651. 2017.PubMed/NCBI View Article : Google Scholar
|
|
24
|
Zhuang T, Liu J, Chen X, Zhang L, Pi J,
Sun H, Li L, Bauer R, Wang H, Yu Z, et al: Endothelial Foxp1
suppresses atherosclerosis via modulation of Nlrp3 inflammasome
activation. Circ Res. 125:590–605. 2019.PubMed/NCBI View Article : Google Scholar
|
|
25
|
Zhang M, Li L, Xie W, Wu JF, Yao F, Tan
YL, Xia XD, Liu XY, Liu D, Lan G, et al: Apolipoprotein A-1 binding
protein promotes macrophage cholesterol efflux by facilitating
apolipoprotein A-1 binding to ABCA1 and preventing ABCA1
degradation. Atherosclerosis. 248:149–159. 2016.PubMed/NCBI View Article : Google Scholar
|
|
26
|
Chistiakov DA, Bobryshev YV and Orekhov
AN: Macrophage-mediated cholesterol handling in atherosclerosis. J
Cell Mol Med. 20:17–28. 2016.PubMed/NCBI View Article : Google Scholar
|
|
27
|
Fisher EA: Regression of atherosclerosis:
The journey from the liver to the plaque and back. Arterioscler
Thromb Vasc Biol. 36:226–235. 2016.PubMed/NCBI View Article : Google Scholar
|
|
28
|
Yu XH, Fu YC, Zhang DW, Yin K and Tang CK:
Foam cells in atherosclerosis. Clin Chim Acta. 424:245–252.
2013.PubMed/NCBI View Article : Google Scholar
|
|
29
|
Castrillo A and Tontonoz P: PPARs in
atherosclerosis: The clot thickens. J Clin Invest. 114:1538–1540.
2004.PubMed/NCBI View
Article : Google Scholar
|
|
30
|
Vattulainen-Collanus S, Akinrinade O, Li
M, Koskenvuo M, Li CG, Rao SP, de Jesus Perez V, Yuan K, Sawada H,
Koskenvuo JW, et al: Loss of PPARγ in endothelial cells leads to
impaired angiogenesis. J Cell Sci. 129:693–705. 2016.PubMed/NCBI View Article : Google Scholar
|
|
31
|
Bruemmer D, Blaschke F and Law RE: New
targets for PPARgamma in the vessel wall: Implications for
restenosis. Int J Obes (Lond). 29 (Suppl 1):S26–S30.
2005.PubMed/NCBI View Article : Google Scholar
|
|
32
|
Ge CX, Yu R, Xu MX, Li PQ, Fan CY, Li JM
and Kong LD: Betaine prevented fructose-induced NAFLD by regulating
LXRα/PPARα pathway and alleviating ER stress in rats. Eur J
Pharmacol. 770:154–164. 2016.PubMed/NCBI View Article : Google Scholar
|
|
33
|
Zhang S, Guo C, Chen Z, Zhang P, Li J and
Li Y: Vitexin alleviates ox-LDL-mediated endothelial injury by
inducing autophagy via AMPK signaling activation. Mol Immunol.
85:214–221. 2017.PubMed/NCBI View Article : Google Scholar
|
|
34
|
Li X, Zhou J, Dou Y, Shi Y, Wang Y, Hong
J, Zhao J, Zhang J, Yuan Y, Zhou M and Wei X: The protective
effects of angelica organic acid against ox-LDL-induced autophagy
dysfunction of HUVECs. BMC Complement Med Ther.
20(164)2020.PubMed/NCBI View Article : Google Scholar
|
|
35
|
Ding Z, Liu S, Wang X, Khaidakov M, Dai Y
and Mehta JL: Oxidant stress in mitochondrial DNA damage, autophagy
and inflammation in atherosclerosis. Sci Rep.
3(1077)2013.PubMed/NCBI View Article : Google Scholar
|
|
36
|
Lin HH: In vitro and in vivo
atheroprotective effects of gossypetin against endothelial cell
injury by induction of autophagy. Chem Res Toxicol. 28:202–215.
2015.PubMed/NCBI View Article : Google Scholar
|
|
37
|
Che J, Liang B, Zhang Y, Wang Y, Tang J
and Shi G: Kaempferol alleviates ox-LDL-induced apoptosis by
up-regulation of autophagy via inhibiting PI3K/Akt/mTOR pathway in
human endothelial cells. Cardiovasc Pathol. 31:57–62.
2017.PubMed/NCBI View Article : Google Scholar
|
|
38
|
Fernández ÁF, Sebti S, Wei Y, Zou Z, Shi
M, McMillan KL, He C, Ting T, Liu Y, Chiang WC, et al: Disruption
of the beclin 1-BCL2 autophagy regulatory complex promotes
longevity in mice. Nature. 558:136–140. 2018.PubMed/NCBI View Article : Google Scholar
|
|
39
|
Kitada M, Ogura Y and Koya D: The
protective role of Sirt1 in vascular tissue: Its relationship to
vascular aging and atherosclerosis. Aging (Albany NY). 8:2290–2307.
2016.PubMed/NCBI View Article : Google Scholar
|
|
40
|
Ouimet M, Ediriweera H, Afonso MS,
Ramkhelawon B, Singaravelu R, Liao X, Bandler RC, Rahman K, Fisher
EA, Rayner KJ, et al: microRNA-33 regulates macrophage autophagy in
atherosclerosis. Arterioscler Thromb Vasc Biol. 37:1058–1067.
2017.PubMed/NCBI View Article : Google Scholar
|
|
41
|
Grootaert MO, da Costa Martins PA, Bitsch
N, Pintelon I, De Meyer GR, Martinet W and Schrijvers DM: Defective
autophagy in vascular smooth muscle cells accelerates senescence
and promotes neointima formation and atherogenesis. Autophagy.
11:2014–2032. 2015.PubMed/NCBI View Article : Google Scholar
|
|
42
|
Cao H, Jia Q, Yan L, Chen C, Xing S and
Shen D: Quercetin suppresses the progression of atherosclerosis by
regulating MST1-mediated autophagy in ox-LDL-induced RAW264.7
macrophage foam cells. Int J Mol Sci. 20(6093)2019.PubMed/NCBI View Article : Google Scholar
|
|
43
|
Mollace V, Gliozzi M, Musolino V, Carresi
C, Muscoli S, Mollace R, Tavernese A, Gratteri S, Palma E, Morabito
C, et al: Oxidized LDL attenuates protective autophagy and induces
apoptotic cell death of endothelial cells: Role of oxidative stress
and LOX-1 receptor expression. Int J Cardiol. 184:152–158.
2015.PubMed/NCBI View Article : Google Scholar
|
|
44
|
Fan X, Wang J, Hou J, Lin C, Bensoussan A,
Chang D, Liu J and Wang B: Berberine alleviates ox-LDL induced
inflammatory factors by up-regulation of autophagy via AMPK/mTOR
signaling pathway. J Transl Med. 13(92)2015.PubMed/NCBI View Article : Google Scholar
|
|
45
|
Gu HF, Li HZ, Tang YL, Tang XQ, Zheng XL
and Liao DF: Nicotinate-curcumin impedes foam cell formation from
THP-1 cells through restoring autophagy flux. PLoS One.
11(e0154820)2016.PubMed/NCBI View Article : Google Scholar
|
|
46
|
Li G, Peng J, Liu Y, Li X, Yang Q, Li Y,
Tang Z, Wang Z, Jiang Z and Wei D: Oxidized low-density lipoprotein
inhibits THP-1-derived macrophage autophagy via TET2
down-regulation. Lipids. 50:177–183. 2015.PubMed/NCBI View Article : Google Scholar
|
|
47
|
Huang B, Jin M, Yan H, Cheng Y, Huang D,
Ying S and Zhang L: Simvastatin enhances oxidized-low density
lipoprotein-induced macrophage autophagy and attenuates lipid
aggregation. Mol Med Rep. 11:1093–1098. 2015.PubMed/NCBI View Article : Google Scholar
|
|
48
|
Zhang BC, Zhang CW, Wang C, Pan DF, Xu TD
and Li DY: Luteolin attenuates foam cell formation and apoptosis in
Ox-LDL-stimulated macrophages by enhancing autophagy. Cell Physiol
Biochem. 39:2065–2076. 2016.PubMed/NCBI View Article : Google Scholar
|
|
49
|
Wu H, Feng K, Zhang C, Zhang H, Zhang J,
Hua Y, Dong Z, Zhu Y, Yang S and Ma C: Metformin attenuates
atherosclerosis and plaque vulnerability by upregulating
KLF2-mediated autophagy in apoE-/-
mice. Biochem Biophys Res Commun. 557:334–341. 2021.PubMed/NCBI View Article : Google Scholar
|
|
50
|
Hsieh PN, Zhou G, Yuan Y, Zhang R,
Prosdocimo DA, Sangwung P, Borton AH, Boriushkin E, Hamik A,
Fujioka H, et al: A conserved KLF-autophagy pathway modulates
nematode lifespan and mammalian age-associated vascular
dysfunction. Nat Commun. 8(914)2017.PubMed/NCBI View Article : Google Scholar
|
|
51
|
Kobayashi A, Kang MI, Okawa H, Ohtsuji M,
Zenke Y, Chiba T, Igarashi K and Yamamoto M: Oxidative stress
sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to
regulate proteasomal degradation of Nrf2. Mol Cell Biol.
24:7130–7139. 2004.PubMed/NCBI View Article : Google Scholar
|
|
52
|
Zhang DD, Lo SC, Cross JV, Templeton DJ
and Hannink M: Keap1 is a redox-regulated substrate adaptor protein
for a Cul3-dependent ubiquitin ligase complex. Mol Cell Biol.
24:10941–10953. 2004.PubMed/NCBI View Article : Google Scholar
|
|
53
|
Donovan EL, McCord JM, Reuland DJ, Miller
BF and Hamilton KL: Phytochemical activation of Nrf2 protects human
coronary artery endothelial cells against an oxidative challenge.
Oxid Med Cell Longev. 2012(132931)2012.PubMed/NCBI View Article : Google Scholar
|
|
54
|
Hu Q, Zhang T, Yi L, Zhou X and Mi M:
Dihydromyricetin inhibits NLRP3 inflammasome-dependent pyroptosis
by activating the Nrf2 signaling pathway in vascular endothelial
cells. Biofactors. 44:123–136. 2018.PubMed/NCBI View Article : Google Scholar
|
|
55
|
Liu Z, Wang J, Huang E, Gao S, Li H, Lu J,
Tian K, Little PJ, Shen X, Xu S and Liu P: Tanshinone IIA
suppresses cholesterol accumulation in human macrophages: Role of
heme oxygenase-1. J Lipid Res. 55:201–213. 2014.PubMed/NCBI View Article : Google Scholar
|
|
56
|
Lu Q, Tang SL, Liu XY, Zhao GJ, Ouyang XP,
Lv YC, He PP, Yao F, Chen WJ, Tang YY, et al:
Tertiary-butylhydroquinone upregulates expression of ATP-binding
cassette transporter A1 via nuclear factor E2-related factor 2/heme
oxygenase-1 signaling in THP-1 macrophage-derived foam cells. Circ
J. 77:2399–2408. 2013.PubMed/NCBI View Article : Google Scholar
|
|
57
|
Wang J, Liu Z, Hu T, Han L, Yu S, Yao Y,
Ruan Z, Tian T, Huang T, Wang M, et al: Nrf2 promotes progression
of non-small cell lung cancer through activating autophagy. Cell
Cycle. 16:1053–1062. 2017.PubMed/NCBI View Article : Google Scholar
|
|
58
|
Lazaro I, Lopez-Sanz L, Bernal S, Oguiza
A, Recio C, Melgar A, Jimenez-Castilla L, Egido J, Madrigal-Matute
J and Gomez-Guerrero C: Nrf2 activation provides atheroprotection
in diabetic mice through concerted upregulation of antioxidant,
anti-inflammatory, and autophagy mechanisms. Front Pharmacol.
9(819)2018.PubMed/NCBI View Article : Google Scholar
|
|
59
|
Fledderus JO, Boon RA, Volger OL, Hurttila
H, Ylä-Herttuala S, Pannekoek H, Levonen AL and Horrevoets AJ: KLF2
primes the antioxidant transcription factor Nrf2 for activation in
endothelial cells. Arterioscler Thromb Vasc Biol. 28:1339–1346.
2008.PubMed/NCBI View Article : Google Scholar
|
|
60
|
He LH, Gao JH, Yu XH, Wen FJ, Luo JJ, Qin
YS, Chen MX, Zhang DW, Wang ZB and Tang CK: Artesunate inhibits
atherosclerosis by upregulating vascular smooth muscle
cells-derived LPL expression via the KLF2/NRF2/TCF7L2 pathway. Eur
J Pharmacol. 884(173408)2020.PubMed/NCBI View Article : Google Scholar
|
