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Efficacy and safety of adjuvant therapy with PD‑1/PD‑L1 inhibitors in cancer

  • Authors:
    • Dun-Chang Mo
    • Zi-Yu Liang
    • Long Chen
    • Jian-Feng Huang
    • Peng-Hui Luo
    • Han-Lei Wang
  • View Affiliations / Copyright

    Affiliations: Radiotherapy Department, The Third Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530000, P.R. China, Department of Gastroenterology, The Third Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530000, P.R. China, Ear, Nose and Throat and Head and Neck Surgery Department, The Third Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530000, P.R. China
    Copyright: © Mo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 749
    |
    Published online on: November 8, 2022
       https://doi.org/10.3892/etm.2022.11685
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Abstract

Anti‑programmed cell death protein‑1 (PD‑1)/programmed cell death 1 ligand 1 (PD‑L1) antibodies have been widely used in cancers. The present study aimed to evaluate the efficacy and safety of PD‑1/PD‑L1 inhibitors in human cancers. Studies were searched from Cochrane Library, PubMed and Embase databases. Randomized controlled trials (RCTs) that investigated adjuvant therapy with anti‑PD‑1/PD‑L1 agents in solid cancers were eligible for inclusion. As the primary focus of the meta‑analysis, clinical outcome measures including overall survival (OS), disease‑free survival (DFS), and adverse events (AEs) were analyzed by Stata 15.0 software. A total of six RCTs (n=4,436) met the inclusion criteria. The DFS [hazard ratio (HR)=0.71; 95% confidence interval (CI): 0.63‑0.78; P<0.001] and OS (HR=0.66, 95% CI: 0.46‑0.86, P<0.001) of patients were significantly prolonged by adjuvant immunotherapy. Subgroup analysis indicated that significantly improved DFS was observed in patients treated with different anti‑PD‑1/PD‑L1 drugs (nivolumab, pembrolizumab, or atezolizumab), as well as in those with different tumors (melanoma, urothelial carcinoma, esophageal or gastroesophageal junction cancer, or renal cell carcinoma), and PD‑L1 status [negative (<1%) or positive (≥1%)]. However, PD‑1/PD‑L1 inhibitors was associated with increased ≥ grade 3 treatment‑related AEs (odds ratio=1.63; 95% CI: 1.20‑2.21; P=0.002). The available evidence suggests that adjuvant therapy with PD‑1/PD‑L1 inhibitors provided more survival benefit than placebo for patients with cancer, with increased grade 3 or higher AEs. Prospero registration no. CRD42021290654.
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1 

Wyld L, Audisio RA and Poston GJ: The evolution of cancer surgery and future perspectives. Nat Rev Clin Oncol. 12:115–124. 2015.PubMed/NCBI View Article : Google Scholar

2 

Hortobagyi GN and Buzdar AU: Current status of adjuvant systemic therapy for primary breast cancer: Progress and controversy. CA Cancer J Clin. 45:199–226. 1995.PubMed/NCBI View Article : Google Scholar

3 

Pondé NF, Zardavas D and Piccart M: Progress in adjuvant systemic therapy for breast cancer. Nat Rev Clin Oncol. 16:27–44. 2019.PubMed/NCBI View Article : Google Scholar

4 

Maehara Y, Baba H and Sugimachi K: Adjuvant chemotherapy for gastric cancer: A comprehensive review. Gastric Cancer. 4:175–184. 2001.PubMed/NCBI View Article : Google Scholar

5 

Minsky BD: Adjuvant radiation therapy for colon cancer. Cancer Treat Rev. 21:407–414. 1995.PubMed/NCBI View Article : Google Scholar

6 

Osborne CK: Tamoxifen in the treatment of breast cancer. N Engl J Med. 339:1609–1618. 1998.PubMed/NCBI View Article : Google Scholar

7 

Joensuu H, Eriksson M, Sundby Hall K, Reichardt A, Hermes B, Schütte J, Cameron S, Hohenberger P, Jost PJ, Al-Batran SE, et al: Survival outcomes associated with 3 years vs 1 year of adjuvant imatinib for patients with high-risk gastrointestinal stromal tumors: An analysis of a randomized clinical trial after 10-year follow-up. JAMA Oncol. 6:1241–1246. 2020.PubMed/NCBI View Article : Google Scholar

8 

Wu YL, Tsuboi M, He J, John T, Grohe C, Majem M, Goldman JW, Laktionov K, Kim SW, Kato T, et al: Osimertinib in resected EGFR-mutated non-small-cell lung cancer. N Engl J Med. 383:1711–1723. 2020.PubMed/NCBI View Article : Google Scholar

9 

Suhail Y, Cain MP, Vanaja K, Kurywchak PA, Levchenko A, Kalluri R and Kshitiz  : Systems biology of cancer metastasis. Cell Syst. 9:109–127. 2019.PubMed/NCBI View Article : Google Scholar

10 

Li T, Jia DD and Teng LS: Adjuvant pembrolizumab versus high-dose interferon α-2b for Chinese patients with resected stage III melanoma: A retrospective cohort study. Invest New Drugs. 38:1334–1341. 2020.PubMed/NCBI View Article : Google Scholar

11 

Ascierto PA, Del Vecchio M, Mandalá M, Gogas H, Arance AM, Dalle S, Cowey CL, Schenker M, Grob JJ, Chiarion-Sileni V, et al: Adjuvant nivolumab versus ipilimumab in resected stage IIIB-C and stage IV melanoma (CheckMate 238): 4-Year results from a multicentre, double-blind, randomised, controlled, phase 3 trial. Lancet Oncol. 21:1465–1477. 2020.PubMed/NCBI View Article : Google Scholar

12 

Felip E, Altorki N, Zhou C, Csőszi T, Vynnychenko I, Goloborodko O, Luft A, Akopov A, Martinez-Marti A, Kenmotsu H, et al: Adjuvant atezolizumab after adjuvant chemotherapy in resected stage IB-IIIA non-small-cell lung cancer (IMpower010): A randomised, multicentre, open-label, phase 3 trial. Lancet. 398:1344–1357. 2021.PubMed/NCBI View Article : Google Scholar

13 

Eggermont AMM, Blank CU, Mandala M, Long GV, Atkinson V, Dalle S, Haydon A, Lichinitser M, Khattak A, Carlino MS, et al: Adjuvant pembrolizumab versus placebo in resected stage III melanoma. N Engl J Med. 378:1789–1801. 2018.PubMed/NCBI View Article : Google Scholar

14 

Choueiri TK, Tomczak P, Park SH, Venugopal B, Ferguson T, Chang YH, Hajek J, Symeonides SN, Lee JL, Sarwar N, et al: Adjuvant pembrolizumab after nephrectomy in renal-cell carcinoma. N Engl J Med. 385:683–694. 2021.PubMed/NCBI View Article : Google Scholar

15 

Bajorin DF, Witjes JA, Gschwend JE, Schenker M, Valderrama BP, Tomita Y, Bamias A, Lebret T, Shariat SF, Park SH, et al: Adjuvant nivolumab versus placebo in muscle-invasive urothelial carcinoma. N Engl J Med. 384:2102–2114. 2021.PubMed/NCBI View Article : Google Scholar

16 

Zimmer L, Livingstone E, Hassel JC, Fluck M, Eigentler T, Loquai C, Haferkamp S, Gutzmer R, Meier F, Mohr P, et al: Adjuvant nivolumab plus ipilimumab or nivolumab monotherapy versus placebo in patients with resected stage IV melanoma with no evidence of disease (IMMUNED): A randomised, double-blind, placebo-controlled, phase 2 trial. Lancet. 395:1558–1568. 2020.PubMed/NCBI View Article : Google Scholar

17 

Kelly RJ, Ajani JA, Kuzdzal J, Zander T, Van Cutsem E, Piessen G, Mendez G, Feliciano J, Motoyama S, Lièvre A, et al: Adjuvant nivolumab in resected esophageal or gastroesophageal junction cancer. N Engl J Med. 384:1191–1203. 2021.PubMed/NCBI View Article : Google Scholar

18 

Bellmunt J, Hussain M, Gschwend JE, Albers P, Oudard S, Castellano D, Daneshmand S, Nishiyama H, Majchrowicz M, Degaonkar V, et al: Adjuvant atezolizumab versus observation in muscle-invasive urothelial carcinoma (IMvigor010): A multicentre, open-label, randomised, phase 3 trial. Lancet Oncol. 22:525–537. 2021.PubMed/NCBI View Article : Google Scholar

19 

Higgins JP, Altman DG, Gøtzsche PC, Jüni P, Moher D, Oxman AD, Savovic J, Schulz KF, Weeks L, Sterne JA, et al: The cochrane collaboration's tool for assessing risk of bias in randomised trials. BMJ. 343(d5928)2011.PubMed/NCBI View Article : Google Scholar

20 

de Miguel M and Calvo E: Clinical challenges of immune checkpoint inhibitors. Cancer Cell. 38:326–333. 2020.PubMed/NCBI View Article : Google Scholar

21 

Xiao BY, Lin GH, Zhao YX and Wang BC: The efficacy and safety of PD-1/PD-L1 inhibitors in breast cancer: A systematic review and meta-analysis. Transl Cancer Res. 9:3804–3818. 2020.PubMed/NCBI View Article : Google Scholar

22 

Topalian SL, Hodi FS, Brahmer JR, Gettinger SN, Smith DC, McDermott DF, Powderly JD, Carvajal RD, Sosman JA, Atkins MB, et al: Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med. 366:2443–2454. 2012.PubMed/NCBI View Article : Google Scholar

23 

Sunshine J and Taube JM: PD-1/PD-L1 inhibitors. Curr Opin Pharmacol. 23:32–38. 2015.PubMed/NCBI View Article : Google Scholar

24 

Eggermont AMM, Blank CU, Mandalà M, Long GV, Atkinson VG, Dalle S, Haydon AM, Meshcheryakov A, Khattak A, Carlino MS, et al: Adjuvant pembrolizumab versus placebo in resected stage III melanoma (EORTC 1325-MG/KEYNOTE-054): Distant metastasis-free survival results from a double-blind, randomised, controlled, phase 3 trial. Lancet Oncol. 22:643–654. 2021.PubMed/NCBI View Article : Google Scholar

25 

Eggermont AM, Chiarion-Sileni V, Grob JJ, Dummer R, Wolchok JD, Schmidt H, Hamid O, Robert C, Ascierto PA, Richards JM, et al: Adjuvant ipilimumab versus placebo after complete resection of high-risk stage III melanoma (EORTC 18071): A randomised, double-blind, phase 3 trial. Lancet Oncol. 16:522–530. 2015.PubMed/NCBI View Article : Google Scholar

26 

Seya T, Takeda Y, Takashima K, Yoshida S, Azuma M and Matsumoto M: Adjuvant immunotherapy for cancer: Both dendritic cell-priming and check-point inhibitor blockade are required for immunotherapy. Proc Jpn Acad Ser B Phys Biol Sci. 94:153–160. 2018.PubMed/NCBI View Article : Google Scholar

27 

Mocellin S, Rossi CR, Lise M and Marincola FM: Adjuvant immunotherapy for solid tumors: From promise to clinical application. Cancer Immunol Immunother. 51:583–595. 2002.PubMed/NCBI View Article : Google Scholar

28 

Naidoo J, Page DB, Li BT, Connell LC, Schindler K, Lacouture ME, Postow MA and Wolchok JD: Toxicities of the anti-PD-1 and anti-PD-L1 immune checkpoint antibodies. Ann Oncol. 26:2375–2391. 2015.PubMed/NCBI View Article : Google Scholar

29 

Gong J, Chehrazi-Raffle A, Reddi S and Salgia R: Development of PD-1 and PD-L1 inhibitors as a form of cancer immunotherapy: A comprehensive review of registration trials and future considerations. J Immunother Cancer. 6(8)2018.PubMed/NCBI View Article : Google Scholar

30 

Galsky MD, Mortazavi A, Milowsky MI, George S, Gupta S, Fleming MT, Dang LH, Geynisman DM, Walling R, Alter RS, et al: Randomized double-blind phase II study of maintenance pembrolizumab versus placebo after first-line chemotherapy in patients with metastatic urothelial cancer. J Clin Oncol. 38:1797–1806. 2020.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Mo D, Liang Z, Chen L, Huang J, Luo P and Wang H: Efficacy and safety of adjuvant therapy with PD‑1/PD‑L1 inhibitors in cancer. Exp Ther Med 24: 749, 2022.
APA
Mo, D., Liang, Z., Chen, L., Huang, J., Luo, P., & Wang, H. (2022). Efficacy and safety of adjuvant therapy with PD‑1/PD‑L1 inhibitors in cancer. Experimental and Therapeutic Medicine, 24, 749. https://doi.org/10.3892/etm.2022.11685
MLA
Mo, D., Liang, Z., Chen, L., Huang, J., Luo, P., Wang, H."Efficacy and safety of adjuvant therapy with PD‑1/PD‑L1 inhibitors in cancer". Experimental and Therapeutic Medicine 24.6 (2022): 749.
Chicago
Mo, D., Liang, Z., Chen, L., Huang, J., Luo, P., Wang, H."Efficacy and safety of adjuvant therapy with PD‑1/PD‑L1 inhibitors in cancer". Experimental and Therapeutic Medicine 24, no. 6 (2022): 749. https://doi.org/10.3892/etm.2022.11685
Copy and paste a formatted citation
x
Spandidos Publications style
Mo D, Liang Z, Chen L, Huang J, Luo P and Wang H: Efficacy and safety of adjuvant therapy with PD‑1/PD‑L1 inhibitors in cancer. Exp Ther Med 24: 749, 2022.
APA
Mo, D., Liang, Z., Chen, L., Huang, J., Luo, P., & Wang, H. (2022). Efficacy and safety of adjuvant therapy with PD‑1/PD‑L1 inhibitors in cancer. Experimental and Therapeutic Medicine, 24, 749. https://doi.org/10.3892/etm.2022.11685
MLA
Mo, D., Liang, Z., Chen, L., Huang, J., Luo, P., Wang, H."Efficacy and safety of adjuvant therapy with PD‑1/PD‑L1 inhibitors in cancer". Experimental and Therapeutic Medicine 24.6 (2022): 749.
Chicago
Mo, D., Liang, Z., Chen, L., Huang, J., Luo, P., Wang, H."Efficacy and safety of adjuvant therapy with PD‑1/PD‑L1 inhibitors in cancer". Experimental and Therapeutic Medicine 24, no. 6 (2022): 749. https://doi.org/10.3892/etm.2022.11685
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