Open Access

Molecular mechanisms of multidrug resistance in clinically relevant enteropathogenic bacteria (Review)

  • Authors:
    • Julia Alexsandra González‑Villarreal
    • Katia Jamileth González‑Lozano
    • Elva Teresa Aréchiga‑Carvajal
    • Jesús Antonio Morlett‑Chávez
    • Miriam Paulina Luévanos‑Escareño
    • Nagamani Balagurusamy
    • Mauricio Andrés Salinas‑santander
  • View Affiliations

  • Published online on: November 8, 2022     https://doi.org/10.3892/etm.2022.11689
  • Article Number: 753
  • Copyright: © González‑Villarreal et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Multidrug resistant (MDR) enteropathogenic bacteria are a growing problem within the clinical environment due to their acquired tolerance to a wide range of antibiotics, thus causing severe illnesses and a tremendous economic impact in the healthcare sector. Due to its difficult treatment, knowledge and understanding of the molecular mechanisms that confer this resistance are needed. The aim of the present review is to describe the mechanisms of antibiotic resistance from a genomic perspective observed in bacteria, including naturally acquired resistance. The present review also discusses common pharmacological and alternative treatments used in cases of infection caused by MDR bacteria, thus covering necessary information for the development of novel antimicrobials and adjuvant molecules inhibiting bacterial proliferation.

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December-2022
Volume 24 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
González‑Villarreal JA, González‑Lozano KJ, Aréchiga‑Carvajal ET, Morlett‑Chávez JA, Luévanos‑Escareño MP, Balagurusamy N and Salinas‑santander MA: Molecular mechanisms of multidrug resistance in clinically relevant enteropathogenic bacteria (Review). Exp Ther Med 24: 753, 2022
APA
González‑Villarreal, J.A., González‑Lozano, K.J., Aréchiga‑Carvajal, E.T., Morlett‑Chávez, J.A., Luévanos‑Escareño, M.P., Balagurusamy, N., & Salinas‑santander, M.A. (2022). Molecular mechanisms of multidrug resistance in clinically relevant enteropathogenic bacteria (Review). Experimental and Therapeutic Medicine, 24, 753. https://doi.org/10.3892/etm.2022.11689
MLA
González‑Villarreal, J. A., González‑Lozano, K. J., Aréchiga‑Carvajal, E. T., Morlett‑Chávez, J. A., Luévanos‑Escareño, M. P., Balagurusamy, N., Salinas‑santander, M. A."Molecular mechanisms of multidrug resistance in clinically relevant enteropathogenic bacteria (Review)". Experimental and Therapeutic Medicine 24.6 (2022): 753.
Chicago
González‑Villarreal, J. A., González‑Lozano, K. J., Aréchiga‑Carvajal, E. T., Morlett‑Chávez, J. A., Luévanos‑Escareño, M. P., Balagurusamy, N., Salinas‑santander, M. A."Molecular mechanisms of multidrug resistance in clinically relevant enteropathogenic bacteria (Review)". Experimental and Therapeutic Medicine 24, no. 6 (2022): 753. https://doi.org/10.3892/etm.2022.11689