Open Access

Genetic association between the PTPN22, IRF5 and TYK2 gene variants and susceptibility to juvenile idiopathic arthritis

  • Authors:
    • Yufeng Qian
    • Bingqian Chen
    • Zhengfei Wang
    • Yuqin Peng
  • View Affiliations

  • Published online on: November 9, 2022     https://doi.org/10.3892/etm.2022.11692
  • Article Number: 756
  • Copyright: © Qian et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Abstract. Juvenile idiopathic arthritis (JIA) refers to a group of chronic childhood arthropathies of unknown etiology. In the present study, the genetic association between the variants in PTPN22, IRF5 and TYK2 genes and susceptibility to JIA was investigated. The distributions of 16 variants in PTPN22, IRF5 and TYK2 genes were analyzed by direct sequencing in 378 patients with JIA and 378 healthy controls. Odds ratios and 95% confidence intervals were used to evaluate the association between the gene variants and JIA. The gene‑gene interactions were investigated using multifactor dimensionality reduction. All allelic and dominant models of PTPN22 rs1214414, rs1214418, rs1746853, rs3765598 and rs3811021 were significantly associated with JIA risk (P<0.05). IRF5 rs10954213 in both allelic and dominant models, as well as the allelic model of rs2004640, was significantly related to JIA risk (P<0.05). In addition, the allelic, recessive and dominant models of TYK2 rs280500, rs280519, rs2304256 and rs12720270 were significantly related to JIA risk (P<0.05). In addition, three haplotypes (HC A G T C C, HC A G T T C and HC G T T C T ) in PTPN22 gene, three haplotypes (HD T A A, HI T A C and HD T G C) in IRF5 gene and two haplotypes (HA G G A T and HG A G G T) in TYK2 gene were associated with the risk of JIA (P<0.05). Furthermore, a three‑way interaction between IRF5 rs10954213, rs2004640 and PTPN22 rs1214414 was shown to be associated with JIA risk. In conclusion, PTPN22 rs1214418, rs1746853, rs3765598, IRF5 rs2004640, TYK2 rs280500, rs2304256 and a three‑way interaction between IRF5 rs10954213, rs2004640 and PTPN22 rs1214414 may be risk factors for JIA.

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December-2022
Volume 24 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Qian Y, Chen B, Wang Z and Peng Y: Genetic association between the <em>PTPN22</em>, <em>IRF5</em> and <em>TYK2</em> gene variants and susceptibility to juvenile idiopathic arthritis. Exp Ther Med 24: 756, 2022
APA
Qian, Y., Chen, B., Wang, Z., & Peng, Y. (2022). Genetic association between the <em>PTPN22</em>, <em>IRF5</em> and <em>TYK2</em> gene variants and susceptibility to juvenile idiopathic arthritis. Experimental and Therapeutic Medicine, 24, 756. https://doi.org/10.3892/etm.2022.11692
MLA
Qian, Y., Chen, B., Wang, Z., Peng, Y."Genetic association between the <em>PTPN22</em>, <em>IRF5</em> and <em>TYK2</em> gene variants and susceptibility to juvenile idiopathic arthritis". Experimental and Therapeutic Medicine 24.6 (2022): 756.
Chicago
Qian, Y., Chen, B., Wang, Z., Peng, Y."Genetic association between the <em>PTPN22</em>, <em>IRF5</em> and <em>TYK2</em> gene variants and susceptibility to juvenile idiopathic arthritis". Experimental and Therapeutic Medicine 24, no. 6 (2022): 756. https://doi.org/10.3892/etm.2022.11692