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Role of macrophage polarization in osteoarthritis (Review)

  • Authors:
    • Baisen Chen
    • Hongxiang Hong
    • Yuyu Sun
    • Chu Chen
    • Chunshuai Wu
    • Guanhua Xu
    • Guofeng Bao
    • Zhiming Cui
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, Nantong City No 1 People's Hospital and Second Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China, Department of Orthopedic, Nantong Third People's Hospital, Nantong, Jiangsu 226003, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 757
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    Published online on: November 9, 2022
       https://doi.org/10.3892/etm.2022.11693
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Abstract

Osteoarthritis (OA) is a disease involving the whole joint that seriously reduces the living standards of individuals. Traditional treatments include physical therapy, administration of anti‑inflammatory and analgesic drugs and injection of glucocorticoids or hyaluronic acid into the joints. However, these methods have limited efficacy and it is difficult to reverse the progression of OA, therefore it is urgent to find new effective treatment methods. Immune microenvironment is significant in the occurrence and development of OA. Recent studies have shown that macrophages are important targets for the treatment of OA. Macrophages are polarized into M1 pro‑inflammatory phenotype and M2 anti‑inflammatory phenotype under stimulation of different factors, which release and regulate inflammatory response and cartilage growth. Accumulating studies have tried to alleviate OA by regulating macrophage homeostasis. The present study summarized the related studies, discuss the mechanism of various therapeutic reagents on OA, expound the molecular mechanism of drug effect on OA and attempted to provide clues for the treatment of OA.
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Copy and paste a formatted citation
Spandidos Publications style
Chen B, Hong H, Sun Y, Chen C, Wu C, Xu G, Bao G and Cui Z: Role of macrophage polarization in osteoarthritis (Review). Exp Ther Med 24: 757, 2022.
APA
Chen, B., Hong, H., Sun, Y., Chen, C., Wu, C., Xu, G. ... Cui, Z. (2022). Role of macrophage polarization in osteoarthritis (Review). Experimental and Therapeutic Medicine, 24, 757. https://doi.org/10.3892/etm.2022.11693
MLA
Chen, B., Hong, H., Sun, Y., Chen, C., Wu, C., Xu, G., Bao, G., Cui, Z."Role of macrophage polarization in osteoarthritis (Review)". Experimental and Therapeutic Medicine 24.6 (2022): 757.
Chicago
Chen, B., Hong, H., Sun, Y., Chen, C., Wu, C., Xu, G., Bao, G., Cui, Z."Role of macrophage polarization in osteoarthritis (Review)". Experimental and Therapeutic Medicine 24, no. 6 (2022): 757. https://doi.org/10.3892/etm.2022.11693
Copy and paste a formatted citation
x
Spandidos Publications style
Chen B, Hong H, Sun Y, Chen C, Wu C, Xu G, Bao G and Cui Z: Role of macrophage polarization in osteoarthritis (Review). Exp Ther Med 24: 757, 2022.
APA
Chen, B., Hong, H., Sun, Y., Chen, C., Wu, C., Xu, G. ... Cui, Z. (2022). Role of macrophage polarization in osteoarthritis (Review). Experimental and Therapeutic Medicine, 24, 757. https://doi.org/10.3892/etm.2022.11693
MLA
Chen, B., Hong, H., Sun, Y., Chen, C., Wu, C., Xu, G., Bao, G., Cui, Z."Role of macrophage polarization in osteoarthritis (Review)". Experimental and Therapeutic Medicine 24.6 (2022): 757.
Chicago
Chen, B., Hong, H., Sun, Y., Chen, C., Wu, C., Xu, G., Bao, G., Cui, Z."Role of macrophage polarization in osteoarthritis (Review)". Experimental and Therapeutic Medicine 24, no. 6 (2022): 757. https://doi.org/10.3892/etm.2022.11693
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