Open Access

Role of macrophage polarization in osteoarthritis (Review)

  • Authors:
    • Baisen Chen
    • Hongxiang Hong
    • Yuyu Sun
    • Chu Chen
    • Chunshuai Wu
    • Guanhua Xu
    • Guofeng Bao
    • Zhiming Cui
  • View Affiliations

  • Published online on: November 9, 2022     https://doi.org/10.3892/etm.2022.11693
  • Article Number: 757
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Osteoarthritis (OA) is a disease involving the whole joint that seriously reduces the living standards of individuals. Traditional treatments include physical therapy, administration of anti‑inflammatory and analgesic drugs and injection of glucocorticoids or hyaluronic acid into the joints. However, these methods have limited efficacy and it is difficult to reverse the progression of OA, therefore it is urgent to find new effective treatment methods. Immune microenvironment is significant in the occurrence and development of OA. Recent studies have shown that macrophages are important targets for the treatment of OA. Macrophages are polarized into M1 pro‑inflammatory phenotype and M2 anti‑inflammatory phenotype under stimulation of different factors, which release and regulate inflammatory response and cartilage growth. Accumulating studies have tried to alleviate OA by regulating macrophage homeostasis. The present study summarized the related studies, discuss the mechanism of various therapeutic reagents on OA, expound the molecular mechanism of drug effect on OA and attempted to provide clues for the treatment of OA.

Related Articles

Journal Cover

December-2022
Volume 24 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Chen B, Hong H, Sun Y, Chen C, Wu C, Xu G, Bao G and Cui Z: Role of macrophage polarization in osteoarthritis (Review). Exp Ther Med 24: 757, 2022
APA
Chen, B., Hong, H., Sun, Y., Chen, C., Wu, C., Xu, G. ... Cui, Z. (2022). Role of macrophage polarization in osteoarthritis (Review). Experimental and Therapeutic Medicine, 24, 757. https://doi.org/10.3892/etm.2022.11693
MLA
Chen, B., Hong, H., Sun, Y., Chen, C., Wu, C., Xu, G., Bao, G., Cui, Z."Role of macrophage polarization in osteoarthritis (Review)". Experimental and Therapeutic Medicine 24.6 (2022): 757.
Chicago
Chen, B., Hong, H., Sun, Y., Chen, C., Wu, C., Xu, G., Bao, G., Cui, Z."Role of macrophage polarization in osteoarthritis (Review)". Experimental and Therapeutic Medicine 24, no. 6 (2022): 757. https://doi.org/10.3892/etm.2022.11693