Open Access

Clinical characteristics and predictors of burn complicated with smoke inhalation injury: A retrospective analysis

  • Authors:
    • Zhifang Niu
    • Ziling Ding
    • Yion Chan
    • Li Yan
    • Wenyu Zhang
    • Hongyu Wang
    • Jie Shi
    • Qi Lv
    • Shike Hou
    • Xiaoqin Guo
    • Haojun Fan
  • View Affiliations

  • Published online on: November 9, 2022     https://doi.org/10.3892/etm.2022.11694
  • Article Number: 758
  • Copyright: © Niu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Fire smoke enters the human lungs through the respiratory tract. The damage to the respiratory tract and lung tissue is known as smoke inhalation injury (SII). Fire smoke can irritate airway epithelium cells, weaken endothelial cell adhesion and lyse alveolar type II epithelia cells, leading to emphysema, decreased lung function, pneumonia and risk of acute lung injury/acute respiratory distress syndrome (ARDS). The purpose of the present study was to analyze the clinical characteristics of patients with SII and the risk factors affecting their prognosis. A total of 103 patients with SII admitted between January 2016 to December 2021 to the Burns Unit of the Characteristic Medical Center of Chinese People's Armed Police Force and 983 Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army were selected for the present study. The demographics and clinical features between different severities of SII were analyzed. Univariate/multivariate logistic regression was used to analyze the potential predictors for severity, ARDS and mortality of patients with SII. Receiver operating characteristic (ROC) curves were used to screen independent risk factors and identify their prediction accuracy. It was concluded that total body surface area (TBSA), III burn area (of total %TBSA), cases of respiratory infections, ARDS morbidity, mortality, acute physiology and chronic health evaluation II, lung injury prediction score, lactic acid, white blood cells (WBC), alanine transaminase, blood urea nitrogen, serum creatinine and uric acid were indicators that were raised with increasing severity of SII. However red blood cells, hemoglobin, platelet count, total protein, albumin, and albumin/globulin were decreased with the increasing severity of SII (P<0.05). WBC >20.91 (109/l) was a reliable indicator for severe SII. Lactic acid >9.60 (mmol/l) demonstrated a high degree of accuracy in predicting ARDS development in patients with SII. Hemoglobin <83.00 (g/l) showed a high degree of accuracy in predicting mortality. In summary, the highlighted assessment parameters could be used to contribute to devising improved treatment plans to preempt worsening conditions (such as shock, ARDS, multiple organ dysfunction syndrome and death).

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December-2022
Volume 24 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Niu Z, Ding Z, Chan Y, Yan L, Zhang W, Wang H, Shi J, Lv Q, Hou S, Guo X, Guo X, et al: Clinical characteristics and predictors of burn complicated with smoke inhalation injury: A retrospective analysis. Exp Ther Med 24: 758, 2022
APA
Niu, Z., Ding, Z., Chan, Y., Yan, L., Zhang, W., Wang, H. ... Fan, H. (2022). Clinical characteristics and predictors of burn complicated with smoke inhalation injury: A retrospective analysis. Experimental and Therapeutic Medicine, 24, 758. https://doi.org/10.3892/etm.2022.11694
MLA
Niu, Z., Ding, Z., Chan, Y., Yan, L., Zhang, W., Wang, H., Shi, J., Lv, Q., Hou, S., Guo, X., Fan, H."Clinical characteristics and predictors of burn complicated with smoke inhalation injury: A retrospective analysis". Experimental and Therapeutic Medicine 24.6 (2022): 758.
Chicago
Niu, Z., Ding, Z., Chan, Y., Yan, L., Zhang, W., Wang, H., Shi, J., Lv, Q., Hou, S., Guo, X., Fan, H."Clinical characteristics and predictors of burn complicated with smoke inhalation injury: A retrospective analysis". Experimental and Therapeutic Medicine 24, no. 6 (2022): 758. https://doi.org/10.3892/etm.2022.11694