Open Access

Lipomembranous fat necrosis: A distinctive and unique morphology (Review)

  • Authors:
    • Susumu Matsukuma
    • Ayano Matsunaga
    • Oh Takahashi
    • Sho Ogata
  • View Affiliations

  • Published online on: November 9, 2022     https://doi.org/10.3892/etm.2022.11695
  • Article Number: 759
  • Copyright: © Matsukuma et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Lipomembranous fat necrosis (LFN) is an uncommon but distinct form of fat necrosis, which is characterized by eosinophilic, crenulated and/or serpiginous membranes. LFN exhibits macrocystic, microcystic and/or crushed features. LFN is routinely detectable on hematoxylin and eosin (H&E)‑stained sections, and is present both in the acute phase and in the later or fibrous stage of necrotic fatty lesions. Smaller crushed LFN embedded within fibrous tissues may be difficult to recognize on H&E‑stained sections, but can be highlighted by some staining techniques, including Masson trichrome, periodic acid‑Schiff, orcein, long Ziehl‑Neelsen stain, silver impregnation, phosphotungstic acid‑hematoxylin and luxol fast blue staining. LFN was initially considered a specific feature of Nasu‑Hakola disease, but has since been identified in various subcutaneous or intraabdominal lesions related to ischemic conditions or venous insufficiency. In addition, LFN is detectable in intra‑articular loose bodies and aortic valves with or without dysfunction, suggesting that LFN is also associated with ischemia‑like hypoxic conditions or malnutrition. LFN is considered to be a histological hallmark of hidden ischemic or hypoxic/malnourished conditions in various diseases; however, the exact mechanisms of LFN remain poorly understood. The present review described the clinicopathological features of this interesting, but poorly characterized, condition.

Related Articles

Journal Cover

December-2022
Volume 24 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Matsukuma S, Matsunaga A, Takahashi O and Ogata S: Lipomembranous fat necrosis: A distinctive and unique morphology (Review). Exp Ther Med 24: 759, 2022
APA
Matsukuma, S., Matsunaga, A., Takahashi, O., & Ogata, S. (2022). Lipomembranous fat necrosis: A distinctive and unique morphology (Review). Experimental and Therapeutic Medicine, 24, 759. https://doi.org/10.3892/etm.2022.11695
MLA
Matsukuma, S., Matsunaga, A., Takahashi, O., Ogata, S."Lipomembranous fat necrosis: A distinctive and unique morphology (Review)". Experimental and Therapeutic Medicine 24.6 (2022): 759.
Chicago
Matsukuma, S., Matsunaga, A., Takahashi, O., Ogata, S."Lipomembranous fat necrosis: A distinctive and unique morphology (Review)". Experimental and Therapeutic Medicine 24, no. 6 (2022): 759. https://doi.org/10.3892/etm.2022.11695