Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
January-2023 Volume 25 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2023 Volume 25 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

miR‑146a‑5p protects against renal injury in MRL/lpr mice via improvement of the Treg/Th17 imbalance by targeting the TRAF6/NF‑κB axis

  • Authors:
    • Jiajia Teng
    • Feng Yang
    • Xiaoling Li
  • View Affiliations / Copyright

    Affiliations: Department of Nephropathy, Yantai Hospital of Traditional Chinese Medicine, Yantai, Shandong 264001, P.R. China, Department of Rheumatology, Yantai Hospital of Traditional Chinese Medicine, Yantai, Shandong 264001, P.R. China
    Copyright: © Teng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 21
    |
    Published online on: November 22, 2022
       https://doi.org/10.3892/etm.2022.11720
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Dysregulated microRNA (miRNA or miR) expression is an important cause of immune homeostasis disorder in patients with systemic lupus erythematosus and lupus nephritis (LN). The present study evaluated the possibility of using miR‑146a‑5p as a therapeutic target for treating LN. The effects of miR‑146a‑5p on lupus syndrome in MRL/lpr mice were evaluated. MRL/lpr mice were injected with miR‑146a‑5p agomir (M146AG) or agomir negative control (NC). Renal function index, pathology and protein expression levels of inflammatory factors in MRL/lpr mice were evaluated after M146AG or agomir NC treatment. Reverse transcription‑quantitative PCR, western blotting and immunofluorescence were used to assess the effect of M146AG on mRNA and protein expression levels of (tumor necrosis factor receptor‑associated factor 6) TRAF6/NF‑κB axis components. A luciferase dual reporter system was used to assess the mechanism of regulation of TRAF6/NF‑κB axis expression. Finally, flow cytometry was used to assess the regulatory effect of M146AG on regulatory T cell (Treg)/T helper 17 (Th17) balance. The findings demonstrated that M146AG ameliorated renal lesions and the inflammatory response in MRL/lpr mice. TRAF6 was demonstrated to be targeted and significantly negatively regulated by miR‑146a‑5p. M146AG intervention significantly increased expression of miR‑146a‑5p and significantly downregulated the mRNA and protein expression levels of TRAF6 and NF‑κB in CD4+ T cells of MRL/lpr mice. Furthermore, M146AG intervention alleviated Treg/Th17 imbalance in MRL/lpr mice peripheral blood. The present findings demonstrated that M146AG improved Treg/Th17 imbalance and alleviated renal lesions in MRL/lpr mice by targeting the TRAF6/NF‑κB axis. This may provide a new theoretical basis for the clinical diagnosis and treatment of LN.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Mok CC and Lau CS: Pathogenesis of systemic lupus erythematosus. J Clin Pathol. 56:481–490. 2003.PubMed/NCBI View Article : Google Scholar

2 

Mohan C and Putterman C: Genetics and pathogenesis of systemic lupus erythematosus and lupus nephritis. Nat Rev Nephrol. 11:329–341. 2015.PubMed/NCBI View Article : Google Scholar

3 

Cheng T, Ding S, Liu S, Li X, Tang X and Sun L: Resolvin D1 improves the Treg/Th17 imbalance in systemic lupus erythematosus through miR-30e-5p. Front Immunol. 12(668760)2021.PubMed/NCBI View Article : Google Scholar

4 

Wu S, Ji L, Fan X, Fang S, Bao J, Yuan X, Fan Y and Xie G: Jieduquyuzishen prescription attenuates renal fibrosis in MRL/lpr mice via inhibiting EMT and TGF-β1/Smad2/3 pathway. Evid Based Complement Alternat Med. 2022(4987323)2022.PubMed/NCBI View Article : Google Scholar

5 

Li M, Yu D, Ni B and Hao F: Interleukin-1 receptor associated kinase 1 is a potential therapeutic target of anti-inflammatory therapy for systemic lupus erythematosus. Mol Immunol. 87:94–101. 2017.PubMed/NCBI View Article : Google Scholar

6 

Poissonnier A, Sanséau D, Le Gallo M, Malleter M, Levoin N, Viel R, Morere L, Penna A, Blanco P, Dupuy A, et al: CD95-mediated calcium signaling promotes T helper 17 trafficking to inflamed organs in lupus-prone mice. Immunity. 45:209–223. 2016.PubMed/NCBI View Article : Google Scholar

7 

Wang N and Tian B: Brain-derived neurotrophic factor in autoimmune inflammatory diseases (review). Exp Ther Med. 22(1292)2021.PubMed/NCBI View Article : Google Scholar

8 

Shan J, Jin H and Xu Y: T cell metabolism: A new perspective on Th17/Treg cell imbalance in systemic lupus erythematosus. Front Immunol. 11(1027)2020.PubMed/NCBI View Article : Google Scholar

9 

Tenbrock K and Rauen T: T cell dysregulation in SLE. Clin Immunol. 239(109031)2022.PubMed/NCBI View Article : Google Scholar

10 

Kubo S, Nakayamada S, Yoshikawa M, Miyazaki Y, Sakata K, Nakano K, Hanami K, Iwata S, Miyagawa I, Saito K and Tanaka Y: Peripheral immunophenotyping identifies three subgroups based on T cell heterogeneity in lupus patients. Arthritis Rheumatol. 69:2029–2037. 2017.PubMed/NCBI View Article : Google Scholar

11 

Xiao JP, Wang DY, Wang XR, Yuan L, Hao L and Wang DG: Increased ratio of Th17 cells to SIGIRR+CD4+ T cells in peripheral blood of patients with SLE is associated with disease activity. Biomed Rep. 9:339–344. 2018.PubMed/NCBI View Article : Google Scholar

12 

Mesquita D Jr, Kirsztajn GM, Franco MF, Reis LA, Perazzio SF, Mesquita FV, Ferreira VDS, Andrade LEC and de Souza AWS: CD4+ T helper cells and regulatory T cells in active lupus nephritis: an imbalance towards a predominant Th1 response? Clin Exp Immunol. 191:50–59. 2018.PubMed/NCBI View Article : Google Scholar

13 

Rafael-Vidal C, Perez N, Altabas I, Garcia S and Pego-Reigosa JM: Blocking IL-17: A promising strategy in the treatment of systemic rheumatic diseases. Int J Mol Sci. 21(7100)2020.PubMed/NCBI View Article : Google Scholar

14 

Wang X, Qiao Y, Yang L, Song S, Han Y, Tian Y, Ding M, Jin H, Shao F and Liu A: Leptin levels in patients with systemic lupus erythematosus inversely correlate with regulatory T cell frequency. Lupus. 26:1401–1406. 2017.PubMed/NCBI View Article : Google Scholar

15 

Liu B, Li J and Cairns MJ: Identifying miRNAs, targets and functions. Brief Bioinform. 15:1–19. 2014.PubMed/NCBI View Article : Google Scholar

16 

Lu Q, Wu R, Zhao M, Garcia-Gomez A and Ballestar E: miRNAs as therapeutic targets in inflammatory disease. Trends Pharmacol Sci. 40:853–865. 2019.PubMed/NCBI View Article : Google Scholar

17 

Schell SL and Rahman ZSM: miRNA-Mediated control of B cell responses in immunity and SLE. Front Immunol. 12(683710)2021.PubMed/NCBI View Article : Google Scholar

18 

Zhang J, Liu Y and Shi G: The circRNA-miRNA-mRNA regulatory network in systemic lupus erythematosus. Clin Rheumatol. 40:331–339. 2021.PubMed/NCBI View Article : Google Scholar

19 

Zhou S, Zhang J, Luan P, Ma Z, Dang J, Zhu H, Ma Q, Wang Y and Huo Z: miR-183-5p is a potential molecular marker of systemic lupus erythematosus. J Immunol Res. 2021(5547635)2021.PubMed/NCBI View Article : Google Scholar

20 

Cheng T, Ding S, Liu S, Li Y and Sun L: Human umbilical cord-derived mesenchymal stem cell therapy ameliorates lupus through increasing CD4+ T cell senescence via MiR-199a-5p/Sirt1/p53 axis. Theranostics. 11:893–905. 2021.PubMed/NCBI View Article : Google Scholar

21 

Tu Y, Guo R, Li J, Wang S, Leng L, Deng J, Bucala R and Lu L: MiRNA regulation of MIF in SLE and attenuation of murine lupus nephritis with miR-654. Front Immunol. 10(2229)2019.PubMed/NCBI View Article : Google Scholar

22 

Tang Y, Luo X, Cui H, Ni X, Yuan M, Guo Y, Huang X, Zhou H, de Vries N, Tak PP, et al: MicroRNA-146A contributes to abnormal activation of the type I interferon pathway in human lupus by targeting the key signaling proteins. Arthritis Rheum. 60:1065–1075. 2009.PubMed/NCBI View Article : Google Scholar

23 

Luo X, Yang W, Ye DQ, Cui H, Zhang Y, Hirankarn N, Qian X, Tang Y, Lau YL, de Vries N, et al: A functional variant in microRNA-146a promoter modulates its expression and confers disease risk for systemic lupus erythematosus. PLoS Genet. 7(e1002128)2011.PubMed/NCBI View Article : Google Scholar

24 

Fu HX, Fan XP, Li M, Liu MJ and Sun QL: MiR-146a relieves kidney injury in mice with systemic lupus erythematosus through regulating NF- κB pathway. Eur Rev Med Pharmacol Sci. 23:7024–7032. 2019.PubMed/NCBI View Article : Google Scholar

25 

Ye X, Lu Q, Yang A, Rao J, Xie W, He C, Wang W, Li H and Zhang Z: MiR-206 regulates the Th17/Treg ratio during osteoarthritis. Mol Med. 27(64)2021.PubMed/NCBI View Article : Google Scholar

26 

Qu X, Han J, Zhang Y, Wang Y, Zhou J, Fan H and Yao R: MiR-384 regulates the Th17/Treg ratio during experimental autoimmune encephalomyelitis pathogenesis. Front Cell Neurosci. 11(88)2017.PubMed/NCBI View Article : Google Scholar

27 

Wang D, Huang S, Yuan X, Liang J, Xu R, Yao G, Feng X and Sun L: The regulation of the Treg/Th17 balance by mesenchymal stem cells in human systemic lupus erythematosus. Cell Mol Immunol. 14:423–431. 2017.PubMed/NCBI View Article : Google Scholar

28 

Geng L, Tang X, Zhou K, Wang D, Wang S, Yao G, Chen W, Gao X, Chen W, Shi S, et al: MicroRNA-663 induces immune dysregulation by inhibiting TGF-β1 production in bone marrow-derived mesenchymal stem cells in patients with systemic lupus erythematosus. Cell Mol Immunol. 16:260–274. 2019.PubMed/NCBI View Article : Google Scholar

29 

Remuzzi G, Zoja C, Gagliardini E, Corna D, Abbate M and Benigni A: Combining an antiproteinuric approach with mycophenolate mofetil fully suppresses progressive nephropathy of experimental animals. J Am Soc Nephrol. 10:1542–1549. 1999.PubMed/NCBI View Article : Google Scholar

30 

Xiong Y, Xiong Y, Zhang H, Zhao Y, Han K, Zhang J, Zhao D, Yu Z, Geng Z, Wang L, et al: hPMSCs-derived exosomal miRNA-21 protects against aging-related oxidative damage of CD4+ T cells by targeting the PTEN/PI3K-Nrf2 axis. Front Immunol. 12(780897)2021.PubMed/NCBI View Article : Google Scholar

31 

Wang Y and Xiong Y, Zhang A, Zhao N, Zhang J, Zhao D, Yu Z, Xu N, Yin Y, Luan X and Xiong Y: Oligosaccharide attenuates aging-related liver dysfunction by activating Nrf2 antioxidant signaling. Food Sci Nutr. 8:3872–3881. 2020.PubMed/NCBI View Article : Google Scholar

32 

Wang Y, Zhao N and Xiong Y, Zhang J, Zhao D, Yin Y, Song L, Yin Y, Wang J, Luan X and Xiong Y: Downregulated recycling process but not de novo synthesis of glutathione limits antioxidant capacity of erythrocytes in hypoxia. Oxid Med Cell Longev. 2020(7834252)2020.PubMed/NCBI View Article : Google Scholar

33 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

34 

Sui W, Liu F, Chen J, Ou M and Dai Y: Microarray technology for analysis of microRNA expression in renal biopsies of lupus nephritis patients. Methods Mol Biol. 1134:211–220. 2014.PubMed/NCBI View Article : Google Scholar

35 

Thai TH, Patterson HC, Pham DH, Kis-Toth K, Kaminski DA and Tsokos GC: Deletion of microRNA-155 reduces autoantibody responses and alleviates lupus-like disease in the Fas(lpr) mouse. Proc Natl Acad Sci USA. 110:20194–20199. 2013.PubMed/NCBI View Article : Google Scholar

36 

Xia Y, Tao JH, Fang X, Xiang N, Dai XJ, Jin L, Li XM, Wang YP and Li XP: MicroRNA-326 upregulates B cell activity and autoantibody production in lupus disease of MRL/lpr mice. Mol Ther Nucleic Acids. 11:284–291. 2018.PubMed/NCBI View Article : Google Scholar

37 

Zhu Y, Xue Z and Di L: Regulation of MiR-146a and TRAF6 in the diagnose of lupus nephritis. Med Sci Monit. 23:2550–2557. 2017.PubMed/NCBI View Article : Google Scholar

38 

Zheng CZ, Shu YB, Luo YL and Luo J: The role of miR-146a in modulating TRAF6-induced inflammation during lupus nephritis. Eur Rev Med Pharmacol Sci. 21:1041–1048. 2017.PubMed/NCBI

39 

Cai Z, Wong CK, Dong J, Jiao D, Chu M, Leung PC, Lau CBS, Lau CP, Tam LS and Lam CWK: Anti-inflammatory activities of Ganoderma lucidum (Lingzhi) and San-Miao-San supplements in MRL/lpr mice for the treatment of systemic lupus erythematosus. Chin Med. 11(23)2016.PubMed/NCBI View Article : Google Scholar

40 

Zickert A, Amoudruz P, Sundstrom Y, Ronnelid J, Malmstrom V and Gunnarsson I: IL-17 and IL-23 in lupus nephritis-association to histopathology and response to treatment. BMC Immunol. 16(7)2015.PubMed/NCBI View Article : Google Scholar

41 

Talaat RM, Mohamed SF, Bassyouni IH and Raouf AA: Th1/Th2/Th17/Treg cytokine imbalance in systemic lupus erythematosus (SLE) patients: Correlation with disease activity. Cytokine. 72:146–53. 2015.PubMed/NCBI View Article : Google Scholar

42 

Ohl K and Tenbrock K: Regulatory T cells in systemic lupus erythematosus. Eur J Immunol. 45:344–355. 2015.PubMed/NCBI View Article : Google Scholar

43 

Choi Y, Jung JH, Lee EG, Kim KM and Yoo WH: 4-phenylbutyric acid mediates therapeutic effect in systemic lupus erythematosus: Observations in an experimental murine lupus model. Exp Ther Med. 21(460)2021.PubMed/NCBI View Article : Google Scholar

44 

Sun F, Teng J, Yu P, Li W, Chang J and Xu H: Involvement of TWEAK and the NF-κB signaling pathway in lupus nephritis. Exp Ther Med. 15:2611–2619. 2018.PubMed/NCBI View Article : Google Scholar

45 

Sun L, Zou LX, Han YC, Wu L, Chen T, Zhu DD and Hu P: A20 overexpression exerts protective effects on podocyte injury in lupus nephritis by downregulating UCH-L1. J Cell Physiol: Feb 25, 2019 (Epub ahead of print).

46 

Zhang H, Liu L and Li L: Lentivirus-mediated knockdown of FcgammaRI (CD64) attenuated lupus nephritis via inhibition of NF-κB regulating NLRP3 inflammasome activation in MRL/lpr mice. J Pharmacol Sci. 137:342–349. 2018.PubMed/NCBI View Article : Google Scholar

47 

Cui C, Zhang D, Sun K, Li H, Xu L, Lin G, Guo Y, Hu J, Chen J, Nong L, et al: Propofol maintains Th17/Treg cell balance and reduces inflammation in rats with traumatic brain injury via the miR1453p/NFATc2/NF-κB axis. Int J Mol Med. 48(135)2021.PubMed/NCBI View Article : Google Scholar

48 

Chen C, Hu N, Wang J, Xu L, Jia XL, Fan X, Shi JX, Chen F, Tu Y, Wang YW and Li XH: Umbilical cord mesenchymal stem cells promote neurological repair after traumatic brain injury through regulating Treg/Th17 balance. Brain Res. 1775(147711)2022.PubMed/NCBI View Article : Google Scholar

49 

Napetschnig J and Wu H: Molecular basis of NF-κB signaling. Annu Rev Biophys. 42:443–468. 2013.PubMed/NCBI View Article : Google Scholar

50 

Dong C, Zhou Q, Fu T, Zhao R, Yang J, Kong X, Zhang Z, Sun C, Bao Y, Ge X, et al: Circulating exosomes derived-miR-146a from systemic lupus erythematosus patients regulates senescence of mesenchymal stem cells. Biomed Res Int. 2019(6071308)2019.PubMed/NCBI View Article : Google Scholar

51 

Meng Q, Liang C, Hua J, Zhang B, Liu J, Zhang Y, Wei M, Yu X, Xu J and Shi S: A miR-146a-5p/TRAF6/NF-kB p65 axis regulates pancreatic cancer chemoresistance: Functional validation and clinical significance. Theranostics. 10:3967–3979. 2020.PubMed/NCBI View Article : Google Scholar

52 

Liu X, Liu B, Li R, Wang F, Wang N, Zhang M, Bai Y, Wu J, Liu L, Han D, et al: miR-146a-5p plays an oncogenic role in NSCLC via suppression of TRAF6. Front Cell Dev Biol. 8(847)2020.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Teng J, Yang F and Li X: miR‑146a‑5p protects against renal injury in MRL/lpr mice via improvement of the Treg/Th17 imbalance by targeting the TRAF6/NF‑κB axis. Exp Ther Med 25: 21, 2023.
APA
Teng, J., Yang, F., & Li, X. (2023). miR‑146a‑5p protects against renal injury in MRL/lpr mice via improvement of the Treg/Th17 imbalance by targeting the TRAF6/NF‑κB axis. Experimental and Therapeutic Medicine, 25, 21. https://doi.org/10.3892/etm.2022.11720
MLA
Teng, J., Yang, F., Li, X."miR‑146a‑5p protects against renal injury in MRL/lpr mice via improvement of the Treg/Th17 imbalance by targeting the TRAF6/NF‑κB axis". Experimental and Therapeutic Medicine 25.1 (2023): 21.
Chicago
Teng, J., Yang, F., Li, X."miR‑146a‑5p protects against renal injury in MRL/lpr mice via improvement of the Treg/Th17 imbalance by targeting the TRAF6/NF‑κB axis". Experimental and Therapeutic Medicine 25, no. 1 (2023): 21. https://doi.org/10.3892/etm.2022.11720
Copy and paste a formatted citation
x
Spandidos Publications style
Teng J, Yang F and Li X: miR‑146a‑5p protects against renal injury in MRL/lpr mice via improvement of the Treg/Th17 imbalance by targeting the TRAF6/NF‑κB axis. Exp Ther Med 25: 21, 2023.
APA
Teng, J., Yang, F., & Li, X. (2023). miR‑146a‑5p protects against renal injury in MRL/lpr mice via improvement of the Treg/Th17 imbalance by targeting the TRAF6/NF‑κB axis. Experimental and Therapeutic Medicine, 25, 21. https://doi.org/10.3892/etm.2022.11720
MLA
Teng, J., Yang, F., Li, X."miR‑146a‑5p protects against renal injury in MRL/lpr mice via improvement of the Treg/Th17 imbalance by targeting the TRAF6/NF‑κB axis". Experimental and Therapeutic Medicine 25.1 (2023): 21.
Chicago
Teng, J., Yang, F., Li, X."miR‑146a‑5p protects against renal injury in MRL/lpr mice via improvement of the Treg/Th17 imbalance by targeting the TRAF6/NF‑κB axis". Experimental and Therapeutic Medicine 25, no. 1 (2023): 21. https://doi.org/10.3892/etm.2022.11720
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team