Open Access

Association between site of infection and mortality in patients with cancer with sepsis or septic shock: A retrospective cohort study

  • Authors:
    • Youli Chen
    • Jianhui Huang
    • Jisong Xu
    • Rongzhe Qiu
    • Tianlai Lin
  • View Affiliations

  • Published online on: November 24, 2022     https://doi.org/10.3892/etm.2022.11732
  • Article Number: 33
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Infections are associated with increased mortality in patients with sepsis or septic shock. However, to the best of our knowledge, the influence of the site of infection on patients with cancer remains unclear. The present study aimed to evaluate the association between the site of infection and mortality in patients with cancer and sepsis or septic shock. The present study was conducted in a Lebanon tertiary care centre from July 2010 to April 2015. A total of 176 patients with active cancer presenting to the emergency department with sepsis or sepsis shock were included in the present analysis. Cox regression and Kaplan‑Meier analysis of the effect of the site of infection on mortality were performed. The most common site of infection was the lung (37.50%), followed by the urinary tract (26.70%), unknown site (13.63%), gastrointestinal (13.07%) and others (9.10%). The overall mortality rate was 47.73%. Gastrointestinal infection (78.26%) was associated with the highest mortality, followed by pneumonia (62.12%). The urinary tract infection with the lowest mortality rate was the reference group. After adjusting for confounding variables, gastrointestinal infection was associated with the highest in‑hospital mortality [hazard ratio (HR), 2.64; 95% CI, 1.25‑5.55], followed by pneumonia (HR, 1.95; 95% CI, 1.03‑3.68). The association between site of infection and 28‑day and 60‑day mortality was analysed by Cox regression, as well as by stratified analysis to investigate the association between site of infection and mortality from haematological and solid tumors. Gastrointestinal infection had a higher mortality rate. In conclusion, the site of infection had the same association with mortality in patients with solid and haematological tumours.
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January-2023
Volume 25 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Chen Y, Huang J, Xu J, Qiu R and Lin T: Association between site of infection and mortality in patients with cancer with sepsis or septic shock: A retrospective cohort study. Exp Ther Med 25: 33, 2023
APA
Chen, Y., Huang, J., Xu, J., Qiu, R., & Lin, T. (2023). Association between site of infection and mortality in patients with cancer with sepsis or septic shock: A retrospective cohort study. Experimental and Therapeutic Medicine, 25, 33. https://doi.org/10.3892/etm.2022.11732
MLA
Chen, Y., Huang, J., Xu, J., Qiu, R., Lin, T."Association between site of infection and mortality in patients with cancer with sepsis or septic shock: A retrospective cohort study". Experimental and Therapeutic Medicine 25.1 (2023): 33.
Chicago
Chen, Y., Huang, J., Xu, J., Qiu, R., Lin, T."Association between site of infection and mortality in patients with cancer with sepsis or septic shock: A retrospective cohort study". Experimental and Therapeutic Medicine 25, no. 1 (2023): 33. https://doi.org/10.3892/etm.2022.11732