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Role of microRNAs regulating trophoblast cell function in the pathogenesis of pre‑eclampsia (Review)

  • Authors:
    • Wenwen Ning
    • Bin Wu
    • Yijie Chen
    • Jiejing Lian
    • Yiming Chen
  • View Affiliations / Copyright

    Affiliations: Fourth Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310003, P.R. China
    Copyright: © Ning et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 50
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    Published online on: December 6, 2022
       https://doi.org/10.3892/etm.2022.11749
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Abstract

Pre‑eclampsia (PE) is a complicated pregnancy‑specific disease and is considered the primary reason for maternal and foetal mortality and morbidity. PE has a multifactorial pathogenesis but the causes of PE remain unclear. The functions of trophoblasts, including differentiation, proliferation, migration, invasion and apoptosis, are essential for successful pregnancy. During the early stages of placental development, trophoblasts are strictly regulated by several molecular pathways; however, an imbalance of these molecular pathways can lead to severe placental lesions and pregnancy complications. Certain microRNAs (miRs) are abnormally expressed in PE, with several miRs involved in the regulation of pregnancy‑associated genes. The present review discusses the miRs regulating trophoblast function, how they affect the pathogenesis of PE and evaluating the possibility of miRs in screening, diagnosis and treatment of PE.
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Copy and paste a formatted citation
Spandidos Publications style
Ning W, Wu B, Chen Y, Lian J and Chen Y: Role of microRNAs regulating trophoblast cell function in the pathogenesis of pre‑eclampsia (Review). Exp Ther Med 25: 50, 2023.
APA
Ning, W., Wu, B., Chen, Y., Lian, J., & Chen, Y. (2023). Role of microRNAs regulating trophoblast cell function in the pathogenesis of pre‑eclampsia (Review). Experimental and Therapeutic Medicine, 25, 50. https://doi.org/10.3892/etm.2022.11749
MLA
Ning, W., Wu, B., Chen, Y., Lian, J., Chen, Y."Role of microRNAs regulating trophoblast cell function in the pathogenesis of pre‑eclampsia (Review)". Experimental and Therapeutic Medicine 25.1 (2023): 50.
Chicago
Ning, W., Wu, B., Chen, Y., Lian, J., Chen, Y."Role of microRNAs regulating trophoblast cell function in the pathogenesis of pre‑eclampsia (Review)". Experimental and Therapeutic Medicine 25, no. 1 (2023): 50. https://doi.org/10.3892/etm.2022.11749
Copy and paste a formatted citation
x
Spandidos Publications style
Ning W, Wu B, Chen Y, Lian J and Chen Y: Role of microRNAs regulating trophoblast cell function in the pathogenesis of pre‑eclampsia (Review). Exp Ther Med 25: 50, 2023.
APA
Ning, W., Wu, B., Chen, Y., Lian, J., & Chen, Y. (2023). Role of microRNAs regulating trophoblast cell function in the pathogenesis of pre‑eclampsia (Review). Experimental and Therapeutic Medicine, 25, 50. https://doi.org/10.3892/etm.2022.11749
MLA
Ning, W., Wu, B., Chen, Y., Lian, J., Chen, Y."Role of microRNAs regulating trophoblast cell function in the pathogenesis of pre‑eclampsia (Review)". Experimental and Therapeutic Medicine 25.1 (2023): 50.
Chicago
Ning, W., Wu, B., Chen, Y., Lian, J., Chen, Y."Role of microRNAs regulating trophoblast cell function in the pathogenesis of pre‑eclampsia (Review)". Experimental and Therapeutic Medicine 25, no. 1 (2023): 50. https://doi.org/10.3892/etm.2022.11749
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