Synchronous mucinous metaplasia and neoplasia of the female genital tract (SMMN‑FGT): A case report and literature review

Xu,Hongliang; Chen,Yong; Zhou,Shuguang; Zhao,Caixia; Wang,Qin; Tang,Man; Zhang,Weiqin; Zhang,Heping

doi:10.3892/etm.2022.11772

February-2023 Volume 25 Issue 2

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February-2023 Volume 25 Issue 2

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Case Report Open Access

Synchronous mucinous metaplasia and neoplasia of the female genital tract (SMMN‑FGT): A case report and literature review

Authors:
- Hongliang Xu
- Yong Chen
- Shuguang Zhou
- Caixia Zhao
- Qin Wang
- Man Tang
- Weiqin Zhang
- Heping Zhang
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Affiliations: Department of Pathology, Anhui Province Maternity and Child Health Hospital, Anhui Medical University, Hefei, Anhui 230000, P.R. China, Department of Gynecology, Anhui Province Maternity and Child Health Hospital, Anhui Medical University, Hefei, Anhui 230000, P.R. China

Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Article Number: 73
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Published online on: December 19, 2022

https://doi.org/10.3892/etm.2022.11772
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Abstract

The present study reported a case of Synchronous Mucinous Metaplasia and Neoplasia of the Female Genital Tract (SMMN‑FGT), which occurred in a 47‑year‑old woman. The patient complained of pelvic mass during a physical examination a month ago. Ultrasound examination found an anechoic spot in the left ovary and several anechoic spots were detected in the cervix. The patient underwent left adnexectomy and the left ovarian frozen section revealed a mucinous borderline tumor. Total abdominal hysterectomy and right salpingo‑oophorectomy were subsequently performed. Microscopically, multifocal mucinous lesions were involved in the female genital tract, including bilateral ovarian mucinous borderline tumor, cervical and endometrial mucinous adenocarcinoma and the bilateral fallopian tube epithelium showed mucinous metaplasia. Immunohistochemistry revealed that the tumor cells of the ovary, cervix and endometrium expressed MUC6, exhibiting features of gastric‑type differentiation. The Ki‑67 proliferative index was ~10‑70%. Cumulative evidence established SMMN‑FGT as the final histopathological diagnosis with International Federation of Gynecology and Obstetrics stage I. Following surgery, the patient received a course of pelvic radiotherapy and survived for 16 months.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Synchronous mucinous metaplasia and neoplasia of the female genital tract (SMMN‑FGT): A case report and literature review

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