Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
February-2023 Volume 25 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2023 Volume 25 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Baricitinib alleviates lipopolysaccharide‑induced human periodontal ligament stem cell injury and promotes osteogenic differentiation by inhibiting JAK/STAT signaling

  • Authors:
    • Ping Yang
    • Fenghua Shi
    • Yanli Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Stomatology, AnTing Campus, The Third Affiliated Hospital of Naval Military Medical University, Shanghai 200438, P.R. China, Department of Radiotherapy, AnTing Campus, The Third Affiliated Hospital of Naval Military Medical University, Shanghai 201805, P.R. China, Outpatient Department, ChangHai Road Campus, The Third Affiliated Hospital of Naval Military Medical University, Shanghai 200438, P.R. China
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 74
    |
    Published online on: December 22, 2022
       https://doi.org/10.3892/etm.2022.11773
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Periodontitis is the chronic inflammation of the periodontal tissue. The present study aimed to investigate the role of baricitinib, a Janus kinase (JAK)1/2 inhibitor, in periodontitis by using a lipopolysaccharide (LPS)‑induced human periodontal ligament stem cell (PDLSC) model. The viability of PDLSCs stimulated by LPS was assessed in the presence of baricitinib by Cell Counting Kit‑8 assay. The induction of oxidative stress was evaluated by detecting the intracellular reactive oxygen species (ROS) levels, superoxide dismutase (SOD) activity and glutathione (GSH) content. ELISA and reverse transcription‑quantitative PCR were used to determine the levels of inflammatory factors TNF‑α, IL‑1β and IL‑6. Alkaline phosphatase (ALP) activity and alizarin red staining were used to assess the osteogenic differentiation of PDLSCs. The expression levels of osteogenic differentiation‑ and JAK/signal transducer and activator of transcription (STAT) signaling‑associated proteins were estimated with western blotting. RO8191, an agonist of the JAK/STAT pathway, was used to treat PDLSCs to investigate the regulatory mechanism of baricitinib. The results indicated that baricitinib elevated the LPS‑induced decrease in cell viability. LPS‑triggered oxidative stress and inflammation were inhibited by baricitinib, as demonstrated by the decreased levels of ROS, TNF‑α, IL‑1β, IL‑6 and increased levels of SOD and GSH. In addition, baricitinib caused a marked elevation in ALP activity and mineralization ability of PDLSCs, as determined by the upregulated osteocalcin and Runt‑related transcription factor 2 expression. Moreover, the expression levels of phosphorylated (p)‑JAK1, p‑JAK2 and p‑STAT3 were downregulated by baricitinib in a dose‑dependent manner. Furthermore, addition of RO8191 restored the effect of baricitinib on the induction of oxidative stress, inflammation and osteogenic differentiation of PDLSCs exposed to LPS. Collectively, these findings suggested that baricitinib alleviated oxidative stress and inflammation and promoted osteogenic differentiation of LPS‑induced PDLSCs by inhibiting JAK/STAT signaling.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Chen MX, Zhong YJ, Dong QQ, Wong HM and Wen YF: Global, regional, and national burden of severe periodontitis, 1990-2019: An analysis of the global burden of disease study 2019. J Clin Periodontol. 48:1165–1188. 2021.PubMed/NCBI View Article : Google Scholar

2 

Socransky SS, Haffajee AD, Cugini MA, Smith C and Kent RL Jr: Microbial complexes in subgingival plaque. J Clin Periodontol. 25:134–144. 1998.PubMed/NCBI View Article : Google Scholar

3 

Byrne SJ, Dashper SG, Darby IB, Adams GG, Hoffmann B and Reynolds EC: Progression of chronic periodontitis can be predicted by the levels of Porphyromonas gingivalis and Treponema denticola in subgingival plaque. Oral Microbiol Immunol. 24:469–477. 2009.PubMed/NCBI View Article : Google Scholar

4 

Papapanou PN, Sanz M, Buduneli N, Dietrich T, Feres M, Fine DH, Flemmig TF, Garcia R, Giannobile WV, Graziani F, et al: Periodontitis: Consensus report of workgroup 2 of the 2017 world workshop on the classification of periodontal and peri-implant diseases and conditions. J Periodontol. 89 (Suppl 1):S173–S182. 2018.PubMed/NCBI View Article : Google Scholar

5 

Hajishengallis G: Periodontitis: From microbial immune subversion to systemic inflammation. Nat Rev Immunol. 15:30–44. 2015.PubMed/NCBI View Article : Google Scholar

6 

Polak D and Shapira L: An update on the evidence for pathogenic mechanisms that may link periodontitis and diabetes. J Clin Periodontol. 45:150–166. 2018.PubMed/NCBI View Article : Google Scholar

7 

Wallace K, Shafique S and Piamjariyakul U: The relationship between oral health and hemodialysis treatment among adults with chronic kidney disease: A systematic review. Nephrol Nurs J. 46:375–394. 2019.PubMed/NCBI

8 

Khumaedi AI, Purnamasari D, Wijaya IP and Soeroso Y: The relationship of diabetes, periodontitis and cardiovascular disease. Diabetes Metab Syndr. 13:1675–1678. 2019.PubMed/NCBI View Article : Google Scholar

9 

Trikka D and Vassilopoulos S: Periodontal regeneration with enamel matrix derivative in the management of generalized aggressive periodontitis: A case report with 11-year follow-up and literature review. J Int Soc Prev Community Dent. 9:13–20. 2019.PubMed/NCBI View Article : Google Scholar

10 

Bella P and Istvan G: The comprehensive periodontal, resorative end prosthodontic therapy of chronic periodontitis case presentation. Fogorv Sz. 109:125–135. 2016.PubMed/NCBI(In English, Hungarian).

11 

Ashouri Moghaddam A, Radafshar G, Jahandideh Y and Kakaei N: Clinical evaluation of effects of local application of aloe vera gel as an adjunct to scaling and root planning in patients with chronic periodontitis. J Dent (Shiraz). 18:165–172. 2017.PubMed/NCBI

12 

Seo BM, Miura M, Gronthos S, Bartold PM, Batouli S, Brahim J, Young M, Robey PG, Wang CY and Shi S: Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet. 364:149–155. 2004.PubMed/NCBI View Article : Google Scholar

13 

Aydin S and Şahin F: Stem cells derived from dental tissues. Adv Exp Med Biol. 1144:123–132. 2019.PubMed/NCBI View Article : Google Scholar

14 

Liu Y, Zheng Y, Ding G, Fang D, Zhang C, Bartold PM, Gronthos S, Shi S and Wang S: Periodontal ligament stem cell-mediated treatment for periodontitis in miniature swine. Stem Cells. 26:1065–1073. 2008.PubMed/NCBI View Article : Google Scholar

15 

Nagata M, Iwasaki K, Akazawa K, Komaki M, Yokoyama N, Izumi Y and Morita I: Conditioned medium from periodontal ligament stem cells enhances periodontal regeneration. Tissue Eng Part A. 23:367–377. 2017.PubMed/NCBI View Article : Google Scholar

16 

Diomede F, D'Aurora M, Gugliandolo A, Merciaro I, Ettorre V, Bramanti A, Piattelli A, Gatta V, Mazzon E, Fontana A and Trubiani O: A novel role in skeletal segment regeneration of extracellular vesicles released from periodontal-ligament stem cells. Int J Nanomed. 13:3805–3825. 2018.PubMed/NCBI View Article : Google Scholar

17 

Trubiani O, Marconi GD, Pierdomenico SD, Piattelli A, Diomede F and Pizzicannella J: Human oral stem cells, biomaterials and extracellular vesicles: A promising tool in bone tissue repair. Int J Mol Sci. 20(4987)2019.PubMed/NCBI View Article : Google Scholar

18 

Ramenzoni LL, Russo G, Moccia MD, Attin T and Schmidlin PR: Periodontal bacterial supernatants modify differentiation, migration and inflammatory cytokine expression in human periodontal ligament stem cells. PLoS One. 14(e0219181)2019.PubMed/NCBI View Article : Google Scholar

19 

Cheng M and Zhou Q: Targeting EZH2 ameliorates the LPS-inhibited PDLSC osteogenesis via Wnt/β-catenin pathway. Cells Tissues Organs. 209:227–235. 2020.PubMed/NCBI View Article : Google Scholar

20 

Wang W, Yuan C, Geng T, Liu Y, Zhu S, Zhang C, Liu Z and Wang P: Lipopolysaccharide inhibits osteogenic differentiation of periodontal ligament stem cells partially through toll-like receptor 4-mediated ephrinB2 downregulation. Clin Oral Investig. 24:3407–3416. 2020.PubMed/NCBI View Article : Google Scholar

21 

Fu Z, Wang X, Li B and Tang Y: Fraxinellone alleviates inflammation and promotes osteogenic differentiation in lipopolysaccharide-stimulated periodontal ligament stem cells by regulating the bone morphogenetic protein 2/Smad pathway. Arch Oral Biol. 121(104927)2021.PubMed/NCBI View Article : Google Scholar

22 

Honda S and Harigai M: The safety of baricitinib in patients with rheumatoid arthritis. Expert Opin Drug Saf. 19:545–551. 2020.PubMed/NCBI View Article : Google Scholar

23 

Ancuța C, Pomîrleanu C, Mihailov C, Chirieac R, Ancuța E, Iordache C, Bran C and Țănculescu O: Efficacy of baricitinib on periodontal inflammation in patients with rheumatoid arthritis. Joint Bone Spine. 87:235–239. 2020.PubMed/NCBI View Article : Google Scholar

24 

Murakami K, Kobayashi Y, Uehara S, Suzuki T, Koide M, Yamashita T, Nakamura M, Takahashi N, Kato H, Udagawa N and Nakamura Y: A Jak1/2 inhibitor, baricitinib, inhibits osteoclastogenesis by suppressing RANKL expression in osteoblasts in vitro. PLoS One. 12(e0181126)2017.PubMed/NCBI View Article : Google Scholar

25 

Adam S, Simon N, Steffen U, Andes FT, Scholtysek C, Müller DIH, Weidner D, Andreev D, Kleyer A, Culemann S, et al: JAK inhibition increases bone mass in steady-state conditions and ameliorates pathological bone loss by stimulating osteoblast function. Sci Transl Med. 12(eaay4447)2020.PubMed/NCBI View Article : Google Scholar

26 

Zheng XY, Mao CY, Qiao H, Zhang X, Yu L, Wang TY and Lu EY: Plumbagin suppresses chronic periodontitis in rats via down-regulation of TNF-α, IL-1β and IL-6 expression. Acta Pharmacol Sin. 38:1150–1160. 2017.PubMed/NCBI View Article : Google Scholar

27 

Shao Q, Liu S, Zou C and Ai Y: Effect of LSD1 on osteogenic differentiation of human periodontal ligament stem cells in periodontitis. Oral Dis: Nov 5, 2021 (Epub ahead of print).

28 

Zheng X, Zhu Y, Wang X, Hou Y and Fang Y: Silencing of ITGB6 inhibits the progression of cervical carcinoma via regulating JAK/STAT3 signaling pathway. Ann Transl Med. 9(803)2021.PubMed/NCBI View Article : Google Scholar

29 

Eruslanov E and Kusmartsev S: Identification of ROS using oxidized DCFDA and flow-cytometry. Methods Mol Biol. 594:57–72. 2010.PubMed/NCBI View Article : Google Scholar

30 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

31 

Sanz M, Marco Del Castillo A, Jepsen S, Gonzalez-Juanatey JR, D'Aiuto F, Bouchard P, Chapple I, Dietrich T, Gotsman I, Graziani F, et al: Periodontitis and cardiovascular diseases: Consensus report. J Clin Periodontol. 47:268–288. 2020.PubMed/NCBI View Article : Google Scholar

32 

Lundmark A, Hu YOO, Huss M, Johannsen G, Andersson AF and Yucel-Lindberg T: Identification of salivary microbiota and its association with host inflammatory mediators in periodontitis. Front Cell Infect Microbiol. 9(216)2019.PubMed/NCBI View Article : Google Scholar

33 

Menicanin D, Mrozik KM, Wada N, Marino V, Shi S, Bartold PM and Gronthos S: Periodontal-ligament-derived stem cells exhibit the capacity for long-term survival, self-renewal, and regeneration of multiple tissue types in vivo. Stem Cells Dev. 23:1001–1011. 2014.PubMed/NCBI View Article : Google Scholar

34 

Li L, Liu W, Wang H, Yang Q, Zhang L, Jin F and Jin Y: Mutual inhibition between HDAC9 and miR-17 regulates osteogenesis of human periodontal ligament stem cells in inflammatory conditions. Cell Death Dis. 9(480)2018.PubMed/NCBI View Article : Google Scholar

35 

Shirasugi M, Nakagawa M, Nishioka K, Yamamoto T, Nakaya T and Kanamura N: Relationship between periodontal disease and butyric acid produced by periodontopathic bacteria. Inflamm Regen. 38(23)2018.PubMed/NCBI View Article : Google Scholar

36 

Hoare A, Soto C, Rojas-Celis V and Bravo D: Chronic inflammation as a link between periodontitis and carcinogenesis. Mediators Inflamm. 2019(1029857)2019.PubMed/NCBI View Article : Google Scholar

37 

Zhao B, Zhang W, Xiong Y, Zhang Y, Zhang D and Xu X: Effects of rutin on the oxidative stress, proliferation and osteogenic differentiation of periodontal ligament stem cells in LPS-induced inflammatory environment and the underlying mechanism. J Mol Histol. 51:161–171. 2020.PubMed/NCBI View Article : Google Scholar

38 

Duan Y, An W, Wu H and Wu Y: Salvianolic acid C attenuates LPS-induced inflammation and apoptosis in human periodontal ligament stem cells via toll-like receptors 4 (TLR4)/nuclear factor kappa B (NF-κB) pathway. Med Sci Monit. 25:9499–9508. 2019.PubMed/NCBI View Article : Google Scholar

39 

Smolen JS, Genovese MC, Takeuchi T, Hyslop DL, Macias WL, Rooney T, Chen L, Dickson CL, Riddle Camp J, Cardillo TE, et al: Safety profile of baricitinib in patients with active rheumatoid arthritis with over 2 years median time in treatment. J Rheumatol. 46:7–18. 2019.PubMed/NCBI View Article : Google Scholar

40 

Sanchez GAM, Reinhardt A, Ramsey S, Wittkowski H, Hashkes PJ, Berkun Y, Schalm S, Murias S, Dare JA, Brown D, et al: JAK1/2 inhibition with baricitinib in the treatment of autoinflammatory interferonopathies. J Clin Invest. 128:3041–3052. 2018.PubMed/NCBI View Article : Google Scholar

41 

Bhaskarmurthy DH and Prince SE: Effect of baricitinib on TPA-induced psoriasis like skin inflammation. Life Sci. 279(119655)2021.PubMed/NCBI View Article : Google Scholar

42 

Douglas TEL, Vandrovcová M, Kročilová N, Keppler JK, Zárubová J, Skirtach AG and Bačáková L: Application of whey protein isolate in bone regeneration: Effects on growth and osteogenic differentiation of bone-forming cells. J Dairy Sci. 101:28–36. 2018.PubMed/NCBI View Article : Google Scholar

43 

Jiang B, Xu J, Zhou Y, Mao J, Guan G, Xu X and Mei L: Estrogen enhances osteogenic differentiation of human periodontal ligament stem cells by activating the Wnt/β-catenin signaling pathway. J Craniofac Surg. 31:583–587. 2020.PubMed/NCBI View Article : Google Scholar

44 

Yu M, Wang L, Ba P, Li L, Sun L, Duan X, Yang P, Yang C and Sun Q: Osteoblast progenitors enhance osteogenic differentiation of periodontal ligament stem cells. J Periodontol. 88:e159–e168. 2017.PubMed/NCBI View Article : Google Scholar

45 

Sun H, Feng K, Hu J, Soker S, Atala A and Ma PX: Osteogenic differentiation of human amniotic fluid-derived stem cells induced by bone morphogenetic protein-7 and enhanced by nanofibrous scaffolds. Biomaterials. 31:1133–1139. 2010.PubMed/NCBI View Article : Google Scholar

46 

Deng Y, Wu S, Zhou H, Bi X, Wang Y, Hu Y, Gu P and Fan X: Effects of a miR-31, Runx2, and Satb2 regulatory loop on the osteogenic differentiation of bone mesenchymal stem cells. Stem Cells Dev. 22:2278–2286. 2013.PubMed/NCBI View Article : Google Scholar

47 

Li J, Li L, Wang X and Xiao L: Porphyromonas gingivalis inhibition of MicroRNA-205-5p expression modulates proinflammatory cytokines in gingival epithelial cells. Biochem Genet. 58:566–579. 2020.PubMed/NCBI View Article : Google Scholar

48 

Wang Q, Li H, Xie H, Fu M, Guo B, Ding Y, Li W and Yu H: 25-Hydroxyvitamin D3 attenuates experimental periodontitis through downregulation of TLR4 and JAK1/STAT3 signaling in diabetic mice. J Steroid Biochem Mol Biol. 135:43–50. 2013.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yang P, Shi F and Zhang Y: Baricitinib alleviates lipopolysaccharide‑induced human periodontal ligament stem cell injury and promotes osteogenic differentiation by inhibiting JAK/STAT signaling. Exp Ther Med 25: 74, 2023.
APA
Yang, P., Shi, F., & Zhang, Y. (2023). Baricitinib alleviates lipopolysaccharide‑induced human periodontal ligament stem cell injury and promotes osteogenic differentiation by inhibiting JAK/STAT signaling. Experimental and Therapeutic Medicine, 25, 74. https://doi.org/10.3892/etm.2022.11773
MLA
Yang, P., Shi, F., Zhang, Y."Baricitinib alleviates lipopolysaccharide‑induced human periodontal ligament stem cell injury and promotes osteogenic differentiation by inhibiting JAK/STAT signaling". Experimental and Therapeutic Medicine 25.2 (2023): 74.
Chicago
Yang, P., Shi, F., Zhang, Y."Baricitinib alleviates lipopolysaccharide‑induced human periodontal ligament stem cell injury and promotes osteogenic differentiation by inhibiting JAK/STAT signaling". Experimental and Therapeutic Medicine 25, no. 2 (2023): 74. https://doi.org/10.3892/etm.2022.11773
Copy and paste a formatted citation
x
Spandidos Publications style
Yang P, Shi F and Zhang Y: Baricitinib alleviates lipopolysaccharide‑induced human periodontal ligament stem cell injury and promotes osteogenic differentiation by inhibiting JAK/STAT signaling. Exp Ther Med 25: 74, 2023.
APA
Yang, P., Shi, F., & Zhang, Y. (2023). Baricitinib alleviates lipopolysaccharide‑induced human periodontal ligament stem cell injury and promotes osteogenic differentiation by inhibiting JAK/STAT signaling. Experimental and Therapeutic Medicine, 25, 74. https://doi.org/10.3892/etm.2022.11773
MLA
Yang, P., Shi, F., Zhang, Y."Baricitinib alleviates lipopolysaccharide‑induced human periodontal ligament stem cell injury and promotes osteogenic differentiation by inhibiting JAK/STAT signaling". Experimental and Therapeutic Medicine 25.2 (2023): 74.
Chicago
Yang, P., Shi, F., Zhang, Y."Baricitinib alleviates lipopolysaccharide‑induced human periodontal ligament stem cell injury and promotes osteogenic differentiation by inhibiting JAK/STAT signaling". Experimental and Therapeutic Medicine 25, no. 2 (2023): 74. https://doi.org/10.3892/etm.2022.11773
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team