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Article Open Access

Inhibition of human oral squamous cell carcinoma proliferation and migration by prodrug‑activating suicide gene therapies

Corrigendum in: /10.3892/etm.2023.12159
  • Authors:
    • Naining Xu
    • Honglei Tian
    • Chun Po Fung
    • Yuntao Lin
    • Yuling Chen
    • Guang Zhu
    • Yuehong Shen
    • Chuanbin Guo
    • Hongyu Yang
  • View Affiliations / Copyright

    Affiliations: Department of Oral and Maxillofacial Surgery, Stomatological Center, Peking University Shenzhen Hospital, Shenzhen Peking University, The Hong Kong University of Science and Technology Medical Center, Shenzhen, Guangdong 518001, P.R. China, Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong 999077, P.R. China, Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing 100081, P.R. China
    Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 92
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    Published online on: January 9, 2023
       https://doi.org/10.3892/etm.2023.11790
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Abstract

Head and neck squamous cell carcinoma (HNSCC), which originates from mucosal epithelium in the oral cavity, pharynx and larynx, is the sixth most common malignancy in the world. The prognosis of HNSCC is not satisfactory due to metastasis, resulting in 5‑year survival rates ranging from 65.9 to 67.2%. Previously, we developed a method to evaluate the effect prodrug‑activating suicide gene (PA‑SG) therapy on the proliferation of HNSCC. The present study investigated PA‑SG therapy on metastatic HNSCC by wound‑healing assay and our previously established method. HSC‑3 cells with stable expression of suicide genes thymidine kinase (TK) or cytosine deaminase (CD) were treated with prodrugs ganciclovir (GCV) or 5‑fluorocytosine (5‑FC), respectively. Both GCV and 5‑FC inhibited HSC‑3 proliferation while the bystander effect of CD/5‑FC was greater compared with that of TK/GCV. GCV showed a greater anti‑migration effect compared with that of 5‑FC. To the best of our knowledge, the present study is the first to evaluate the anti‑migratory and anti‑proliferative effects of PA‑SG therapies on metastatic HNSCC. This may also serve as a general method to quantify other types of PA‑SC therapy. The present results demonstrated that PA‑SG therapy is a promising treatment for anti‑metastatic HNSCC therapy development.
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Copy and paste a formatted citation
Spandidos Publications style
Xu N, Tian H, Fung CP, Lin Y, Chen Y, Zhu G, Shen Y, Guo C and Yang H: Inhibition of human oral squamous cell carcinoma proliferation and migration by prodrug‑activating suicide gene therapies Corrigendum in /10.3892/etm.2023.12159. Exp Ther Med 25: 92, 2023.
APA
Xu, N., Tian, H., Fung, C.P., Lin, Y., Chen, Y., Zhu, G. ... Yang, H. (2023). Inhibition of human oral squamous cell carcinoma proliferation and migration by prodrug‑activating suicide gene therapies Corrigendum in /10.3892/etm.2023.12159. Experimental and Therapeutic Medicine, 25, 92. https://doi.org/10.3892/etm.2023.11790
MLA
Xu, N., Tian, H., Fung, C. P., Lin, Y., Chen, Y., Zhu, G., Shen, Y., Guo, C., Yang, H."Inhibition of human oral squamous cell carcinoma proliferation and migration by prodrug‑activating suicide gene therapies Corrigendum in /10.3892/etm.2023.12159". Experimental and Therapeutic Medicine 25.2 (2023): 92.
Chicago
Xu, N., Tian, H., Fung, C. P., Lin, Y., Chen, Y., Zhu, G., Shen, Y., Guo, C., Yang, H."Inhibition of human oral squamous cell carcinoma proliferation and migration by prodrug‑activating suicide gene therapies Corrigendum in /10.3892/etm.2023.12159". Experimental and Therapeutic Medicine 25, no. 2 (2023): 92. https://doi.org/10.3892/etm.2023.11790
Copy and paste a formatted citation
x
Spandidos Publications style
Xu N, Tian H, Fung CP, Lin Y, Chen Y, Zhu G, Shen Y, Guo C and Yang H: Inhibition of human oral squamous cell carcinoma proliferation and migration by prodrug‑activating suicide gene therapies Corrigendum in /10.3892/etm.2023.12159. Exp Ther Med 25: 92, 2023.
APA
Xu, N., Tian, H., Fung, C.P., Lin, Y., Chen, Y., Zhu, G. ... Yang, H. (2023). Inhibition of human oral squamous cell carcinoma proliferation and migration by prodrug‑activating suicide gene therapies Corrigendum in /10.3892/etm.2023.12159. Experimental and Therapeutic Medicine, 25, 92. https://doi.org/10.3892/etm.2023.11790
MLA
Xu, N., Tian, H., Fung, C. P., Lin, Y., Chen, Y., Zhu, G., Shen, Y., Guo, C., Yang, H."Inhibition of human oral squamous cell carcinoma proliferation and migration by prodrug‑activating suicide gene therapies Corrigendum in /10.3892/etm.2023.12159". Experimental and Therapeutic Medicine 25.2 (2023): 92.
Chicago
Xu, N., Tian, H., Fung, C. P., Lin, Y., Chen, Y., Zhu, G., Shen, Y., Guo, C., Yang, H."Inhibition of human oral squamous cell carcinoma proliferation and migration by prodrug‑activating suicide gene therapies Corrigendum in /10.3892/etm.2023.12159". Experimental and Therapeutic Medicine 25, no. 2 (2023): 92. https://doi.org/10.3892/etm.2023.11790
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