Open Access

Repeated bleeding caused by acquired hemophilia A after endoscopic submucosal dissection: A case report and literature review

  • Authors:
    • Song Liu
    • Nian Wang
    • Zhimou Mei
    • Xiaoyang Gao
    • Zhaohong Shi
  • View Affiliations

  • Published online on: February 8, 2023     https://doi.org/10.3892/etm.2023.11828
  • Article Number: 129
  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Endoscopic submucosal dissection (ESD) has been widely used in the treatment of gastrointestinal tract lesions, and hemorrhage is one of the most common complications. The aim of the present study was to investigate the clinical characteristics of hemorrhage after ESD in patients with acquired hemophilia A (AHA). Firstly, a case of AHA with multiple bleeding events after ESD is reported. Colonoscopy was used to perform ESD treatment of the submucosal tumor, and immunohistochemical analysis was used to analyze the tumor properties. Secondly, literature relevant to postoperative hemorrhage caused by AHA was researched and analyzed, with the changes in activated partial thromboplastin time (APTT) before and after operation, coagulation factor VIII (FVIII) activity, FVIII inhibitor value and treatment plan noted. The majority of patients with AHA had no history of coagulation disorder or genetic disease and showed a normal APTT. However, it was found that the APTT value gradually increased after bleeding. In addition, the APTT correction test did not correct for prolonged APTT and FVIII antibody positivity in AHA. There was no bleeding or bleeding tendency prior to surgery in patients with AHA. The study concludes that when repeated bleeding and a poor hemostatic effect occurs, it is necessary to be alerted to the possibility of AHA, as an early diagnosis is essential for effective hemostasis.
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March-2023
Volume 25 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Liu S, Wang N, Mei Z, Gao X and Shi Z: Repeated bleeding caused by acquired hemophilia A after endoscopic submucosal dissection: A case report and literature review. Exp Ther Med 25: 129, 2023
APA
Liu, S., Wang, N., Mei, Z., Gao, X., & Shi, Z. (2023). Repeated bleeding caused by acquired hemophilia A after endoscopic submucosal dissection: A case report and literature review. Experimental and Therapeutic Medicine, 25, 129. https://doi.org/10.3892/etm.2023.11828
MLA
Liu, S., Wang, N., Mei, Z., Gao, X., Shi, Z."Repeated bleeding caused by acquired hemophilia A after endoscopic submucosal dissection: A case report and literature review". Experimental and Therapeutic Medicine 25.3 (2023): 129.
Chicago
Liu, S., Wang, N., Mei, Z., Gao, X., Shi, Z."Repeated bleeding caused by acquired hemophilia A after endoscopic submucosal dissection: A case report and literature review". Experimental and Therapeutic Medicine 25, no. 3 (2023): 129. https://doi.org/10.3892/etm.2023.11828