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Association of polycythemia vera with non‑cirrhotic portal hypertension in five patients: A case series

  • Authors:
    • Lili Zhang
    • Yitong Wang
    • Wenliang Lv
    • Jianhua Hu
    • Chunyan Gou
  • View Affiliations / Copyright

    Affiliations: Integrated Traditional Chinese and Western Medicine Center, Beijing You'an Hospital, Capital Medical University, Beijing 100069, P.R. China, Department of Infectious Diseases, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 149
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    Published online on: February 16, 2023
       https://doi.org/10.3892/etm.2023.11848
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Abstract

Polycythemia vera (PV) and non‑cirrhotic portal hypertension (NCPH) are relatively independent diseases, and few studies have linked them. However, in clinical settings, there may be a causal relationship. The aim of the present study was to analyze the clinical data of five patients with portal hypertension caused by PV and summarize the characteristics of PV with portal hypertension, to enhance the knowledge of this disease. The clinical data of five patients with PV and portal hypertension treated at Beijing You'an Hospital (Beijing, China) from January 2010 to March 2022 were retrospectively collected. The characteristics of these patients were then summarized and analyzed, including general information, laboratory tests, imaging and gastroscopy data. Overall, four patients were diagnosed with PV earlier compared with those with NCPH (ranging between days and years), whereas one patient was diagnosed with NCPH at the time of PV diagnosis. These four patients had blood cell elevations of 2‑3 categories (red blood cells, white blood cells or platelets). The Child classification of liver functions in all five patients were found to be grades A‑B. All five patients had splenomegaly, where three patients had portal vein thrombosis and cavernous degeneration. In addition, four patients had moderate or severe esophageal varices. In conclusion, to the best of our knowledge, this was the first case series of NCPH caused by PV. Among the patients, it was revealed that: i) NCPH caused by PV had milder liver function damage compared with cirrhosis‑induced portal hypertension; ii) splenomegaly, ascites and esophageal varicose veins were prominent symptoms of NCPH caused by PV; iii) If PV is diagnosed, esophagogastroduodenoscopy should be performed as early as possible and regularly, where primary prevention measures for esophageal variceal hemorrhage are recommended; and iv) patients with PV with portal hypertension are at risk of thrombosis and bleeding, but it remains to be determined whether early antithrombotic therapy can reduce complications.
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1 

Barbui T, Tefferi A, Vannucchi AM, Passamonti F, Silver RT, Hoffman R, Verstovsek S, Mesa R, Kiladjian JJ, Hehlmann R, et al: Philadelphia chromosome-negative classical myeloproliferative neoplasms: Revised management recommendations from European LeukemiaNet. Leukemia. 32:1057–1069. 2018.PubMed/NCBI View Article : Google Scholar

2 

Arber DA, Orazi A, Hasserjian R, Thiele J, Borowitz MJ, Le Beau MM, Bloomfield CD, Cazzola M and Vardiman JW: The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood. 127:2391–2405. 2016.PubMed/NCBI View Article : Google Scholar

3 

Ongenae K, Janssens A, Noens L, Wieme N, Geerts ML, Beele H and Naeyaert JM: Erythromelalgia: A clue to the diagnosis of polycythemia vera. Dermatology. 192:408–410. 1996.PubMed/NCBI View Article : Google Scholar

4 

Corredoira Sánchez JC, González López M, Cortés Laiño JA, Gomara García S, Pérez Alvarez R, Casariego Vales B, López Alvarez MJ and García Rodríguez JF: Neurologic manifestations of polycythemia vera. Analysis of 24 cases and review of the literature. An Med Interna. 7:67–70. 1990.PubMed/NCBI(In Spanish).

5 

Torgano G, Mandelli C, Massaro P, Abbiati C, Ponzetto A, Bertinieri G, Bogetto SF, Terruzzi E and de Franchis R: Gastroduodenal lesions in polycythaemia vera: Frequency and role of Helicobacter pylori. Br J Haematol. 117:198–202. 2002.PubMed/NCBI View Article : Google Scholar

6 

Lelonek E, Matusiak L, Wrobel T and Szepietowski JC: Aquagenic pruritus in polycythemia vera: Clinical characteristics. Acta Derm Venereol. 98:496–500. 2018.PubMed/NCBI View Article : Google Scholar

7 

Ong E, Barraco F, Nighoghossian N, Praire A, Desestret V, Derex L, Vighetto A and Biotti D: Cerebrovascular events as presenting manifestations of Myeloproliferative Neoplasm. Rev Neurol (Paris). 172:703–708. 2016.PubMed/NCBI View Article : Google Scholar

8 

Akdi A, Ozeke O, Karanfil M, Ertem AG, Yayla C, Demirtas K, Guney T, Unal S and Selcuk MT: Diurnal rhythm of blood pressure in patients with polycythemia vera. Blood Press Monit. 25:69–74. 2020.PubMed/NCBI View Article : Google Scholar

9 

Venton G, Turcanu M, Colle J, Thuny F, Chebrek S, Farnault L, Mercier C, Ivanov V, Fanciullino R, Suchon P, et al: Pulmonary hypertension in patients with myeloproliferative neoplasms: A large cohort of 183 patients. Eur J Intern Med. 68:71–75. 2019.PubMed/NCBI View Article : Google Scholar

10 

Rossi C, Randi ML, Zerbinati P, Rinaldi V and Girolami A: Acute coronary disease in essential thrombocythemia and polycythemia vera. J Intern Med. 244:49–53. 1998.PubMed/NCBI View Article : Google Scholar

11 

Monge M, Vaida I, Modeliar SS, Solanilla A, Airapetian N, Presne C, Makdassi R, Fournier A and Choukroun G: Retroperitoneal hematoma compressing a single functioning kidney: An unusual Cause of obstructive renal failure. Clin Nephrol. 67:318–320. 2007.PubMed/NCBI View Article : Google Scholar

12 

Cerquozzi S, Barraco D, Lasho T, Finke C, Hanson CA, Ketterling RP, Pardanani A, Gangat N and Tefferi A: Risk factors for arterial versus venous thrombosis in polycythemia vera: A single center experience in 587 patients. Blood Cancer J. 7(662)2017.PubMed/NCBI View Article : Google Scholar

13 

Barbui T, Carobbio A, Rumi E, Finazzi G, Gisslinger H, Rodeghiero F, Randi ML, Rambaldi A, Gisslinger B, Pieri L, et al: In contemporary patients with polycythemia vera, rates of thrombosis and risk factors delineate a new clinical epidemiology. Blood. 124:3021–3023. 2014.PubMed/NCBI View Article : Google Scholar

14 

Plessier A, Darwish-Murad S, Hernandez-Guerra M, Consigny Y, Fabris F, Trebicka J, Heller J, Morard I, Lasser L, Langlet P, et al: Acute portal vein thrombosis unrelated to cirrhosis: A prospective multicenter follow-up study. Hepatology. 51:210–218. 2010.PubMed/NCBI View Article : Google Scholar

15 

Khanna R and Sarin SK: Non-cirrhotic portal hypertension-diagnosis and management. J Hepatol. 60:421–441. 2014.PubMed/NCBI View Article : Google Scholar

16 

European Association for the Study of the Liver. Electronic address: simpleeasloffice@easloffice.eu. EASL clinical practice guidelines: Vascular diseases of the liver. J Hepatol. 64:179–202. 2016.PubMed/NCBI View Article : Google Scholar

17 

de Franchis R: Baveno VI Faculty. Expanding consensus in portal hypertension: Report of the Baveno VI Consensus Workshop: Stratifying risk and individualizing care for portal hypertension. J Hepatol. 63:743–752. 2015.PubMed/NCBI View Article : Google Scholar

18 

Sarin SK, Sethi KK and Nanda R: Measurement and correlation of wedged hepatic, intrahepatic, intrasplenic and intravariceal pressures in patients with cirrhosis of liver and non-cirrhotic portal fibrosis. Gut. 28:260–266. 1987.PubMed/NCBI View Article : Google Scholar

19 

Garcia-Pagan JC, Hernandez-Guerra M and Bosch J: Extrahepatic portal vein thrombosis. Semin Liver Dis. 28:282–292. 2008.PubMed/NCBI View Article : Google Scholar

20 

Sarin SK and Kumar A: Noncirrhotic portal hypertension. Clin Liver Dis. 10:627–651, x. 2006.PubMed/NCBI View Article : Google Scholar

21 

Schouten JN, Garcia-Pagan JC, Valla DC and Janssen HL: Idiopathic noncirrhotic portal hypertension. Hepatology. 54:1071–1081. 2011.PubMed/NCBI View Article : Google Scholar

22 

Vollmar B and Menger MD: The hepatic microcirculation: Mechanistic contributions and therapeutic targets in liver injury and repair. Physiol Rev. 89:1269–1339. 2009.PubMed/NCBI View Article : Google Scholar

23 

Intagliata NM, Caldwell SH and Tripodi A: Diagnosis, development, and treatment of portal vein thrombosis in patients with and without cirrhosis. Gastroenterology. 156:1582–1599.e1. 2019.PubMed/NCBI View Article : Google Scholar

24 

Pugh RN, Murray-Lyon IM, Dawson JL, Pietroni MC and Williams R: Transection of the oesophagus for bleeding oesophageal varices. Br J Surg. 60:646–649. 1973.PubMed/NCBI View Article : Google Scholar

25 

Llop E, de Juan C, Seijo S, Garcia-Criado A, Abraldes JG, Bosch J and Garcia-Pagan JC: Portal cholangiopathy: Radiological classification and natural history. Gut. 60:853–860. 2011.PubMed/NCBI View Article : Google Scholar

26 

Dhiman RK, Behera A, Chawla YK, Dilawari JB and Suri S: Portal hypertensive biliopathy. Gut. 56:1001–1008. 2007.PubMed/NCBI View Article : Google Scholar

27 

Spencer RP and Pearson HA: The spleen as a hematological organ. Semin Nucl Med. 5:95–102. 1975.PubMed/NCBI View Article : Google Scholar

28 

Noronha FC, Seijo S, Plessier A, Silva-Junior G, Turon F, Rautou PE, Baiges A, Bureau C, Bosch J, Hernandez-Gea V, et al: Natural history and management of esophagogastric varices in chronic noncirrhotic, nontumoral portal vein thrombosis. Hepatology. 63:1640–1650. 2016.PubMed/NCBI View Article : Google Scholar

29 

Kovacs TOG and Jensen DM: Varices: Esophageal, gastric, and rectal. Clin Liver Dis. 23:625–642. 2019.PubMed/NCBI View Article : Google Scholar

30 

Nagashima K, Irisawa A, Kashima K, Sakuma F, Minaguchi T, Yamamiya A, Yamabe A, Hoshi K, Tominaga K, Iijima M and Goda K: The risk of bleeding in small/straight esophageal varices with red color sign on endoscopy: A retrospective analysis from the natural course. Healthcare (Basel). 10(1193)2022.PubMed/NCBI View Article : Google Scholar

31 

Tefferi A, Vannucchi AM and Barbui T: Polycythemia vera: Historical oversights, diagnostic details, and therapeutic views. Leukemia. 35:3339–3351. 2021.PubMed/NCBI View Article : Google Scholar

32 

Latagliata R, Spadea A, Cedrone M, Di Giandomenico J, De Muro M, Villiva N, Breccia M, Anaclerico B, Porrini R, Spirito F, et al: Symptomatic mucocutaneous toxicity of hydroxyurea in Philadelphia chromosome-negative myeloproliferative neoplasms: The Mister Hyde face of a safe drug. Cancer. 118:404–409. 2012.PubMed/NCBI View Article : Google Scholar

33 

Bjornsson ES and Andrade RJ: Long-term sequelae of drug-induced liver injury. J Hepatol. 76:435–445. 2022.PubMed/NCBI View Article : Google Scholar

34 

Shepherd PC, Fooks J, Gray R and Allan NC: Thioguanine used in maintenance therapy of chronic myeloid leukaemia causes non-cirrhotic portal hypertension. Results from MRC CML. II. Trial comparing busulphan with busulphan and thioguanine. Br J Haematol. 79:185–192. 1991.PubMed/NCBI View Article : Google Scholar

35 

Kim HP, Navarro V, Zacks S, Odin J, Kleiner DE and Hayashi PH: Drug-Induced Liver Injury Network Investigators. The clinical spectrum and diagnosis of oxaliplatin liver injury in the era of nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol. 19:2199–2201. 2021.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Zhang L, Wang Y, Lv W, Hu J and Gou C: Association of polycythemia vera with non‑cirrhotic portal hypertension in five patients: A case series. Exp Ther Med 25: 149, 2023.
APA
Zhang, L., Wang, Y., Lv, W., Hu, J., & Gou, C. (2023). Association of polycythemia vera with non‑cirrhotic portal hypertension in five patients: A case series. Experimental and Therapeutic Medicine, 25, 149. https://doi.org/10.3892/etm.2023.11848
MLA
Zhang, L., Wang, Y., Lv, W., Hu, J., Gou, C."Association of polycythemia vera with non‑cirrhotic portal hypertension in five patients: A case series". Experimental and Therapeutic Medicine 25.4 (2023): 149.
Chicago
Zhang, L., Wang, Y., Lv, W., Hu, J., Gou, C."Association of polycythemia vera with non‑cirrhotic portal hypertension in five patients: A case series". Experimental and Therapeutic Medicine 25, no. 4 (2023): 149. https://doi.org/10.3892/etm.2023.11848
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang L, Wang Y, Lv W, Hu J and Gou C: Association of polycythemia vera with non‑cirrhotic portal hypertension in five patients: A case series. Exp Ther Med 25: 149, 2023.
APA
Zhang, L., Wang, Y., Lv, W., Hu, J., & Gou, C. (2023). Association of polycythemia vera with non‑cirrhotic portal hypertension in five patients: A case series. Experimental and Therapeutic Medicine, 25, 149. https://doi.org/10.3892/etm.2023.11848
MLA
Zhang, L., Wang, Y., Lv, W., Hu, J., Gou, C."Association of polycythemia vera with non‑cirrhotic portal hypertension in five patients: A case series". Experimental and Therapeutic Medicine 25.4 (2023): 149.
Chicago
Zhang, L., Wang, Y., Lv, W., Hu, J., Gou, C."Association of polycythemia vera with non‑cirrhotic portal hypertension in five patients: A case series". Experimental and Therapeutic Medicine 25, no. 4 (2023): 149. https://doi.org/10.3892/etm.2023.11848
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