Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
April-2023 Volume 25 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2023 Volume 25 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article

IFITM3 rs12252 polymorphism and coronavirus disease 2019 severity: A meta‑analysis

  • Authors:
    • Kai Yu
    • Jingjing Wang
    • Haibin Li
    • Wenjun Wang
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Affiliated Hospital of Beihua University, Jilin, Jilin 132011, P.R. China, Department of Pediatrics, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China, Department of Infectious Diseases, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China
  • Article Number: 158
    |
    Published online on: February 21, 2023
       https://doi.org/10.3892/etm.2023.11857
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Interferon‑induced transmembrane protein 3 (IFITM3) serves a critical role in the immune defense against viral infection, including that of severe acute respiratory syndrome coronavirus 2. To the best of our knowledge, the association between IFITM3 rs12252 polymorphism and coronavirus disease 2019 (COVID‑19) severity has not been determined. In the present study, a meta‑analysis of published case‑control studies assessing the association between the IFITM3 rs12252 polymorphism and COVID‑19 severity was performed. PubMed, EMBASE, China National Knowledge Infrastructure, Wanfang and preprint servers were searched up to March 30, 2022. A fixed‑effect model was used to calculate odds ratio (OR) and 95% confidence interval (95% CI). Analyses were conducted for additive, dominant and recessive genetic models. A total of five studies were identified, with 1,443 mild‑to‑moderate cases and 667 severe cases, including 121 deaths. Overall, the CC genotype of IFITM3 rs12252 was associated with increased risk of severe COVID‑19 (OR=1.97, 95% CI, 1.06‑3.69) and mortality (OR=4.61, 95% CI, 1.44‑14.75) compared with the CT/TT genotypes. Stratified analysis by ethnicity revealed that this association was strong in Chinese individuals (severity, OR=2.84, 95% CI, 1.34‑6.04; mortality, OR=7.91, 95% CI, 1.29‑48.44), but not notable in Caucasians (severity, OR=0.79, 95% CI, 0.23‑2.80; mortality, OR=2.16, 95% CI, 0.37‑12.55). A significant association with mortality was observed in Caucasians when comparing patients with the C allele of IFITM3 rs12252 and those without (CC/CT vs. TT: OR=1.73, 95% CI, 1.09‑2.75). The results suggested that the IFTM3‑rs12252 CC genotype is associated with severe COVID‑19 and mortality in Chinese individuals and the IFTM3‑rs12252 C allele may be associated with COVID‑19 mortality in Caucasians. Large‑scale studies are needed to confirm the association in different global populations.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

World Health Organization: WHO Coronavirus (COVID-19) Dashboard. https://covid19.who.int/. Accessed April 9, 2022.

2 

The National Health Commission of China: The diagnosis and treatment of COVID-19. http://www.nhc.gov.cn/yzygj/s7653p/202203/b74ade1ba4494583805a3d2e40093d88.shtml. Accessed 1 April 2022, 2022.

3 

Ferreira de Araújo JL, Menezes D, Saraiva Duarte JM, de Lima Ferreira L, Santana de Aguiar R and Pedra de Souza R: Systematic review of host genetic association with Covid-19 prognosis and susceptibility: What have we learned in 2020? Rev Med Virol. 32(e2283)2022.PubMed/NCBI View Article : Google Scholar

4 

Suh S, Lee S, Gym H, Yoon S, Park S, Cha J, Kwon DH, Yang Y and Jee SH: A systematic review on papers that study on single nucleotide polymorphism that affects coronavirus 2019 severity. BMC Infect Dis. 22(47)2022.PubMed/NCBI View Article : Google Scholar

5 

Brass AL, Huang IC, Benita Y, John SP, Krishnan MN, Feeley EM, Ryan BJ, Weyer JL, van der Weyden L, Fikrig E, et al: The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus. Cell. 139:1243–1254. 2009.PubMed/NCBI View Article : Google Scholar

6 

Perreira JM, Chin CR, Feeley EM and Brass AL: IFITMs restrict the replication of multiple pathogenic viruses. J Mol Biol. 425:4937–4955. 2013.PubMed/NCBI View Article : Google Scholar

7 

Ren L, Du S, Xu W, Li T, Wu S, Jin N and Li C: Current progress on host antiviral factor IFITMs. Front Immunol. 11(543444)2020.PubMed/NCBI View Article : Google Scholar

8 

Everitt AR, Clare S, Pertel T, John SP, Wash RS, Smith SE, Chin CR, Feeley EM, Sims JS, Adams DJ, et al: IFITM3 restricts the morbidity and mortality associated with influenza. Nature. 484:519–523. 2012.PubMed/NCBI View Article : Google Scholar

9 

Prabhu SS, Chakraborty TT, Kumar N and Banerjee I: Association between IFITM3 rs12252 polymorphism and influenza susceptibility and severity: A meta-analysis. Gene. 674:70–79. 2018.PubMed/NCBI View Article : Google Scholar

10 

Zhang Y, Qin L, Zhao Y, Zhang P, Xu B, Li K, Liang L, Zhang C, Dai Y, Feng Y, et al: Interferon-induced transmembrane protein 3 genetic variant rs12252-C associated with disease severity in coronavirus disease 2019. J Infect Dis. 222:34–37. 2020.PubMed/NCBI View Article : Google Scholar

11 

Pan Y, Li F, Wang X, Liang Z, Cui S, Peng X, Lu G, Zhao J, Liu Y, Wang Q and Zhang D: Association between rs12252 polymorphism in IFITM3 gene and COVID-19. Int J Virology. 28:192–195. 2021.

12 

Alghamdi J, Alaamery M, Barhoumi T, Rashid M, Alajmi H, Aljasser N, Alhendi Y, Alkhalaf H, Alqahtani H, Algablan O, et al: Interferon-induced transmembrane protein-3 genetic variant rs12252 is associated with COVID-19 mortality. Genomics. 113:1733–1741. 2021.PubMed/NCBI View Article : Google Scholar

13 

Cuesta-Llavona E, Albaiceta GM, García-Clemente M, Duarte-Herrera ID, Amado-Rodríguez L, Hermida-Valverde T, Enríquez-Rodriguez AI, Hernández-González C, Melón S, Alvarez-Argüelles ME, et al: Association between the interferon-induced transmembrane protein 3 gene (IFITM3) rs34481144 / rs12252 haplotypes and COVID-19. Curr Res Virol Sci. 2(100016)2021.PubMed/NCBI View Article : Google Scholar

14 

Schönfelder K, Breuckmann K, Elsner C, Dittmer U, Fistera D, Herbstreit F, Risse J, Schmidt K, Sutharsan S, Taube C, et al: The influence of IFITM3 polymorphisms on susceptibility to SARS-CoV-2 infection and severity of COVID-19. Cytokine. 142(155492)2021.PubMed/NCBI View Article : Google Scholar

15 

Wells GA, Shea B, O'Connell D, Peterson J, Welch V, Losos M and Tugwell P: The Newcastle-Ottawa scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. Ottawa Hospital Research Institute, Ottawa, ON, 2000. http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp.

16 

Harbord RM, Harris RJ and Sterne JAC: Updated tests for small-study effects in meta-analyses. Stata J. 9:197–210. 2009.

17 

Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, Rennie D, Moher D, Becker BJ, Sipe TA and Thacker SB: Meta-analysis of observational studies in epidemiology: A proposal for reporting. Meta-analysis Of observational studies in epidemiology (MOOSE) group. JAMA. 283:2008–2012. 2000.PubMed/NCBI View Article : Google Scholar

18 

Zhang YH, Zhao Y, Li N, Peng YC, Giannoulatou E, Jin RH, Yan HP, Wu H, Liu JH, Liu N, et al: Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with severe influenza in Chinese individuals. Nat Commun. 4(1418)2013.PubMed/NCBI View Article : Google Scholar

19 

Randolph AG, Yip WK, Allen EK, Rosenberger CM, Agan AA, Ash SA, Zhang Y, Bhangale TR, Finkelstein D, Cvijanovich NZ, et al: Evaluation of IFITM3 rs12252 association with severe pediatric influenza infection. J Infect Dis. 216:14–21. 2017.PubMed/NCBI View Article : Google Scholar

20 

López-Rodríguez M, Herrera-Ramos E, Solé-Violán J, Ruíz-Hernández JJ, Borderías L, Horcajada JP, Lerma-Chippirraz E, Rajas O, Briones M, Pérez-González MC, et al: IFITM3 and severe influenza virus infection. No evidence of genetic association. Eur J Clin Microbiol Infect Dis. 35:1811–1817. 2016.PubMed/NCBI View Article : Google Scholar

21 

Prelli Bozzo C, Nchioua R, Volcic M, Koepke L, Krüger J, Schütz D, Heller S, Stürzel CM, Kmiec D, Conzelmann C, et al: IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro. Nat Commun. 12(4584)2021.PubMed/NCBI View Article : Google Scholar

22 

Shi G, Kenney AD, Kudryashova E, Zani A, Zhang L, Lai KK, Hall-Stoodley L, Robinson RT, Kudryashov DS, Compton AA and Yount JS: Opposing activities of IFITM proteins in SARS-CoV-2 infection. EMBO J. 40(e106501)2021.PubMed/NCBI View Article : Google Scholar

23 

Wang YS, Luo QL, Guan YG, Fan DY, Luan GM and Jing A: HCMV infection and IFITM3 rs12252 are associated with Rasmussen's encephalitis disease progression. Ann Clin Transl Neurol. 8:558–570. 2021.PubMed/NCBI View Article : Google Scholar

24 

Li M, Li YP, Deng HL, Wang MQ, Chen Y, Zhang YF, Wang J and Dang SS: DNA methylation and SNP in IFITM3 are correlated with hand, foot and mouth disease caused by enterovirus 71. Int J Infect Dis. 105:199–208. 2021.PubMed/NCBI View Article : Google Scholar

25 

Xu-Yang Z, Pei-Yu B, Chuan-Tao Y, Wei Y, Hong-Wei M, Kang T, Chun-Mei Z, Ying-Feng L, Xin W, Ping-Zhong W, et al: Interferon-induced transmembrane protein 3 inhibits Hantaan virus infection, and its single nucleotide polymorphism rs12252 influences the severity of hemorrhagic fever with renal syndrome. Front Immunol. 7(535)2016.PubMed/NCBI View Article : Google Scholar

26 

Zhang Y, Makvandi-Nejad S, Qin L, Zhao Y, Zhang T, Wang L, Repapi E, Taylor S, McMichael A, Li N, et al: Interferon-induced transmembrane protein-3 rs12252-C is associated with rapid progression of acute HIV-1 infection in Chinese MSM cohort. AIDS. 29:889–894. 2015.PubMed/NCBI View Article : Google Scholar

27 

Makvandi-Nejad S, Laurenson-Schafer H, Wang L, Wellington D, Zhao Y, Jin B, Qin L, Kite K, Moghadam HK, Song C, et al: Lack of truncated IFITM3 transcripts in cells homozygous for the rs12252-C variant that is associated with severe influenza infection. J Infect Dis. 217:257–262. 2018.PubMed/NCBI View Article : Google Scholar

28 

Neagu M, Calina D, Docea AO, Constantin C, Filippini T, Vinceti M, Drakoulis N, Poulas K, Nikolouzakis TK, Spandidos DA and Tsatsakis A: Back to basics in COVID-19: Antigens and antibodies-completing the puzzle. J Cell Mol Med. 25:4523–4533. 2021.PubMed/NCBI View Article : Google Scholar

29 

Petrakis D, Nikolouzakis TK, Karzi V, Vardavas AI, Vardavas CI and Tsatsakis A: The growing anthropogenic immune deficit and the COVID-19 pandemic. Public Health Toxicol. 1:1–5. 2021.

30 

Tsatsakis A, Vakonaki E, Tzatzarakis M, Flamourakis M, Nikolouzakis TK, Poulas K, Papazoglou G, Hatzidaki E, Papanikolaou NC, Drakoulis N, et al: Immune response (IgG) following full inoculation with BNT162b2 COVID-19 mRNA among healthcare professionals. Int J Mol Med. 48(200)2021.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yu K, Wang J, Li H and Wang W: <em>IFITM3</em> rs12252 polymorphism and coronavirus disease 2019 severity: A meta‑analysis. Exp Ther Med 25: 158, 2023.
APA
Yu, K., Wang, J., Li, H., & Wang, W. (2023). <em>IFITM3</em> rs12252 polymorphism and coronavirus disease 2019 severity: A meta‑analysis. Experimental and Therapeutic Medicine, 25, 158. https://doi.org/10.3892/etm.2023.11857
MLA
Yu, K., Wang, J., Li, H., Wang, W."<em>IFITM3</em> rs12252 polymorphism and coronavirus disease 2019 severity: A meta‑analysis". Experimental and Therapeutic Medicine 25.4 (2023): 158.
Chicago
Yu, K., Wang, J., Li, H., Wang, W."<em>IFITM3</em> rs12252 polymorphism and coronavirus disease 2019 severity: A meta‑analysis". Experimental and Therapeutic Medicine 25, no. 4 (2023): 158. https://doi.org/10.3892/etm.2023.11857
Copy and paste a formatted citation
x
Spandidos Publications style
Yu K, Wang J, Li H and Wang W: <em>IFITM3</em> rs12252 polymorphism and coronavirus disease 2019 severity: A meta‑analysis. Exp Ther Med 25: 158, 2023.
APA
Yu, K., Wang, J., Li, H., & Wang, W. (2023). <em>IFITM3</em> rs12252 polymorphism and coronavirus disease 2019 severity: A meta‑analysis. Experimental and Therapeutic Medicine, 25, 158. https://doi.org/10.3892/etm.2023.11857
MLA
Yu, K., Wang, J., Li, H., Wang, W."<em>IFITM3</em> rs12252 polymorphism and coronavirus disease 2019 severity: A meta‑analysis". Experimental and Therapeutic Medicine 25.4 (2023): 158.
Chicago
Yu, K., Wang, J., Li, H., Wang, W."<em>IFITM3</em> rs12252 polymorphism and coronavirus disease 2019 severity: A meta‑analysis". Experimental and Therapeutic Medicine 25, no. 4 (2023): 158. https://doi.org/10.3892/etm.2023.11857
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team