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Association of microRNA gene polymorphisms with recurrent spontaneous abortion: An updated meta‑analysis

  • Authors:
    • Xueqin Wang
    • Yan Xing
    • Yongyong Wang
    • Zhaoxia Du
    • Chang Zhang
    • Jing Gao
  • View Affiliations / Copyright

    Affiliations: Department of Reproductive Medicine, Qingdao Municipal Hospital, Qingdao, Shandong 266071, P.R. China, Department of Reproductive Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 179
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    Published online on: March 10, 2023
       https://doi.org/10.3892/etm.2023.11878
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Abstract

Numerous studies have reported single nucleotide polymorphisms (SNPs) in microRNAs (miRNAs) associated with unexplained recurrent spontaneous abortion (URSA). The present study aimed to conduct an updated meta‑analysis to confirm a pooled effect size of the association between miRNA SNPs and URSA. The relevant literature was searched on PubMed, EMBASE, Web of Science and Cochrane Library before July 2022 to identify case‑control studies. The pooled odds ratio and confidence intervals at 95% of the eligible studies were extracted and evaluated under five genetic models. A total of 18 studies involving 3,850 cases and 4,312 controls were included. miR499a rs3746444 A>G, miR‑149 rs2292832 T>C, miR‑125a rs41275794 G>A and miR‑10a rs3809783 A>T may enhance the risk of recurrent spontaneous abortion (RSA) under various genetic models. Although no separate association was found between the miR‑125a rs12976445 C>T and miR‑27a rs895819 A>G polymorphisms and RSA, statistical significance was found in certain ethnic groups only. The current analysis suggests a high significance of an up‑to‑date meta‑analysis for screening out and preventing URSA among high‑risk women by testing miRNA SNPs and RSA susceptibility.
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Copy and paste a formatted citation
Spandidos Publications style
Wang X, Xing Y, Wang Y, Du Z, Zhang C and Gao J: Association of microRNA gene polymorphisms with recurrent spontaneous abortion: An updated meta‑analysis. Exp Ther Med 25: 179, 2023.
APA
Wang, X., Xing, Y., Wang, Y., Du, Z., Zhang, C., & Gao, J. (2023). Association of microRNA gene polymorphisms with recurrent spontaneous abortion: An updated meta‑analysis. Experimental and Therapeutic Medicine, 25, 179. https://doi.org/10.3892/etm.2023.11878
MLA
Wang, X., Xing, Y., Wang, Y., Du, Z., Zhang, C., Gao, J."Association of microRNA gene polymorphisms with recurrent spontaneous abortion: An updated meta‑analysis". Experimental and Therapeutic Medicine 25.4 (2023): 179.
Chicago
Wang, X., Xing, Y., Wang, Y., Du, Z., Zhang, C., Gao, J."Association of microRNA gene polymorphisms with recurrent spontaneous abortion: An updated meta‑analysis". Experimental and Therapeutic Medicine 25, no. 4 (2023): 179. https://doi.org/10.3892/etm.2023.11878
Copy and paste a formatted citation
x
Spandidos Publications style
Wang X, Xing Y, Wang Y, Du Z, Zhang C and Gao J: Association of microRNA gene polymorphisms with recurrent spontaneous abortion: An updated meta‑analysis. Exp Ther Med 25: 179, 2023.
APA
Wang, X., Xing, Y., Wang, Y., Du, Z., Zhang, C., & Gao, J. (2023). Association of microRNA gene polymorphisms with recurrent spontaneous abortion: An updated meta‑analysis. Experimental and Therapeutic Medicine, 25, 179. https://doi.org/10.3892/etm.2023.11878
MLA
Wang, X., Xing, Y., Wang, Y., Du, Z., Zhang, C., Gao, J."Association of microRNA gene polymorphisms with recurrent spontaneous abortion: An updated meta‑analysis". Experimental and Therapeutic Medicine 25.4 (2023): 179.
Chicago
Wang, X., Xing, Y., Wang, Y., Du, Z., Zhang, C., Gao, J."Association of microRNA gene polymorphisms with recurrent spontaneous abortion: An updated meta‑analysis". Experimental and Therapeutic Medicine 25, no. 4 (2023): 179. https://doi.org/10.3892/etm.2023.11878
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