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Effect of Sodium selenite administration on the process of tendon healing in Wistar male rats

  • Authors:
    • Dragos C. Cotor
    • Serban Dragosloveanu
    • Alina Ionescu
    • Gavrila Zagrai
    • Aurel Damian
  • View Affiliations / Copyright

    Affiliations: Department of Anatomy, University of Agricultural Sciences and Veterinary Medicine, 400372 Cluj‑Napoca, Romania, Department of Orthopedics, Foisor Orthopedics Hospital, 020021 Bucharest, Romania, Department of Anatomy, University of Agricultural Sciences and Veterinary Medicine, 011464 Bucharest, Romania
    Copyright: © Cotor et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 181
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    Published online on: March 10, 2023
       https://doi.org/10.3892/etm.2023.11880
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Abstract

Tendon lesions have a great effect on the quality of life and medical spending. Thus is important to investigate the mechanisms responsible for tendon healing and to identify novel treatment options. The aim of the present study was to evaluate the effect of Selenium on the healing processes of injured tendons. A total of 20 Wistar male rats were used and were split into two groups with two different treatment methods. The first group received a normal food administration, while the second group received Na2SeO3. The animals were kept for 28 days. During the eighth day, all animals underwent surgical experimental Achilles tendon lesion and a Kessler‑type suture. After three weeks, the animals were sacrificed and the tendon was extracted for histological evaluation in order to do a comparison according to the Movin scale (modified by Bonar). The histological evaluation revealed an even orientation of the collagen fibers in the case of the experimental group (Se) compared with the second group. The Bonar score was 1.62 for the Se group, while the control group had a Bonar score of 1.98. The average number of tenocytes in the Se group was lower which is demonstrated by a lower Bonar score (1.22), compared with the second group (Bonar Score 1.85). In addition, a slightly higher number of tenocytes compared with the intact tendon areas was recorded. In vascularization, a decreased amount of blood vessels in the experimental group (Se) was observed (Bonar Score 1.70), compared with the control group (Bonar score 1.96). The present study demonstrated that Selenium administration on murine models could be beneficial for tendon healing. Further clinical research is required in order for this to be confidently recommended.
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1 

Astrom M and Rausing A: Chronic Achilles tendinopathy: A survey of surgical and histopathologic findings. Clin Orthop. 316:151–164. 1995.PubMed/NCBI

2 

Maffulli N, Wong J and Almekinders LC: Types and epidemiology of tendinopathy. Clin Sports Med. 22:675–692. 2003.PubMed/NCBI View Article : Google Scholar

3 

Ghita M, Cotor G, Viţălaru AB and Braslasu D: Comparative study on the effect of prednisone and dexamethasone on leukocytes, in rabbit. J Biotechnol. 208(S92)2015.

4 

Longo UG, Oliva F, Denaro V and Maffulli N: Oxygen species and overuse tendinopathy in athletes. Disabil Rehabil. 30:1563–1571. 2008.PubMed/NCBI View Article : Google Scholar

5 

Cotor G, Birtoiu IA, Ionita L, Tanase A and Vitalaru BA: The anti-inflammatory effect of a Cannabis sativa oil supplement in experimental acute inflammation in rats. J Biotechnol. 185(S45)2014.

6 

DePhillipo NN, Aman ZS, Kennedy MI, Begley JP, Moatshe G and LaPrade RF: Efficacy of Vitamin C supplementation on collagen synthesis and oxidative stress after musculoskeletal injuries: A systematic review. Orthop J Sports Med. 6(2325967118804544)2018.PubMed/NCBI View Article : Google Scholar

7 

Hung LK, Fu SC, Lee YW, Mok TY and Chan KM: Local vitamin-C injection reduced tendon adhesion in a chicken model of flexor digitorum profundus tendon injury. J Bone Joint Surg Am. 95(e41)2013.PubMed/NCBI View Article : Google Scholar

8 

Gajaila G, Gajaila I, Cotor G and Ionita L: Testing the killing ability of pig neutrophils after stimulation with an ethanolamine derivative. J Biotechnol. 231(S63)2016.

9 

Stadtman TC: Selenium biochemistry. Mammalian selenoenzymes. Ann N Y Acad Sci. 899:399–402. 2000.PubMed/NCBI View Article : Google Scholar

10 

Rayman MP: The importance of selenium to human health. Lancet. 356:233–241. 2000.PubMed/NCBI View Article : Google Scholar

11 

Toxicological Profile for Selenium. Agency for Toxic Substances and Disease Registry. U.S. Department of Health and Human Services, Atlanta, GA, 2003.

12 

Moreno-Reyes R, Suetens C, Mathieu F, Begaux F, Zhu D, Rivera MT, Boelaert M, Nève J, Perlmutter N and Vanderpas J: Kashin-Beck osteoarthropathy in rural Tibet in relation to selenium and iodine status. N Engl J Med. 339:1112–1120. 1998.PubMed/NCBI View Article : Google Scholar

13 

Thompson KM, Haibach H and Sunde RA: Growth and plasma triiodothyronine concentrations are modified by selenium deficiency and repletion in second-generation selenium-deficient rats. J Nutr. 125:864–873. 1995.PubMed/NCBI View Article : Google Scholar

14 

Yang C, Wolf E, Roser K, Delling G and Muller PK: Selenium deficiency and fulvic acid supplementation induces fibrosis of cartilage and disturbs subchondral ossification in knee joints of mice: An animal model study of Kashin-Beck disease. Virchows Arch A Pathol Anat Histopathol. 423:483–491. 1993.PubMed/NCBI View Article : Google Scholar

15 

Vinceti M, Filippini T, Cilloni S, Bargellini A, Vergoni AV, Tsatsakis A and Ferrante M: Health risk assessment of environmental selenium: Emerging evidence and challenges (Review). Mol Med Rep. 15:3323–3335. 2017.PubMed/NCBI View Article : Google Scholar

16 

Perri G, Hill TR, Mathers JC, Walsh JS, Gossiel F, Winther K, Frölich J, Folkestad L, Cold S and Eastell R: Long-term selenium-yeast supplementation does not affect bone turnover markers: A randomized placebo-controlled trial. J Bone Miner Res. 37:2165–2173. 2022.PubMed/NCBI View Article : Google Scholar

17 

Woth G, Nagy B, Mérei Á, Ernyey B, Vincze R, Kaurics Z, Lantos J, Bogár L and Mühl D: The effect of Na-selenite treatment on the oxidative stress-antioxidants balance of multiple organ failure. J Crit Care. 29:883.e7–11. 2014.PubMed/NCBI View Article : Google Scholar

18 

Vinceti M, Chiari A, Eichmüller M, Rothman KJ, Filippini T, Malagoli C, Weuve J, Tondelli M, Zamboni G, Nichelli PF and Michalke B: A selenium species in cerebrospinal fluid predicts conversion to Alzheimer's dementia in persons with mild cognitive impairment. Alzheimers Res Ther. 9(100)2017.PubMed/NCBI View Article : Google Scholar

19 

Mandrioli J, Michalke B, Solovyev N, Grill P, Violi F, Lunetta C, Conte A, Sansone VA, Sabatelli M and Vinceti M: Elevated levels of selenium species in cerebrospinal fluid of amyotrophic lateral sclerosis patients with disease-associated gene mutations. Neurodegener Dis. 17:171–180. 2017.PubMed/NCBI View Article : Google Scholar

20 

Jacevic V, Jokic G, Dragojevic-Simic V, Bokonjic D, Vucinic S and Vuksa M: Acute toxicity of sodium selenite in rodents: Pathomorphological study. Mil Med Sci Lett (Voj Zdrav Listy). 80:90–96. 2011.

21 

Maffulli N, Longo UG, Franceschi F, Rabitti C and Denaro V: Movin and Bonar scores assess the same characteristics of tendon histology. Clin Orthop Relat Res. 466:1605–1611. 2008.PubMed/NCBI View Article : Google Scholar

22 

Fearon A, Dahlstrom JE, Twin J, Cook J and Scott A: The Bonar score revisited: region of evaluation significantly influences the standardized assessment of tendon degeneration. J Sci Med Sport. 17:346–350. 2014.PubMed/NCBI View Article : Google Scholar

23 

Leadbetter WB: Cell-matrix response in tendon injury. Clin Sports Med. 11:533–578. 1992.PubMed/NCBI

24 

Longo UG, Franceschi F, Ruzzini L, Rabitti C, Morini S, Maffulli N and Denaro V: Histopathology of the supraspinatus tendon in rotator cuff tears. Am J Sports Med. 36:533–538. 2008.PubMed/NCBI View Article : Google Scholar

25 

Murrell GA, Szabo C, Hannafin JA, Jang D, Dolan MM, Deng XH, Murrell DF and Warren RF: Modulation of tendon healing by nitric oxide. Inflamm Res. 46:19–27. 1997.PubMed/NCBI View Article : Google Scholar

26 

Sun J, Wu Y, Long C, He P, Gu J, Yang L, Liang Y and Wang Y: Anthocyanins isolated from blueberry ameliorates CCl4 induced liver fibrosis by modulation of oxidative stress, inflammation and stellate cell activation in mice. Food Chem Toxicol. 120:491–499. 2018.PubMed/NCBI View Article : Google Scholar

27 

Murrell GA: Oxygen free radicals and tendon healing. J Shoulder Elbow Surg. 16 (5 Suppl):S208–S214. 2007.PubMed/NCBI View Article : Google Scholar

28 

Moraes SA, Oliveira KR, Crespo-López ME, Picanço-Diniz DL and Herculano AM: Local NO synthase inhibition produces histological and functional recovery in Achilles tendon of rats after tenotomy: Tendon repair and local NOS inhibition. Cell Tissue Res. 353:457–463. 2013.PubMed/NCBI View Article : Google Scholar

29 

Zhao Q, Yang F, Meng L, Chen D, Wang M, Lu X, Chen D, Jiang Y and Xing N: Lycopene attenuates chronic prostatitis/chronic pelvic pain syndrome by inhibiting oxidative stress and inflammation via the interaction of NF-κB, MAPKs, and Nrf2 signaling pathways in rats. Andrology. 8:747–755. 2020.PubMed/NCBI View Article : Google Scholar

30 

Roman M, Jitaru P and Barbante C: Selenium biochemistry and its role for human health. Metallomics. 6:25–54. 2014.PubMed/NCBI View Article : Google Scholar

31 

Flohé L and Brigelius-Flohé R: Selenoproteins of the Glutathione Peroxidase Family. In: Selenium. Hatfield D, Berry M and Gladyshev V (eds). Springer, New York, NY, 2011.

32 

Kaushal N, Gandhi UH, Nelson SM, Narayan V and Prabhu KS: Selenium and Inflammation. In: Selenium. Hatfield D, Berry M and Gladyshev V (eds). Springer, New York, NY, 2011.

33 

Tirosh O, Levy E and Reifen R: . High selenium diet protects against TNBS-induced acute inflammation, mitochondrial dysfunction and secondary necrosis in rat colon. Nutrition. 23:878–886. 2007.PubMed/NCBI View Article : Google Scholar

34 

Maehira F, Luyo GA, Miyagi I, Oshiro M, Yamane N, Kuba M and Nakazato Y: Alterations of serum selenium concentrations in the acute phase of pathological conditions. Clin Chim Acta. 316:137–146. 2002.PubMed/NCBI View Article : Google Scholar

35 

Sakr Y, Reinhart K, Bloos F, Marx G, Russwurm S, Bauer M and Brunkhorst F: Time course and relationship between plasma selenium concentrations, systemic inflammatory response, sepsis, and multiorgan failure. Br J Anaesth. 98:775–784. 2007.PubMed/NCBI View Article : Google Scholar

36 

Dragosloveanu Ş, Cotor DC, Dragosloveanu CDM, Stoian C and Stoica CI: Preclinical study analysis of massive magnesium alloy graft for calcaneal fractures. Exp Ther Med. 22(731)2021.PubMed/NCBI View Article : Google Scholar

37 

Walsh JS, Jacques RM, Schomburg L, Hill TR, Mathers JC, Williams GR and Eastell R: Effect of selenium supplementation on musculoskeletal health in older women: A randomised, double-blind, placebo-controlled trial. Lancet Healthy Longev. 2:e212–e221. 2021.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Cotor DC, Dragosloveanu S, Ionescu A, Zagrai G and Damian A: Effect of Sodium selenite administration on the process of tendon healing in Wistar male rats. Exp Ther Med 25: 181, 2023.
APA
Cotor, D.C., Dragosloveanu, S., Ionescu, A., Zagrai, G., & Damian, A. (2023). Effect of Sodium selenite administration on the process of tendon healing in Wistar male rats. Experimental and Therapeutic Medicine, 25, 181. https://doi.org/10.3892/etm.2023.11880
MLA
Cotor, D. C., Dragosloveanu, S., Ionescu, A., Zagrai, G., Damian, A."Effect of Sodium selenite administration on the process of tendon healing in Wistar male rats". Experimental and Therapeutic Medicine 25.4 (2023): 181.
Chicago
Cotor, D. C., Dragosloveanu, S., Ionescu, A., Zagrai, G., Damian, A."Effect of Sodium selenite administration on the process of tendon healing in Wistar male rats". Experimental and Therapeutic Medicine 25, no. 4 (2023): 181. https://doi.org/10.3892/etm.2023.11880
Copy and paste a formatted citation
x
Spandidos Publications style
Cotor DC, Dragosloveanu S, Ionescu A, Zagrai G and Damian A: Effect of Sodium selenite administration on the process of tendon healing in Wistar male rats. Exp Ther Med 25: 181, 2023.
APA
Cotor, D.C., Dragosloveanu, S., Ionescu, A., Zagrai, G., & Damian, A. (2023). Effect of Sodium selenite administration on the process of tendon healing in Wistar male rats. Experimental and Therapeutic Medicine, 25, 181. https://doi.org/10.3892/etm.2023.11880
MLA
Cotor, D. C., Dragosloveanu, S., Ionescu, A., Zagrai, G., Damian, A."Effect of Sodium selenite administration on the process of tendon healing in Wistar male rats". Experimental and Therapeutic Medicine 25.4 (2023): 181.
Chicago
Cotor, D. C., Dragosloveanu, S., Ionescu, A., Zagrai, G., Damian, A."Effect of Sodium selenite administration on the process of tendon healing in Wistar male rats". Experimental and Therapeutic Medicine 25, no. 4 (2023): 181. https://doi.org/10.3892/etm.2023.11880
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