Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
April-2023 Volume 25 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2023 Volume 25 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report Open Access

Different interventions and outcomes in four teeth with regenerative endodontic procedures in the same patient: A case report with 7‑year follow‑up

  • Authors:
    • Jing Yang
    • Xiaohang Guan
    • Rui Han
    • Jin Yue
    • Libin Xu
    • Lei Ma
  • View Affiliations / Copyright

    Affiliations: Department of Stomatology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, P.R. China, Department of Stomatology, Hexi Clinic of Tianjin Stomatological Hospital, Tianjin 300000, P.R. China
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 182
    |
    Published online on: March 10, 2023
       https://doi.org/10.3892/etm.2023.11881
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study reported on the case of a 10‑year‑old male patient with four second premolar teeth undergoing regenerative endodontic procedures (REPs) for periapical periodontitis due to abnormal central cusp fracture, and the follow‑up over 7 years. Annual follow‑up clinical and radiographic examinations were performed to assess the effectiveness of treatment. After the initial RPEs, the apical inflammation of teeth #15 and #45 disappeared and their roots continued to develop. However, teeth #25 and #35 exhibited different signs of inflammation and were treated with calcium hydroxide apexification and the second REPs, respectively. Subsequently, the narrowing of the apical foramen and healing of periapical inflammation were observed. The root of tooth #35 continued to develop but still exhibited apical inflammation. In the present case, apexification with calcium hydroxide and the second REPs were used as alternative interventions for teeth that failed after REPs. However, interventional treatment after a failure was not able to predict outcomes, necessitating a further study with a large number of cases for observational description.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Levitan ME and Himel VT: Dens evaginatus: Literature review, pathophysiology, and comprehensive treatment regimen. J Endod. 32:1–9. 2006.PubMed/NCBI View Article : Google Scholar

2 

Cho SY: Dental abscess in a tooth with intact dens evaginatus. Int J Paediatr Dent. 16:135–138. 2006.PubMed/NCBI View Article : Google Scholar

3 

Rafter M: Apexification: A review. Dent Traumatol. 21:1–8. 2005.PubMed/NCBI View Article : Google Scholar

4 

Kim SG, Malek M, Sigurdsson A, Lin LM and Kahler B: Regenerative endodontics: A comprehensive review. Int Endod J. 51:1367–1388. 2018.PubMed/NCBI View Article : Google Scholar

5 

Nagy MM, Tawfik HE, Hashem AA and Abu-Seida AM: Regenerative potential of immature permanent teeth with necrotic pulps after different regenerative protocols. J Endod. 40:192–198. 2014.PubMed/NCBI View Article : Google Scholar

6 

American Association of Endodontists: AAE Clinical Considerations for a Regenerative Procedures. American Association of Endodontists, Chicago, IL, 2021. https://www.aae.org/specialty/wp-content/uploads/sites/2/2021/08/Clinical Considerations ApprovedByREC062921.pdf. Accessed February 8, 2021.

7 

Meschi N, Palma PJ and Cabanillas-Balsera D: Effectiveness of revitalization in treating apical periodontitis: A systematic review and meta-analysis. Int Endod J: May 17, 2022 (Epub ahead of print).

8 

Hargreaves KM, Diogenes A and Teixeira FB: Treatment options: Biological basis of regenerative endodontic procedures. J Endod. 39 (3 Suppl):S30–S43. 2013.PubMed/NCBI View Article : Google Scholar

9 

Torabinejad M, Nosrat A, Verma P and Udochukwu O: Regenerative endodontic treatment or mineral trioxide aggregate apical plug in teeth with necrotic pulps and open apices: A systematic review and meta-analysis. J Endod. 43:1806–1820. 2017.PubMed/NCBI View Article : Google Scholar

10 

Jafarzadeh H and Abbott PV: Review of pulp sensibility tests. Part II: Electric pulp tests and test cavities. Int Endod J. 43:945–958. 2010.PubMed/NCBI View Article : Google Scholar

11 

Jafarzadeh H and Abbott PV: Review of pulp sensibility tests. Part I: General information and thermal tests. Int Endod J. 43:738–762. 2010.PubMed/NCBI View Article : Google Scholar

12 

Bose R, Nummikoski P and Hargreaves K: A retrospective evaluation of radiographic outcomes in immature teeth with necrotic root canal systems treated with regenerative endodontic procedures. J Endod. 35:1343–1349. 2009.PubMed/NCBI View Article : Google Scholar

13 

Flake NM, Gibbs JL, Diogenes A, Hargreaves KM and Khan AA: A standardized novel method to measure radiographic root changes after endodontic therapy in immature teeth. J Endod. 40:46–50. 2014.PubMed/NCBI View Article : Google Scholar

14 

Alobaid AS, Cortes LM, Lo J, Nguyen TT, Albert J, Abu-Melha AS, Lin LM and Gibbs JL: Radiographic and clinical outcomes of the treatment of immature permanent teeth by revascularization or apexification: A pilot retrospective cohort study. J Endod. 40:1063–1070. 2014.PubMed/NCBI View Article : Google Scholar

15 

Saoud TM, Zaazou A, Nabil A, Moussa S, Lin LM and Gibbs JL: Clinical and radiographic outcomes of traumatized immature permanent necrotic teeth after revascularization/revitalization therapy. J Endod. 40:1946–1952. 2014.PubMed/NCBI View Article : Google Scholar

16 

Geisler TM: Clinical considerations for regenerative endodontic procedures. Dent Clin North Am. 56:603–626. 2012.PubMed/NCBI View Article : Google Scholar

17 

Galler KM, Krastl G, Simon S, Van Gorp G, Meschi N, Vahedi B and Lambrechts P: European Society of Endodontology position statement: Revitalization procedures. Int Endod J. 49:717–723. 2016.PubMed/NCBI View Article : Google Scholar

18 

Wei X, Yang M, Yue L, Huang D, Zhou X, Wang X, Zhang Q, Qiu L, Huang Z, Wang H, et al: Expert consensus on regenerative endodontic procedures. Int J Oral Sci. 14(55)2022.PubMed/NCBI View Article : Google Scholar

19 

Chan EK, Desmeules M, Cielecki M, Dabbagh B and Ferraz Dos Santos B: Longitudinal cohort study of regenerative endodontic treatment for immature necrotic permanent teeth. J Endod. 43:395–400. 2017.PubMed/NCBI View Article : Google Scholar

20 

Ong TK, Lim GS, Singh M and Fial AV: Quantitative assessment of root development after regenerative endodontic therapy: A systematic review and meta-analysis. J Endod. 46:1856–1866 e2. 2020.PubMed/NCBI View Article : Google Scholar

21 

Ricucci D and Siqueira JF Jr: Fate of the tissue in lateral canals and apical ramifications in response to pathologic conditions and treatment procedures. J Endod. 36:1–15. 2010.PubMed/NCBI View Article : Google Scholar

22 

Abbaszadegan A, Dadolahi S, Gholami A, Moein MR, Hamedani S, Ghasemi Y and Abbott PV: Antimicrobial and cytotoxic activity of cinnamomum zeylanicum, calcium hydroxide, and triple antibiotic paste as root canal dressing materials. J Contemp Dent Pract. 17:105–113. 2016.PubMed/NCBI View Article : Google Scholar

23 

Ruparel NB, Teixeira FB, Ferraz CC and Diogenes A: Direct effect of intracanal medicaments on survival of stem cells of the apical papilla. J Endod. 38:1372–1375. 2012.PubMed/NCBI View Article : Google Scholar

24 

Montero-Miralles P, Martin-Gonzalez J, Alonso-Ezpeleta O, Jimenez-Sanchez MC, Velasco-Ortega E and Segura-Egea JJ: Effectiveness and clinical implications of the use of topical antibiotics in regenerative endodontic procedures: A review. Int Endod J. 51:981–988. 2018.PubMed/NCBI View Article : Google Scholar

25 

Lui JN, Lim WY and Ricucci D: An Immunofluorescence study to analyze wound healing outcomes of regenerative endodontics in an immature premolar with chronic apical abscess. J Endod. 46:627–640. 2020.PubMed/NCBI View Article : Google Scholar

26 

Almutairi W, Yassen GH, Aminoshariae A, Williams KA and Mickel A: Regenerative endodontics: A systematic analysis of the failed cases. J Endod. 45:567–577. 2019.PubMed/NCBI View Article : Google Scholar

27 

Zizka R, Sedy J and Voborna I: Retreatment of failed revascularization/revitalization of immature permanent tooth-A case report. J Clin Exp Dent. 10:e185–e188. 2018.PubMed/NCBI View Article : Google Scholar

28 

Brogni JK, Vitali FC, Cardoso IV, Dos Santos JD, Prado M, Alves AMH and Duque TM: A second attempt at pulp revascularisation on an immature traumatised anterior tooth: A case report with two-year follow-up. Aust Endod J. 47:90–96. 2021.PubMed/NCBI View Article : Google Scholar

29 

Fang Y, Wang X, Zhu J, Su C, Yang Y and Meng L: Influence of apical diameter on the outcome of regenerative endodontic treatment in teeth with pulp necrosis: A review. J Endod. 44:414–431. 2018.PubMed/NCBI View Article : Google Scholar

30 

Chen MY, Chen KL, Chen CA, Tayebaty F, Rosenberg PA and Lin LM: Responses of immature permanent teeth with infected necrotic pulp tissue and apical periodontitis/abscess to revascularization procedures. Int Endod J. 45:294–305. 2012.PubMed/NCBI View Article : Google Scholar

31 

Petridis X, van der Sluis LWM, Dijkstra RJB, Brinker MGL, van der Mei HC and Harmsen MC: Secreted products of oral bacteria and biofilms impede mineralization of apical papilla stem cells in TLR-, species-, and culture-dependent fashion. Sci Rep. 8(12529)2018.PubMed/NCBI View Article : Google Scholar

32 

Rakhimova O, Schmidt A, Landstrom M, Johansson A, Kelk P and Romani Vestman N: Cytokine secretion, viability, and real-time proliferation of apical-papilla stem cells upon exposure to oral bacteria. Front Cell Infect Microbiol. 10(620801)2020.PubMed/NCBI View Article : Google Scholar

33 

Casey SM, Fox D, Duong W, Bui N, Latifi N, Ramesh V, Podborits E, Flake NM, Khan AA and Gibbs JL: Patient centered outcomes among a cohort receiving regenerative endodontic procedures or apexification treatments. J Endod. 48:345–354. 2022.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yang J, Guan X, Han R, Yue J, Xu L and Ma L: Different interventions and outcomes in four teeth with regenerative endodontic procedures in the same patient: A case report with 7‑year follow‑up. Exp Ther Med 25: 182, 2023.
APA
Yang, J., Guan, X., Han, R., Yue, J., Xu, L., & Ma, L. (2023). Different interventions and outcomes in four teeth with regenerative endodontic procedures in the same patient: A case report with 7‑year follow‑up. Experimental and Therapeutic Medicine, 25, 182. https://doi.org/10.3892/etm.2023.11881
MLA
Yang, J., Guan, X., Han, R., Yue, J., Xu, L., Ma, L."Different interventions and outcomes in four teeth with regenerative endodontic procedures in the same patient: A case report with 7‑year follow‑up". Experimental and Therapeutic Medicine 25.4 (2023): 182.
Chicago
Yang, J., Guan, X., Han, R., Yue, J., Xu, L., Ma, L."Different interventions and outcomes in four teeth with regenerative endodontic procedures in the same patient: A case report with 7‑year follow‑up". Experimental and Therapeutic Medicine 25, no. 4 (2023): 182. https://doi.org/10.3892/etm.2023.11881
Copy and paste a formatted citation
x
Spandidos Publications style
Yang J, Guan X, Han R, Yue J, Xu L and Ma L: Different interventions and outcomes in four teeth with regenerative endodontic procedures in the same patient: A case report with 7‑year follow‑up. Exp Ther Med 25: 182, 2023.
APA
Yang, J., Guan, X., Han, R., Yue, J., Xu, L., & Ma, L. (2023). Different interventions and outcomes in four teeth with regenerative endodontic procedures in the same patient: A case report with 7‑year follow‑up. Experimental and Therapeutic Medicine, 25, 182. https://doi.org/10.3892/etm.2023.11881
MLA
Yang, J., Guan, X., Han, R., Yue, J., Xu, L., Ma, L."Different interventions and outcomes in four teeth with regenerative endodontic procedures in the same patient: A case report with 7‑year follow‑up". Experimental and Therapeutic Medicine 25.4 (2023): 182.
Chicago
Yang, J., Guan, X., Han, R., Yue, J., Xu, L., Ma, L."Different interventions and outcomes in four teeth with regenerative endodontic procedures in the same patient: A case report with 7‑year follow‑up". Experimental and Therapeutic Medicine 25, no. 4 (2023): 182. https://doi.org/10.3892/etm.2023.11881
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team