Open Access

Research advances in crosstalk between muscle and bone in osteosarcopenia (Review)

  • Authors:
    • Chen Yu
    • Yongjun Du
    • Zhi Peng
    • Chengjie Ma
    • Junhua Fang
    • Langtao Ma
    • Fei Chen
    • Chaoqun Zhang
    • Ruizhi Geng
    • Yangyang Zhang
    • Xi Han
    • Jiayi Li
    • Yan Lv
    • Sheng Lu
  • View Affiliations

  • Published online on: March 14, 2023     https://doi.org/10.3892/etm.2023.11888
  • Article Number: 189
  • Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Osteosarcopenia is a burgeoning geriatric syndrome and a familiar disease among older individuals. It is characterized by reduced skeletal muscle mass and bone mineral density due to osteoporosis and sarcopenia. Its clinical manifestations include reduced physical performance and individuals becoming prone to falls during the aging process resulting in fractures and hospitalization, which seriously affects the quality of life of patients and increases the risk of death. Due to the aging social structure of the global population, the morbidity of osteosarcopenia is expected to continue to increase. Both muscle and bone belong to the motor system and originate from the mesoderm; therefore, sarcopenia and osteoporosis also share similar pathogenical factors, which influence and regulate each other. Studying the pathogenesis and treatment of osteosarcopenia is of great significance to improve the quality of life of patients. Therefore, the present study reviewed the research progress on sarcopenia and osteoporosis in osteosarcopenia from the standpoints of its definition, epidemiology, clinical manifestations and diagnosis, prevention and treatment.
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April-2023
Volume 25 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Yu C, Du Y, Peng Z, Ma C, Fang J, Ma L, Chen F, Zhang C, Geng R, Zhang Y, Zhang Y, et al: Research advances in crosstalk between muscle and bone in osteosarcopenia (Review). Exp Ther Med 25: 189, 2023
APA
Yu, C., Du, Y., Peng, Z., Ma, C., Fang, J., Ma, L. ... Lu, S. (2023). Research advances in crosstalk between muscle and bone in osteosarcopenia (Review). Experimental and Therapeutic Medicine, 25, 189. https://doi.org/10.3892/etm.2023.11888
MLA
Yu, C., Du, Y., Peng, Z., Ma, C., Fang, J., Ma, L., Chen, F., Zhang, C., Geng, R., Zhang, Y., Han, X., Li, J., Lv, Y., Lu, S."Research advances in crosstalk between muscle and bone in osteosarcopenia (Review)". Experimental and Therapeutic Medicine 25.4 (2023): 189.
Chicago
Yu, C., Du, Y., Peng, Z., Ma, C., Fang, J., Ma, L., Chen, F., Zhang, C., Geng, R., Zhang, Y., Han, X., Li, J., Lv, Y., Lu, S."Research advances in crosstalk between muscle and bone in osteosarcopenia (Review)". Experimental and Therapeutic Medicine 25, no. 4 (2023): 189. https://doi.org/10.3892/etm.2023.11888