Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
May-2023 Volume 25 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2023 Volume 25 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

SHFM1 deficiency suppresses esophageal squamous cell carcinomas progression via modulating NF‑κB signaling and enhancing nature killer cell‑mediated tumor surveillance

  • Authors:
    • Yijuan Wu
    • Zhiyu Wang
    • Shengmian Li
    • Xianliang Chen
    • Shengyun Zhou
  • View Affiliations / Copyright

    Affiliations: Department of Oncology and Immunology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050010, P.R. China, Department of Gastroenterology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050010, P.R. China, Department of Gastroenterology, Xingtai People's Hospital, Xingtai, Hebei 054031, P.R. China, Endoscopy Center, Xingtai People's Hospital, Xingtai, Hebei 054031, P.R. China
    Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 195
    |
    Published online on: March 17, 2023
       https://doi.org/10.3892/etm.2023.11894
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Excessive proliferation, metastasis and immune escape are considered to be hallmarks of cancer contributing to tumor progression. Split hand and foot malformation 1 (SHFM1) is highly expressed in various cancers and has been reported to increase malignant behaviors. However, the biological functions of SHFM1 in esophageal squamous cell carcinomas (ESCC) progression remain to be elucidated. An integrated bioinformatics analysis was performed to identify candidate genes in ESCC progression based on GSE microarrays. SHFM1 was found to be profoundly upregulated in ESCC tissues compared with normal tissues and SHFM1 expression was positively associated with poor prognosis. The biological effects of SHFM1 on cell growth, metastasis and immune escape were investigated following depletion or overexpression of SHFM1 in vitro. A xenograft mouse model was established to investigate the effect of SHFM1 on ESCC progression in vivo. SHFM1 overexpression promoted ESCC cell proliferation and migration in vitro as well as tumorigenesis in vivo, while SHFM1 knockdown restored those phenotype changes. Additionally, the present study demonstrated that the effects of SHFM1 on malignant behaviors of ESCC cells were achieved by activating the NF‑κB signaling accompanied by increased P65 phosphorylation and nuclear translocation. Furthermore, SHFM1 was also found to regulate the sensitivity of cancer cells to natural killer (NK) cells. Specifically, inhibition of SHFM1 enhanced cell‑mediated cell apoptosis and increased NK toxicity, which might involve the downregulation of c‑Myc and programmed death‑ligand 1, key targets in cancer immunotherapy. In conclusion, these findings suggested that SHFM1 probably promoted ESCC progression by activating the NF‑κB pathway and enhancing the resistance of ESCC cells to NK cell cytotoxicity, indicating that SHFM1 may be a promising target for ESCC treatment.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Figure 9

Figure 10

View References

1 

Zhou X, Ren T, Zan H, Hua C and Guo X: Novel immune checkpoints in esophageal cancer: From biomarkers to therapeutic targets. Front Immunol. 13(864202)2022.PubMed/NCBI View Article : Google Scholar

2 

Jun Y, Tang Z, Luo C, Jiang B, Li X, Tao M, Gu H, Liu L, Zhang Z, Sun S, et al: Leukocyte-mediated combined targeted chemo and gene therapy for esophageal cancer. ACS Appl Mater Interfaces. 12:47330–47341. 2020.PubMed/NCBI View Article : Google Scholar

3 

Abnet CC, Arnold M and Wei WQ: Epidemiology of esophageal squamous cell carcinoma. Gastroenterology. 154:360–373. 2018.PubMed/NCBI View Article : Google Scholar

4 

Yang YM, Hong P, Xu WW, He QY and Li B: Advances in targeted therapy for esophageal cancer. Signal Transduct Target Ther. 5(229)2020.PubMed/NCBI View Article : Google Scholar

5 

Lambert AW, Pattabiraman DR and Weinberg RA: Emerging biological principles of metastasis. Cell. 168:670–691. 2017.PubMed/NCBI View Article : Google Scholar

6 

He S, Xu J, Liu X and Zhen Y: Advances and challenges in the treatment of esophageal cancer. Acta Pharm Sin B. 11:3379–3392. 2021.PubMed/NCBI View Article : Google Scholar

7 

Sharma P, Wagner K, Wolchok JD and Allison JP: Novel cancer immunotherapy agents with survival benefit: Recent successes and next steps. Nat Rev Cancer. 11:805–812. 2011.PubMed/NCBI View Article : Google Scholar

8 

Tan Y and Testa JR: DLX genes: Roles in development and cancer. Cancers. 13(3005)2021.PubMed/NCBI View Article : Google Scholar

9 

Zhang J, Wu J, Chen Y and Zhang W: Dlx5 promotes cancer progression through regulation of CCND1 in oral squamous cell carcinoma (OSCC). Biochem Cell Biol. 99:424–434. 2021.PubMed/NCBI View Article : Google Scholar

10 

Zhang X, Bian H, Wei W, Wang Q, Chen J, Hei R, Chen C, Wu X, Yuan H, Gu J, et al: DLX5 promotes osteosarcoma progression via activation of the NOTCH signaling pathway. Am J Cancer Res. 11:3354–3374. 2021.PubMed/NCBI

11 

Sun S, Yang F, Zhu Y and Zhang S: KDM4A promotes the growth of non-small cell lung cancer by mediating the expression of Myc via DLX5 through the Wnt/β-catenin signaling pathway. Life Sci. 262(118508)2020.PubMed/NCBI View Article : Google Scholar

12 

Tan Y, Cheung M, Pei J, Menges CW, Godwin AK and Testa JR: Upregulation of DLX5 promotes ovarian cancer cell proliferation by enhancing IRS-2-AKT signaling. Cancer Res. 70:9197–9206. 2010.PubMed/NCBI View Article : Google Scholar

13 

Wang L, Zhou W, Zhong Y, Huo Y, Fan P, Zhan S, Xiao J, Jin X, Gou S, Yin T, et al: Overexpression of G protein-coupled receptor GPR87 promotes pancreatic cancer aggressiveness and activates NF-κB signaling pathway. Mol Cancer. 16(61)2017.PubMed/NCBI View Article : Google Scholar

14 

Zhang Y and Zhang Z: The history and advances in cancer immunotherapy: Understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications. Cell Mol Immunol. 17:807–821. 2020.PubMed/NCBI View Article : Google Scholar

15 

Prager I, Liesche C, van Ooijen H, Urlaub D, Verron Q, Sandström N, Fasbender F, Claus M, Eils R, Beaudouin J, et al: NK cells switch from granzyme B to death receptor-mediated cytotoxicity during serial killing. J Exp Med. 216:2113–2127. 2019.PubMed/NCBI View Article : Google Scholar

16 

Lourenco C, Resetca D, Redel C, Lin P, MacDonald AS, Ciaccio R, Kenney TMG, Wei Y, Andrews DW, Sunnerhagen M, et al: MYC protein interactors in gene transcription and cancer. Nat Rev Cancer. 21:579–591. 2021.PubMed/NCBI View Article : Google Scholar

17 

Wu X, Nelson M, Basu M, Srinivasan P, Lazarski C, Zhang P, Zheng P and Sandler AD: MYC oncogene is associated with suppression of tumor immunity and targeting Myc induces tumor cell immunogenicity for therapeutic whole cell vaccination. J Immunother Cancer. 9(e001388)2021.PubMed/NCBI View Article : Google Scholar

18 

Zhang P, Wu X, Basu M, Dong C, Zheng P, Liu Y and Sandler AD: MYCN amplification is associated with repressed cellular immunity in neuroblastoma: An in ailico immunological analysis of TARGET satabase. Front Immunol. 8(1473)2017.PubMed/NCBI View Article : Google Scholar

19 

Casey SC, Baylot V and Felsher DW: The MYC oncogene is a global regulator of the immune response. Blood. 131:2007–2015. 2018.PubMed/NCBI View Article : Google Scholar

20 

Xu J and Testa JR: DLX5 (distal-less homeobox 5) promotes tumor cell proliferation by transcriptionally regulating MYC. J Biol Chem. 284:20593–20601. 2009.PubMed/NCBI View Article : Google Scholar

21 

Casey SC, Baylot V and Felsher DW: MYC: Master regulator of immune privilege. Trends Immunol. 38:298–305. 2017.PubMed/NCBI View Article : Google Scholar

22 

Casey SC, Tong L, Li Y, Do R, Walz S, Fitzgerald KN, Gouw AM, Baylot V, Gütgemann I, Eilers M and Felsher DW: MYC regulates the antitumor immune response through CD47 and PD-L1. Science. 352:227–231. 2016.PubMed/NCBI View Article : Google Scholar

23 

Kim EY, Kim A, Kim SK and Chang YS: MYC expression correlates with PD-L1 expression in non-small cell lung cancer. Lung Cancer. 110:63–67. 2017.PubMed/NCBI View Article : Google Scholar

24 

Liang MQ, Yu FQ and Chen C: C-Myc regulates PD-L1 expression in esophageal squamous cell carcinoma. Am J Transl Res. 12:379–388. 2020.PubMed/NCBI

25 

Chiossone L, Vienne M, Kerdiles YM and Vivier E: Natural killer cell immunotherapies against cancer: Checkpoint inhibitors and more. Semin Immunol. 31:55–63. 2017.PubMed/NCBI View Article : Google Scholar

26 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

27 

Sun X, Zhang J, Hou Z, Han Q, Zhang C and Tian Z: MiR-146a is directly regulated by STAT3 in human hepatocellular carcinoma cells and involved in anti-tumor immune suppression. Cell Cycle. 14:243–252. 2015.PubMed/NCBI View Article : Google Scholar

28 

Percie N, Hurst V, Ahluwalia A, Alam S, Avey MT, Baker M, Browne WJ, Clark A, Cuthill IC, Dirnagl U, et al: The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research. PLoS Biol. 18(e3000410)2020.PubMed/NCBI View Article : Google Scholar

29 

Lian Y, Niu X, Cai H, Yang X, Ma H, Ma S, Zhang Y and Chen Y: Clinicopathological significance of c-MYC in esophageal squamous cell carcinoma. Tumour Biol. 39(1010428317715804)2017.PubMed/NCBI View Article : Google Scholar

30 

Ito S, Okano S, Morita M, Saeki H, Tsutsumi S, Tsukihara H, Nakashima Y, Ando K, Imamura Y, Ohgaki K, et al: Expression of PD-L1 and HLA class I in esophageal squamous cell carcinoma: Prognostic factors for patient outcome. Ann Surg Oncol. 23:508–515. 2016.PubMed/NCBI View Article : Google Scholar

31 

Sefid F, Payandeh Z, Azamirad G, Baradaran B, Afjadi MN, Islami M, Darvish M, Kalantar SM, Kahroba H and Ardakani MA: Atezolizumab and granzyme B as immunotoxin against PD-L1 antigen; an insilico study. In Silico Pharmacol. 9(20)2021.PubMed/NCBI View Article : Google Scholar

32 

Li Y, Wang X, Shi L, Xu J and Sun B: Predictions for high and expression resulting in a poor prognosis in esophageal squamous cell carcinoma by bioinformatics analyses. Transl Cancer Res. 9:85–94. 2020.PubMed/NCBI View Article : Google Scholar

33 

Fang S, Dai Y, Mei Y, Yang M, Hu L, Yang H, Guan X and Li J: Clinical significance and biological role of cancer-derived type I collagen in lung and esophageal cancers. Thorac Cancer. 10:277–288. 2019.PubMed/NCBI View Article : Google Scholar

34 

Li M, Wang K, Pang Y, Zhang H, Peng H, Shi Q, Zhang Z, Cui X and Li F: Secreted phosphoprotein 1 (SPP1) and fibronectin 1 (FN1) are associated with progression and prognosis of esophageal cancer as identified by integrated expression profiles analysis. Med Sci Monit. 26(e920355)2020.PubMed/NCBI View Article : Google Scholar

35 

Karsli-Ceppioglu S, Dagdemir A, Judes G, Lebert A, Penault-Llorca F, Bignon YJ and Bernard-Gallon D: The epigenetic landscape of promoter genome-wide analysis in breast cancer. Sci Rep. 7(6597)2017.PubMed/NCBI View Article : Google Scholar

36 

Tamilzhalagan S, Muthuswami M, Periasamy J, Lee MH, Rha SY, Tan P and Ganesan K: Upregulated, 7q21-22 amplicon candidate gene SHFM1 confers oncogenic advantage by suppressing p53 function in gastric cancer. Cell Signal. 27:1075–1086. 2015.PubMed/NCBI View Article : Google Scholar

37 

Huang Y, Yang Q, Zheng Y, Lin L, Xu X, Xu XE, Silva TC, Hazawa M, Peng L, Cao H, et al: Activation of bivalent factor DLX5 cooperates with master regulator TP63 to promote squamous cell carcinoma. Nucleic Acids Res. 49:9246–9263. 2021.PubMed/NCBI View Article : Google Scholar

38 

Zhao Y, Wei L, Shao M, Huang X, Chang J, Zheng J, Chu J, Cui Q, Peng L, Luo Y, et al: BRCA1-associated protein increases invasiveness of esophageal squamous cell carcinoma. Gastroenterology. 153:1304–1319.e1305. 2017.PubMed/NCBI View Article : Google Scholar

39 

Haria D, Trinh BQ, Ko SY, Barengo N, Liu J and Naora H: The homeoprotein DLX4 stimulates NF-κB activation and CD44-mediated tumor-mesothelial cell interactions in ovarian cancer. Am J Pathol. 185:2298–2308. 2015.PubMed/NCBI View Article : Google Scholar

40 

Chen L and Han X: Anti-PD-1/PD-L1 therapy of human cancer: Past, present, and future. J Clin Invest. 125:3384–3391. 2015.PubMed/NCBI View Article : Google Scholar

41 

Doi T, Piha-Paul SA, Jalal SI, Saraf S, Lunceford J, Koshiji M and Bennouna J: Safety and antitumor activity of the anti-programmed death-1 antibody pembrolizumab in patients with advanced esophageal carcinoma. J Clin Oncol. 36:61–67. 2018.PubMed/NCBI View Article : Google Scholar

42 

Wang X, Teng F, Kong L and Yu J: PD-L1 expression in human cancers and its association with clinical outcomes. Onco Targets Ther. 9:5023–5039. 2016.PubMed/NCBI View Article : Google Scholar

43 

Zhou C, Che G, Zheng X, Qiu J, Xie Z, Cong Y, Pei X, Zhang H, Sun H and Ma H: Expression and clinical significance of PD-L1 and c-Myc in non-small cell lung cancer. J Cancer Res Clin Oncol. 145:2663–2674. 2019.PubMed/NCBI View Article : Google Scholar

44 

Qu S, Jiao Z, Lu G, Yao B, Wang T, Rong W, Xu J, Fan T, Sun X, Yang R, et al: PD-L1 lncRNA splice isoform promotes lung adenocarcinoma progression via enhancing c-Myc activity. Genome Biol. 22(104)2021.PubMed/NCBI View Article : Google Scholar

45 

Han H, Jain AD, Truica MI, Izquierdo-Ferrer J, Anker JF, Lysy B, Sagar V, Luan Y, Chalmers ZR, Unno K, et al: Small-molecule MYC inhibitors suppress tumor growth and enhance immunotherapy. Cancer Cell. 36:483–497.e415. 2019.PubMed/NCBI View Article : Google Scholar

46 

Wu Y, Xie J, Jin X, Lenchine RV, Wang X, Fang DM, Nassar ZD, Butler LM, Li J and Proud CG: eEF2K enhances expression of PD-L1 by promoting the translation of its mRNA. Biochem J. 477:4367–4381. 2020.PubMed/NCBI View Article : Google Scholar

47 

Uppendahl LD, Felices M, Bendzick L, Ryan C, Kodal B, Hinderlie P, Boylan KLM, Skubitz APN, Miller JS and Geller MA: Cytokine-induced memory-like natural killer cells have enhanced function, proliferation, and in vivo expansion against ovarian cancer cells. Gynecol Oncol. 153:149–157. 2019.PubMed/NCBI View Article : Google Scholar

48 

Lorenzo-Herrero S, Sordo-Bahamonde C, González S and López-Soto A: A flow cytometric NK cell-mediated cytotoxicity assay to evaluate anticancer immune responses in vitro. Methods Mol Biol. 1884:131–139. 2019.PubMed/NCBI View Article : Google Scholar

49 

Prager I and Watzl C: Mechanisms of natural killer cell-mediated cellular cytotoxicity. J Leukoc Biol. 105:1319–1329. 2019.PubMed/NCBI View Article : Google Scholar

50 

Zhou Z, He H, Wang K, Shi X, Wang Y, Su Y, Wang Y, Li D, Liu W, Zhang Y, et al: Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells. Science. 368(eaaz7548)2020.PubMed/NCBI View Article : Google Scholar

51 

Cerwenka A and Lanier LL: Natural killer cell memory in infection, inflammation and cancer. Nat Rev Immunol. 16:112–123. 2016.PubMed/NCBI View Article : Google Scholar

52 

Aptsiauri N, Ruiz-Cabello F and Garrido F: The transition from HLA-I positive to HLA-I negative primary tumors: The road to escape from T-cell responses. Curr Opin Immunol. 51:123–132. 2018.PubMed/NCBI View Article : Google Scholar

53 

Ramia E, Chiaravalli AM, Eddine FBN, Tedeschi A, Sessa F, Accolla RS and Forlani G: CIITA-related block of HLA class II expression, upregulation of HLA class I, and heterogeneous expression of immune checkpoints in hepatocarcinomas: Implications for new therapeutic approaches. Oncoimmunology. 8(1548243)2019.PubMed/NCBI View Article : Google Scholar

54 

Garrido F, Aptsiauri N, Doorduijn EM, Lora AM and van Hall T: The urgent need to recover MHC class I in cancers for effective immunotherapy. Curr Opin Immunol. 39:44–51. 2016.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wu Y, Wang Z, Li S, Chen X and Zhou S: SHFM1 deficiency suppresses esophageal squamous cell carcinomas progression via modulating NF‑κB signaling and enhancing nature killer cell‑mediated tumor surveillance. Exp Ther Med 25: 195, 2023.
APA
Wu, Y., Wang, Z., Li, S., Chen, X., & Zhou, S. (2023). SHFM1 deficiency suppresses esophageal squamous cell carcinomas progression via modulating NF‑κB signaling and enhancing nature killer cell‑mediated tumor surveillance. Experimental and Therapeutic Medicine, 25, 195. https://doi.org/10.3892/etm.2023.11894
MLA
Wu, Y., Wang, Z., Li, S., Chen, X., Zhou, S."SHFM1 deficiency suppresses esophageal squamous cell carcinomas progression via modulating NF‑κB signaling and enhancing nature killer cell‑mediated tumor surveillance". Experimental and Therapeutic Medicine 25.5 (2023): 195.
Chicago
Wu, Y., Wang, Z., Li, S., Chen, X., Zhou, S."SHFM1 deficiency suppresses esophageal squamous cell carcinomas progression via modulating NF‑κB signaling and enhancing nature killer cell‑mediated tumor surveillance". Experimental and Therapeutic Medicine 25, no. 5 (2023): 195. https://doi.org/10.3892/etm.2023.11894
Copy and paste a formatted citation
x
Spandidos Publications style
Wu Y, Wang Z, Li S, Chen X and Zhou S: SHFM1 deficiency suppresses esophageal squamous cell carcinomas progression via modulating NF‑κB signaling and enhancing nature killer cell‑mediated tumor surveillance. Exp Ther Med 25: 195, 2023.
APA
Wu, Y., Wang, Z., Li, S., Chen, X., & Zhou, S. (2023). SHFM1 deficiency suppresses esophageal squamous cell carcinomas progression via modulating NF‑κB signaling and enhancing nature killer cell‑mediated tumor surveillance. Experimental and Therapeutic Medicine, 25, 195. https://doi.org/10.3892/etm.2023.11894
MLA
Wu, Y., Wang, Z., Li, S., Chen, X., Zhou, S."SHFM1 deficiency suppresses esophageal squamous cell carcinomas progression via modulating NF‑κB signaling and enhancing nature killer cell‑mediated tumor surveillance". Experimental and Therapeutic Medicine 25.5 (2023): 195.
Chicago
Wu, Y., Wang, Z., Li, S., Chen, X., Zhou, S."SHFM1 deficiency suppresses esophageal squamous cell carcinomas progression via modulating NF‑κB signaling and enhancing nature killer cell‑mediated tumor surveillance". Experimental and Therapeutic Medicine 25, no. 5 (2023): 195. https://doi.org/10.3892/etm.2023.11894
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team