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Oxymatrine inhibits TGF‑β1‑mediated mitochondrial apoptotic signaling in alveolar epithelial cells via activation of PI3K/AKT signaling

  • Authors:
    • Tong Feng
    • Ran Duan
    • Pengcheng Zheng
    • Jing Qiu
    • Qingyuan Li
    • Wancheng Li
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan 610500, P.R. China, School of Clinical Medicine, Chengdu Medical College, Chengdu, Sichuan 610500, P.R. China
    Copyright: © Feng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 198
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    Published online on: March 20, 2023
       https://doi.org/10.3892/etm.2023.11897
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Abstract

Although pulmonary fibrosis (PF) causes respiratory failure and death, effective therapies for PF have not been developed. Oxymatrine (OMT), an active ingredient in the Chinese herb Sophora flavescens, exerts antifibrotic effects; however, its effect on PF remains unclear. The present study aimed to determine whether OMT decreases transforming growth factor‑β1 (TGF‑β1)‑induced PF in human lung cancer A549 cells by inhibiting apoptosis and targeting the phosphoinositide 3‑kinase (PI3K)/protein kinase B (AKT) pathway. To construct a PF cell model, A549 cells were stimulated with TGF‑β1. The experimental groups were as follows: control (untreated cells grown in complete medium), TGF‑β1 (cells treated with 5 ng/ml TGF‑β1), OMT (cells treated with 5 ng/ml TGF‑β1 and 0.25, 0.50, or 1.00 mg/ml OMT), and OMT + LY294002 (cells treated with 5 ng/ml TGF‑β1, 1.0 mg/ml OMT. and 25 µmol/l LY294002). The effects of OMT on cell morphology (via electron microscopy), apoptosis (via Annexin V‑PI staining), mitochondrial apoptosis signaling [using JC‑1 method to analyze mitochondrial membrane potential (MMP)], and Bcl‑2, as well as Bax expression (via western blotting and reverse transcription‑quantitative polymerase chain reaction), were analyzed. OMT significantly protected cells against TGF‑β1‑induced PF by inhibiting apoptosis. The specific manifestations were cell injury, as evidenced by morphological changes and decreased MMP. Following OMT treatment, the expression of the pro‑apoptotic protein Bax increased, whereas that of the anti‑apoptotic protein Bcl‑2 decreased. The PI3K/AKT‑specific inhibitor LY294002 significantly inhibited the ameliorative effects of OMT on TGF‑β1‑induced apoptosis. Collectively, OMT attenuated TGF‑β1‑mediated mitochondrial apoptosis of alveolar epithelial cells by activating the PI3K/AKT signaling pathway. Therefore, OMT may be a promising drug for PF treatment.
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1 

Wang J, Hu K, Cai X, Yang B, He Q, Wang J and Weng Q: Targeting PI3K/AKT signaling for treatment of idiopathic pulmonary fibrosis. Acta Pharm Sin B. 12:18–32. 2022.PubMed/NCBI View Article : Google Scholar

2 

Yanagihara T, Sato S, Upagupta C and Kolb M: What have we learned from basic science studies on idiopathic pulmonary fibrosis? Eur Respir Rev. 28(190029)2019.PubMed/NCBI View Article : Google Scholar

3 

Otoupalova E, Smith S, Cheng G and Thannickal VJ: Oxidative stress in pulmonary fibrosis. Compr Physiol. 10:509–547. 2020.PubMed/NCBI View Article : Google Scholar

4 

Richeldi L, Collard HR and Jones MG: Idiopathic pulmonary fibrosis. Lancet. 389:1941–1952. 2017.PubMed/NCBI View Article : Google Scholar

5 

Somogyi V, Chaudhuri N, Torrisi SE, Kahn N, Müller V and Kreuter M: The therapy of idiopathic pulmonary fibrosis: What is next? Eur Respir Rev. 28(190021)2019.PubMed/NCBI View Article : Google Scholar

6 

Kropski JA and Blackwell TS: Progress in understanding and treating idiopathic pulmonary fibrosis. Annu Rev Med. 70:211–224. 2019.PubMed/NCBI View Article : Google Scholar

7 

Tepede A and Yogaratnam D: Nintedanib for idiopathic pulmonary fibrosis. J Pharm Pract. 32:199–206. 2019.PubMed/NCBI View Article : Google Scholar

8 

George PM, Patterson CM, Reed AK and Thillai M: Lung transplantation for idiopathic pulmonary fibrosis. Lancet Respir Med. 7:271–282. 2019.PubMed/NCBI View Article : Google Scholar

9 

Chambers DC, Cherikh WS, Harhay MO, Hayes D Jr, Hsich E, Khush KK, Meiser B, Potena L, Rossano JW, Toll AE, et al: The international thoracic organ transplant registry of the international society for heart and lung transplantation: Thirty-sixth adult lung and heart-lung transplantation Report-2019; Focus theme: Donor and recipient size match. J Heart Lung Transplant. 38:1042–1055. 2019.PubMed/NCBI View Article : Google Scholar

10 

Fattman CL: Apoptosis in pulmonary fibrosis: Too much or not enough? Antioxid Redox Signal. 10:379–385. 2008.PubMed/NCBI View Article : Google Scholar

11 

Olajuyin AM, Zhang X and Ji HL: Alveolar type 2 progenitor cells for lung injury repair. Cell Death Discov. 5(63)2019.PubMed/NCBI View Article : Google Scholar

12 

Corrin B, Dewar A, Rodriguez-Roisin R and Turner-Warwick M: Fine structural changes in cryptogenic fibrosing alveolitis and asbestosis. J Pathol. 147:107–119. 1985.PubMed/NCBI View Article : Google Scholar

13 

Myers JL and Katzenstein AL: Epithelial necrosis and alveolar collapse in the pathogenesis of usual interstitial pneumonia. Chest. 94:1309–1311. 1988.PubMed/NCBI View Article : Google Scholar

14 

Li XP, Shu RJ, Filippatos G and Uhal BD: Apoptosis in lung injury and remodeling. J Appl Physiol (1985). 97:1535–1542. 2004.PubMed/NCBI View Article : Google Scholar

15 

Uhal BD, Joshi I, Hughes WF, Ramos C, Pardo A and Selman M: Alveolar epithelial cell death adjacent to underlying myofibroblasts in advanced fibrotic human lung. Am J Physiol. 275:L1192–L1199. 1998.PubMed/NCBI View Article : Google Scholar

16 

Barbas-Filho JV, Ferreira MA, Sesso A, Kairalla RA, Carvalho CR and Capelozzi VL: Evidence of type II pneumocyte apoptosis in the pathogenesis of idiopathic pulmonary fibrosis (IFP)/usual interstitial pneumonia (UIP). J Clin Pathol. 54:132–138. 2001.PubMed/NCBI View Article : Google Scholar

17 

Chen F, Gong L, Zhang L, Wang H, Qi X, Wu X, Xiao Y, Cai Y, Liu L, Li X and Ren J: Short courses of low dose dexamethasone delay bleomycin-induced lung fibrosis in rats. Eur J Pharmacol. 536:287–295. 2006.PubMed/NCBI View Article : Google Scholar

18 

Bock FJ and Tait SWG: Mitochondria as multifaceted regulators of cell death. Nat Rev Mol Cell Biol. 21:85–100. 2020.PubMed/NCBI View Article : Google Scholar

19 

Budinger GR, Mutlu GM, Eisenbart J, Fuller AC, Bellmeyer AA, Baker CM, Wilson M, Ridge K, Barrett TA, Lee VY and Chandel NS: Proapoptotic Bid is required for pulmonary fibrosis. Proc Natl Acad Sci USA. 103:4604–4609. 2006.PubMed/NCBI View Article : Google Scholar

20 

Hu X, Xu Q, Wan H, Hu Y, Xing S, Yang H, Gao Y and He Z: PI3K-AKT-mTOR/PFKFB3 pathway mediated lung fibroblast aerobic glycolysis and collagen synthesis in lipopolysaccharide-induced pulmonary fibrosis. Lab Invest. 100:801–811. 2020.PubMed/NCBI View Article : Google Scholar

21 

Engelman JA, Luo J and Cantley LC: The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat Rev Genet. 7:606–619. 2006.PubMed/NCBI View Article : Google Scholar

22 

Zhao H, Li C, Li L, Liu J, Gao Y, Mu K, Chen D, Lu A, Ren Y and Li Z: Baicalin alleviates bleomycin-induced pulmonary fibrosis and fibroblast proliferation in rats via the PI3K/AKT signaling pathway. Mol Med Rep. 21:2321–2334. 2020.PubMed/NCBI View Article : Google Scholar

23 

Schmitt-Ney M: The FOXO's advantages of being a family: Considerations on function and evolution. Cells. 9(787)2020.PubMed/NCBI View Article : Google Scholar

24 

Li H, Kan B, Song L, Liu Y and Jian X: Role of the Hippo signaling pathway in safflower yellow pigment treatment of paraquat-induced pulmonary fibrosis. J Int Med Res. 48(300060520905425)2020.PubMed/NCBI View Article : Google Scholar

25 

Takano M, Deguchi J, Senoo S, Izumi M, Kawami M and Yumoto R: Suppressive effect of quercetin against bleomycin-induced epithelial-mesenchymal transition in alveolar epithelial cells. Drug Metab Pharmacokinet. 35:522–526. 2020.PubMed/NCBI View Article : Google Scholar

26 

Sun X, Cui X, Chen X and Jiang X: Baicalein alleviated TGF β1-induced type I collagen production in lung fibroblasts via downregulation of connective tissue growth factor. Biomed Pharmacother. 131(110744)2020.PubMed/NCBI View Article : Google Scholar

27 

Zhou Y, Zhu WP, Cai XJ and Chen M: Atomized paclitaxel liposome inhalation treatment of bleomycin-induced pulmonary fibrosis in rats. Genet Mol Res. 15(10)2016.PubMed/NCBI View Article : Google Scholar

28 

Hu Y, Li M, Zhang M and Jin Y: Inhalation treatment of idiopathic pulmonary fibrosis with curcumin large porous microparticles. Int J Pharm. 551:212–222. 2018.PubMed/NCBI View Article : Google Scholar

29 

Zhang YY, Yi M and Huang YP: Oxymatrine ameliorates doxorubicin-induced cardiotoxicity in rats. Cell Physiol Biochem. 43:626–635. 2017.PubMed/NCBI View Article : Google Scholar

30 

Xiang X, Tu C, Li Q, Wang W, Huang X, Zhao Z, Xiong H and Mei Z: Oxymatrine ameliorates imiquimod-induced psoriasis pruritus and inflammation through inhibiting heat shock protein 90 and heat shock protein 60 expression in keratinocytes. Toxicol Appl Pharmacol. 405(115209)2020.PubMed/NCBI View Article : Google Scholar

31 

Wang D, Lou XQ, Jiang XM, Yang C, Liu XL and Zhang N: Oxymatrine protects against the effects of cardiopulmonary resuscitation via modulation of the TGF-β1/Smad3 signaling pathway. Mol Med Rep. 17:4747–4752. 2018.PubMed/NCBI View Article : Google Scholar

32 

Ying XJ, Jin B, Chen XW, Xie J, Xu HM and Dong P: Oxymatrine downregulates HPV16E7 expression and inhibits cell proliferation in laryngeal squamous cell carcinoma Hep-2 cells in vitro. Biomed Res Int. 2015(150390)2015.PubMed/NCBI View Article : Google Scholar

33 

Liu Y, Xu Y, Ji W, Li X, Sun B, Gao Q and Su C: Anti-tumor activities of matrine and oxymatrine: Literature review. Tumour Biol. 35:5111–5119. 2014.PubMed/NCBI View Article : Google Scholar

34 

Song WJ, Luo J, Wu T and Yao SK: Oral oxymatrine preparation for chronic hepatitis B: A systematic review of randomized controlled trials. Chin J Integr Med. 22:141–149. 2016.PubMed/NCBI View Article : Google Scholar

35 

Shi HJ, Zhou H, Ma AL, Wang L, Gao Q, Zhang N, Song HB, Bo KP and Ma W: Oxymatrine therapy inhibited epidermal cell proliferation and apoptosis in severe plaque psoriasis. Br J Dermatol. 181:1028–1037. 2019.PubMed/NCBI View Article : Google Scholar

36 

Huang Y, Li X, Zhang X and Tang J: Oxymatrine ameliorates memory impairment in diabetic rats by regulating oxidative stress and apoptosis: Involvement of NOX2/NOX4. Oxid Med Cell Longev. 2020(3912173)2020.PubMed/NCBI View Article : Google Scholar

37 

Chen Q, Duan X, Fan H, Xu M, Tang Q, Zhang L, Shou Z, Liu X, Zuo D, Yang J, et al: Oxymatrine protects against DSS-induced colitis via inhibiting the PI3K/AKT signaling pathway. Int Immunopharmacol. 53:149–157. 2017.PubMed/NCBI View Article : Google Scholar

38 

Liu Y, Wang H, Liu N, Du J, Lan X, Qi X, Zhuang C, Sun T, Li Y and Yu J: Oxymatrine protects neonatal rat against hypoxic-ischemic brain damage via PI3K/AKT/GSK3β pathway. Life Sci. 254(116444)2020.PubMed/NCBI View Article : Google Scholar

39 

Liu L, Lu W, Ma Z and Li Z: Oxymatrine attenuates bleomycin-induced pulmonary fibrosis in mice via the inhibition of inducible nitric oxide synthase expression and the TGF-β/Smad signaling pathway. Int J Mol Med. 29:815–822. 2012.PubMed/NCBI View Article : Google Scholar

40 

Morikawa M, Derynck R and Miyazono K: TGF-β and the TGF-β family: Context-dependent roles in cell and tissue physiology. Cold Spring Harb Perspect Biol. 8(a021873)2018.PubMed/NCBI View Article : Google Scholar

41 

Kim KK, Sheppard D and Chapman HA: TGF-β1 signaling and tissue fibrosis. Cold Spring Harb Perspect Biol. 10(34)2018.PubMed/NCBI View Article : Google Scholar

42 

Zhang C, Zhu X, Hua Y, Zhao Q, Wang K, Zhen L, Wang G, Lü J, Luo A, Cho WC, et al: YY1 mediates TGF-β1-induced EMT and pro-fibrogenesis in alveolar epithelial cells. Respir Res. 20(249)2019.PubMed/NCBI View Article : Google Scholar

43 

Chen X, Sun R, Hu J, Mo Z, Yang Z, Liao D and Zhong N: Attenuation of bleomycin-induced lung fibrosis by OMT is associated with regulation of fibroblast proliferation and collagen production in primary culture. Basic Clin Pharmacol Toxicol. 103:278–286. 2008.PubMed/NCBI View Article : Google Scholar

44 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

45 

Ruwanpura SM, Thomas BJ and Bardin PG: Pirfenidone: Molecular mechanisms and potential clinical applications in lung disease. Am J Respir Cell Mol Biol. 62:413–422. 2020.PubMed/NCBI View Article : Google Scholar

46 

Hosseini SA, Zahedipour F, Sathyapalan T, Jamialahmadi T and Sahebkar A: Pulmonary fibrosis: Therapeutic and mechanistic insights into the role of phytochemicals. Biofactors. 47:250–269. 2021.PubMed/NCBI View Article : Google Scholar

47 

Hu C, Wang Y, Fan Y, Li H, Wang C, Zhang J, Zhang S, Han X and Wen C: Lipidomics revealed idiopathic pulmonary fibrosis-induced hepatic lipid disorders corrected with treatment of baicalin in a murine model. AAPS J. 17:711–722. 2015.PubMed/NCBI View Article : Google Scholar

48 

Elmore S: Apoptosis: A review of programmed cell death. Toxicol Pathol. 35:495–516. 2007.PubMed/NCBI View Article : Google Scholar

49 

Kumar RK: Idiopathic pulmonary fibrosis: An epithelial/fibroblasticcross-talk disorder. Respir Res. 3(29)2002.

50 

Snijder J, Peraza J, Padilla M, Capaccione K and Salvatore MM: Pulmonary fibrosis: A disease of alveolar collapse and collagen deposition. Expert Rev Respir Med. 13:615–619. 2019.PubMed/NCBI View Article : Google Scholar

51 

Guillot L, Nathan N, Tabary O, Thouvenin G, Rouzic PL, Corvol H, Amselem S and Clement A: Alveolar epithelial cells: Master regulators of lung homeostasis. Int J Biochem Cell Biol. 45:2568–2573. 2013.PubMed/NCBI View Article : Google Scholar

52 

Serrano-Mollar A: Alveolar epithelial cell injury as an etiopathogenic factor in pulmonary fibrosis. Arch Bronconeumol. 48:2–6. 2012.PubMed/NCBI View Article : Google Scholar : (In Spanish).

53 

Lu J, Wu L, Wang X, Zhu J, Du J and Shen B: Detection of mitochondria membrane potential to study CLIC4 knockdown-induced HN4 cell apoptosis in vitro. J Vis Exp. 137(56137)2018.PubMed/NCBI View Article : Google Scholar

54 

Hill C, Jones MG, Davies DE and Wang Y: Epithelial-mesenchymal transition contributes to pulmonary fibrosis via aberrant epithelial/fibroblastic cross-talk. J Lung Health Dis. 3:31–35. 2019.PubMed/NCBI

55 

Wang YC, Liu JS, Tang HK, Nie J, Zhu JX, Wen LL and Guo QL: miR 221 targets HMGA2 to inhibit bleomycin induced pulmonary fibrosis by regulating TGF β1/Smad3-induced EMT. Int J Mol Med. 38:1208–1216. 2016.PubMed/NCBI View Article : Google Scholar

56 

Liu Y, Li Y, Xu Q, Yao W, Wu Q, Yuan J, Yan W, Xu T, Ji X and Ni C: Long non-coding RNA-ATB promotes EMT during silica-induced pulmonary fibrosis by competitively binding miR-200c. Biochim Biophys Acta Mol Basis Dis. 1864:420–431. 2018.PubMed/NCBI View Article : Google Scholar

57 

Braun F, de Carné Trécesson S, Bertin-Ciftci J and Juin P: Protect and serve: Bcl-2 proteins as guardians and rulers of cancer cell survival. Cell Cycle. 12:2937–2947. 2013.PubMed/NCBI View Article : Google Scholar

58 

Willis S, Day CL, Hinds MG and Huang DC: The Bcl-2-regulated apoptotic pathway. J Cell Sci. 15:4053–4056. 2003.PubMed/NCBI View Article : Google Scholar

59 

Kuwano K, Hagimoto N, Tanaka T, Kawasaki M, Kunitake R, Miyazaki H, Kaneko Y, Matsuba T, Maeyama T and Hara N: Expression of apoptosis-regulatory genes in epithelial cells in pulmonary fibrosis in mice. J Pathol. 190:221–229. 2000.PubMed/NCBI View Article : Google Scholar

60 

Youle RJ and Strasser A: The BCL-2 protein family: Opposing activities that mediate cell death. Nat Rev Mol Cell Biol. 9:47–59. 2008.PubMed/NCBI View Article : Google Scholar

61 

Franke TF, Hornik CP, Segev L, Shostak GA and Sugimoto C: PI3K/AKT and apoptosis: Size matters. Oncogene. 22:8983–8998. 2003.PubMed/NCBI View Article : Google Scholar

62 

Liu R, Chen Y, Liu G, Li C, Song Y, Cao Z, Li W, Hu J, Lu C and Liu Y: PI3K/AKT pathway as a key link modulates the multidrug resistance of cancers. Cell Death Dis. 11(797)2020.PubMed/NCBI View Article : Google Scholar

63 

Sun Y, Zhang Y and Chi P: Pirfenidone suppresses TGF-β1-induced human intestinal fibroblasts activities by regulating proliferation and apoptosis via the inhibition of the Smad and PI3K/AKT signaling pathway. Mol Med Rep. 18:3907–3913. 2018.PubMed/NCBI View Article : Google Scholar

64 

Liu MW, Su MX, Tang DY, Hao L, Xun XH and Huang YQ: Ligustrazin increases lung cell autophagy and ameliorates paraquat-induced pulmonary fibrosis by inhibiting PI3K/AKT/mTOR and hedgehog signalling via increasing miR-193a expression. BMC Pulm Med. 19(35)2019.PubMed/NCBI View Article : Google Scholar

65 

Moodley YP, Caterina P, Scaffidi AK, Misso NL, Papadimitriou JM, McAnulty RJ, Laurent GJ, Thompson PJ and Knight DA: Comparison of the morphological and biochemical changes in normal human lung fibroblasts and fibroblasts derived from lungs of patients with idiopathic pulmonary fibrosis during FasL-induced apoptosis. J Pathol. 202:486–495. 2004.PubMed/NCBI View Article : Google Scholar

66 

Lu Y, Azad N, Wang L, Iyer AK, Castranova V, Jiang BH and Rojanasakul Y: Phosphatidylinositol-3-kinase/AKT regulates bleomycin-induced fibroblast proliferation and collagen production. Am J Respir Cell Mol Biol. 42:432–441. 2010.PubMed/NCBI View Article : Google Scholar

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Feng T, Duan R, Zheng P, Qiu J, Li Q and Li W: Oxymatrine inhibits TGF‑β1‑mediated mitochondrial apoptotic signaling in alveolar epithelial cells via activation of PI3K/AKT signaling. Exp Ther Med 25: 198, 2023.
APA
Feng, T., Duan, R., Zheng, P., Qiu, J., Li, Q., & Li, W. (2023). Oxymatrine inhibits TGF‑β1‑mediated mitochondrial apoptotic signaling in alveolar epithelial cells via activation of PI3K/AKT signaling. Experimental and Therapeutic Medicine, 25, 198. https://doi.org/10.3892/etm.2023.11897
MLA
Feng, T., Duan, R., Zheng, P., Qiu, J., Li, Q., Li, W."Oxymatrine inhibits TGF‑β1‑mediated mitochondrial apoptotic signaling in alveolar epithelial cells via activation of PI3K/AKT signaling". Experimental and Therapeutic Medicine 25.5 (2023): 198.
Chicago
Feng, T., Duan, R., Zheng, P., Qiu, J., Li, Q., Li, W."Oxymatrine inhibits TGF‑β1‑mediated mitochondrial apoptotic signaling in alveolar epithelial cells via activation of PI3K/AKT signaling". Experimental and Therapeutic Medicine 25, no. 5 (2023): 198. https://doi.org/10.3892/etm.2023.11897
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Spandidos Publications style
Feng T, Duan R, Zheng P, Qiu J, Li Q and Li W: Oxymatrine inhibits TGF‑β1‑mediated mitochondrial apoptotic signaling in alveolar epithelial cells via activation of PI3K/AKT signaling. Exp Ther Med 25: 198, 2023.
APA
Feng, T., Duan, R., Zheng, P., Qiu, J., Li, Q., & Li, W. (2023). Oxymatrine inhibits TGF‑β1‑mediated mitochondrial apoptotic signaling in alveolar epithelial cells via activation of PI3K/AKT signaling. Experimental and Therapeutic Medicine, 25, 198. https://doi.org/10.3892/etm.2023.11897
MLA
Feng, T., Duan, R., Zheng, P., Qiu, J., Li, Q., Li, W."Oxymatrine inhibits TGF‑β1‑mediated mitochondrial apoptotic signaling in alveolar epithelial cells via activation of PI3K/AKT signaling". Experimental and Therapeutic Medicine 25.5 (2023): 198.
Chicago
Feng, T., Duan, R., Zheng, P., Qiu, J., Li, Q., Li, W."Oxymatrine inhibits TGF‑β1‑mediated mitochondrial apoptotic signaling in alveolar epithelial cells via activation of PI3K/AKT signaling". Experimental and Therapeutic Medicine 25, no. 5 (2023): 198. https://doi.org/10.3892/etm.2023.11897
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