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Prognostic significance of controlling nutritional status score for patients with gastric cancer: A systematic review and meta‑analysis

  • Authors:
    • Jian Yin
    • Jin Qu
    • Xiaoxiao Liang
    • Meimei Wang
  • View Affiliations / Copyright

    Affiliations: Third Department of Chest Medicine, The Fifth People's Hospital of Dalian, Dalian, Liaoning 116021, P.R. China
    Copyright: © Yin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 202
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    Published online on: March 21, 2023
       https://doi.org/10.3892/etm.2023.11901
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Abstract

There is a need to identify potentially useful biomarker(s) for the prediction of prognostic outcomes in patients diagnosed with gastric cancer. This meta‑analysis provided updated evidence on the association of controlling nutritional status (CONUT) score with survival and other clinicopathological outcomes in patients with gastric cancer. PubMed and Scopus databases were systematically searched. The review included studies, observational in design, that were conducted among patients with gastric cancer and had documented the association of CONUT score with outcomes of interest. The primary outcomes of interest were overall survival (OS), cancer‑specific survival (CSS) and recurrence‑free survival (RFS) along with tumour size and extent (T status), nodal status (N status) and tumour staging (TNM staging). STATA was used for statistical analysis. The meta‑analysis was conducted with 17 studies. The 5‑year OS [hazard ratio (HR), 1.75; 95% confidence interval (CI): 1.55, 1.96], RFS (HR, 1.58; 95% CI: 1.30, 1.91) and CSS (HR, 1.89; 95% CI: 1.01, 3.52) were comparatively poorer in the high CONUT group, than in low CONUT group. High CONUT score was associated with increased risk of having T3/T4 tumour [odds ratio (OR), 1.64; 95% CI: 1.16, 2.34], N2/N3 nodal status (OR, 1.44; 95% CI: 1.17, 1.77) and stage III/IV tumour (OR, 1.64; 95% CI: 1.43, 1.88). The risk of microvascular invasion (OR, 1.46; 95% CI: 1.20, 1.77) and post‑operative complications (OR, 1.64; 95% CI: 1.31, 2.06) was higher in those with high CONUT. There were no differences in the risk of poorly differentiated tumour and need for adjuvant chemotherapy between the two groups. Findings suggested that preoperative assessment of CONUT score may be included in the routine assessment of patients with gastric cancer due to its association with survival and other clinical as well as pathological outcomes.
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Spandidos Publications style
Yin J, Qu J, Liang X and Wang M: Prognostic significance of controlling nutritional status score for patients with gastric cancer: A systematic review and meta‑analysis. Exp Ther Med 25: 202, 2023.
APA
Yin, J., Qu, J., Liang, X., & Wang, M. (2023). Prognostic significance of controlling nutritional status score for patients with gastric cancer: A systematic review and meta‑analysis. Experimental and Therapeutic Medicine, 25, 202. https://doi.org/10.3892/etm.2023.11901
MLA
Yin, J., Qu, J., Liang, X., Wang, M."Prognostic significance of controlling nutritional status score for patients with gastric cancer: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 25.5 (2023): 202.
Chicago
Yin, J., Qu, J., Liang, X., Wang, M."Prognostic significance of controlling nutritional status score for patients with gastric cancer: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 25, no. 5 (2023): 202. https://doi.org/10.3892/etm.2023.11901
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Spandidos Publications style
Yin J, Qu J, Liang X and Wang M: Prognostic significance of controlling nutritional status score for patients with gastric cancer: A systematic review and meta‑analysis. Exp Ther Med 25: 202, 2023.
APA
Yin, J., Qu, J., Liang, X., & Wang, M. (2023). Prognostic significance of controlling nutritional status score for patients with gastric cancer: A systematic review and meta‑analysis. Experimental and Therapeutic Medicine, 25, 202. https://doi.org/10.3892/etm.2023.11901
MLA
Yin, J., Qu, J., Liang, X., Wang, M."Prognostic significance of controlling nutritional status score for patients with gastric cancer: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 25.5 (2023): 202.
Chicago
Yin, J., Qu, J., Liang, X., Wang, M."Prognostic significance of controlling nutritional status score for patients with gastric cancer: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 25, no. 5 (2023): 202. https://doi.org/10.3892/etm.2023.11901
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