Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
May-2023 Volume 25 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2023 Volume 25 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Potential role of TREM2 in high cholesterol‑induced cell injury and metabolic dysfunction in SH‑SY5Y cells

  • Authors:
    • Qiang Zheng
    • Yinxiu Han
    • Min Fan
    • Xinran Gao
    • Mengdie Ma
    • Jingxian Xu
    • Sen Liu
    • Jinfang Ge
  • View Affiliations / Copyright

    Affiliations: School of Pharmacy, Anhui Medical University, Hefei, Anhui 230032, P.R. China
    Copyright: © Zheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 205
    |
    Published online on: March 22, 2023
       https://doi.org/10.3892/etm.2023.11904
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Triggering receptor expressed on myeloid cells 2 (TREM2) is an important member of the immunoglobulin family of inflammatory stimulating receptors and is involved in a number of pathophysiological processes. The present study aimed to investigate the role of TREM2 in neurotoxicity induced by high cholesterol levels in SH‑SY5Y cells and explore the potential mechanism. SH‑SY5Y cells were routinely cultured and stimulated with a range of cholesterol concentrations. Cell viability was assessed using an MTT assay, morphological changes were observed, and the cell cycle distribution was measured using flow cytometry. Lipid deposition was measured by Oil red O staining, and the mRNA and protein expression levels of SRBEP‑1 and SRBEP‑2 were detected by quantitative PCR and western blotting, respectively. Moreover, the protein expression levels of BDNF, Copine‑6, TREM1, TREM2, and key molecules of the Wnt signaling pathways were detected by western blotting. Finally, TREM2 was overexpressed to investigate its potential role in high cholesterol‑induced neurotoxicity. The results showed that cell viability was significantly decreased in SH‑SY5Y cells stimulated with cholesterol (0.1~100 µM) in a dose‑ and time‑dependent manner. Stimulation with 100 µM cholesterol for 24 h resulted in morphological injuries, increased the proportion of SH‑SY5Y cells at G0/G1, the degree of lipid accumulation, and the protein expression levels of sterol regulatory element binding protein (SREBP)1 and SREBP2, markedly decreased the protein expression levels of BDNF, Copine‑6, and TREM2, and the p‑β‑catenin/β‑catenin ratio, and increased the expression levels of nesfatin‑1, TREM1 and the p‑GSK3β/GSK3β ratio. Furthermore, the imbalanced expression of BDNF, Copine‑6, nesfatin‑1, and p‑GSK3β induced by high cholesterol levels was reversed after overexpression of TREM2. These results suggest that a high concentration of cholesterol could induce cell injury and lipid deposition in SH‑SY5Y cells and that the underlying mechanism may be associated with imbalanced TREM2 expression.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

View References

1 

Sun L, Clarke R, Bennett D, Guo Y, Walters RG, Hill M, Parish S, Millwood IY, Bian Z, Chen Y, et al: Causal associations of blood lipids with risk of ischemic stroke and intracerebral hemorrhage in Chinese adults. Nat Med. 25:569–574. 2019.PubMed/NCBI View Article : Google Scholar

2 

Yusuf S, Bosch J, Dagenais G, Zhu J, Xavier D, Liu L, Pais P, Lopez-Jaramillo P, Leiter LA, Dans A, et al: Cholesterol lowering in intermediate-risk persons without cardiovascular disease. N Engl J Med. 374:2021–2031. 2016.PubMed/NCBI View Article : Google Scholar

3 

Alenghat FJ and Davis AM: Management of blood cholesterol. JAMA. 321:800–801. 2019.PubMed/NCBI View Article : Google Scholar

4 

Grundy SM, Stone NJ, Bailey AL, Beam C, Birtcher KK, Blumenthal RS, Braun LT, de Ferranti S, Faiella-Tommasino J, Forman DE, et al: 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation. 139:e1082–e1143. 2019.PubMed/NCBI View Article : Google Scholar

5 

Wilson PWF, Polonsky TS, Miedema MD, Khera A, Kosinski AS and Kuvin JT: Systematic Review for the 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation. 139:e1144–e1161. 2019.PubMed/NCBI View Article : Google Scholar

6 

Holt RI, Phillips DI, Jameson KA, Cooper C, Dennison EM and Peveler RC: Hertfordshire Cohort Study Group. The relationship between depression, anxiety and cardiovascular disease: Findings from the Hertfordshire Cohort Study. J Affect Disord. 150:84–90. 2013.PubMed/NCBI View Article : Google Scholar

7 

Stough C, Pipingas A, Camfield D, Nolidin K, Savage K, Deleuil S and Scholey A: Increases in total cholesterol and low density lipoprotein associated with decreased cognitive performance in healthy elderly adults. Metab Brain Dis. 34:477–484. 2019.PubMed/NCBI View Article : Google Scholar

8 

Song Y, Liu J, Zhao K, Gao L and Zhao J: Cholesterol-induced toxicity: An integrated view of the role of cholesterol in multiple diseases. Cell Metab. 33:1911–1925. 2021.PubMed/NCBI View Article : Google Scholar

9 

Zhu X, Tang HD, Dong WY, Kang F, Liu A, Mao Y, Xie W, Zhang X, Cao P, Zhou W, et al: Distinct thalamocortical circuits underlie allodynia induced by tissue injury and by depression-like states. Nat Neurosci. 24:542–553. 2021.PubMed/NCBI View Article : Google Scholar

10 

Zou Y, Zhu Q, Deng Y, Duan J, Pan L, Tu Q, Dai R, Zhang X, Chu LW and Lu Y: Vascular risk factors and mild cognitive impairment in the elderly population in Southwest China. Am J Alzheimers Dis Other Demen. 29:242–247. 2014.PubMed/NCBI View Article : Google Scholar

11 

Reed B, Villeneuve S, Mack W, DeCarli C, Chui HC and Jagust W: Associations between serum cholesterol levels and cerebral amyloidosis. JAMA Neurol. 71:195–200. 2014.PubMed/NCBI View Article : Google Scholar

12 

Liu AH, Chu M and Wang YP: Up-Regulation of Trem2 inhibits hippocampal neuronal apoptosis and alleviates oxidative stress in epilepsy via the PI3K/Akt pathway in mice. Neurosci Bull. 35:471–485. 2019.PubMed/NCBI View Article : Google Scholar

13 

Roca-Agujetas V, de Dios C, Abadin X and Colell A: Upregulation of brain cholesterol levels inhibits mitophagy in Alzheimer disease. Autophagy. 17:1555–1557. 2021.PubMed/NCBI View Article : Google Scholar

14 

Gao XR, Chen Z, Fang K, Xu JX and Ge JF: Protective effect of quercetin against the metabolic dysfunction of glucose and lipids and its associated learning and memory impairments in NAFLD rats. Lipids Health Dis. 20(164)2021.PubMed/NCBI View Article : Google Scholar

15 

Leritz EC, McGlinchey RE, Salat DH and Milberg WP: Elevated levels of serum cholesterol are associated with better performance on tasks of episodic memory. Metab Brain Dis. 31:465–473. 2016.PubMed/NCBI View Article : Google Scholar

16 

Zhou F, Deng W, Ding D, Zhao Q, Liang X, Wang F, Luo J, Zheng L, Guo Q and Hong Z: High Low-density lipoprotein cholesterol inversely relates to dementia in community-dwelling older adults: The shanghai aging study. Front Neurol. 9(952)2018.PubMed/NCBI View Article : Google Scholar

17 

Banach M, Rizzo M, Nikolic D, Howard G, Howard V and Mikhailidis D: Intensive LDL-cholesterol lowering therapy and neurocognitive function. Pharmacol Ther. 170:181–191. 2017.PubMed/NCBI View Article : Google Scholar

18 

Bertolio R, Napoletano F, Mano M, Maurer-Stroh S, Fantuz M, Zannini A, Bicciato S, Sorrentino G and Del Sal G: Sterol regulatory element binding protein 1 couples mechanical cues and lipid metabolism. Nat Commun. 10(1326)2019.PubMed/NCBI View Article : Google Scholar

19 

Oh IS, Shimizu H, Satoh T, Okada S, Adachi S, Inoue K, Eguchi H, Yamamoto M, Imaki T, Hashimoto K, et al: Identification of nesfatin-1 as a satiety molecule in the hypothalamus. Nature. 443:709–712. 2006.PubMed/NCBI View Article : Google Scholar

20 

Zhang Z, Li L, Yang M, Liu H, Boden G and Yang G: Increased plasma levels of nesfatin-1 in patients with newly diagnosed type 2 diabetes mellitus. Exp Clin Endocrinol Diabetes. 120:91–95. 2012.PubMed/NCBI View Article : Google Scholar

21 

Catak Z, Aydin S, Sahin I, Kuloglu T, Aksoy A and Dagli AF: Regulatory neuropeptides (ghrelin, obestatin and nesfatin-1) levels in serum and reproductive tissues of female and male rats with fructose-induced metabolic syndrome. Neuropeptides. 48:167–177. 2014.PubMed/NCBI View Article : Google Scholar

22 

Prinz P and Stengel A: Nesfatin-1: Current status as a peripheral hormone and future prospects. Curr Opin Pharmacol. 31:19–24. 2016.PubMed/NCBI View Article : Google Scholar

23 

Yin Y, Li Z, Gao L, Li Y, Zhao J and Zhang W: AMPK-dependent modulation of hepatic lipid metabolism by nesfatin-1. Mol Cell Endocrinol. 417:20–26. 2015.PubMed/NCBI View Article : Google Scholar

24 

Stengel A, Goebel M, Wang L, Rivier J, Kobelt P, Mönnikes H, Lambrecht NW and Taché Y: Central nesfatin-1 reduces dark-phase food intake and gastric emptying in rats: Differential role of corticotropin-releasing factor2 receptor. Endocrinology. 150:4911–4919. 2009.PubMed/NCBI View Article : Google Scholar

25 

Yoshida N, Maejima Y, Sedbazar U, Ando A, Kurita H, Damdindorj B, Takano E, Gantulga D, Iwasaki Y, Kurashina T, et al: Stressor-responsive central nesfatin-1 activates corticotropin-releasing hormone, noradrenaline and serotonin neurons and evokes hypothalamic-pituitary-adrenal axis. Aging (Albany NY). 2:775–784. 2010.PubMed/NCBI View Article : Google Scholar

26 

Han YX, Tao C, Gao XR, Wang LL, Jiang FH, Wang C, Fang K, Chen XX, Chen Z and Ge JF: BDNF-related imbalance of copine 6 and synaptic plasticity markers couples with depression-like behavior and immune activation in CUMS rats. Front Neurosci. 12(731)2018.PubMed/NCBI View Article : Google Scholar

27 

Xu YY, Ge JF, Qin G, Peng YN, Zhang CF, Liu XR, Liang LC, Wang ZZ, Chen FH and Li J: Acute, but not chronic, stress increased the plasma concentration and hypothalamic mRNA expression of NUCB2/nesfatin-1 in rats. Neuropeptides. 54:47–53. 2015.PubMed/NCBI View Article : Google Scholar

28 

Ge JF, Xu YY, Qin G, Pan XY, Cheng JQ and Chen FH: Nesfatin-1, a potent anorexic agent, decreases exploration and induces anxiety-like behavior in rats without altering learning or memory. Brain Res. 1629:171–181. 2015.PubMed/NCBI View Article : Google Scholar

29 

Ge JF, Xu YY, Qin G, Peng YN, Zhang CF, Liu XR, Liang LC, Wang ZZ and Chen FH: Depression-like behavior induced by nesfatin-1 in rats: Involvement of increased immune activation and imbalance of synaptic vesicle proteins. Front Neurosci. 9(429)2015.PubMed/NCBI View Article : Google Scholar

30 

Liu J, Xiao Q, Xiao J, Niu C, Li Y, Zhang X, Zhou Z, Shu G and Yin G: Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities. Signal Transduct Target Ther. 7(3)2022.PubMed/NCBI View Article : Google Scholar

31 

Schlupf J and Steinbeisser H: IGF antagonizes the Wnt/β-Catenin pathway and promotes differentiation of extra-embryonic endoderm. Differentiation. 87:209–219. 2014.PubMed/NCBI View Article : Google Scholar

32 

Xu X, Wang L, Liu B, Xie W and Chen YG: Activin/Smad2 and Wnt/β-catenin up-regulate HAS2 and ALDH3A2 to facilitate mesendoderm differentiation of human embryonic stem cells. J Biol Chem. 293:18444–18453. 2018.PubMed/NCBI View Article : Google Scholar

33 

Logan CY and Nusse R: The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol. 20:781–810. 2004.PubMed/NCBI View Article : Google Scholar

34 

Yi H, Hu J, Qian J and Hackam AS: Expression of brain-derived neurotrophic factor is regulated by the Wnt signaling pathway. Neuroreport. 23:189–194. 2012.PubMed/NCBI View Article : Google Scholar

35 

Chen J, Park CS and Tang SJ: Activity-dependent synaptic Wnt release regulates hippocampal long term potentiation. J Biol Chem. 281:11910–11916. 2006.PubMed/NCBI View Article : Google Scholar

36 

Spagnuolo MS, Donizetti A, Iannotta L, Aliperti V, Cupidi C, Bruni AC and Cigliano L: Brain-derived neurotrophic factor modulates cholesterol homeostasis and Apolipoprotein E synthesis in human cell models of astrocytes and neurons. J Cell Physiol. 233:6925–6943. 2018.PubMed/NCBI View Article : Google Scholar

37 

Ge JF, Xu YY, Qin G, Cheng JQ and Chen FH: Resveratrol ameliorates the anxiety- and depression-like behavior of subclinical hypothyroidism rat: Possible Involvement of the HPT Axis, HPA Axis, and Wnt/beta-Catenin pathway. Front Endocrinol (Lausanne). 7(44)2016.PubMed/NCBI View Article : Google Scholar

38 

Ford JW and McVicar DW: TREM and TREM-like receptors in inflammation and disease. Curr Opin Immunol. 21:38–46. 2009.PubMed/NCBI View Article : Google Scholar

39 

Ulland TK and Colonna M: TREM2-a key player in microglial biology and Alzheimer disease. Nat Rev Neurol. 14:667–675. 2018.PubMed/NCBI View Article : Google Scholar

40 

Zheng H, Jia L, Liu CC, Rong Z, Zhong L, Yang L, Chen XF, Fryer JD, Wang X, Zhang YW, et al: TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway. J Neurosci. 37:1772–1784. 2017.PubMed/NCBI View Article : Google Scholar

41 

Fan Y, Ma Y, Huang W, Cheng X, Gao N, Li G and Tian S: Up-regulation of TREM2 accelerates the reduction of amyloid deposits and promotes neuronal regeneration in the hippocampus of amyloid beta1-42 injected mice. J Chem Neuroanat. 97:71–79. 2019.PubMed/NCBI View Article : Google Scholar

42 

Jiang T, Tan L, Zhu XC, Zhang QQ, Cao L, Tan MS, Gu LZ, Wang HF, Ding ZZ, Zhang YD and Yu JT: Upregulation of TREM2 ameliorates neuropathology and rescues spatial cognitive impairment in a transgenic mouse model of Alzheimer's disease. Neuropsychopharmacology. 39:2949–2962. 2014.PubMed/NCBI View Article : Google Scholar

43 

Parhizkar S, Arzberger T, Brendel M, Kleinberger G, Deussing M, Focke C, Nuscher B, Xiong M, Ghasemigharagoz A, Katzmarski N, et al: Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE. Nat Neurosci. 22:191–204. 2019.PubMed/NCBI View Article : Google Scholar

44 

Jiang T, Tan L, Zhu XC, Zhou JS, Cao L, Tan MS, Wang HF, Chen Q, Zhang YD and Yu JT: Silencing of TREM2 exacerbates tau pathology, neurodegenerative changes, and spatial learning deficits in P301S tau transgenic mice. Neurobiol Aging. 36:3176–3186. 2015.PubMed/NCBI View Article : Google Scholar

45 

Jiang T, Wan Y, Zhang YD, Zhou JS, Gao Q, Zhu XC, Shi JQ, Lu H, Tan L and Yu JT: TREM2 Overexpression has No Improvement on Neuropathology and Cognitive Impairment in Aging APPswe/PS1dE9 Mice. Mol Neurobiol. 54:855–865. 2017.PubMed/NCBI View Article : Google Scholar

46 

Chen Z, Xu YY, Wu R, Han YX, Yu Y, Ge JF and Chen FH: Impaired learning and memory in rats induced by a high-fat diet: Involvement with the imbalance of nesfatin-1 abundance and copine 6 expression. J Neuroendocrinol. (29)2017.PubMed/NCBI View Article : Google Scholar : doi: 10.1111/jne.12462.

47 

Arenas F, Garcia-Ruiz C and Fernandez-Checa JC: Intracellular cholesterol trafficking and impact in neurodegeneration. Front Mol Neurosci. 10(382)2017.PubMed/NCBI View Article : Google Scholar

48 

Dietschy JM and Turley SD: Thematic review series: Brain Lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal. J Lipid Res. 45:1375–1397. 2004.PubMed/NCBI View Article : Google Scholar

49 

Schilling S, Tzourio C, Soumare A, Kaffashian S, Dartigues JF, Ancelin ML, Samieri C, Dufouil C and Debette S: Differential associations of plasma lipids with incident dementia and dementia subtypes in the 3C Study: A longitudinal, population-based prospective cohort study. PLoS Med. 14(e1002265)2017.PubMed/NCBI View Article : Google Scholar

50 

Chen H, Du Y, Liu S, Ge B, Ji Y and Huang G: Association between serum cholesterol levels and Alzheimer's disease in China: A case-control study. Int J Food Sci Nutr. 70:405–411. 2019.PubMed/NCBI View Article : Google Scholar

51 

Knowles TP, Vendruscolo M and Dobson CM: The amyloid state and its association with protein misfolding diseases. Nat Rev Mol Cell Biol. 15:384–396. 2014.PubMed/NCBI View Article : Google Scholar

52 

Habchi J, Chia S, Galvagnion C, Michaels TCT, Bellaiche MMJ, Ruggeri FS, Sanguanini M, Idini I, Kumita JR, Sparr E, et al: Cholesterol catalyses Abeta42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes. Nat Chem. 10:673–683. 2018.PubMed/NCBI View Article : Google Scholar

53 

Di Scala C, Chahinian H, Yahi N, Garmy N and Fantini J: Interaction of Alzheimer's β-amyloid peptides with cholesterol: Mechanistic insights into amyloid pore formation. Biochemistry. 53:4489–4502. 2014.PubMed/NCBI View Article : Google Scholar

54 

Huang YN, Lin CI, Liao H, Liu CY, Chen YH, Chiu WC and Lin SH: Cholesterol overload induces apoptosis in SH-SY5Y human neuroblastoma cells through the up regulation of flotillin-2 in the lipid raft and the activation of BDNF/Trkb signaling. Neuroscience. 328:201–209. 2016.PubMed/NCBI View Article : Google Scholar

55 

Reinhard JR, Kriz A, Galic M, Angliker N, Rajalu M, Vogt KE and Ruegg MA: The calcium sensor Copine-6 regulates spine structural plasticity and learning and memory. Nat Commun. 7(11613)2016.PubMed/NCBI View Article : Google Scholar

56 

Burk K, Ramachandran B, Ahmed S, Hurtado-Zavala JI, Awasthi A, Benito E, Faram R, Ahmad H, Swaminathan A, McIlhinney J, et al: Regulation of Dendritic Spine Morphology in Hippocampal Neurons by Copine-6. Cereb Cortex. 28:1087–1104. 2018.PubMed/NCBI View Article : Google Scholar

57 

Zhang W, Shi Y, Peng Y, Zhong L, Zhu S, Zhang W and Tang SJ: Neuron activity-induced Wnt signaling up-regulates expression of brain-derived neurotrophic factor in the pain neural circuit. J Biol Chem. 293:15641–15651. 2018.PubMed/NCBI View Article : Google Scholar

58 

Motamedi S, Karimi I and Jafari F: The interrelationship of metabolic syndrome and neurodegenerative diseases with focus on brain-derived neurotrophic factor (BDNF): Kill two birds with one stone. Metab Brain Dis. 32:651–665. 2017.PubMed/NCBI View Article : Google Scholar

59 

Sharma D, Barhwal KK, Biswal SN, Srivastava AK, Bhardwaj P, Kumar A, Chaurasia OP and Hota SK: Hypoxia-mediated alteration in cholesterol oxidation and raft dynamics regulates BDNF signalling and neurodegeneration in hippocampus. J Neurochem. 148:238–251. 2019.PubMed/NCBI View Article : Google Scholar

60 

Sayed FA, Telpoukhovskaia M, Kodama L, Li Y, Zhou Y, Le D, Hauduc A, Ludwig C, Gao F, Clelland C, et al: Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy. Proc Natl Acad Sci USA. 115:10172–10177. 2018.PubMed/NCBI View Article : Google Scholar

61 

Sheng R, Kim H, Lee H, Xin Y, Chen Y, Tian W, Cui Y, Choi JC, Doh J, Han JK and Cho W: Cholesterol selectively activates canonical Wnt signalling over non-canonical Wnt signalling. Nat Commun. 5(4393)2014.PubMed/NCBI View Article : Google Scholar

62 

Damisah EC, Hill RA, Rai A, Chen F, Rothlin CV, Ghosh S and Grutzendler J: Astrocytes and microglia play orchestrated roles and respect phagocytic territories during neuronal corpse removal in vivo. Sci Adv. 6(eaba3239)2020.PubMed/NCBI View Article : Google Scholar

63 

Wang S, Mustafa M, Yuede CM, Salazar SV, Kong P, Long H, Ward M, Siddiqui O, Paul R, Gilfillan S, et al: Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer's disease model. J Exp Med. 217(e20200785)2020.PubMed/NCBI View Article : Google Scholar

64 

Zhou Y, Song WM, Andhey PS, Swain A, Levy T, Miller KR, Poliani PL, Cominelli M, Grover S, Gilfillan S, et al: Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer's disease. Nat Med. 26:131–142. 2020.PubMed/NCBI View Article : Google Scholar

65 

Diaz-Lucena D, Kruse N, Thüne K, Schmitz M, Villar-Piqué A, da Cunha JEG, Hermann P, López-Pérez Ó, Andrés-Benito P, Ladogana A, et al: TREM2 expression in the brain and biological fluids in prion diseases. Acta Neuropathol. 141:841–859. 2021.PubMed/NCBI View Article : Google Scholar

66 

Nugent AA, Lin K, van Lengerich B, Lianoglou S, Przybyla L, Davis SS, Llapashtica C, Wang J, Kim DJ, Xia D, et al: TREM2 regulates microglial cholesterol metabolism upon chronic phagocytic challenge. Neuron. 105:837–854.e839. 2020.PubMed/NCBI View Article : Google Scholar

67 

Jaitin DA, Adlung L, Thaiss CA, Weiner A, Li B, Descamps H, Lundgren P, Bleriot C, Liu Z, Deczkowska A, et al: Lipid-Associated macrophages control metabolic homeostasis in a Trem2-Dependent manner. Cell. 178:686–698.e14. 2019.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zheng Q, Han Y, Fan M, Gao X, Ma M, Xu J, Liu S and Ge J: Potential role of TREM2 in high cholesterol‑induced cell injury and metabolic dysfunction in SH‑SY5Y cells. Exp Ther Med 25: 205, 2023.
APA
Zheng, Q., Han, Y., Fan, M., Gao, X., Ma, M., Xu, J. ... Ge, J. (2023). Potential role of TREM2 in high cholesterol‑induced cell injury and metabolic dysfunction in SH‑SY5Y cells. Experimental and Therapeutic Medicine, 25, 205. https://doi.org/10.3892/etm.2023.11904
MLA
Zheng, Q., Han, Y., Fan, M., Gao, X., Ma, M., Xu, J., Liu, S., Ge, J."Potential role of TREM2 in high cholesterol‑induced cell injury and metabolic dysfunction in SH‑SY5Y cells". Experimental and Therapeutic Medicine 25.5 (2023): 205.
Chicago
Zheng, Q., Han, Y., Fan, M., Gao, X., Ma, M., Xu, J., Liu, S., Ge, J."Potential role of TREM2 in high cholesterol‑induced cell injury and metabolic dysfunction in SH‑SY5Y cells". Experimental and Therapeutic Medicine 25, no. 5 (2023): 205. https://doi.org/10.3892/etm.2023.11904
Copy and paste a formatted citation
x
Spandidos Publications style
Zheng Q, Han Y, Fan M, Gao X, Ma M, Xu J, Liu S and Ge J: Potential role of TREM2 in high cholesterol‑induced cell injury and metabolic dysfunction in SH‑SY5Y cells. Exp Ther Med 25: 205, 2023.
APA
Zheng, Q., Han, Y., Fan, M., Gao, X., Ma, M., Xu, J. ... Ge, J. (2023). Potential role of TREM2 in high cholesterol‑induced cell injury and metabolic dysfunction in SH‑SY5Y cells. Experimental and Therapeutic Medicine, 25, 205. https://doi.org/10.3892/etm.2023.11904
MLA
Zheng, Q., Han, Y., Fan, M., Gao, X., Ma, M., Xu, J., Liu, S., Ge, J."Potential role of TREM2 in high cholesterol‑induced cell injury and metabolic dysfunction in SH‑SY5Y cells". Experimental and Therapeutic Medicine 25.5 (2023): 205.
Chicago
Zheng, Q., Han, Y., Fan, M., Gao, X., Ma, M., Xu, J., Liu, S., Ge, J."Potential role of TREM2 in high cholesterol‑induced cell injury and metabolic dysfunction in SH‑SY5Y cells". Experimental and Therapeutic Medicine 25, no. 5 (2023): 205. https://doi.org/10.3892/etm.2023.11904
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team