Open Access

Drug‑resistant Acinetobacter baumannii: From molecular mechanisms to potential therapeutics (Review)

  • Authors:
    • Hao-Jia Wu
    • Zhi-Gang Xiao
    • Xiao-Juan Lv
    • Hai-Tang Huang
    • Chu Liao
    • Chen-Yang Hui
    • Yue Xu
    • Heng-Fei Li
  • View Affiliations

  • Published online on: March 23, 2023     https://doi.org/10.3892/etm.2023.11908
  • Article Number: 209
  • Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Bacterial drug resistance is increasingly becoming an important problem that needs to be solved urgently in modern clinical practices. Infection caused by Acinetobacter baumannii is a serious threat to the life and health of patients. The drug resistance rate of Acinetobacter baumannii strains is increasing, thus research on the drug resistance of Acinetobacter baumannii has also seen an increase. When patients are infected with drug‑resistant Acinetobacter baumannii, the availability of suitable antibiotics commonly used in clinical practices is becoming increasingly limited and the prognosis of patients is worsening. Studying the molecular mechanism of the drug resistance of Acinetobacter baumannii is fundamental to solving the problem of drug‑resistant Acinetobacter baumannii and potentially other ‘super bacteria’. Drug resistance mechanisms primarily include enzymes, membrane proteins, efflux pumps and beneficial mutations. Research on the underlying mechanisms provides a theoretical basis for the use and development of antibiotics and the development of novel treatment methods.
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May-2023
Volume 25 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Wu H, Xiao Z, Lv X, Huang H, Liao C, Hui C, Xu Y and Li H: Drug‑resistant <em>Acinetobacter baumannii</em>: From molecular mechanisms to potential therapeutics (Review). Exp Ther Med 25: 209, 2023
APA
Wu, H., Xiao, Z., Lv, X., Huang, H., Liao, C., Hui, C. ... Li, H. (2023). Drug‑resistant <em>Acinetobacter baumannii</em>: From molecular mechanisms to potential therapeutics (Review). Experimental and Therapeutic Medicine, 25, 209. https://doi.org/10.3892/etm.2023.11908
MLA
Wu, H., Xiao, Z., Lv, X., Huang, H., Liao, C., Hui, C., Xu, Y., Li, H."Drug‑resistant <em>Acinetobacter baumannii</em>: From molecular mechanisms to potential therapeutics (Review)". Experimental and Therapeutic Medicine 25.5 (2023): 209.
Chicago
Wu, H., Xiao, Z., Lv, X., Huang, H., Liao, C., Hui, C., Xu, Y., Li, H."Drug‑resistant <em>Acinetobacter baumannii</em>: From molecular mechanisms to potential therapeutics (Review)". Experimental and Therapeutic Medicine 25, no. 5 (2023): 209. https://doi.org/10.3892/etm.2023.11908