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Article

3,4,5‑Trihydroxycinnamic acid suppresses phorbol‑12‑myristate‑13‑acetate and A23187‑induced mast cell activation in RBL‑2H3 cells

  • Authors:
    • Jin-Young Park
    • Hee Jae Lee
    • Eun-Taek Han
    • Jin-Hee Han
    • Won Sun Park
    • Yong-Soo Kwon
    • Wanjoo Chun
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology, Kangwon National University School of Medicine, Chuncheon, Gangwon 24341, Republic of Korea, Department of Medical Environmental Biology and Tropical Medicine, Kangwon National University School of Medicine, Chuncheon, Gangwon 24341, Republic of Korea, Department of Physiology, Kangwon National University School of Medicine, Chuncheon, Gangwon 24341, Republic of Korea, College of Pharmacy, Kangwon National University, Chuncheon, Gangwon 24341, Republic of Korea
  • Article Number: 227
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    Published online on: March 30, 2023
       https://doi.org/10.3892/etm.2023.11926
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Abstract

Previously, anti‑inflammatory properties of 3,4,5‑Trihydroxycinnamic acid (THC) has been reported in lipopolysaccharide (LPS)‑induced RAW264.7 murine macrophage cells and in an LPS‑induced sepsis BALB/c mice animal model. However, the effect of THC on the anti‑allergic effect in mast cells has not been elucidated. The current study aimed to demonstrate the anti‑allergic properties of THC and its underlying mechanism. Rat basophilic leukemia (RBL‑2H3) cells were treated with phorbol‑12‑myristate‑13‑acetate (PMA) and A23187, a calcium ionophore, to be activated. The anti‑allergic effect of THC was determined by measuring cytokine and histamine release. Western blotting was conducted to determine mitogen‑activated protein kinases (MAPKs) activation and nuclear factor‑κB (NF‑κB) translocation. THC significantly suppressed PMA/A23187‑induced tumor necrosis factor α secretion and THC also significantly attenuated degranulation, releasing β‑hexosaminidase and histamine in concentration‑dependent manners. Furthermore, THC significantly attenuated PMA/A23187‑induced cyclooxygenase 2 expression and nuclear translocation of NF‑κB. THC significantly suppressed PMA/A23187‑induced increased phosphorylation of p38 mitogen‑activated protein kinase, phosphorylated (p‑)extracellular signal‑regulated kinase 1/2 and p‑c‑Jun N‑terminal kinase in RBL‑2H3 cells. Overall, the results demonstrated that THC exhibited anti‑allergic action by significantly attenuating degranulation of mast cells through the inhibition of MAPKs/NF‑κB signaling pathway in RBL‑2H3 cells.
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1 

Marshall JS: Mast-cell responses to pathogens. Nat Rev Immunol. 4:787–799. 2004.PubMed/NCBI View Article : Google Scholar

2 

Johnzon CF, Ronnberg E and Pejler G: The role of mast cells in bacterial infection. Am J Pathol. 186:4–14. 2016.PubMed/NCBI View Article : Google Scholar

3 

Wernersson S and Pejler G: Mast cell secretory granules: Armed for battle. Nat Rev Immunol. 14:478–494. 2014.PubMed/NCBI View Article : Google Scholar

4 

Voehringer D: Protective and pathological roles of mast cells and basophils. Nat Rev Immunol. 13:362–375. 2013.PubMed/NCBI View Article : Google Scholar

5 

Galli SJ, Grimbaldeston M and Tsai M: Immunomodulatory mast cells: Negative, as well as positive, regulators of immunity. Nat Rev Immunol. 8:478–486. 2008.PubMed/NCBI View Article : Google Scholar

6 

Cho MS, Park WS, Jung WK, Qian ZJ, Lee DS, Choi JS, Lee DY, Park SG, Seo SK, Kim HJ, et al: Caffeic acid phenethyl ester promotes anti-inflammatory effects by inhibiting MAPK and NF-κB signaling in activated HMC-1 human mast cells. Pharm Biol. 52:926–932. 2014.PubMed/NCBI View Article : Google Scholar

7 

Kong R, Kang OH, Seo YS, Zhou T, Kim SA, Shin DW and Kwon DY: MAPKs and NFkappaB pathway inhibitory effect of bisdemethoxycurcumin on phorbol 12-myristate13-acetate and A23187-induced inflammation in human mast cells. Mol Med Rep. 17:630–635. 2018.PubMed/NCBI View Article : Google Scholar

8 

Li L, Zhang XH, Liu GR, Liu C and Dong YM: Isoquercitrin suppresses the expression of histamine and pro-inflammatory cytokines by inhibiting the activation of MAP Kinases and NF-κB in human KU812 cells. Chin J Nat Med. 14:407–412. 2016.PubMed/NCBI View Article : Google Scholar

9 

Cagnol S and Chambard JC: ERK and cell death: Mechanisms of ERK-induced cell death-apoptosis, autophagy and senescence. FEBS J. 277:2–21. 2010.PubMed/NCBI View Article : Google Scholar

10 

Zhao J, Wang L, Dong X, Hu X, Zhou L, Liu Q, Song B, Wu Q and Li L: The c-Jun N-terminal kinase (JNK) pathway is activated in human interstitial cystitis (IC) and rat protamine sulfate induced cystitis. Sci Rep. 6(19670)2016.PubMed/NCBI View Article : Google Scholar

11 

Zhou Y, Yang Q, Xu H, Zhang J, Deng H, Gao H, Yang J, Zhao D and Liu F: miRNA-221-3p enhances the secretion of interleukin-4 in mast cells through the phosphatase and tensin Homolog/p38/Nuclear Factor-kappaB pathway. PLoS One. 11(e0148821)2016.PubMed/NCBI View Article : Google Scholar

12 

Bose JS, Gangan V, Jain SK and Manna SK: Novel caffeic acid ester derivative induces apoptosis by expressing FasL and downregulating NF-KappaB: Potentiation of cell death mediated by chemotherapeutic agents. J Cell Physiol. 218:653–662. 2009.PubMed/NCBI View Article : Google Scholar

13 

Murtaza G, Karim S, Akram MR, Khan SA, Azhar S, Mumtaz A and Bin Asad MH: Caffeic acid phenethyl ester and therapeutic potentials. Biomed Res Int. 2014(145342)2014.PubMed/NCBI View Article : Google Scholar

14 

Armutcu F, Akyol S, Ustunsoy S and Turan FF: Therapeutic potential of caffeic acid phenethyl ester and its anti-inflammatory and immunomodulatory effects (Review). Exp Ther Med. 9:1582–1588. 2015.PubMed/NCBI View Article : Google Scholar

15 

Choi HG, Tran PT, Lee JH, Min BS and Kim JA: Anti-inflammatory activity of caffeic acid derivatives isolated from the roots of Salvia miltiorrhiza Bunge. Arch Pharm Res. 41:64–70. 2018.PubMed/NCBI View Article : Google Scholar

16 

Rabe C, Steenkamp AJ, Joubert E, Burger JFW and Ferreira D: Phenolic metabolites from rooibos tea. Phytochemistry. 35:1559–1565. 1994.

17 

Nagasaka R, Chotimarkorn C, Shafiqul IM, Hori M, Ozaki H and Ushio H: Anti-inflammatory effects of hydroxycinnamic acid derivatives. Biochem Biophys Res Commun. 358:615–619. 2007.PubMed/NCBI View Article : Google Scholar

18 

Kim YC: Neuroprotective phenolics in medicinal plants. Arch Pharm Res. 33:1611–1632. 2010.PubMed/NCBI View Article : Google Scholar

19 

Lee JW, Cheong IY, Kim HS, Lee JJ, Lee YS, Kwon YS, Kim MJ, Lee HJ, Kim SS and Chun W: Anti-inflammatory activity of 1-docosanoyl cafferate isolated from Rhus verniciflua in LPS-stimulated BV2 microglial cells. Korean J Physiol Pharmacol. 15:9–15. 2011.PubMed/NCBI View Article : Google Scholar

20 

Itharat A and Hiransai P: Dioscoreanone suppresses LPS-induced nitric oxide production and inflammatory cytokine expression in RAW 264.7 macrophages by NF-κB and ERK1/2 signaling transduction. J Cell Biochem. 113:3427–3435. 2012.PubMed/NCBI View Article : Google Scholar

21 

Kim YJ, Shin Y, Lee KH and Kim TJ: Anethum graveloens flower extracts inhibited a lipopolysaccharide-induced inflammatory response by blocking iNOS expression and NF-κB activity in macrophages. Biosci Biotechnol Biochem. 76:1122–1127. 2012.PubMed/NCBI View Article : Google Scholar

22 

Rehman MU, Yoshihisa Y, Miyamoto Y and Shimizu T: The anti-inflammatory effects of platinum nanoparticles on the lipopolysaccharide-induced inflammatory response in RAW 264.7 macrophages. Inflamm Res. 61:1177–1185. 2012.PubMed/NCBI View Article : Google Scholar

23 

Lee Y, Shin DH, Kim JH, Hong S, Choi D, Kim YJ, Kwak MK and Jung Y: Caffeic acid phenethyl ester-mediated Nrf2 activation and IkappaB kinase inhibition are involved in NFkappaB inhibitory effect: Structural analysis for NFkappaB inhibition. Eur J Pharmacol. 643:21–28. 2010.PubMed/NCBI View Article : Google Scholar

24 

Fidan H, Sahin O, Yavuz Y, Kilbas A, Cetinkaya Z, Ela Y, Ozen OA and Altuntas I: Caffeic acid phenethyl ester reduces mortality and sepsis-induced lung injury in rats. Crit Care Med. 35:2822–2829. 2007.PubMed/NCBI View Article : Google Scholar

25 

Schwartz LB, Lewis RA, Seldin D and Austen KF: Acid hydrolases and tryptase from secretory granules of dispersed human lung mast cells. J Immunol. 126:1290–1294. 1981.PubMed/NCBI

26 

Schoonbroodt S, Legrand-Poels S, Best-Belpomme M and Piette J: Activation of the NF-kappaB transcription factor in a T-lymphocytic cell line by hypochlorous acid. Biochem J. 321:777–785. 1997.PubMed/NCBI View Article : Google Scholar

27 

Ock J, Kim S and Suk K: Anti-inflammatory effects of a fluorovinyloxyacetamide compound KT-15087 in microglia cells. Pharmacol Res. 59:414–422. 2009.PubMed/NCBI View Article : Google Scholar

28 

Lee JW, Bae CJ, Choi YJ, Kim SI, Kim NH, Lee HJ, Kim SS, Kwon YS and Chun W: 3,4,5-trihydroxycinnamic acid inhibits LPS-Induced iNOS expression by suppressing NF-κB Activation in BV2 microglial cells. Korean J Physiol Pharmacol. 16:107–112. 2012.PubMed/NCBI View Article : Google Scholar

29 

Kunder CA, St John AL and Abraham SN: Mast cell modulation of the vascular and lymphatic endothelium. Blood. 118:5383–5393. 2011.PubMed/NCBI View Article : Google Scholar

30 

Hundley TR, Prasad AR and Beaven MA: Elevated levels of cyclooxygenase-2 in antigen-stimulated mast cells is associated with minimal activation of p38 mitogen-activated protein kinase. J Immunol. 167:1629–1636. 2001.PubMed/NCBI View Article : Google Scholar

31 

Hu Frisk JM, Kjellen L, Melo FR, Ohrvik H and Pejler G: Mitogen-Activated protein kinase signaling regulates proteoglycan composition of mast cell secretory granules. Front Immunol. 9(1670)2018.PubMed/NCBI View Article : Google Scholar

32 

Kim DH, Jung WS, Kim ME, Lee HW, Youn HY, Seon JK, Lee HN and Lee JS: Genistein inhibits proinflammatory cytokines in human mast cell activation through the inhibition of the ERK pathway. Int J Mol Med. 34:1669–1674. 2014.PubMed/NCBI View Article : Google Scholar

33 

Su-Jin Kim SJ, Kim YJ, Lee JH, Oh SR, Park CI, Jeong JW, Um JY, Hong SH and Ahn EM: Genistein-4'-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside from Sophora japonica (Leguminosae) ameliorates mast cell-mediated allergic inflammation in vivo and in vitro. Orient Pharm Exp Med. 11:207–213. 2011.

34 

Woolley DE and Tetlow LC: Mast cell activation and its relation to proinflammatory cytokine production in the rheumatoid lesion. Arthritis Res. 2:65–74. 2000.PubMed/NCBI View Article : Google Scholar

35 

Chen BH, Hung MH, Chen JYF, Chang HW, Yu ML, Wan L, Tsai FJ, Wang TP, Fu TF and Chiu CC: Anti-allergic activity of grapeseed extract (GSE) on RBL-2H3 mast cells. Food Chem. 132:968–974. 2012.

36 

Tang T, Scambler TE, Smallie T, Cunliffe HE, Ross EA, Rosner DR, O'Neil JD and Clark AR: Macrophage responses to lipopolysaccharide are modulated by a feedback loop involving prostaglandin E2, dual specificity phosphatase 1 and tristetraprolin. Sci Rep. 7(4350)2017.PubMed/NCBI View Article : Google Scholar

37 

Johnson GL and Lapadat R: Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science. 298:1911–1912. 2002.PubMed/NCBI View Article : Google Scholar

38 

Kaminska B: MAPK signalling pathways as molecular targets for anti-inflammatory therapy-from molecular mechanisms to therapeutic benefits. Biochim Biophys Acta. 1754:253–262. 2005.PubMed/NCBI View Article : Google Scholar

39 

Oliver JM, Kepley CL, Ortega E and Wilson BS: Immunologically mediated signaling in basophils and mast cells: Finding therapeutic targets for allergic diseases in the human FcvarepsilonR1 signaling pathway. Immunopharmacology. 48:269–281. 2000.PubMed/NCBI View Article : Google Scholar

40 

Kang OH, Jang HJ, Chae HS, Oh YC, Choi JG, Lee YS, Kim JH, Kim YC, Sohn DH, Park H and Kwon DY: Anti-inflammatory mechanisms of resveratrol in activated HMC-1 cells: Pivotal roles of NF-kappaB and MAPK. Pharmacol Res. 59:330–337. 2009.PubMed/NCBI View Article : Google Scholar

41 

Yoo G, Lee K and Lee DC: Inhibitory effects of 2-oxo-2H-chromen-4-yl 4-methylbenzenesulfonate on allergic inflammatory responses in rat basophilic leukemia cells. Int Immunopharmacol. 48:196–202. 2017.PubMed/NCBI View Article : Google Scholar

42 

Wan M, Liu J and Ouyang X: Nucleotide-binding oligomerization domain 1 regulates Porphyromonas gingivalis-induced vascular cell adhesion molecule 1 and intercellular adhesion molecule 1 expression in endothelial cells through NF-κB pathway. J Periodontal Res. 50:189–196. 2015.PubMed/NCBI View Article : Google Scholar

43 

Wang L, Xu Y, Yu Q, Sun Q, Xu Y, Gu Q and Xu X: H-RN, a novel antiangiogenic peptide derived from hepatocyte growth factor inhibits inflammation in vitro and in vivo through PI3K/AKT/IKK/NF-κB signal pathway. Biochem Pharmacol. 89:255–265. 2014.PubMed/NCBI View Article : Google Scholar

44 

Blackwell TS, Blackwell TR and Christman JW: Impaired activation of nuclear factor-kappaB in endotoxin-tolerant rats is associated with down-regulation of chemokine gene expression and inhibition of neutrophilic lung inflammation. J Immunol. 158:5934–5940. 1997.PubMed/NCBI

45 

Lee JW, Bae CJ, Choi YJ, Kim SI, Kwon YS, Lee HJ, Kim SS and Chun W: 3,4,5-trihydroxycinnamic acid inhibits lipopolysaccharide (LPS)-induced inflammation by Nrf2 activation in vitro and improves survival of mice in LPS-induced endotoxemia model in vivo. Mol Cell Biochem. 390:143–153. 2014.PubMed/NCBI View Article : Google Scholar

46 

Lee JW, Kwon JH, Lim MS, Lee HJ, Kim SS, Lim SY and Chun W: 3,4,5-Trihydroxycinnamic acid increases heme-oxygenase-1 (HO-1) and decreases macrophage infiltration in LPS-induced septic kidney. Mol Cell Biochem. 397:109–116. 2014.PubMed/NCBI View Article : Google Scholar

47 

Park JW, Oh JH, Hwang D, Kim SM, Min JH, Seo JY, Chun W, Lee HJ, Oh SR, Lee JW and Ahn KS: 3,4,5Trihydroxycinnamic acid exerts antiinflammatory effects on TNF-α/IFN-ү-stimulated HaCaT cells. Mol Med Rep. 24(509)2021.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Park J, Lee H, Han E, Han J, Park WS, Kwon Y and Chun W: 3,4,5‑Trihydroxycinnamic acid suppresses phorbol‑12‑myristate‑13‑acetate and A23187‑induced mast cell activation in RBL‑2H3 cells. Exp Ther Med 25: 227, 2023.
APA
Park, J., Lee, H., Han, E., Han, J., Park, W.S., Kwon, Y., & Chun, W. (2023). 3,4,5‑Trihydroxycinnamic acid suppresses phorbol‑12‑myristate‑13‑acetate and A23187‑induced mast cell activation in RBL‑2H3 cells. Experimental and Therapeutic Medicine, 25, 227. https://doi.org/10.3892/etm.2023.11926
MLA
Park, J., Lee, H., Han, E., Han, J., Park, W. S., Kwon, Y., Chun, W."3,4,5‑Trihydroxycinnamic acid suppresses phorbol‑12‑myristate‑13‑acetate and A23187‑induced mast cell activation in RBL‑2H3 cells". Experimental and Therapeutic Medicine 25.5 (2023): 227.
Chicago
Park, J., Lee, H., Han, E., Han, J., Park, W. S., Kwon, Y., Chun, W."3,4,5‑Trihydroxycinnamic acid suppresses phorbol‑12‑myristate‑13‑acetate and A23187‑induced mast cell activation in RBL‑2H3 cells". Experimental and Therapeutic Medicine 25, no. 5 (2023): 227. https://doi.org/10.3892/etm.2023.11926
Copy and paste a formatted citation
x
Spandidos Publications style
Park J, Lee H, Han E, Han J, Park WS, Kwon Y and Chun W: 3,4,5‑Trihydroxycinnamic acid suppresses phorbol‑12‑myristate‑13‑acetate and A23187‑induced mast cell activation in RBL‑2H3 cells. Exp Ther Med 25: 227, 2023.
APA
Park, J., Lee, H., Han, E., Han, J., Park, W.S., Kwon, Y., & Chun, W. (2023). 3,4,5‑Trihydroxycinnamic acid suppresses phorbol‑12‑myristate‑13‑acetate and A23187‑induced mast cell activation in RBL‑2H3 cells. Experimental and Therapeutic Medicine, 25, 227. https://doi.org/10.3892/etm.2023.11926
MLA
Park, J., Lee, H., Han, E., Han, J., Park, W. S., Kwon, Y., Chun, W."3,4,5‑Trihydroxycinnamic acid suppresses phorbol‑12‑myristate‑13‑acetate and A23187‑induced mast cell activation in RBL‑2H3 cells". Experimental and Therapeutic Medicine 25.5 (2023): 227.
Chicago
Park, J., Lee, H., Han, E., Han, J., Park, W. S., Kwon, Y., Chun, W."3,4,5‑Trihydroxycinnamic acid suppresses phorbol‑12‑myristate‑13‑acetate and A23187‑induced mast cell activation in RBL‑2H3 cells". Experimental and Therapeutic Medicine 25, no. 5 (2023): 227. https://doi.org/10.3892/etm.2023.11926
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