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Effect of Momordica charantia polysaccharide on immunomodulatory activity in mice

  • Authors:
    • Arzugul Ablimit
    • Yang Yu
    • Xin Jin
    • Jing-Shuang Li
  • View Affiliations / Copyright

    Affiliations: Department of Food Science and Engineering, Jinzhou Medical University, Jinzhou, Liaoning 121001, P.R. China, Department of Animal Husbandry Medicine, Jinzhou Medical University, Jinzhou, Liaoning 121001, P.R. China
    Copyright: © Ablimit et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 307
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    Published online on: May 10, 2023
       https://doi.org/10.3892/etm.2023.12006
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Abstract

Momordica charantia polysaccharides (MCPs) have been reported to exert beneficial roles, such as disease healing, in medicine and pharmacy. However, little is known about their effects on immunomodulation. The present study aimed to explore the possible effects of Momordica charantia polysaccharide (MCP) on the immunomodulatory activity of mice lymphocytes. To this aim, male BALB/c mice aged 6‑8 weeks were assigned to the following six experimental groups: i) Normal (NG); ii) model (MG); iii) positive (PG); iv) MCP low‑dose (MLG); v) MCP medium‑dose (MMG); and vi) MCP high‑dose (MHG). An immunosuppressive model was established by the intraperitoneal injection of cyclophosphamide in all groups apart from NG. The NG and MG mice were fed with distilled water, whereas the PG mice were administered with levamisole and the MLG, MMG and MHG mice were fed on low, medium and high (100, 200 and 300 mg/kg, respectively) doses of MCP for 21 consecutive days. Subsequently, the mice underwent surgical procedure and were analysed using a range of procedures, including measurement of the thymus index (TI) and spleen index (SI), assessment of the lymphocyte proliferation rate and cell phagocytosis of peritoneal macrophages, lymphocyte proliferation, secretion and mRNA expression of cytokines IFN‑γ, IL‑6 and IL‑12. The mice divided into six groups as mentioned above and treated for 7 days, in the first 6 days, except NG group, mice in each group were desiccated in the abdominal cavity and sensitized by 1% dinitrofluorobenzene (DNFB). On day 6, mice were sensitized with 20 µl DNFB/acetone/olive oil solution behind the right ear and in front of the right ear. Compared with those in the NG mice (not injected with 80 mg/kg cyclophosphamide), the TIs and SIs of the PG, MLG, MMG and MHG mice were increased. In addition, the inhibitory rate of ear swelling and the phagocytic activity of peritoneal macrophages in the PG, MLG, MMG and MHG mice were increased compared with those of MG. Furthermore, the lymphocyte proliferation rate, the secretion and relative mRNA expression levels of cytokines IFN‑γ, IL‑6 and IL‑12 were significantly increased in the PG, MMG and MHG mice compared with those in the NG mice. The results from the present study suggest that treatment with MCP led to an upregulation of the organ indices of immunosuppressed mice, reduced their delayed allergic reaction indicated by the differential cytokine levels, improved the phagocytic activity of peritoneal macrophages, enhanced the proliferation rate of lymphocytes, increased the secretion and expression of IFN‑γ, IL‑6 and IL‑12. Therefore, MCP may improve the immune function of the immunosuppressed mice.
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1 

Joseph B and Jini D: Antidiabetic effects of Momordica charantia (bitter melon) and its medicinal potency. Asian Pac J Trop Dis. 3:93–102. 2013.

2 

Rajasekhar MD, Badri KR, Vinay Kumar K, Babu KR, Fatima SS, Sampath Kumar MT and Appa Rao C: Isolation and characterization of a novel antihyperglycemic protein from the fruits of Momordica cymbalaria. J Ethnopharmacol. 128:58–62. 2010.PubMed/NCBI View Article : Google Scholar

3 

Lucas EA, Dumancas GG, Smith BJ, Clarke SL and Arjmandi BH: Health benefits of bitter melon (Momordica charantia). Bioact Foods Promot Health. 35:525–549. 2010.

4 

Zhang F, Lin L and Xie J: Mini-review of chemical and biological properties of polysaccharides from Momordica charantia. Int J Biol Macromol. 92:246–253. 2016.PubMed/NCBI View Article : Google Scholar

5 

Spreafico F, Malfiore C, Moras ML, Marmonti L, Filippeschi S, Barbieri L, Perocco P and Stripe F: The immunomodulatory activity of the plant proteins Momordica charantia inhibitor and Pokeweed antiviral protein. Int J Immunopharmacol. 5:335–343. 1983.PubMed/NCBI View Article : Google Scholar

6 

Puri M, Kaur I, Kanwar RK, Gupta R, Chauhan A and Kanwar J: Ribosome inactivating proteins (RIPs) from Momordica charantia for anti viral therapy. Curr Mol Med. 9:1080–1094. 2009.PubMed/NCBI View Article : Google Scholar

7 

Panda BC, Mondal S, Devi KS, Maiti TK, Khatua S, Acharya K and Islam SS: Pectic polysaccharide from the green fruits of Momordica charantia (Karela): Structural characterization and study of immunoenhancing and antioxidant properties. Carbohydr Res. 401:24–31. 2015.PubMed/NCBI View Article : Google Scholar

8 

Elangovan A, Subramanian A, Durairaj S, Ramachandran J, Lakshmanan DK, Ravichandran G, Nambirajan G and Thilagar S: Antidiabetic and hypolipidemic efficacy of skin and seed extracts of Momordica cymbalaria on alloxan induced diabetic model in rats. J Ethnopharmacol. 24(111989)2019.PubMed/NCBI View Article : Google Scholar

9 

Mei YX, Chen HX, Zhang J, Zhang XD and Liang YX: Protective effect of chitooligosaccharides agaist cyclophosphamide-induced immunosuppression in mice. Int J Biol Macromol. 62:330–335. 2013.PubMed/NCBI View Article : Google Scholar

10 

Yu JH, Cong L, Wang CM, Li H, Zhang C, Guan X, Liu P, Xie Y, Chen J and Sun J: Immunomodulatory effect of Schisandra polysaccharides in cyclophosphamide-induced immunocompromised mice. Exp Ther Med. 15:4755–4762. 2018.PubMed/NCBI View Article : Google Scholar

11 

Nishi C, Toda S, Segawa K and Nagata S: Tim4-and Mer TK-mediated engulfment of apoptotic Cells by mouse resident peritoneal macrophages. Mol Cell Biol. 34:1512–1520. 2014.PubMed/NCBI View Article : Google Scholar

12 

Liu Z, Xing J, Huang Y, Bo R, Zheng S, Luo L, Niu Y, Zhang Y, Hu Y, Liu J, et al: Activation effect of Ganoderma lucidum polysaccharides liposomes on murine peritoneal macrophages. Int J Biol Macromol. 82:973–978. 2016.PubMed/NCBI View Article : Google Scholar

13 

Khan D, Dai R, Karpuzoglu E and Ahmed SA: Estrogen increase, whereas IL-27 and IFN-γ decrease, splenocyte IL-17 production in WT mice. Eur J Immunol. 40:2459–2556. 2010.PubMed/NCBI View Article : Google Scholar

14 

Jiang P, Ni Z, Wang B, Ma B, Duan H, Li X, Ma X, Wei Q, Ji X, Liu Q, et al: Acutetoxicity, twenty-eight days repeated dose toxicity and genotoxicity of vanadyl trehalose in kunming mice. Regul Toxicol Pharmacol. 85:86–97. 2017.PubMed/NCBI View Article : Google Scholar

15 

Wang C, Jin E, Deng J, Pei Y, Ren M, Hu Q, Gu Y and Li S: GRP30 mediated effects of boron on ret spleen lymphocyte proliferation, apoptosis and immune function. Food and Chemical Toxicol. 146(111838)2020.PubMed/NCBI View Article : Google Scholar

16 

Bharshiv CK, Grag CK and Bhatia AK: Immunomodulatory activity of aqucous extract of Nyctanthes arbor-tristis flowers with particular reference to splenocytes proliferation an cytokine induction. Indian J Pharmacol. 48:412–417. 2016.PubMed/NCBI View Article : Google Scholar

17 

Yamada S, Zaima N, YoshimuraY Inaba S, Fujimori T, Sogon T and Moriyama T: Vasualization of the distribution of anthocyanin species in mice eyeball by matrix-assisted laser desorption/ionization masss pectrometry imaging. Rapid Commun Mass Spectrom. 32:380–384. 2018.PubMed/NCBI View Article : Google Scholar

18 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

19 

Ahlmanm M and Hempel G: The effect of cyclophosphamide on the immune system: Implications for clinical cencer therapy. Cancer Chemother Pharmacol. 78:661–671. 2016.PubMed/NCBI View Article : Google Scholar

20 

Yamazaki M and Iwasawa H: Anti-oxidant and immunoactivating effects of vegetables and fruits. Food Sci. 47:73–77. 2005.

21 

Ueda H and Yamazaki M: Anti-inflammatory effect of orally administration of xanthine derivatives. Inflammation Res. 46(s220)1997.

22 

Zhang R, He C, Fan Y, Si H, Wang Y, Shi Z, Zhao X, Zheng Y, Liu Q and Zhang H: Immune-enhancing activity of polysaccharides from Cyrtomium macrophyllum. Int J Biol Macromol. 70:590–595. 2014.PubMed/NCBI View Article : Google Scholar

23 

Lan MB, Zhang YH, Zheng Y, Yuan HH and Zhao HL: Antioxidant and immunomodulatory activities of polysaccharides from moxa (artemisia argyi) leaf. Food Sci Biotechnol. 19:1463–1469. 2010.

24 

Oh MJ, Choi HD, Ha SK, Choi I and Park HY: Immunomodulatory effects of polysaccharide fraction isolated from Fagopyrum esculentum on innate immune system. Biochem Biophys Res Commun. 49:1210–1216. 2018.PubMed/NCBI View Article : Google Scholar

25 

Chao CW, Han CJ, Rhee YK, Lee YC, Shin KS, Shin JS, Lee KT and Hong HD: Cheonggukjang polysaccharides enhance immune activities and prevent cyclophosphamide-induced immunosuppression. Int J Biol Macromol. 72:519–525. 2015.PubMed/NCBI View Article : Google Scholar

26 

Dai Z, Zhang H, Zhang Y and Wang H: Chemical properties and immunostimulatory activity of a water-soluble polysaccharide from the clam of Hyriopsis cumingii Lea. Carbohydr Polym. 77:365–369. 2009.

27 

Xie X, Zou G and Li C: Antitumor and immunomodulatory activities of a water-soluble polysaccharide from Chaenomeles speciose. Carbohydr Polym. 132:323–329. 2015.PubMed/NCBI View Article : Google Scholar

28 

Nakano K and Matsushita S: The immunomodulatory effect of dopamine. Allergy. 56:679–684. 2007.PubMed/NCBI(In Japanese).

29 

Li H, Hong T, Jinag H, Liu S and Di L: The effects of Rehmannia glutinosa polysaccharide on immune function of mice. International Conference on Informaton Technology in Medicine and Education. 63:286–288. 2015.

30 

Wang M, Meng XY, Yang RL, Qin T, Wang XY, Zhang KY, Fei CZ, Li Y, Hu YL and Xue FQ: Cordyceps militaris polysaccharides can enhance the immunity and antioxidation activity in immunosuppressed mice. Carbohydr Polym. 89:461–466. 2012.PubMed/NCBI View Article : Google Scholar

31 

Chen JR, Yang ZQ, Hu TJ, Yan ZT, Niu TX, Wang L, Cui DA and Wang M: Immunomodulatory activity in vitro and in vivo of polysaccharide from Potentilla anserine. Fitoterapia. 81:1117–1124. 2010.PubMed/NCBI View Article : Google Scholar

32 

Sattler A, Wagner U, Rossol M, Sieper J, Wu P, Krause A, Schmidt WA, Radmer S, Kohler S, Romagnani C and Thiel A: Cytokine-induced human IFN-gamma-secreting effector-memory Th cells in chronic autoimmune inflammation. Blood. 113:1948–1956. 2009.PubMed/NCBI View Article : Google Scholar

33 

Mosmann TR and Coffman RL: Heterogeneity of cytokine secretion patterns and functions of helper T cells. Adv Immunol. 46:111–147. 1989.PubMed/NCBI View Article : Google Scholar

34 

Fan Y, Hu Y, Wang D, Liu J, Zhang J, Zhao X, Liu X, Liu C, Yuan J and Ruan S: Effects of Astragalus polysaccharide liposome on lymphocyte proliferation in vitro and adjuvanticity in vivo. Carbohydr Polym. 88:68–74. 2012.

35 

Huang Y, Jiang C, Hu Y, Zhao X, Shi C, Yu Y, Liu C, Tao Y, Pan H, Feng Y, et al: Immunoenhancement effect of Rehmannia glutinosa polysaccharide on lymphocyte proliferation and dendritic cell. Carbohydr Polym. 96:516–521. 2013.PubMed/NCBI View Article : Google Scholar

36 

Nakahara H, Song J, Sugimoto M, Hagihara K, Kishimoto T, Yoshizaki K and Nishimoto N: Anti-interleukin-6 receptor antibody therapy reduces vascular endothelial growth factor production in rheumatoid arthritis. Arthritis Rheum. 48:1521–1529. 2003.PubMed/NCBI View Article : Google Scholar

37 

Hennekes H, Gerhard D and Klein HU: Detection of interleukin-4-induced tyrosine phosphorylation of the IL-4 receptor by an enzyme linked immuno sorbent assay. J Dermatol Sci. 16(s168)1998.

38 

Habijanic J, Berovic M, Boh B, Plankl M and Wraber B: Submerged cultivation of Ganoderma lucidum and the effects of its polysaccharides on the production of human cytokines TFN-α, IL-12, IFN-γ, IL-2, IL-4, IL-10 and IL-17. N Biotechnol. 32:85–95. 2015.PubMed/NCBI View Article : Google Scholar

39 

Trinchier G: Interleukin-12:A cytokine produced byantigenpresenting cells with immunoregulatory functionsin the generation of T-helper cells type I and cytotoxiclymphocytes. Blood. 84:4008–4027. 1994.PubMed/NCBI

40 

Kataoka TR, Komazawa N, Oboki K, Morii E and Nakano T: Reduced expression of IL-12 receptor beta and IL-18 receptor alpha genes in natural killer cells and macrophages derived from B6-mi/mi mice. Lab Invest. 105:146–153. 2005.PubMed/NCBI View Article : Google Scholar

41 

Han J, Jiang X and Zhang L: Optimisisation of extraction conditions for polysaccharides from the roots of Isatis tinctoria L. by response surface methodology and their in vitro free radicals scavenging activities and effects on IL-4 AND IFN-gamma mRNA expression in chicken lymphocytes. Carbohydr Polym. 86:1320–1326. 2011.

42 

Wang H, Deng X, Zhou T, Wang C, Hou Y, Jiang H and Liu G: The in vitro immunomodulatory activity of a polysaccharides isolated from Kadsura marmorata. Carbohydr Polym. 97:710–715. 2013.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Ablimit A, Yu Y, Jin X and Li J: Effect of <em>Momordica charantia</em> polysaccharide on immunomodulatory activity in mice. Exp Ther Med 26: 307, 2023.
APA
Ablimit, A., Yu, Y., Jin, X., & Li, J. (2023). Effect of <em>Momordica charantia</em> polysaccharide on immunomodulatory activity in mice. Experimental and Therapeutic Medicine, 26, 307. https://doi.org/10.3892/etm.2023.12006
MLA
Ablimit, A., Yu, Y., Jin, X., Li, J."Effect of <em>Momordica charantia</em> polysaccharide on immunomodulatory activity in mice". Experimental and Therapeutic Medicine 26.1 (2023): 307.
Chicago
Ablimit, A., Yu, Y., Jin, X., Li, J."Effect of <em>Momordica charantia</em> polysaccharide on immunomodulatory activity in mice". Experimental and Therapeutic Medicine 26, no. 1 (2023): 307. https://doi.org/10.3892/etm.2023.12006
Copy and paste a formatted citation
x
Spandidos Publications style
Ablimit A, Yu Y, Jin X and Li J: Effect of <em>Momordica charantia</em> polysaccharide on immunomodulatory activity in mice. Exp Ther Med 26: 307, 2023.
APA
Ablimit, A., Yu, Y., Jin, X., & Li, J. (2023). Effect of <em>Momordica charantia</em> polysaccharide on immunomodulatory activity in mice. Experimental and Therapeutic Medicine, 26, 307. https://doi.org/10.3892/etm.2023.12006
MLA
Ablimit, A., Yu, Y., Jin, X., Li, J."Effect of <em>Momordica charantia</em> polysaccharide on immunomodulatory activity in mice". Experimental and Therapeutic Medicine 26.1 (2023): 307.
Chicago
Ablimit, A., Yu, Y., Jin, X., Li, J."Effect of <em>Momordica charantia</em> polysaccharide on immunomodulatory activity in mice". Experimental and Therapeutic Medicine 26, no. 1 (2023): 307. https://doi.org/10.3892/etm.2023.12006
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