Open Access

Role of non‑coding RNAs in cartilage endplate (Review)

  • Authors:
    • Xiaokun Zhao
    • Jinghong Yuan
    • Jingyu Jia
    • Jian Zhang
    • Jiahao Liu
    • Qi Chen
    • Tao Li
    • Zhiwen Wu
    • Hui Wu
    • Xinxin Miao
    • Tianlong Wu
    • Bin Li
    • Xigao Cheng
  • View Affiliations

  • Published online on: May 11, 2023     https://doi.org/10.3892/etm.2023.12011
  • Article Number: 312
  • Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cartilage endplate (CEP) degeneration is considered one of the major causes of intervertebral disc degeneration (IDD), which causes non‑specific neck and lower back pain. In addition, several non‑coding RNAs (ncRNAs), including long ncRNAs, microRNAs and circular RNAs have been shown to be involved in the regulation of various diseases. However, the particular role of ncRNAs in CEP remains unclear. Identifying these ncRNAs and their interactions may prove to be is useful for the understanding of CEP health and disease. These RNA molecules regulate signaling pathways and biological processes that are critical for a healthy CEP. When dysregulated, they can contribute to the development disease. Herein, studies related to ncRNAs interactions and regulatory functions in CEP are reviewed. In addition, a summary of the current knowledge regarding the deregulation of ncRNAs in IDD in relation to their actions on CEP cell functions, including cell proliferation, apoptosis and extracellular matrix synthesis/degradation is presented. The present review provides novel insight into the pathogenesis of IDD and may shed light on future therapeutic approaches.
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July-2023
Volume 26 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Zhao X, Yuan J, Jia J, Zhang J, Liu J, Chen Q, Li T, Wu Z, Wu H, Miao X, Miao X, et al: Role of non‑coding RNAs in cartilage endplate (Review). Exp Ther Med 26: 312, 2023
APA
Zhao, X., Yuan, J., Jia, J., Zhang, J., Liu, J., Chen, Q. ... Cheng, X. (2023). Role of non‑coding RNAs in cartilage endplate (Review). Experimental and Therapeutic Medicine, 26, 312. https://doi.org/10.3892/etm.2023.12011
MLA
Zhao, X., Yuan, J., Jia, J., Zhang, J., Liu, J., Chen, Q., Li, T., Wu, Z., Wu, H., Miao, X., Wu, T., Li, B., Cheng, X."Role of non‑coding RNAs in cartilage endplate (Review)". Experimental and Therapeutic Medicine 26.1 (2023): 312.
Chicago
Zhao, X., Yuan, J., Jia, J., Zhang, J., Liu, J., Chen, Q., Li, T., Wu, Z., Wu, H., Miao, X., Wu, T., Li, B., Cheng, X."Role of non‑coding RNAs in cartilage endplate (Review)". Experimental and Therapeutic Medicine 26, no. 1 (2023): 312. https://doi.org/10.3892/etm.2023.12011