Role of non‑coding RNAs in cartilage endplate (Review)
- Authors:
- Xiaokun Zhao
- Jinghong Yuan
- Jingyu Jia
- Jian Zhang
- Jiahao Liu
- Qi Chen
- Tao Li
- Zhiwen Wu
- Hui Wu
- Xinxin Miao
- Tianlong Wu
- Bin Li
- Xigao Cheng
-
Affiliations: Department of Orthopedics, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China, Department of Orthopedics, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China - Published online on: May 11, 2023 https://doi.org/10.3892/etm.2023.12011
- Article Number: 312
-
Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
GBD 2015 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: A systematic analysis for the Global Burden of Disease Study 2015. Lancet. 388:1545–1602. 2016.PubMed/NCBI View Article : Google Scholar | |
Minghelli B: Musculoskeletal spine pain in adolescents: Epidemiology of non-specific neck and low back pain and risk factors. J Orthop Sci. 25:776–780. 2020.PubMed/NCBI View Article : Google Scholar | |
Frymoyer JW and Cats-Baril WL: An overview of the incidences and costs of low back pain. Orthop Clin North Am. 22:263–271. 1991.PubMed/NCBI | |
Steenstra IA, Verbeek JH, Prinsze FJ and Knol DL: Changes in the incidence of occupational disability as a result of back and neck pain in the Netherlands. BMC Public Health. 6(190)2006.PubMed/NCBI View Article : Google Scholar | |
Maniadakis N and Gray A: The economic burden of back pain in the UK. Pain. 84:95–103. 2000.PubMed/NCBI View Article : Google Scholar | |
Dagenais S, Caro J and Haldeman S: A systematic review of low back pain cost of illness studies in the United States and internationally. Spine J. 8:8–20. 2008.PubMed/NCBI View Article : Google Scholar | |
Borghouts JAJ, Koes BW, Vondeling H and Bouter LM: Cost-of-illness of neck pain in The Netherlands in 1996. Pain. 80:629–636. 1999.PubMed/NCBI View Article : Google Scholar | |
Brockow T, Dillner A, Franke A and Resch KL: Analgesic effectiveness of subcutaneous carbon-dioxide insufflations as an adjunct treatment in patients with non-specific neck or low back pain. Complement Ther Med. 9:68–76. 2001.PubMed/NCBI View Article : Google Scholar | |
Miyamoto GC, Lin CC, Cabral CMN, van Dongen JM and van Tulder MW: Cost-effectiveness of exercise therapy in the treatment of non-specific neck pain and low back pain: A systematic review with meta-analysis. Br J Sports Med. 53:172–181. 2019.PubMed/NCBI View Article : Google Scholar | |
Nakamura M, Nishiwaki Y, Ushida T and Toyama Y: Prevalence and characteristics of chronic musculoskeletal pain in Japan. J Orthop Sci. 16:424–432. 2011.PubMed/NCBI View Article : Google Scholar | |
Nakamura M, Toyama Y, Nishiwaki Y and Ushida T: Prevalence and characteristics of chronic musculoskeletal pain in Japan: A second survey of people with or without chronic pain. J Orthop Sci. 19:339–350. 2014.PubMed/NCBI View Article : Google Scholar | |
Samartzis D, Karppinen J, Mok F, Fong DY, Luk KD and Cheung KM: A population-based study of juvenile disc degeneration and its association with overweight and obesity, low back pain, and diminished functional status. J Bone Joint Surg Am. 93:662–670. 2011.PubMed/NCBI View Article : Google Scholar | |
Gibson J, Nouri A, Krueger B, Lakomkin N, Nasser R, Gimbel D and Cheng J: Degenerative cervical myelopathy: A clinical review. Yale J Biol Med. 91:43–48. 2018.PubMed/NCBI | |
Slade SC and Keating JL: Unloaded movement facilitation exercise compared to no exercise or alternative therapy on outcomes for people with nonspecific chronic low back pain: A systematic review. J Manipulative Physiol Ther. 30:301–311. 2007.PubMed/NCBI View Article : Google Scholar | |
Furlan AD, Imamura M, Dryden T and Irvin E: Massage for low-back pain. Cochrane Database Syst Rev. (4)(Cd001929)2008.PubMed/NCBI View Article : Google Scholar | |
Hall J, Swinkels A, Briddon J and McCabe CS: Does aquatic exercise relieve pain in adults with neurologic or musculoskeletal disease? A systematic review and meta-analysis of randomized controlled trials. Arch Phys Med Rehabil. 89:873–883. 2008.PubMed/NCBI View Article : Google Scholar | |
Hendrick P, Te Wake AM, Tikkisetty AS, Wulff L, Yap C and Milosavljevic S: The effectiveness of walking as an intervention for low back pain: A systematic review. Eur Spine J. 19:1613–1620. 2010.PubMed/NCBI View Article : Google Scholar | |
Miller J, Gross A, D'Sylva J, Burnie SJ, Goldsmith CH, Graham N, Haines T, Brønfort G and Hoving J: Manual therapy and exercise for neck pain: A systematic review. Man Ther. 15:334–354. 2010.PubMed/NCBI View Article : Google Scholar | |
Rubinstein SM, van Middelkoop M, Assendelft WJ, de Boer MR and van Tulder MW: Spinal manipulative therapy for chronic low-back pain: An update of a Cochrane review. Spine (Phila Pa 1976). 36:E825–E846. 2011.PubMed/NCBI View Article : Google Scholar | |
van Middelkoop M, Rubinstein SM, Kuijpers T, Verhagen AP, Ostelo R, Koes BW and van Tulder MW: A systematic review on the effectiveness of physical and rehabilitation interventions for chronic non-specific low back pain. Eur Spine J. 20:19–39. 2011.PubMed/NCBI View Article : Google Scholar | |
Noble M, Treadwell JR, Tregear SJ, Coates VH, Wiffen PJ, Akafomo C and Schoelles KM: Long-term opioid management for chronic noncancer pain. Cochrane Database Syst Rev. 2010(Cd006605)2010.PubMed/NCBI View Article : Google Scholar | |
Chou R and Huffman LH: American Pain Society; American College of Physicians. Medications for acute and chronic low back pain: A review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline. Ann Intern Med. 147:505–514. 2007.PubMed/NCBI View Article : Google Scholar | |
Roelofs PD, Deyo RA, Koes BW, Scholten RJ and van Tulder MW: Non-steroidal anti-inflammatory drugs for low back pain. Cochrane Database Syst Rev. (1)(Cd000396)2008.PubMed/NCBI View Article : Google Scholar | |
Mason L, Moore RA, Edwards JE, Derry S and McQuay HJ: Topical NSAIDs for chronic musculoskeletal pain: Systematic review and meta-analysis. BMC Musculoskelet Disord. 5(28)2004.PubMed/NCBI View Article : Google Scholar | |
van Geen JW, Edelaar MJ, Janssen M and van Eijk JT: The long-term effect of multidisciplinary back training: A systematic review. Spine (Phila Pa 1976). 32:249–255. 2007.PubMed/NCBI View Article : Google Scholar | |
Scascighini L, Toma V, Dober-Spielmann S and Sprott H: Multidisciplinary treatment for chronic pain: A systematic review of interventions and outcomes. Rheumatology (Oxford). 47:670–678. 2008.PubMed/NCBI View Article : Google Scholar | |
Ravenek MJ, Hughes ID, Ivanovich N, Tyrer K, Desrochers C, Klinger L and Shaw L: A systematic review of multidisciplinary outcomes in the management of chronic low back pain. Work. 35:349–367. 2010.PubMed/NCBI View Article : Google Scholar | |
Sakai D and Andersson GB: Stem cell therapy for intervertebral disc regeneration: Obstacles and solutions. Nat Rev Rheumatol. 11:243–256. 2015.PubMed/NCBI View Article : Google Scholar | |
Yang X, Chen Y, Guo J, Li J, Zhang P, Yang H, Rong K, Zhou T, Fu J and Zhao J: Polydopamine nanoparticles targeting ferroptosis mitigate intervertebral disc degeneration via reactive oxygen species depletion, iron ions chelation, and GPX4 ubiquitination suppression. Adv Sci (Weinh). 10(e2207216)2023.PubMed/NCBI View Article : Google Scholar | |
Haufe SM and Mork AR: Intradiscal injection of hematopoietic stem cells in an attempt to rejuvenate the intervertebral discs. Stem Cells Dev. 15:136–137. 2006.PubMed/NCBI View Article : Google Scholar | |
Hoogendoorn RJ, Lu ZF, Kroeze RJ, Bank RA, Wuisman PI and Helder MN: Adipose stem cells for intervertebral disc regeneration: Current status and concepts for the future. J Cell Mol Med. 12:2205–2216. 2008.PubMed/NCBI View Article : Google Scholar | |
Orozco L, Soler R, Morera C, Alberca M, Sanchez A and Garcia-Sancho J: Intervertebral disc repair by autologous mesenchymal bone marrow cells: A pilot study. Transplantation. 92:822–828. 2011.PubMed/NCBI View Article : Google Scholar | |
Noriega DC, Ardura F, Hernandez-Ramajo R, Martín-Ferrero MÁ, Sánchez-Lite I, Toribio B, Alberca M, García V, Moraleda JM, Sánchez A and García-Sancho J: Intervertebral disc repair by allogeneic mesenchymal bone marrow cells: A randomized controlled trial. Transplantation. 101:1945–1951. 2017.PubMed/NCBI View Article : Google Scholar | |
Zhou T, Yang X, Chen Z, Yang Y, Wang X, Cao X, Chen C, Han C, Tian H, Qin A, et al: Prussian blue nanoparticles stabilize SOD1 from ubiquitination-proteasome degradation to rescue intervertebral disc degeneration. Adv Sci (Weinh). 9(e2105466)2022.PubMed/NCBI View Article : Google Scholar | |
Šećerović A, Ristaniemi A, Cui S, Li Z, Soubrier A, Alini M, Ferguson SJ, Weder G, Heub S, Ledroit D and Grad S: Toward the next generation of spine bioreactors: Validation of an ex vivo intervertebral disc organ model and customized specimen holder for multiaxial loading. ACS Biomater Sci Eng. 8:3969–3976. 2022.PubMed/NCBI View Article : Google Scholar | |
Grunhagen T, Wilde G, Soukane DM, Shirazi-Adl SA and Urban JP: Nutrient supply and intervertebral disc metabolism. J Bone Joint Surg Am. 88 (Suppl 2):S30–S35. 2006.PubMed/NCBI View Article : Google Scholar | |
Song Y, Lu S, Geng W, Feng X, Luo R, Li G and Yang C: Mitochondrial quality control in intervertebral disc degeneration. Exp Mol Med. 53:1124–1133. 2021.PubMed/NCBI View Article : Google Scholar | |
Roughley PJ: Biology of intervertebral disc aging and degeneration: Involvement of the extracellular matrix. Spine (Phila Pa 1976). 29:2691–2699. 2004.PubMed/NCBI View Article : Google Scholar | |
Urban JP, Holm S and Maroudas A: Diffusion of small solutes into the intervertebral disc: As in vivo study. Biorheology. 15:203–221. 1978.PubMed/NCBI View Article : Google Scholar | |
Ogata K and Whiteside LA: 1980 Volvo award winner in basic science. Nutritional pathways of the intervertebral disc. An experimental study using hydrogen washout technique. Spine (Phila Pa 1976). 6:211–216. 1981.PubMed/NCBI | |
van der Werf M, Lezuo P, Maissen O, van Donkelaar CC and Ito K: Inhibition of vertebral endplate perfusion results in decreased intervertebral disc intranuclear diffusive transport. J Anat. 211:769–774. 2007.PubMed/NCBI View Article : Google Scholar | |
Rajasekaran S, Babu JN, Arun R, Armstrong BR, Shetty AP and Murugan S: ISSLS prize winner: A study of diffusion in human lumbar discs: A serial magnetic resonance imaging study documenting the influence of the endplate on diffusion in normal and degenerate discs. Spine (Phila Pa 1976). 29:2654–2667. 2004.PubMed/NCBI View Article : Google Scholar | |
Kang R, Li H, Ringgaard S, Rickers K, Sun H, Chen M, Xie L and Bünger C: Interference in the endplate nutritional pathway causes intervertebral disc degeneration in an immature porcine model. Int Orthop. 38:1011–1017. 2014.PubMed/NCBI View Article : Google Scholar | |
Yin S, Du H, Zhao W, Ma S, Zhang M, Guan M and Liu M: Inhibition of both endplate nutritional pathways results in intervertebral disc degeneration in a goat model. J Orthop Surg Res. 14(138)2019.PubMed/NCBI View Article : Google Scholar | |
Hutton WC, Murakami H, Li J, Elmer WA, Yoon ST, Minamide A, Akamaru T and Tomita K: The effect of blocking a nutritional pathway to the intervertebral disc in the dog model. J Spinal Disord Tech. 17:53–63. 2004.PubMed/NCBI View Article : Google Scholar | |
Jiang C, Guo Q, Jin Y, Xu JJ, Sun ZM, Zhu DC, Lin JH, Tian NF, Sun LJ, Zhang XL and Wu YS: Inhibition of EZH2 ameliorates cartilage endplate degeneration and attenuates the progression of intervertebral disc degeneration via demethylation of Sox-9. EBioMedicine. 48:619–629. 2019.PubMed/NCBI View Article : Google Scholar | |
Määttä JH, Kraatari M, Wolber L, Niinimäki J, Wadge S, Karppinen J and Williams FM: Vertebral endplate change as a feature of intervertebral disc degeneration: A heritability study. Eur Spine J. 23:1856–1862. 2014.PubMed/NCBI View Article : Google Scholar | |
Wang Y, Videman T and Battié MC: ISSLS prize winner: Lumbar vertebral endplate lesions: Associations with disc degeneration and back pain history. Spine (Phila Pa 1976). 37:1490–1496. 2012.PubMed/NCBI View Article : Google Scholar | |
Livshits G, Popham M, Malkin I, Sambrook PN, Macgregor AJ, Spector T and Williams FM: Lumbar disc degeneration and genetic factors are the main risk factors for low back pain in women: The UK Twin Spine Study. Ann Rheum Dis. 70:1740–1745. 2011.PubMed/NCBI View Article : Google Scholar | |
Pennicooke B, Moriguchi Y, Hussain I, Bonssar L and Härtl R: Biological treatment approaches for degenerative disc disease: A review of clinical trials and future directions. Cureus. 8(e892)2016.PubMed/NCBI View Article : Google Scholar | |
Mattick JS: Non-coding RNAs: The architects of eukaryotic complexity. EMBO Rep. 2:986–991. 2001.PubMed/NCBI View Article : Google Scholar | |
Patrushev LI and Kovalenko TF: Functions of noncoding sequences in mammalian genomes. Biochemistry (Mosc). 79:1442–1469. 2014.PubMed/NCBI View Article : Google Scholar | |
Palazzo AF and Lee ES: Non-coding RNA: What is functional and what is junk? Front Genet. 6(2)2015.PubMed/NCBI View Article : Google Scholar | |
Watson CN, Belli A and Di Pietro V: Small Non-coding RNAs: New class of biomarkers and potential therapeutic targets in neurodegenerative disease. Front Genet. 10(364)2019.PubMed/NCBI View Article : Google Scholar | |
Braicu C, Calin GA and Berindan-Neagoe I: MicroRNAs and cancer therapy - from bystanders to major players. Curr Med Chem. 20:3561–3573. 2013.PubMed/NCBI View Article : Google Scholar | |
Cătană CS, Pichler M, Giannelli G, Mader RM and Berindan-Neagoe I: Non-coding RNAs, the Trojan horse in two-way communication between tumor and stroma in colorectal and hepatocellular carcinoma. Oncotarget. 8:29519–29534. 2017.PubMed/NCBI View Article : Google Scholar | |
Guo TF, Zhou MW, Li SH, Ye BL, Chen W and Fu ZB: Long non-coding RNA for metabolism of bone tissue. Zhongguo Gu Shang. 31:286–291. 2018.PubMed/NCBI View Article : Google Scholar : (In Chinese). | |
Wang J, Sun Y, Liu J, Yang B, Wang T, Zhang Z, Jiang X, Guo Y and Zhang Y: Roles of long non-coding RNA in osteoarthritis (Review). Int J Mol Med. 48(133)2021.PubMed/NCBI View Article : Google Scholar | |
Liu Q, Peng F and Chen J: The role of exosomal MicroRNAs in the tumor microenvironment of breast cancer. Int J Mol Sci. 20(3884)2019.PubMed/NCBI View Article : Google Scholar | |
Lan T, Shiyu-Hu Shen Z, Yan B and Chen J: New insights into the interplay between miRNAs and autophagy in the aging of intervertebral discs. Ageing Res Rev. 65(101227)2021.PubMed/NCBI View Article : Google Scholar | |
Guo HY, Guo MK, Wan ZY, Song F and Wang HQ: Emerging evidence on noncoding-RNA regulatory machinery in intervertebral disc degeneration: A narrative review. Arthritis Res Ther. 22(270)2020.PubMed/NCBI View Article : Google Scholar | |
Wang T, Hao Z, Liu C, Yuan L, Li L, Yin M, Li Q, Qi Z and Wang Z: LEF1 mediates osteoarthritis progression through circRNF121/miR-665/MYD88 axis via NF-кB signaling pathway. Cell Death Dis. 11(598)2020.PubMed/NCBI View Article : Google Scholar | |
Zhao R, Fu J, Zhu L, Chen Y and Liu B: Designing strategies of small-molecule compounds for modulating non-coding RNAs in cancer therapy. J Hematol Oncol. 15(14)2022.PubMed/NCBI View Article : Google Scholar | |
Matsui M and Corey DR: Non-coding RNAs as drug targets. Nat Rev Drug Discov. 16:167–179. 2017.PubMed/NCBI View Article : Google Scholar | |
Huang W, Li H, Yu Q, Xiao W and Wang DO: LncRNA-mediated DNA methylation: An emerging mechanism in cancer and beyond. J Exp Clin Cancer Res. 41(100)2022.PubMed/NCBI View Article : Google Scholar | |
Zhao Y, Ling S, Li J, Zhong G, Du R, Li Y, Wang Y, Liu C, Jin X, Liu W, et al: 3' untranslated region of Ckip-1 inhibits cardiac hypertrophy independently of its cognate protein. Eur Heart J. 42:3786–3799. 2021.PubMed/NCBI View Article : Google Scholar | |
Wu AC, Yang WB, Chang KY, Lee JS, Liou JP, Su RY, Cheng SM, Hwang DY, Kikkawa U, Hsu TI, et al: HDAC6 involves in regulating the lncRNA-microRNA-mRNA network to promote the proliferation of glioblastoma cells. J Exp Clin Cancer Res. 41(47)2022.PubMed/NCBI View Article : Google Scholar | |
Chen X, Gong W, Shao X, Shi T, Zhang L, Dong J, Shi Y, Shen S, Qin J, Jiang Q and Guo B: METTL3-mediated m(6)A modification of ATG7 regulates autophagy-GATA4 axis to promote cellular senescence and osteoarthritis progression. Ann Rheum Dis. 81:87–99. 2022.PubMed/NCBI View Article : Google Scholar | |
Chen J, Huang T, Liu R, Wang C, Jiang H and Sun H: Congenital microtia patients: The genetically engineered exosomes released from porous gelatin methacryloyl hydrogel for downstream small RNA profiling, functional modulation of microtia chondrocytes and tissue-engineered ear cartilage regeneration. J Nanobiotechnology. 20(164)2022.PubMed/NCBI View Article : Google Scholar | |
Li Z, Yu X, Shen J, Chan MT and Wu WK: MicroRNA in intervertebral disc degeneration. Cell Prolif. 48:278–283. 2015.PubMed/NCBI View Article : Google Scholar | |
Ambros V and Chen X: The regulation of genes and genomes by small RNAs. Development. 134:1635–1641. 2007.PubMed/NCBI View Article : Google Scholar | |
Krol J, Loedige I and Filipowicz W: The widespread regulation of microRNA biogenesis, function and decay. Nat Rev Genet. 11:597–610. 2010.PubMed/NCBI View Article : Google Scholar | |
Zhu Y, Li K, Yan L, He Y, Wang L and Sheng L: miR-223-3p promotes cell proliferation and invasion by targeting Arid1a in gastric cancer. Acta Biochim Biophys Sin (Shanghai). 52:150–159. 2020.PubMed/NCBI View Article : Google Scholar | |
Lu TX and Rothenberg ME: MicroRNA. J Allergy Clin Immunol. 141:1202–1207. 2018.PubMed/NCBI View Article : Google Scholar | |
Rau CS, Yang JC, Wu SC, Chen YC, Lu TH, Lin MW, Wu YC, Tzeng SL, Wu CJ and Hsieh CH: Profiling circulating microRNA expression in a mouse model of nerve allotransplantation. J Biomed Sci. 20(64)2013.PubMed/NCBI View Article : Google Scholar | |
Guerau-de-Arellano M, Smith KM, Godlewski J, Liu Y, Winger R, Lawler SE, Whitacre CC, Racke MK and Lovett-Racke AE: Micro-RNA dysregulation in multiple sclerosis favours pro-inflammatory T-cell-mediated autoimmunity. Brain. 134(Pt 12):3578–3589. 2011.PubMed/NCBI View Article : Google Scholar | |
Nie H, Zhang K, Xu J, Liao K, Zhou W and Fu Z: Combining bioinformatics techniques to study diabetes biomarkers and related molecular mechanisms. Front Genet. 11(367)2020.PubMed/NCBI View Article : Google Scholar | |
Shen P, Yang Y, Liu G, Chen W, Chen J, Wang Q, Gao H, Fan S, Shen S and Zhao X: CircCDK14 protects against Osteoarthritis by sponging miR-125a-5p and promoting the expression of Smad2. Theranostics. 10:9113–9131. 2020.PubMed/NCBI View Article : Google Scholar | |
Li S, Liu J, Liu S, Jiao W and Wang X: Mesenchymal stem cell-derived extracellular vesicles prevent the development of osteoarthritis via the circHIPK3/miR-124-3p/MYH9 axis. J Nanobiotechnology. 9(194)2021.PubMed/NCBI View Article : Google Scholar | |
Wu Z, Qiu X, Gao B, Lian C, Peng Y, Liang A, Xu C, Gao W, Zhang L, Su P, et al: Melatonin-mediated miR-526b-3p and miR-590-5p upregulation promotes chondrogenic differentiation of human mesenchymal stem cells. J Pineal Res. 65(e12483)2018.PubMed/NCBI View Article : Google Scholar | |
Chen L, Li Q, Wang J, Jin S, Zheng H, Lin J, He F, Zhang H, Ma S, Mei J and Yu J: MiR-29b-3p promotes chondrocyte apoptosis and facilitates the occurrence and development of osteoarthritis by targeting PGRN. J Cell Mol Med. 21:3347–3359. 2017.PubMed/NCBI View Article : Google Scholar | |
Razmara E, Bitaraf A, Yousefi H, Nguyen TH, Garshasbi M, Cho WC and Babashah S: Non-Coding RNAs in cartilage development: An updated review. Int J Mol Sci. 20(4475)2019.PubMed/NCBI View Article : Google Scholar | |
Peng B, Hou S, Shi Q and Jia L: The relationship between cartilage end-plate calcification and disc degeneration: An experimental study. Chin Med J (Engl). 114:308–312. 2001.PubMed/NCBI | |
Bian Q, Liang QQ, Wan C, Hou W, Li CG, Zhao YJ, Lu S, Shi Q and Wang YJ: Prolonged upright posture induces calcified hypertrophy in the cartilage end plate in rat lumbar spine. Spine (Phila Pa 1976). 36:2011–2020. 2011.PubMed/NCBI View Article : Google Scholar | |
Feng C, Liu M, Fan X, Yang M, Liu H and Zhou Y: Intermittent cyclic mechanical tension altered the microRNA expression profile of human cartilage endplate chondrocytes. Mol Med Rep. 17:5238–5246. 2018.PubMed/NCBI View Article : Google Scholar | |
Chen H, Wang J, Hu B, Wu X, Chen Y, Li R and Yuan W: MiR-34a promotes Fas-mediated cartilage endplate chondrocyte apoptosis by targeting Bcl-2. Mol Cell Biochem. 406:21–30. 2015.PubMed/NCBI View Article : Google Scholar | |
Onodera K, Takahashi I, Sasano Y, Bae JW and Mitani H, Kagayama M and Mitani H: Stepwise mechanical stretching inhibits chondrogenesis through cell-matrix adhesion mediated by integrins in embryonic rat limb-bud mesenchymal cells. Eur J Cell Biol. 84:45–58. 2005.PubMed/NCBI View Article : Google Scholar | |
Bleuel J, Zaucke F, Brüggemann GP and Niehoff A: Effects of cyclic tensile strain on chondrocyte metabolism: A systematic review. PLoS One. 10(e0119816)2015.PubMed/NCBI View Article : Google Scholar | |
Yuan W, Che W, Jiang YQ, Yuan FL, Wang HR, Zheng GL, Li XL and Dong J: Establishment of intervertebral disc degeneration model induced by ischemic sub-endplate in rat tail. Spine J. 15:1050–1059. 2015.PubMed/NCBI View Article : Google Scholar | |
Xiao L, Xu S, Xu Y, Liu C, Yang B, Wang J and Xu H: TGF-β/SMAD signaling inhibits intermittent cyclic mechanical tension-induced degeneration of endplate chondrocytes by regulating the miR-455-5p/RUNX2 axis. J Cell Biochem. 119:10415–10425. 2018.PubMed/NCBI View Article : Google Scholar | |
Liu MH, Sun C, Yao Y, Fan X, Liu H, Cui YH, Bian XW, Huang B and Zhou Y: Matrix stiffness promotes cartilage endplate chondrocyte calcification in disc degeneration via miR-20a targeting ANKH expression. Sci Rep. 6(25401)2016.PubMed/NCBI View Article : Google Scholar | |
Zhang F, Zhao X, Shen H and Zhang C: Molecular mechanisms of cell death in intervertebral disc degeneration (Review). Int J Mol Med. 37:1439–1448. 2016.PubMed/NCBI View Article : Google Scholar | |
Chen WK, Yu XH, Yang W, Wang C, He WS, Yan YG, Zhang J and Wang WJ: lncRNAs: Novel players in intervertebral disc degeneration and osteoarthritis. Cell Prolif. 50(e12313)2017.PubMed/NCBI View Article : Google Scholar | |
Sheng B, Yuan Y, Liu X, Zhang Y, Liu H, Shen X, Liu B and Chang L: Protective effect of estrogen against intervertebral disc degeneration is attenuated by miR-221 through targeting estrogen receptor α. Acta Biochim Biophys Sin (Shanghai). 50:345–354. 2018.PubMed/NCBI View Article : Google Scholar | |
Chen Y, Chen Q, Zhong M, Xu C, Wu Y and Chen R: miR-637 inhibits osteogenic differentiation of human intervertebral disc cartilage endplate stem cells by targeting WNT5A. J Invest Surg. 35:1313–1321. 2022.PubMed/NCBI View Article : Google Scholar | |
Chen D and Jiang X: Exosomes-derived miR-125-5p from cartilage endplate stem cells regulates autophagy and ECM metabolism in nucleus pulposus by targeting SUV38H1. Exp Cell Res. 414(113066)2022.PubMed/NCBI View Article : Google Scholar | |
Wang B, Ji D, Xing W, Li F, Huang Z, Zheng W, Xue J, Zhu Y and Yang X: miR-142-3p and HMGB1 are negatively regulated in proliferation, apoptosis, migration, and autophagy of cartilage endplate cells. Cartilage. 13 (2_suppl):592S–603S. 2021.PubMed/NCBI View Article : Google Scholar | |
Jarroux J, Morillon A and Pinskaya M: History, discovery, and classification of lncRNAs. Adv Exp Med Biol. 1008:1–46. 2017.PubMed/NCBI View Article : Google Scholar | |
Qian X, Zhao J, Yeung PY, Zhang QC and Kwok CK: Revealing lncRNA structures and interactions by sequencing-based approaches. Trends Biochem Sci. 44:33–52. 2019.PubMed/NCBI View Article : Google Scholar | |
Khan S, Masood M, Gaur H, Ahmad S and Syed MA: Long non-coding RNA: An immune cells perspective. Life Sci. 271(119152)2021.PubMed/NCBI View Article : Google Scholar | |
Bridges MC, Daulagala AC and Kourtidis A: LNCcation: lncRNA localization and function. J Cell Biol. 220(e202009045)2021.PubMed/NCBI View Article : Google Scholar | |
Huang H, Xing D, Zhang Q, Li H and Lin J, He Z and Lin J: LncRNAs as a new regulator of chronic musculoskeletal disorder. Cell Prolif. 54(e13113)2021.PubMed/NCBI View Article : Google Scholar | |
Liu X, Li W, Jiang L, Lü Z, Liu M, Gong L, Liu B, Liu L and Yin X: Immunity-associated long non-coding RNA and expression in response to bacterial infection in large yellow croaker (Larimichthys crocea). Fish Shellfish Immunol. 94:634–642. 2019.PubMed/NCBI View Article : Google Scholar | |
Li Z, Li X, Chen C, Li S, Shen J, Tse G, Chan MTV and Wu WKK: Long non-coding RNAs in nucleus pulposus cell function and intervertebral disc degeneration. Cell Prolif. 51(e12483)2018.PubMed/NCBI View Article : Google Scholar | |
Zhu J, Zhang X, Gao W, Hu H, Wang X and Hao D: lncRNA/circRNA-miRNA-mRNA ceRNA network in lumbar intervertebral disc degeneration. Mol Med Rep. 20:3160–3174. 2019.PubMed/NCBI View Article : Google Scholar | |
Wan ZY, Song F, Sun Z, Chen YF, Zhang WL, Samartzis D, Ma CJ, Che L, Liu X, Ali MA, et al: Aberrantly expressed long noncoding RNAs in human intervertebral disc degeneration: A microarray related study. Arthritis Res Ther. 16(465)2014.PubMed/NCBI View Article : Google Scholar | |
Kitagawa M, Kitagawa K, Kotake Y, Niida H and Ohhata T: Cell cycle regulation by long non-coding RNAs. Cell Mol Life Sci. 70:4785–4794. 2013.PubMed/NCBI View Article : Google Scholar | |
Solé C, Nadal-Ribelles M, de Nadal E and Posas F: A novel role for lncRNAs in cell cycle control during stress adaptation. Curr Genet. 61:299–308. 2015.PubMed/NCBI View Article : Google Scholar | |
Guiducci G and Stojic L: Long Noncoding RNAs at the crossroads of cell cycle and genome integrity. Trends Genet. 37:528–546. 2021.PubMed/NCBI View Article : Google Scholar | |
Fatica A and Bozzoni I: Long non-coding RNAs: New players in cell differentiation and development. Nat Rev Genet. 15:7–21. 2014.PubMed/NCBI View Article : Google Scholar | |
Ballarino M, Morlando M, Fatica A and Bozzoni I: Non-coding RNAs in muscle differentiation and musculoskeletal disease. J Clin Invest. 126:2021–2030. 2016.PubMed/NCBI View Article : Google Scholar | |
Delás MJ, Sabin LR, Dolzhenko E, Knott SR, Munera Maravilla E, Jackson BT, Wild SA, Kovacevic T, Stork EM, Zhou M, et al: lncRNA requirements for mouse acute myeloid leukemia and normal differentiation. Elife. 6(e25607)2017.PubMed/NCBI View Article : Google Scholar | |
Deniz E and Erman B: Long noncoding RNA (lincRNA), a new paradigm in gene expression control. Funct Integr Genomics. 17:135–143. 2017.PubMed/NCBI View Article : Google Scholar | |
Mondal T, Subhash S, Vaid R, Enroth S, Uday S, Reinius B, Mitra S, Mohammed A, James AR, Hoberg E, et al: MEG3 long noncoding RNA regulates the TGF-β pathway genes through formation of RNA-DNA triplex structures. Nat Commun. 6(7743)2015.PubMed/NCBI View Article : Google Scholar | |
Mi D, Cai C, Zhou B, Liu X, Ma P, Shen S, Lu W and Huang W: Long non-coding RNA FAF1 promotes intervertebral disc degeneration by targeting the Erk signaling pathway. Mol Med Rep. 17:3158–3163. 2018.PubMed/NCBI View Article : Google Scholar | |
Yuan J, Jia J, Wu T, Liu X, Hu S, Zhang J, Ding R, Pang C and Cheng X: Comprehensive evaluation of differential long non-coding RNA and gene expression in patients with cartilaginous endplate degeneration of cervical vertebra. Exp Ther Med. 20(260)2020.PubMed/NCBI View Article : Google Scholar | |
Li B, Balasubramanian K, Krakow D and Cohn DH: Genes uniquely expressed in human growth plate chondrocytes uncover a distinct regulatory network. BMC Genomics. 18(983)2017.PubMed/NCBI View Article : Google Scholar | |
Gu W, Zhu Q, Gao X and Brown MD: Simulation of the progression of intervertebral disc degeneration due to decreased nutritional supply. Spine (Phila Pa 1976). 39:E1411–E1417. 2014.PubMed/NCBI View Article : Google Scholar | |
Fields AJ, Berg-Johansen B, Metz LN, Miller S, La B, Liebenberg EC, Coughlin DG, Graham JL, Stanhope KL, Havel PJ and Lotz JC: Alterations in intervertebral disc composition, matrix homeostasis and biomechanical behavior in the UCD-T2DM rat model of type 2 diabetes. J Orthop Res. 33:738–746. 2015.PubMed/NCBI View Article : Google Scholar | |
Agius R, Galea R and Fava S: Bone mineral density and intervertebral disc height in type 2 diabetes. J Diabetes Complications. 30:644–650. 2016.PubMed/NCBI View Article : Google Scholar | |
Jiang Z, Lu W, Zeng Q, Li D, Ding L and Wu J: High glucose-induced excessive reactive oxygen species promote apoptosis through mitochondrial damage in rat cartilage endplate cells. J Orthop Res. 36:2476–2483. 2018.PubMed/NCBI View Article : Google Scholar | |
Li X, Wu FR, Xu RS, Hu W, Jiang DL, Ji C, Chen FH and Yuan FL: Acid-sensing ion channel 1a-mediated calcium influx regulates apoptosis of endplate chondrocytes in intervertebral discs. Expert Opin Ther Targets. 18:1–14. 2014.PubMed/NCBI View Article : Google Scholar | |
Yuan FL, Wang HR, Zhao MD, Yuan W, Cao L, Duan PG, Jiang YQ, Li XL and Dong J: Ovarian cancer G protein-coupled receptor 1 is involved in acid-induced apoptosis of endplate chondrocytes in intervertebral discs. J Bone Miner Res. 29:67–77. 2014.PubMed/NCBI View Article : Google Scholar | |
Jiang Z, Zeng Q, Li D, Ding L, Lu W, Bian M and Wu J: Long non-coding RNA MALAT1 promotes high glucose-induced rat cartilage endplate cell apoptosis via the p38/MAPK signalling pathway. Mol Med Rep. 21:2220–2226. 2020.PubMed/NCBI View Article : Google Scholar | |
Sanger HL, Klotz G, Riesner D, Gross HJ and Kleinschmidt AK: Viroids are single-stranded covalently closed circular RNA molecules existing as highly base-paired rod-like structures. Proc Natl Acad Sci USA. 73:3852–3856. 1976.PubMed/NCBI View Article : Google Scholar | |
Hsu MT and Coca-Prados M: Electron microscopic evidence for the circular form of RNA in the cytoplasm of eukaryotic cells. Nature. 280:339–340. 1979.PubMed/NCBI View Article : Google Scholar | |
Capel B, Swain A, Nicolis S, Hacker A, Walter M, Koopman P, Goodfellow P and Lovell-Badge R: Circular transcripts of the testis-determining gene Sry in adult mouse testis. Cell. 73:1019–1030. 1993.PubMed/NCBI View Article : Google Scholar | |
Grabowski PJ, Zaug AJ and Cech TR: The intervening sequence of the ribosomal RNA precursor is converted to a circular RNA in isolated nuclei of Tetrahymena. Cell. 23:467–476. 1981.PubMed/NCBI View Article : Google Scholar | |
Ford E and Ares M Jr: Synthesis of circular RNA in bacteria and yeast using RNA cyclase ribozymes derived from a group I intron of phage T4. Proc Natl Acad Sci USA. 91:3117–3121. 1994.PubMed/NCBI View Article : Google Scholar | |
Kos A, Dijkema R, Arnberg AC, van der Meide PH and Schellekens H: The hepatitis delta (delta) virus possesses a circular RNA. Nature. 323:558–560. 1986.PubMed/NCBI View Article : Google Scholar | |
Chen LL: The expanding regulatory mechanisms and cellular functions of circular RNAs. Nat Rev Mol Cell Biol. 21:475–490. 2020.PubMed/NCBI View Article : Google Scholar | |
Xiao MS, Ai Y and Wilusz JE: Biogenesis and functions of circular RNAs come into focus. Trends Cell Biol. 30:226–240. 2020.PubMed/NCBI View Article : Google Scholar | |
Jeck WR and Sharpless NE: Detecting and characterizing circular RNAs. Nat Biotechnol. 32:453–461. 2014.PubMed/NCBI View Article : Google Scholar | |
O'Conor CJ, Case N and Guilak F: Mechanical regulation of chondrogenesis. Stem Cell Res Ther. 4(61)2013.PubMed/NCBI View Article : Google Scholar | |
Xia DD, Lin SL, Wang XY, Wang YL, Xu HM, Zhou F and Tan J: Effects of shear force on intervertebral disc: An in vivo rabbit study. Eur Spine J. 24:1711–1719. 2015.PubMed/NCBI View Article : Google Scholar | |
Xiao L, Ding B, Xu S, Gao J, Yang B, Wang J and Xu H: circRNA_0058097 promotes tension-induced degeneration of endplate chondrocytes by regulating HDAC4 expression through sponge adsorption of miR-365a-5p. J Cell Biochem. 121:418–429. 2020.PubMed/NCBI View Article : Google Scholar | |
Li X, Yang L and Chen LL: The biogenesis, functions, and challenges of circular RNAs. Mol Cell. 71:428–442. 2018.PubMed/NCBI View Article : Google Scholar | |
Ren S, Lin P, Wang J, Yu H, Lv T, Sun L and Du G: Circular RNAs: Promising molecular biomarkers of human aging-related diseases via functioning as an miRNA Sponge. Mol Ther Methods Clin Dev. 18:215–229. 2020.PubMed/NCBI View Article : Google Scholar | |
Xu D, Ma X, Sun C, Han J, Zhou C, Wong SH, Chan MTV and Wu WKK: Circular RNAs in intervertebral disc degeneration: An updated review. Front Mol Biosci. 8(781424)2022.PubMed/NCBI View Article : Google Scholar | |
Zhang J, Hu S, Ding R, Yuan J, Jia J, Wu T and Cheng X: CircSNHG5 Sponges Mir-495-3p and Modulates CITED2 to protect cartilage endplate from degradation. Front Cell Dev Biol. 9(668715)2021.PubMed/NCBI View Article : Google Scholar | |
Larsson ME and Nordholm LA: Responsibility for managing musculoskeletal disorders-a cross-sectional postal survey of attitudes. BMC Musculoskelet Disord. 9(110)2008.PubMed/NCBI View Article : Google Scholar | |
Hu B, Xiao L, Wang C, Liu C, Zhang Y, Ding B, Gao D, Lu Y and Xu H: Circ_0022382 ameliorated intervertebral disc degeneration by regulating TGF-β3 expression through sponge adsorption of miR-4726-5p. Bone. 154(116185)2022.PubMed/NCBI View Article : Google Scholar | |
Zhang H, Wu S, Chen W, Hu Y, Geng Z and Su J: Bone/cartilage targeted hydrogel: Strategies and applications. Bioact Mater. 23:156–169. 2022.PubMed/NCBI View Article : Google Scholar | |
Guo J, Wang F, Hu Y, Luo Y, Wei Y, Xu K, Zhang H, Liu H, Bo L, Lv S, et al: Exosome-based bone-targeting drug delivery alleviates impaired osteoblastic bone formation and bone loss in inflammatory bowel diseases. Cell Rep Med. 4(100881)2023.PubMed/NCBI View Article : Google Scholar | |
Ji ML, Jiang H, Zhang XJ, Shi PL, Li C, Wu H, Wu XT, Wang YT, Wang C and Lu J: Preclinical development of a microRNA-based therapy for intervertebral disc degeneration. Nat Commun. 9(5051)2018.PubMed/NCBI View Article : Google Scholar | |
Hu Y, Li X, Zhang Q, Gu Z, Luo Y, Guo J, Wang X, Jing Y, Chen X and Su J: Exosome-guided bone targeted delivery of Antagomir-188 as an anabolic therapy for bone loss. Bioact Mater. 6:2905–2913. 2021.PubMed/NCBI View Article : Google Scholar | |
Wang Y, Chu X and Wang B: Recombinant adeno-associated virus-based gene therapy combined with tissue engineering for musculoskeletal regenerative medicine. Biomater Transl. 2:19–29. 2021.PubMed/NCBI View Article : Google Scholar | |
Ahn J, Park EM, Kim BJ, Kim JS, Choi B, Lee SH and Han I: Transplantation of human Wharton's jelly-derived mesenchymal stem cells highly expressing TGFβ receptors in a rabbit model of disc degeneration. Stem Cell Res Ther. 6(190)2015.PubMed/NCBI View Article : Google Scholar |