Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
July-2023 Volume 26 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2023 Volume 26 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Establishment and assessment of a preclinical model of acute kidney injury induced by contrast media combined acute myocardial ischemia reperfusion surgery

  • Authors:
    • Sijia Yu
    • Xiaoli Dong
    • Wenguang Lai
    • Hongyu Lu
    • Yun Xie
    • Jun-Yan Xu
    • Yewen Zeng
    • Kedong Han
    • Jinqiang Liang
    • Jin Liu
    • Yong Liu
    • Jiyan Chen
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China, Department of Cardiology, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, Hainan 570102, P.R. China, Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510080, P.R. China, Guangdong Provincial Key Laboratory of Laboratory Animals, Guangdong Laboratory Animal Monitoring Institute, Guangzhou, Guangdong 523136, P.R. China, Department of Cardiology, Maoming People's Hospital, Maoming, Guangdong 525000, P.R. China, Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Pharmaceutical Sciences, Hainan University, Haikou, Hainan 570228, P.R. China
    Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 321
    |
    Published online on: May 15, 2023
       https://doi.org/10.3892/etm.2023.12020
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Acute kidney injury (AKI) is a common complication after acute myocardial infarction (AMI) in clinical practice, and the majority of previous preclinical models were induced by a single factor. The objective of the present study was to establish a stable preclinic model of AKI induced by contrast media (CM) with acute myocardial ischemia reperfusion surgery and to identify the effect of oxidative stress on kidney injury. Rats were treated individually or with CM or myocardial ischemia reperfusion surgery. Renal baseline and AKI parameters, the level of oxidative stress and histopathological images were examined along with AKI biomarkers. Results showed the incidence of AKI in the CM group and ischemia reperfusion injury (IRI) group was 40%, χ2 test (P<0.05 vs. CM‑IRI) and 35%, χ2 test (P<0.05 vs. CM‑IRI) and the combination group had the highest incidence rate 75%. IRI surgery combined with CM diminished kidney function and induced oxidative stress by increasing creatinine, blood urea nitrogen and reactive oxygen species levels. Western blotting showed that the early AKI biomarker of NGAL and KIM‑1 increased and that the combination group had the highest value. Pathology damage exhibited severe kidney damage in the combination group compared with other control groups. The present research established a reliable preclinic model of post‑AMI AKI with a stable and high postoperative AKI rate. Additionally, CM was demonstrated to exacerbate AKI caused by acute myocardial infarction through oxidative stress and, thus, oxidative stress may be a potential therapeutic target.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Tsai TT, Patel UD, Chang TI, Kennedy KF, Masoudi FA, Matheny ME, Kosiborod M, Amin AP, Messenger JC, Rumsfeld JS and Spertus JA: Contemporary incidence, predictors, and outcomes of acute kidney injury in patients undergoing percutaneous coronary interventions: Insights from the NCDR Cath-PCI registry. JACC Cardiovasc Interv. 7:1–9. 2014.PubMed/NCBI View Article : Google Scholar

2 

Tao J, Dai W, Ye C, Yao Q, Zhou M and Li Y: Preprocedural Lp(a) level and ApoB/ApoA-Ι ratio and the risk for contrast-induced acute kidney injury in patients undergoing emergency PCI. Lipids Health Dis. 20(130)2021.PubMed/NCBI View Article : Google Scholar

3 

Anzai A, Anzai T, Naito K, Kaneko H, Mano Y, Jo Y, Nagatomo Y, Maekawa Y, Kawamura A, Yoshikawa T and Ogawa S: Prognostic significance of acute kidney injury after reperfused ST-elevation myocardial infarction: Synergistic acceleration of renal dysfunction and left ventricular remodeling. J Card Fail. 16:381–389. 2010.PubMed/NCBI View Article : Google Scholar

4 

Khoury S, Margolis G, Ravid D, Rozenbaum Z, Keren G and Shacham Y: Outcomes of early and reversible renal impairment in patients with ST segment elevation myocardial infarction undergoing percutaneous coronary intervention. Eur Heart J Acute Cardiovasc Care. 9:684–689. 2020.PubMed/NCBI View Article : Google Scholar

5 

Marenzi G, Cosentino N, Milazzo V, De Metrio M, Rubino M, Campodonico J, Moltrasio M, Marana I, Grazi M, Lauri G, et al: Acute kidney injury in diabetic patients with acute myocardial infarction: Role of acute and chronic glycemia. J Am Heart Assoc. 7(e008122)2018.PubMed/NCBI View Article : Google Scholar

6 

Fox CS, Muntner P, Chen AY, Alexander KP, Roe MT and Wiviott SD: Short-term outcomes of acute myocardial infarction in patients with acute kidney injury: A report from the national cardiovascular data registry. Circulation. 125:497–504. 2012.PubMed/NCBI View Article : Google Scholar

7 

Xie XC, Cao Y, Yang X, Xu QH, Wei W and Wang M: Relaxin attenuates contrast-induced human proximal tubular epithelial cell apoptosis by activation of the PI3K/Akt signaling pathway in vitro. Biomed Res Int. 2017(2869405)2017.PubMed/NCBI View Article : Google Scholar

8 

Zhao L, Hu C, Zhang P, Jiang H and Chen J: Novel preconditioning strategies for enhancing the migratory ability of mesenchymal stem cells in acute kidney injury. Stem Cell Res Ther. 9(225)2018.PubMed/NCBI View Article : Google Scholar

9 

Li Z, Wu J, Wei W, Cai X, Yan J, Song J, Wang C and Wang J: Association of serum miR-186-5p with the prognosis of acute coronary syndrome patients after percutaneous coronary intervention. Front Physiol. 10(686)2019.PubMed/NCBI View Article : Google Scholar

10 

Besseling PJ, Pieters TT, Nguyen ITN, de Bree PM, Willekes N, Dijk AH, Bovée DM, Hoorn EJ, Rookmaaker MB, Gerritsen KG, et al: A plasma creatinine- and urea-based equation to estimate glomerular filtration rate in rats. Am J Physiol Renal Physiol. 320:F518–F524. 2021.PubMed/NCBI View Article : Google Scholar

11 

Stacul F, van der Molen AJ, Reimer P, Webb JA, Thomsen HS, Morcos SK, Almén T, Aspelin P, Bellin MF, Clement O, et al: Contrast induced nephropathy: Updated ESUR contrast media safety committee guidelines. Eur Radiol. 21:2527–2541. 2011.PubMed/NCBI View Article : Google Scholar

12 

Lameire N and Kellum JA: KDIGO AKI Guideline Work Group. Contrast-induced acute kidney injury and renal support for acute kidney injury: A KDIGO summary (part 2). Crit Care. 17(205)2013.PubMed/NCBI View Article : Google Scholar

13 

Cheng H, Fan X, Lawson WE, Paueksakon P and Harris RC: Telomerase deficiency delays renal recovery in mice after ischemia-reperfusion injury by impairing autophagy. Kidney Int. 88:85–94. 2015.PubMed/NCBI View Article : Google Scholar

14 

Liu YH, Xue JH, Wu DX, Bei WJ, Wang K, Liu Y, Chen JY and Tan N: A novel simple experimental model for low-osmolar contrast-induced acute kidney injury using different definitions based on the levels of serum creatinine and cystatin C. BMC Nephrol. 20(243)2019.PubMed/NCBI View Article : Google Scholar

15 

Zhou Q, Zhao C, Xie D, Xu D, Bin J, Chen P, Liang M, Zhang X and Hou F: Acute and acute-on-chronic kidney injury of patients with decompensated heart failure: Impact on outcomes. BMC Nephrol. 13(51)2012.PubMed/NCBI View Article : Google Scholar

16 

Jost G, Lengsfeld P, Lenhard DC, Pietsch H, Hütter J and Sieber MA: Viscosity of iodinated contrast agents during renal excretion. Eur J Radiol. 80:373–377. 2011.PubMed/NCBI View Article : Google Scholar

17 

Ye Z, Lu H, Su Q, Guo W, Dai W, Li H, Yang H and Li L: Clinical effect of trimetazidine on prevention of contrast-induced nephropathy in patients with renal insufficiency: An updated systematic review and meta-analysis. Medicine (Baltimore). 96(e6059)2017.PubMed/NCBI View Article : Google Scholar

18 

Cheng W, Zhao F, Tang CY, Li XW, Luo M and Duan SB: Comparison of iohexol and iodixanol induced nephrotoxicity, mitochondrial damage and mitophagy in a new contrast-induced acute kidney injury rat model. Arch Toxicol. 92:2245–2257. 2018.PubMed/NCBI View Article : Google Scholar

19 

Sharma A, Kilari S, Cai C, Simeon ML and Misra S: Increased fibrotic signaling in a murine model for intra-arterial contrast-induced acute kidney injury. Am J Physiol Renal Physiol. 318:F1210–F1219. 2020.PubMed/NCBI View Article : Google Scholar

20 

Hašková P, Jansová H, Bureš J, Macháček M, Jirkovská A, Franz KJ, Kovaříková P and Šimůnek T: Cardioprotective effects of iron chelator HAPI and ROS-activated boronate prochelator BHAPI against catecholamine-induced oxidative cellular injury. Toxicology. 371:17–28. 2016.PubMed/NCBI View Article : Google Scholar

21 

Rubinstein I, Abassi Z, Milman F, Ovcharenko E, Coleman R, Winaver J and Better OS: Hyperbaric oxygen treatment improves GFR in rats with ischaemia/reperfusion renal injury: A possible role for the antioxidant/oxidant balance in the ischaemic kidney. Nephrol Dial Transplant. 24:428–436. 2009.PubMed/NCBI View Article : Google Scholar

22 

Tanaka S, Sugiura Y, Saito H, Sugahara M, Higashijima Y, Yamaguchi J, Inagi R, Suematsu M, Nangaku M and Tanaka T: Sodium-glucose cotransporter 2 inhibition normalizes glucose metabolism and suppresses oxidative stress in the kidneys of diabetic mice. Kidney Int. 94:912–925. 2018.PubMed/NCBI View Article : Google Scholar

23 

Boekhoud L, Koeze J, van der Slikke EC, Bourgonje AR, Moser J, Zijlstra JG, Muller Kobold AC, Bulthuis MLC, van Meurs M, van Goor H, et al: Acute kidney injury is associated with lowered plasma-free thiol levels. Antioxidants (Basel). 9(1135)2020.PubMed/NCBI View Article : Google Scholar

24 

Quintavalle C, Brenca M, De Micco F, Fiore D, Romano S, Romano MF, Apone F, Bianco A, Zabatta MA, Troncone G, et al: In vivo and in vitro assessment of pathways involved in contrast media-induced renal cells apoptosis. Cell Death Dis. 2(e155)2011.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yu S, Dong X, Lai W, Lu H, Xie Y, Xu J, Zeng Y, Han K, Liang J, Liu J, Liu J, et al: Establishment and assessment of a preclinical model of acute kidney injury induced by contrast media combined acute myocardial ischemia reperfusion surgery. Exp Ther Med 26: 321, 2023.
APA
Yu, S., Dong, X., Lai, W., Lu, H., Xie, Y., Xu, J. ... Chen, J. (2023). Establishment and assessment of a preclinical model of acute kidney injury induced by contrast media combined acute myocardial ischemia reperfusion surgery. Experimental and Therapeutic Medicine, 26, 321. https://doi.org/10.3892/etm.2023.12020
MLA
Yu, S., Dong, X., Lai, W., Lu, H., Xie, Y., Xu, J., Zeng, Y., Han, K., Liang, J., Liu, J., Liu, Y., Chen, J."Establishment and assessment of a preclinical model of acute kidney injury induced by contrast media combined acute myocardial ischemia reperfusion surgery". Experimental and Therapeutic Medicine 26.1 (2023): 321.
Chicago
Yu, S., Dong, X., Lai, W., Lu, H., Xie, Y., Xu, J., Zeng, Y., Han, K., Liang, J., Liu, J., Liu, Y., Chen, J."Establishment and assessment of a preclinical model of acute kidney injury induced by contrast media combined acute myocardial ischemia reperfusion surgery". Experimental and Therapeutic Medicine 26, no. 1 (2023): 321. https://doi.org/10.3892/etm.2023.12020
Copy and paste a formatted citation
x
Spandidos Publications style
Yu S, Dong X, Lai W, Lu H, Xie Y, Xu J, Zeng Y, Han K, Liang J, Liu J, Liu J, et al: Establishment and assessment of a preclinical model of acute kidney injury induced by contrast media combined acute myocardial ischemia reperfusion surgery. Exp Ther Med 26: 321, 2023.
APA
Yu, S., Dong, X., Lai, W., Lu, H., Xie, Y., Xu, J. ... Chen, J. (2023). Establishment and assessment of a preclinical model of acute kidney injury induced by contrast media combined acute myocardial ischemia reperfusion surgery. Experimental and Therapeutic Medicine, 26, 321. https://doi.org/10.3892/etm.2023.12020
MLA
Yu, S., Dong, X., Lai, W., Lu, H., Xie, Y., Xu, J., Zeng, Y., Han, K., Liang, J., Liu, J., Liu, Y., Chen, J."Establishment and assessment of a preclinical model of acute kidney injury induced by contrast media combined acute myocardial ischemia reperfusion surgery". Experimental and Therapeutic Medicine 26.1 (2023): 321.
Chicago
Yu, S., Dong, X., Lai, W., Lu, H., Xie, Y., Xu, J., Zeng, Y., Han, K., Liang, J., Liu, J., Liu, Y., Chen, J."Establishment and assessment of a preclinical model of acute kidney injury induced by contrast media combined acute myocardial ischemia reperfusion surgery". Experimental and Therapeutic Medicine 26, no. 1 (2023): 321. https://doi.org/10.3892/etm.2023.12020
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team