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Diospyros lotus leaf extract and its main component myricitrin regulate pruritus through the inhibition of astrocyte activation

  • Authors:
    • Jae Young Shin
    • Byoung Ok Cho
    • Ji Hyeon Park
    • Eun Seo Kang
    • Young Soo Kim
    • Seon Il Jang
  • View Affiliations / Copyright

    Affiliations: Department of Food Science and Technology, Jeonbuk National University, Deokjin, Jeonju, Jeollabuk 54896, Republic of Korea, Institute of Health and Science, Jeonju University, Wansan, Jeonju, Jeollabuk 55069, Republic of Korea
    Copyright: © Shin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 323
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    Published online on: May 16, 2023
       https://doi.org/10.3892/etm.2023.12022
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Abstract

Diospyros lotus is a deciduous plant native to Asian countries, including Korea, Japan and China, and southeast Europe. In traditional medicine, Diospyros lotus is used as an anticancer, antidiabetic and antipyretic agent. The present study aimed to evaluate the effect of Diospyros lotus leaf extract (DLE) in ameliorating histamine‑independent pruritus. Activation of signal transducer and activator of transcription 3 (STAT3) in astrocytes contributes to pruritus. In this study, the effects of DLE and its main component, myricetin (MC), on the activation of STAT3, expression of glial fibrillary acidic protein (GFAP), and production of lipocalin‑2 (LCN2) in IL‑6‑treated astrocytes and chloroquine‑injected mice were investigated through western blot, reverse transcription‑quantitative PCR, and immunofluorescence staining. DLE and MC inhibited STAT3 activation, GFAP expression and LCN2 release via inositol 1,4,5‑trisphosphate receptor type 1 blockade in astrocytes. DLE and MC ameliorated scratching behavior, expression of GFAP, mast cell infiltration and serum IL‑6 levels in chloroquine‑injected mice. These results suggested that DLE and MC can be used as oral therapeutic agents for the treatment and management of pruritus.
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Copy and paste a formatted citation
Spandidos Publications style
Shin JY, Cho BO, Park JH, Kang ES, Kim YS and Jang SI: <em>Diospyros lotus</em> leaf extract and its main component myricitrin regulate pruritus through the inhibition of astrocyte activation. Exp Ther Med 26: 323, 2023.
APA
Shin, J.Y., Cho, B.O., Park, J.H., Kang, E.S., Kim, Y.S., & Jang, S.I. (2023). <em>Diospyros lotus</em> leaf extract and its main component myricitrin regulate pruritus through the inhibition of astrocyte activation. Experimental and Therapeutic Medicine, 26, 323. https://doi.org/10.3892/etm.2023.12022
MLA
Shin, J. Y., Cho, B. O., Park, J. H., Kang, E. S., Kim, Y. S., Jang, S. I."<em>Diospyros lotus</em> leaf extract and its main component myricitrin regulate pruritus through the inhibition of astrocyte activation". Experimental and Therapeutic Medicine 26.1 (2023): 323.
Chicago
Shin, J. Y., Cho, B. O., Park, J. H., Kang, E. S., Kim, Y. S., Jang, S. I."<em>Diospyros lotus</em> leaf extract and its main component myricitrin regulate pruritus through the inhibition of astrocyte activation". Experimental and Therapeutic Medicine 26, no. 1 (2023): 323. https://doi.org/10.3892/etm.2023.12022
Copy and paste a formatted citation
x
Spandidos Publications style
Shin JY, Cho BO, Park JH, Kang ES, Kim YS and Jang SI: <em>Diospyros lotus</em> leaf extract and its main component myricitrin regulate pruritus through the inhibition of astrocyte activation. Exp Ther Med 26: 323, 2023.
APA
Shin, J.Y., Cho, B.O., Park, J.H., Kang, E.S., Kim, Y.S., & Jang, S.I. (2023). <em>Diospyros lotus</em> leaf extract and its main component myricitrin regulate pruritus through the inhibition of astrocyte activation. Experimental and Therapeutic Medicine, 26, 323. https://doi.org/10.3892/etm.2023.12022
MLA
Shin, J. Y., Cho, B. O., Park, J. H., Kang, E. S., Kim, Y. S., Jang, S. I."<em>Diospyros lotus</em> leaf extract and its main component myricitrin regulate pruritus through the inhibition of astrocyte activation". Experimental and Therapeutic Medicine 26.1 (2023): 323.
Chicago
Shin, J. Y., Cho, B. O., Park, J. H., Kang, E. S., Kim, Y. S., Jang, S. I."<em>Diospyros lotus</em> leaf extract and its main component myricitrin regulate pruritus through the inhibition of astrocyte activation". Experimental and Therapeutic Medicine 26, no. 1 (2023): 323. https://doi.org/10.3892/etm.2023.12022
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