Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
July-2023 Volume 26 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2023 Volume 26 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Effectiveness of zinc supplementation on the incidence of oral mucositis during chemotherapy and radiation: A meta‑analysis

  • Authors:
    • Xin Liu
    • Weifang Zhang
    • Yifan Chen
    • Sanjay Rastogi
    • Rupshikha Choudhury
  • View Affiliations / Copyright

    Affiliations: Department of Stomatology, Fifth Medical Center of Chinese PLA General Hospital, Beijing 100071, P.R. China, Department of Oncology Chemotherapy, Central South University Xiangya School of Medicine Affiliated Haikou People's Hospital, Haikou, Hainan 570208, P.R. China, Department of Outpatient Stomatology, Huzhou Traditional Chinese Medicine Hospital, Zhejiang Chinese Medicinal University, Huzhou, Wuxing, Zhejiang 313000, P.R. China, Deptartment of Oral and Maxillofacial Surgery, Regional Dental College, Guwahati, Assam 781021, India
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 347
    |
    Published online on: May 26, 2023
       https://doi.org/10.3892/etm.2023.12046
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Oral mucositis (OM) is a commonly observed and debilitating side effect of chemotherapy and radiation therapy in patients with cancer, especially head and neck cancer. Although there is no proven therapy for the prevention and treatment of OM, zinc supplementation effectively decreases the incidence of OM. This paper provides a current and comprehensive meta‑analysis of the efficacy of zinc compared with placebo/control in OM. A systematic literature review was conducted using MEDLINE and Central databases for randomized control trials (RCTs) comparing zinc supplementation (oral or rinse) with placebo/control in patients with various types of cancer undergoing chemotherapy, radiation therapy or combined chemo‑radiation. The outcome was OM incidence, independent of the severity. A random‑effects model was used to calculate the pooled risk ratio and subgroup analyses were performed. A total of 12 RCTs were included, containing information from 783 patients. A decrease in OM incidence was observed overall when all cancer therapies were considered. However, subgroup analyses showed that zinc did not significantly decrease the incidence of OM when studies were stratified by cancer therapy or scale/criteria used to assess OM. The results of the meta‑analysis support the use of zinc supplementation in decreasing OM incidence in patients with cancer receiving chemotherapy or radiation therapy. However, the high heterogeneity between studies and the small number of studies are limitations of the meta‑analysis.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Global Cancer Observatory: International Agency for Research on Cancer. World Health Organization. Available at: https://gco.iarc.fr. Accessed 20.2.2022.

2 

Stenson K: Epidemiology and risk factors for head and neck cancer-UpToDate. Accessed 22.2.2022.

3 

Galbiatti AL, Padovani-Junior JA, Maníglia JV, Rodrigues CD, Pavarino EC and Goloni-Bertello EM: Head and neck cancer: Causes, prevention and treatment. Braz J Otorhinolaryngol. 79:239–247. 2013.PubMed/NCBI View Article : Google Scholar : (In English, Portuguese).

4 

National Cancer Institute: Head and Neck Cancer: Statistics | CancerNet. Accessed February 2023.

5 

Cognetti DM, Weber RS and Lai SY: Head and neck cancer: An evolving treatment paradigm. Cancer. 113 (7 Suppl):S1911–S1932. 2008.PubMed/NCBI View Article : Google Scholar

6 

Rodríguez-Caballero A, Torres-Lagares D, Robles-García M, Pachón-Ibáez J, González-Padilla D and Gutiérrez-Pérez JL: Cancer treatment-induced oral mucositis: A critical review. Int J Oral Maxillofac Surg. 41:225–238. 2012.PubMed/NCBI View Article : Google Scholar

7 

Raber-Durlacher JE, Elad S and Barasch A: Oral mucositis. Oral Oncol. 46:452–456. 2010.PubMed/NCBI View Article : Google Scholar

8 

Al Ibraheemi AA and Shamoun S: Incidence and risk factors of oral mucositis in patients with breast cancer who receiving chemotherapy in Al-Bashir Hospital. Int J Hematol Oncol Stem Cell Res. 10:217–223. 2016.PubMed/NCBI

9 

Naidu UR, Ramana GV, Rani PU, Mohan LK, Suman A and Roy P: Chemotherapy-induced and/or radiation therapy-induced oral mucositis-complicating the treatment of cancer. Neoplasia. 6:423–431. 2004.PubMed/NCBI View Article : Google Scholar

10 

Martinez JM, Pereira D, Chacim S, Mesquita E, Sousa I, Martins Â, Azevedo T and Mariz JM: Mucositis care in acute leukemia and non-Hodgkin lymphoma patients undergoing high-dose chemotherapy. Support Care Cancer. 22:2563–2569. 2014.PubMed/NCBI View Article : Google Scholar

11 

Pulito C, Cristaudo A, Porta C, Zapperi S, Blandino G, Morrone A and Strano S: Oral mucositis: The hidden side of cancer therapy. J Exp Clin Cancer Res. 39(210)2020.PubMed/NCBI View Article : Google Scholar

12 

Umeta M, West CE, Haidar J, Deurenberg P and Hautvast JG: Zinc supplementation and stunted infants in Ethiopia: A randomised controlled trial. Lancet. 355:2021–2026. 2000.PubMed/NCBI View Article : Google Scholar

13 

Ertekin MV, Koç M, Karslioǧlu I and Sezen O: Zinc sulfate in the prevention of radiation-induced oropharyngeal mucositis: A prospective, placebo-controlled, randomized study. Int J Radiat Oncol Biol Phys. 58:167–174. 2004.PubMed/NCBI View Article : Google Scholar

14 

Mehdipour M, Taghavi Zenoz A, Asvadi Kermani I and Hosseinpour A: A comparison between zinc sulfate and chlorhexidine gluconate mouthwashes in the prevention of chemotherapy-induced oral mucositis. Daru. 19:71–73. 2011.PubMed/NCBI

15 

Sonis ST, Oster G, Fuchs H, Bellm L, Bradford WZ, Edelsberg J, Hayden V, Eilers J, Epstein JB, LeVeque FG, et al: Oral mucositis and the clinical and economic outcomes of hematopoietic stem-cell transplantation. J Clin Oncol. 19:2201–2205. 2001.PubMed/NCBI View Article : Google Scholar

16 

Elting LS, Cooksley C, Chambers M, Cantor SB, Manzullo E and Rubenstein EB: The burdens of cancer therapy. Clinical and economic outcomes of chemotherapy-induced mucositis. Cancer. 98:1531–1539. 2003.PubMed/NCBI View Article : Google Scholar

17 

Elad S, Cheng KKF, Lalla RV, Yarom N, Hong C, Logan RM, Bowen J, Gibson R, Saunders DP, Zadik Y, et al: MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. Cancer. 126:4423–4431. 2020.PubMed/NCBI View Article : Google Scholar

18 

Rambod M, Pasyar N and Ramzi M: The effect of zinc sulfate on prevention, incidence, and severity of mucositis in leukemia patients undergoing chemotherapy. Eur J Oncol Nurs. 33:14–21. 2018.PubMed/NCBI View Article : Google Scholar

19 

Arbabikalati F, Arbabikalati F, Deghatipour M and Ansari MA: Evaluation of the efficacy of zinc sulfate in the prevention of chemotherapy-induced mucositis: A double-blind randomized clinical trial. Arch Iran Med. 15:413–417. 2012.PubMed/NCBI

20 

Gholizadeh N, Mehdipour M, Chavashi SH, Kahani S and Sadrzadeh-Afshar MS: The effect of orally administered zinc in the prevention of chemotherapy-induced oral mucositis in patients with acute myeloid leukemia. Int J Cancer Manage. 10(e9252)2017.

21 

Fatima T, Haji Abdul Rahim ZB, Lin CW and Qamar Z: Zinc: A precious trace element for oral health care? J Pak Med Assoc. 66:1019–1023. 2016.PubMed/NCBI

22 

Rosing CK, Cavagni J, Gaio EJ, Muniz FWMG, Ranzan N, Oballe HJR, Friedrich SA, Severo RM, Stewart B and Zhang YP: Efficacy of two mouthwashes with cetylpyridinium chloride: A controlled randomized clinical trial. Braz Oral Res. 31(e47)2017.PubMed/NCBI View Article : Google Scholar

23 

Seyedmajidi SA, Seyedmajidi M, Moghadamnia A, Khani Z, Zahedpasha S, Jenabian N, Jorsaraei G, Halalkhor S and Motallebnejad M: Effect of zinc-deficient diet on oral tissues and periodontal indices in rats. Int J Mol Cell Med. 3:81–87. 2014.PubMed/NCBI

24 

Prasad AS: Zinc in human health: Effect of zinc on immune cells. Mol Med. 14:353–357. 2008.PubMed/NCBI View Article : Google Scholar

25 

Gupta M, Mahajan V, Mehta K and Chauhan P: Zinc therapy in dermatology: A review. Dermatol Res Pract. 2014(709152)2014.PubMed/NCBI View Article : Google Scholar

26 

Tian X, Liu XL, Pi YP, Chen H and Chen WQ: Oral zinc sulfate for prevention and treatment of chemotherapy-induced oral mucositis: A meta-analysis of five randomized controlled trials. Front Oncol. 8(484)2018.PubMed/NCBI View Article : Google Scholar

27 

Shuai T, Tian X, Shi B, Chen H, Liu XL, Yi LJ, Chen WQ and Li XE: Prophylaxis with oral zinc sulfate against radiation induced oral mucositis in patients with head and neck cancers: A systematic review and meta-analysis of four randomized controlled trials. Front Oncol. 9(165)2019.PubMed/NCBI View Article : Google Scholar

28 

Chaitanya NC, Shugufta K, Suvarna C, Bhopal T, Mekala S, Ponnuru H, Madathanapalle R, Patel M, Abhyankar S, Reddy C and Deveneni P: A meta-analysis on the efficacy of zinc in oral mucositis during cancer chemo and/or radiotherapy-an evidence-based approach. J Nutr Sci Vitaminol. 65:184–191. 2019.PubMed/NCBI View Article : Google Scholar

29 

Anandhi P, Sharief RM and Rahila C: The benefit of zinc sulfate in oropharyngeal mucositis during hyperfractionated accelerated concomitant boost radiotherapy with concurrent cisplatin for advanced-stage oropharyngeal and hypopharyngeal cancers. Indian J Palliat Care. 26:437–443. 2020.PubMed/NCBI View Article : Google Scholar

30 

Gorgu SZ, Ilknur AF, Sercan O, Rahsan H and Nalan A: The effect of zinc sulphate in the prevention of radiation induced oral mucositis in patients with head and neck cancer. Int J Rad Res. 11:111–116. 2013.

31 

Mansouri A, Hadjibabaie M, Iravani M, Shamshiri AR, Hayatshahi A, Javadi MR, Khoee SH, Alimoghaddam K and Ghavamzadeh A: The effect of zinc sulfate in the prevention of high-dose chemotherapy-induced mucositis: A double-blind, randomized, placebo-controlled study. Hematol Oncol. 30:22–26. 2012.PubMed/NCBI View Article : Google Scholar

32 

Mosalaei A, Nasrolahi H, Shafizad A, Ahmadloo N, Ansari M, Mosleh-Shirazi MA, Omidvari S and Mohammadianpanah M: Effect of oral zinc sulphate in prevention of radiation induced oropharyngeal mucositis during and after radiotherapy in patients with head and neck cancers. Middle East J Cancer. 1:69–76. 2010.

33 

Moslemi D, Babaee N, Damavandi M, Pourghasem M and Moghadamnia AA: Oral zinc sulphate and prevention of radiation-induced oropharyngealmucositis in patients with head and neck cancers: A double blind, randomized controlled trial. Int J Radiat Res. 12:235–241. 2014.

34 

Oshvandi K, Vafaei SY, Kamallan SR, Khazaei S, Ranjbar H and Mohammadi F: Effectiveness of zinc chloride mouthwashes on oral mucositis and weight of patients with cancer undergoing chemotherapy. BMC Oral Health. 21(364)2021.PubMed/NCBI View Article : Google Scholar

35 

Sangthawan D, Phungrassami T and Sinkitjarurnchai W: A randomized double-blind, placebo-controlled trial of zinc sulfate supplementation for alleviation of radiation-induced oral mucositis and pharyngitis in head and neck cancer patients. J Med Assoc Thai. 96:69–76. 2013.PubMed/NCBI

36 

Watanabe T, Ishihara M, Matsuura K, Mizuta K and Itoh Y: Polaprezinc prevents oral mucositis associated with radiochemotherapy in patients with head and neck cancer. Int J Cancer. 127:1984–1990. 2010.PubMed/NCBI View Article : Google Scholar

37 

Fekrazad R and Chiniforush N: Oral mucositis prevention and management by therapeutic laser in head and neck cancers. J Lasers Med Sci. 5:1–7. 2014.PubMed/NCBI

38 

Trotti A, Bellm LA, Epstein JB, Frame D, Fuchs HJ, Gwede CK, Komaroff E, Nalysnyk L and Zilberberg MD: Mucositis incidence, severity and associated outcomes in patients with head and neck cancer receiving radiotherapy with or without chemotherapy: A systematic literature review. Radiother Oncol. 66:253–262. 2003.PubMed/NCBI View Article : Google Scholar

39 

Mitsuhashi H, Suemaru K, Li B, Cui R and Araki H: Evaluation of topical external medicine for 5-fluorouracil-induced oral mucositis in hamsters. Eur J Pharmacol. 551:152–155. 2006.PubMed/NCBI View Article : Google Scholar

40 

Katayama S, Nishizawa K, Hirano M, Yamamura S and Momose Y: Effect of polaprezinc on healing of acetic acid-induced stomatitis in hamsters. J Pharm Pharm Sci. 3:114–117. 2000.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Liu X, Zhang W, Chen Y, Rastogi S and Choudhury R: Effectiveness of zinc supplementation on the incidence of oral mucositis during chemotherapy and radiation: A meta‑analysis. Exp Ther Med 26: 347, 2023.
APA
Liu, X., Zhang, W., Chen, Y., Rastogi, S., & Choudhury, R. (2023). Effectiveness of zinc supplementation on the incidence of oral mucositis during chemotherapy and radiation: A meta‑analysis. Experimental and Therapeutic Medicine, 26, 347. https://doi.org/10.3892/etm.2023.12046
MLA
Liu, X., Zhang, W., Chen, Y., Rastogi, S., Choudhury, R."Effectiveness of zinc supplementation on the incidence of oral mucositis during chemotherapy and radiation: A meta‑analysis". Experimental and Therapeutic Medicine 26.1 (2023): 347.
Chicago
Liu, X., Zhang, W., Chen, Y., Rastogi, S., Choudhury, R."Effectiveness of zinc supplementation on the incidence of oral mucositis during chemotherapy and radiation: A meta‑analysis". Experimental and Therapeutic Medicine 26, no. 1 (2023): 347. https://doi.org/10.3892/etm.2023.12046
Copy and paste a formatted citation
x
Spandidos Publications style
Liu X, Zhang W, Chen Y, Rastogi S and Choudhury R: Effectiveness of zinc supplementation on the incidence of oral mucositis during chemotherapy and radiation: A meta‑analysis. Exp Ther Med 26: 347, 2023.
APA
Liu, X., Zhang, W., Chen, Y., Rastogi, S., & Choudhury, R. (2023). Effectiveness of zinc supplementation on the incidence of oral mucositis during chemotherapy and radiation: A meta‑analysis. Experimental and Therapeutic Medicine, 26, 347. https://doi.org/10.3892/etm.2023.12046
MLA
Liu, X., Zhang, W., Chen, Y., Rastogi, S., Choudhury, R."Effectiveness of zinc supplementation on the incidence of oral mucositis during chemotherapy and radiation: A meta‑analysis". Experimental and Therapeutic Medicine 26.1 (2023): 347.
Chicago
Liu, X., Zhang, W., Chen, Y., Rastogi, S., Choudhury, R."Effectiveness of zinc supplementation on the incidence of oral mucositis during chemotherapy and radiation: A meta‑analysis". Experimental and Therapeutic Medicine 26, no. 1 (2023): 347. https://doi.org/10.3892/etm.2023.12046
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team