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Ferroptosis: A potential therapeutic target in autoimmune disease (Review)

  • Authors:
    • Liang Shen
    • Xiaohan Wang
    • Changlin Zhai
    • Yunqing Chen
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang 314000, P.R. China, Department of Gastroenterology, Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang 314000, P.R. China, Department of Infectious Diseases, Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang 314000, P.R. China
    Copyright: © Shen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 368
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    Published online on: June 15, 2023
       https://doi.org/10.3892/etm.2023.12067
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Abstract

Ferroptosis is a distinct type of regulated cell death characterized by iron overload and lipid peroxidation. Ferroptosis is regulated by numerous factors and controlled by several mechanisms. This cell death type has a relationship with the immune system, which may be regulated by damage‑associated molecular patterns. Ferroptosis participates in the progression of autoimmune diseases, including autoimmune hepatitis, rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel disease, multiple sclerosis, Parkinson's Disease, psoriasis and insulin‑dependent diabetes mellitus. The present review summarizes the role of ferroptosis in autoimmune disorders and discusses ferroptosis as a potential therapeutic target for autoimmune disease.
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Spandidos Publications style
Shen L, Wang X, Zhai C and Chen Y: Ferroptosis: A potential therapeutic target in autoimmune disease (Review). Exp Ther Med 26: 368, 2023.
APA
Shen, L., Wang, X., Zhai, C., & Chen, Y. (2023). Ferroptosis: A potential therapeutic target in autoimmune disease (Review). Experimental and Therapeutic Medicine, 26, 368. https://doi.org/10.3892/etm.2023.12067
MLA
Shen, L., Wang, X., Zhai, C., Chen, Y."Ferroptosis: A potential therapeutic target in autoimmune disease (Review)". Experimental and Therapeutic Medicine 26.2 (2023): 368.
Chicago
Shen, L., Wang, X., Zhai, C., Chen, Y."Ferroptosis: A potential therapeutic target in autoimmune disease (Review)". Experimental and Therapeutic Medicine 26, no. 2 (2023): 368. https://doi.org/10.3892/etm.2023.12067
Copy and paste a formatted citation
x
Spandidos Publications style
Shen L, Wang X, Zhai C and Chen Y: Ferroptosis: A potential therapeutic target in autoimmune disease (Review). Exp Ther Med 26: 368, 2023.
APA
Shen, L., Wang, X., Zhai, C., & Chen, Y. (2023). Ferroptosis: A potential therapeutic target in autoimmune disease (Review). Experimental and Therapeutic Medicine, 26, 368. https://doi.org/10.3892/etm.2023.12067
MLA
Shen, L., Wang, X., Zhai, C., Chen, Y."Ferroptosis: A potential therapeutic target in autoimmune disease (Review)". Experimental and Therapeutic Medicine 26.2 (2023): 368.
Chicago
Shen, L., Wang, X., Zhai, C., Chen, Y."Ferroptosis: A potential therapeutic target in autoimmune disease (Review)". Experimental and Therapeutic Medicine 26, no. 2 (2023): 368. https://doi.org/10.3892/etm.2023.12067
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