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Experimental and Therapeutic Medicine
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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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August-2023 Volume 26 Issue 2

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Lithium chloride promotes diabetic corneal epithelial wound healing by activating the Wnt/β‑catenin signaling pathway

  • Authors:
    • Jing Dan
    • Ting Tan
    • Man Wu
    • Jin Gong
    • Qingguo Yang
    • Linling Wang
    • Ping Wang

  • View Affiliations / Copyright

    Affiliations: Department of Ophthalmology, Affiliated Renhe Hospital of China Three Gorges University, Second Clinical Medical College of China, Three Gorges University, Yichang, Hubei 443000, P.R. China, Department of Ophthalmology, Yiling Hospital, Yichang, Hubei 443100, P.R. China
    Copyright: © Dan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 373
    |
    Published online on: June 20, 2023
       https://doi.org/10.3892/etm.2023.12072
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Abstract

Corneal epithelial abnormality is a common manifestation of diabetic keratopathy and leads to delayed epithelial wound healing. The Wnt/β‑catenin signaling pathway participates in the development, differentiation and stratification of corneal epithelial cells. The present study compared the expression of Wnt/β‑catenin signaling pathway related factors, including Wnt7a, β‑catenin, cyclin D1 and phosphorylated (p‑) glycogen synthase kinase 3 β (Gsk3b) between normal and diabetic mouse corneas, by reverse transcription‑quantitative PCR, western blotting and immunofluorescence staining. It was found that the expression of the Wnt/β‑catenin signaling pathway related factors was downregulated in diabetic corneas. Upon corneal epithelium scraping, the wound healing rate was significantly increased in diabetic mice after topical treatment with lithium chloride. After further investigation, significantly upregulated levels of Wnt7a, β‑catenin, cyclin D1 and p‑Gsk3b were found in the diabetic group 24 h after treatment, accompanied by β‑catenin nuclear translocation observed by immunofluorescence staining. These results suggest that active Wnt/β‑catenin pathway can promote diabetic corneal epithelial wound healing.

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Copy and paste a formatted citation
Spandidos Publications style
Dan J, Tan T, Wu M, Gong J, Yang Q, Wang L and Wang P: Lithium chloride promotes diabetic corneal epithelial wound healing by activating the Wnt/β‑catenin signaling pathway. Exp Ther Med 26: 373, 2023.
APA
Dan, J., Tan, T., Wu, M., Gong, J., Yang, Q., Wang, L., & Wang, P. (2023). Lithium chloride promotes diabetic corneal epithelial wound healing by activating the Wnt/β‑catenin signaling pathway. Experimental and Therapeutic Medicine, 26, 373. https://doi.org/10.3892/etm.2023.12072
MLA
Dan, J., Tan, T., Wu, M., Gong, J., Yang, Q., Wang, L., Wang, P."Lithium chloride promotes diabetic corneal epithelial wound healing by activating the Wnt/β‑catenin signaling pathway". Experimental and Therapeutic Medicine 26.2 (2023): 373.
Chicago
Dan, J., Tan, T., Wu, M., Gong, J., Yang, Q., Wang, L., Wang, P."Lithium chloride promotes diabetic corneal epithelial wound healing by activating the Wnt/β‑catenin signaling pathway". Experimental and Therapeutic Medicine 26, no. 2 (2023): 373. https://doi.org/10.3892/etm.2023.12072
Copy and paste a formatted citation
x
Spandidos Publications style
Dan J, Tan T, Wu M, Gong J, Yang Q, Wang L and Wang P: Lithium chloride promotes diabetic corneal epithelial wound healing by activating the Wnt/β‑catenin signaling pathway. Exp Ther Med 26: 373, 2023.
APA
Dan, J., Tan, T., Wu, M., Gong, J., Yang, Q., Wang, L., & Wang, P. (2023). Lithium chloride promotes diabetic corneal epithelial wound healing by activating the Wnt/β‑catenin signaling pathway. Experimental and Therapeutic Medicine, 26, 373. https://doi.org/10.3892/etm.2023.12072
MLA
Dan, J., Tan, T., Wu, M., Gong, J., Yang, Q., Wang, L., Wang, P."Lithium chloride promotes diabetic corneal epithelial wound healing by activating the Wnt/β‑catenin signaling pathway". Experimental and Therapeutic Medicine 26.2 (2023): 373.
Chicago
Dan, J., Tan, T., Wu, M., Gong, J., Yang, Q., Wang, L., Wang, P."Lithium chloride promotes diabetic corneal epithelial wound healing by activating the Wnt/β‑catenin signaling pathway". Experimental and Therapeutic Medicine 26, no. 2 (2023): 373. https://doi.org/10.3892/etm.2023.12072
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