|
1
|
Huang SW, Kiang D, Smith DJ and Wang JR:
Evolution of re-emergent virus and its impact on enterovirus 71
epidemics. Exp Biol Med (Maywood). 236:899–908. 2011.PubMed/NCBI View Article : Google Scholar
|
|
2
|
Chen Y, Hu L, Xu F, Liu C and Li J: A case
report of a teenager with severe hand, foot, and mouth disease with
brainstem encephalitis caused by enterovirus 71. BMC Pediatr.
19(59)2019.PubMed/NCBI View Article : Google Scholar
|
|
3
|
Xing J, Wang K, Wei H and Wei D:
Pathologic and molecular studies of enterovirus 71 infection in a
fatal case from a recent epidemic in China. Medicine (Baltimore).
97(e13447)2018.PubMed/NCBI View Article : Google Scholar
|
|
4
|
Sun X, Liu Y, Huang Z, Xu W, Hu W, Yi L,
Liu Z, Chan H, Zeng J, Liu X, et al: SARS-CoV-2 non-structural
protein 6 triggers NLRP3-dependent pyroptosis by targeting ATP6AP1.
Cell Death Differ. 29:1240–1254. 2022.PubMed/NCBI View Article : Google Scholar
|
|
5
|
Allen IC, Scull MA, Moore CB, Holl EK,
McElvania-TeKippe E, Taxman DJ, Guthrie EH, Pickles RJ and Ting JP:
The NLRP3 inflammasome mediates in vivo innate immunity to
influenza A virus through recognition of viral RNA. Immunity.
30:556–565. 2009.PubMed/NCBI View Article : Google Scholar
|
|
6
|
Xie WH, Ding J, Xie XX, Yang XH, Wu XF,
Chen ZX, Guo QL, Gao WY, Wang XZ and Li D: Hepatitis B virus X
protein promotes liver cell pyroptosis under oxidative stress
through NLRP3 inflammasome activation. Inflamm Res. 69:683–696.
2020.PubMed/NCBI View Article : Google Scholar
|
|
7
|
Ramos HJ, Lanteri MC, Blahnik G, Negash A,
Suthar MS, Brassil MM, Sodhi K, Treuting PM, Busch MP, Norris PJ
and Gale M Jr: IL-1β signaling promotes CNS-intrinsic immune
control of West Nile virus infection. PLoS Pathog.
8(e1003039)2012.PubMed/NCBI View Article : Google Scholar
|
|
8
|
Zhang X, Hao J, Sun C, Du J, Han Q and Li
Q: Total astragalosides decrease apoptosis and pyroptosis by
inhibiting enterovirus 71 replication in gastric epithelial cells.
Exp Ther Med. 23(237)2022.PubMed/NCBI View Article : Google Scholar
|
|
9
|
Kayagaki N, Stowe IB, Lee BL, O'Rourke K,
Anderson K, Warming S, Cuellar T, Haley B, Roose-Girma M, Phung QT,
et al: Caspase-11 cleaves gasdermin D for non-canonical
inflammasome signalling. Nature. 526:666–671. 2015.PubMed/NCBI View Article : Google Scholar
|
|
10
|
Fink SL and Cookson BT:
Caspase-1-dependent pore formation during pyroptosis leads to
osmotic lysis of infected host macrophages. Cell Microbiol.
8:1812–1825. 2006.PubMed/NCBI View Article : Google Scholar
|
|
11
|
Kesavardhana S, Malireddi RKS and
Kanneganti T: Caspases in cell death, inflammation, and
gasdermin-induced pyroptosis. Annu Rev Immunol. 38:567–595.
2020.PubMed/NCBI View Article : Google Scholar
|
|
12
|
Shi J, Zhao Y, Wang K, Shi X, Wang Y,
Huang H, Zhuang Y, Cai T, Wang F and Shao F: Cleavage of GSDMD by
inflammatory caspases determines pyroptotic cell death. Nature.
526:660–665. 2015.PubMed/NCBI View Article : Google Scholar
|
|
13
|
He WT, Wan H, Hu L, Chen P, Wang X, Huang
Z, Yang ZH, Zhong CQ and Han J: Gasdermin D is an executor of
pyroptosis and required for interleukin-1β secretion: Gasdermin D
is an executor of pyroptosis and required for interleukin-1beta
secretion. Cell Res. 25:1285–1298. 2015.PubMed/NCBI View Article : Google Scholar
|
|
14
|
Lamkanfi M and Dixit VM: Mechanisms and
functions of inflammasomes. Cell. 157:1013–1022. 2014.PubMed/NCBI View Article : Google Scholar
|
|
15
|
Humphries F, Shmuel-Galia L,
Ketelut-Carneiro N, Li S, Wang B, Nemmara VV, Wilson R, Jiang Z,
Khalighinejad F, Muneeruddin K, et al: Succination inactivates
gasdermin D and blocks pyroptosis. Science. 369:1633–1637.
2020.PubMed/NCBI View Article : Google Scholar
|
|
16
|
An X, Zhang Y, Cao Y, Chen J, Qin H and
Yang L: Punicalagin protects diabetic nephropathy by inhibiting
pyroptosis based on TXNIP/NLRP3 pathway. Nutrients.
12(1516)2020.PubMed/NCBI View Article : Google Scholar
|
|
17
|
Tian DD, Wang M, Liu A, Gao MR, Qiu C, Yu
W, Wang WJ, Zhang K, Yang L, Jia YY, et al: Antidepressant effect
of paeoniflorin is through inhibiting pyroptosis CASP-11/GSDMD
pathway. Mol Neurobiol. 58:761–776. 2021.PubMed/NCBI View Article : Google Scholar
|
|
18
|
Bailey CJ: Metformin: Historical overview.
Diabetologia. 60:1566–1576. 2017.PubMed/NCBI View Article : Google Scholar
|
|
19
|
Agius L, Ford BE and Chachra SS: The
metformin mechanism on gluconeogenesis and AMPK activation: The
metabolite perspective. Int J Mol Sci. 21(3240)2020.PubMed/NCBI View Article : Google Scholar
|
|
20
|
Qing L, Fu J, Wu P, Zhou Z, Yu F and Tang
J: Metformin induces the M2 macrophage polarization to accelerate
the wound healing via regulating AMPK/mTOR/NLRP3 inflammasome
singling pathway. Am J Transl Res. 11:655–668. 2019.PubMed/NCBI
|
|
21
|
Chen X, Li X, Zhang W, He J, Xu B, Lei B,
Wang Z, Cates C, Rousselle T and Li J: Activation of AMPK inhibits
inflammatory response during hypoxia and reoxygenation through
modulating JNK-mediated NF-κB pathway. Metabolism. 83:256–270.
2018.PubMed/NCBI View Article : Google Scholar
|
|
22
|
Yan J, Ding D, Feng G, Yang Y, Zhou Y, Ma
L, Guo H, Lu Z and Jin Q: Metformin reduces chondrocyte pyroptosis
in an osteoarthritis mouse model by inhibiting NLRP3 inflammasome
activation. Exp Ther Med. 23(222)2022.PubMed/NCBI View Article : Google Scholar
|
|
23
|
Jia Y, Cui R, Wang C, Feng Y, Li Z, Tong
Y, Qu K, Liu C and Zhang J: Metformin protects against intestinal
ischemia-reperfusion injury and cell pyroptosis via
TXNIP-NLRP3-GSDMD pathway. Redox Biol. 32(101534)2020.PubMed/NCBI View Article : Google Scholar
|
|
24
|
Samuel SM, Varghese E and Büsselberg D:
Therapeutic potential of metformin in COVID-19: Reasoning for its
protective role. Trends Microbiol. 29:894–907. 2021.PubMed/NCBI View Article : Google Scholar
|
|
25
|
Obara A, Fujita Y, Abudukadier A,
Fukushima T, Oguri Y, Ogura M, Harashima S, Hosokawa M and Inagaki
N: DEPTOR-related mTOR suppression is involved in metformin's
anti-cancer action in human liver cancer cells. Biochem Biophys Res
Commun. 460:1047–1052. 2015.PubMed/NCBI View Article : Google Scholar
|
|
26
|
Wang Y, Wang Y, Li Y, Lu L, Peng Y, Zhang
S and Xia A: Metformin attenuates renal interstitial fibrosis
through upregulation of Deptor in unilateral ureteral obstruction
in rats. Exp Ther Med. 20(1)2020.PubMed/NCBI View Article : Google Scholar
|
|
27
|
Caron A, Briscoe DM, Richard D and
Laplante M: DEPTOR at the nexus of cancer, metabolism, and
immunity. Physiol Rev. 98:1765–1803. 2018.PubMed/NCBI View Article : Google Scholar
|
|
28
|
Wedel J, Bruneau S, Liu K, Kong SW, Sage
PT, Sabatini DM, Laplante M and Briscoe DM: DEPTOR modulates
activation responses in CD4+ T cells and enhances immunoregulation
following transplantation. Am J Transplant. 19:77–88.
2018.PubMed/NCBI View Article : Google Scholar
|
|
29
|
Zhai Y, Lin P, Feng Z, Lu H, Han Q, Chen
J, Zhang Y, He Q, Nan G, Luo X, et al: TNFAIP3-DEPTOR complex
regulates inflammasome secretion through autophagy in ankylosing
spondylitis monocytes. Autophagy. 14:1629–1643. 2018.PubMed/NCBI View Article : Google Scholar
|
|
30
|
Bruneau S, Nakayama H, Woda CB, Flynn EA
and Briscoe DM: DEPTOR regulates vascular endothelial cell
activation and proinflammatory and angiogenic responses. Blood.
122:1833–1842. 2013.PubMed/NCBI View Article : Google Scholar
|
|
31
|
Laplante M, Horvat S, Festuccia WT, Birsoy
K, Prevorsek Z, Efeyan A and Sabatini DM: DEPTOR cell-autonomously
promotes adipogenesis, and its expression is associated with
obesity. Cell Metab. 16:202–212. 2012.PubMed/NCBI View Article : Google Scholar
|
|
32
|
Cadegiani FA, McCoy J, Gustavo Wambier C,
Vaño-Galván S, Shapiro J, Tosti A, Zimerman RA and Goren A:
Proxalutamide significantly accelerates viral clearance and reduces
time to clinical remission in patients with mild to moderate
COVID-19: Results from a randomized, double-blinded,
placebo-controlled trial. Cureus. 13(e13492)2021.PubMed/NCBI View Article : Google Scholar
|
|
33
|
Kanno Y, Zhao S, Yamashita N, Yanai K,
Nemoto K and Inouye Y: Androgen receptor functions as a negative
transcriptional regulator of DEPTOR, mTOR inhibitor. J Toxicol Sci.
40:753–758. 2015.PubMed/NCBI View Article : Google Scholar
|
|
34
|
Reed LJ and Muench H: A simple method for
estimating fifty percent endpoints. Am J Hyg. 27:493–497. 1938.
|
|
35
|
Nayak G, Bhuyan SK, Bhuyan R, Sahu A, Kar
D and Kuanar A: Global emergence of Enterovirus 71: A systematic
review. Beni Suef Univ J Basic Appl Sci. 11(78)2022.PubMed/NCBI View Article : Google Scholar
|
|
36
|
Yogarajah T, Ong KC, Perera D and Wong KT:
AIM2 inflammasome-mediated pyroptosis in enterovirus A71-infected
neuronal cells restricts viral replication. Sci Rep.
7(5845)2017.PubMed/NCBI View Article : Google Scholar
|
|
37
|
Bai J, Chen X, Liu Q, Zhou X and Long JE:
Characteristics of enterovirus 71-induced cell death and genome
scanning to identify viral genes involved in virus-induced cell
apoptosis. Virus Res. 265:104–114. 2019.PubMed/NCBI View Article : Google Scholar
|
|
38
|
Wang H, Lei X, Xiao X, Yang C, Lu W, Huang
Z, Leng Q, Jin Q, He B, Meng G and Wang J: Reciprocal regulation
between enterovirus 71 and the NLRP3 inflammasome. Cell Rep.
12:42–48. 2015.PubMed/NCBI View Article : Google Scholar
|
|
39
|
Chen H, Ning X and Jiang Z: Caspases
control antiviral innate immunity. Cell Mol Immunol. 14:736–747.
2017.PubMed/NCBI View Article : Google Scholar
|
|
40
|
Wang SM, Lei HY and Liu CC: Cytokine
immunopathogenesis of enterovirus 71 brain stem encephalitis. Clin
Dev Immunol. 2012(876241)2012.PubMed/NCBI View Article : Google Scholar
|
|
41
|
Peterson TR, Laplante M, Thoreen CC,
Sancak Y, Kang SA, Kuehl WM, Gray NS and Sabatini DM: DEPTOR is an
mTOR inhibitor frequently overexpressed in multiple myeloma cells
and required for their survival. Cell. 137:873–886. 2009.PubMed/NCBI View Article : Google Scholar
|
|
42
|
Zhao W, Shi CS, Harrison K, Hwang IY,
Nabar NR, Wang M and Kehrl JH: AKT regulates NLRP3 inflammasome
activation by phosphorylating NLRP3 serine 5. J Immunol.
205:2255–2264. 2020.PubMed/NCBI View Article : Google Scholar
|
