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Predictors of COVID‑19‑associated mortality among hospitalized elderly patients with dementia

  • Authors:
    • Vasiliki Epameinondas Georgakopoulou
    • Aikaterini Gkoufa
    • Aristeidis Tsakanikas
    • Sotiria Makrodimitri
    • Georgios Karamanakos
    • Dimitrios Basoulis
    • Pantazis M. Voutsinas
    • Irene Eliadi
    • Anastasia Bougea
    • Demetrios A. Spandidos
    • Efthalia Angelopoulou
    • Paschalis Steiropoulos
    • Nikolaos V. Sipsas
  • View Affiliations / Copyright

    Affiliations: Department of Infectious Diseases and COVID‑19 Unit, Laiko General Hospital, Medical School, 11527 Athens, Greece, Department of Pathophysiology, Laiko General Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece, 1st Department of Neurology, Eginition Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece, Laboratory of Clinical Virology, School of Medicine, University of Crete, 71003 Heraklion, Greece, Department of Pulmonology, Medical School, Democritus University of Thrace, 68100 Alexandroupolis, Greece
    Copyright: © Georgakopoulou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 395
    |
    Published online on: July 3, 2023
       https://doi.org/10.3892/etm.2023.12094
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Abstract

The mortality of elderly patients with dementia hospitalized with coronavirus disease 2019 (COVID‑19)‑associated pneumonia is high. The mortality rate of these patients continues to be high following their discharge. However, data on the outcomes of these patients in all phases of the pandemic are limited. The aim of the present study was to examine the clinical characteristics and the in‑hospital and 90‑day mortality rates of elderly patients with dementia hospitalized due to COVID‑19‑associated pneumonia during all phases of the pandemic. During the time period between February 15, 2021 to July 15, 2022, 105 elderly patients (≥65 years old) with dementia of various etiologies were hospitalized due to COVID‑19‑associated pneumonia. The patient characteristics and in‑hospital outcomes within 90 days of admission were recorded. The mean age of the patients was 84.03±7.61 years and 60 (57.1%) patients were females. A total of 52 (49.5%) patients were hospitalized during the omicron variant period, 27 (25.7%) were fully vaccinated (three doses) and 38 (36.2%) patients succumbed during their hospitalization. In total, 52 (49.5%) patients succumbed within the first 90 days of admission. According to the univariate regression analysis, the omicron variant [hazard ratio (HR), 2.126; 95% confidence interval (CI), 1.073‑4.213; P=0.031] and the absence of full vaccination (HR, 6.231; 95% CI, 1.500‑25.87; P=0.012) were associated with a higher in‑hospital mortality. In the multivariate regression analysis, only the absence of complete vaccination was an independent predictor of mortality (HR, 5.182; 95% CI, 1.205‑22.28; P=0.027). According to the univariate regression analysis, age (HR, 1.045; 95% CI, 1.006‑1.085; P=0.023) and the lack of complete vaccination (HR, 3.254; 95% CI, 1.294‑8.181; P=0.012) were associated with 90‑day mortality; in addition, by multivariate regression analysis, age (HR, 1.047; 95% CI, 1.007‑1.048; P=0.021) and the absence of full vaccination (HR, 3.286; 95% CI, 1.307‑8.265; P=0.011) exhibited an independent association with the 90‑day mortality rate. Based on the findings presented herein, the in‑hospital and 90‑day mortality rates of elderly patients with dementia and COVID‑19‑associated pneumonia is high. An older age and the lack of complete vaccination are independently associated with poor outcomes.
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1 

Zheng Z, Peng F, Xu B, Zhao J, Liu H, Peng J, Li Q, Jiang C, Zhou Y, Liu S, et al: Risk factors of critical & mortal COVID-19 cases: A systematic literature review and meta-analysis. J Infect. 81:e16–e25. 2020.PubMed/NCBI View Article : Google Scholar

2 

Tahira AC, Verjovski-Almeida S and Ferreira ST: Dementia is an age-independent risk factor for severity and death in COVID-19 inpatients. Alzheimers Dement. 17:1818–1831. 2021.PubMed/NCBI View Article : Google Scholar

3 

Mok VCT, Pendlebury S, Wong A, Alladi S, Au L, Bath PM, Biessels GJ, Chen C, Cordonnier C, Dichgans M, et al: Tackling challenges in care of Alzheimer's disease and other dementias amid the COVID-19 pandemic, now and in the future. Alzheimers Dement. 16:1571–1581. 2020.PubMed/NCBI View Article : Google Scholar

4 

Saragih ID, Saragih IS, Batubara SO and Lin CJ: Dementia as a mortality predictor among older adults with COVID-19: A systematic review and meta-analysis of observational study. Geriatr Nurs. 42:1230–1239. 2021.PubMed/NCBI View Article : Google Scholar

5 

Liu N, Sun J, Wang X, Zhao M, Huang Q and Li H: The impact of dementia on the clinical outcome of COVID-19: A systematic review and meta-analysis. J Alzheimers Dis. 78:1775–1782. 2020.PubMed/NCBI View Article : Google Scholar

6 

Bauer K, Schwarzkopf L, Graessel E and Holle R: A claims data-based comparison of comorbidity in individuals with and without dementia. BMC Geriatr. 14(10)2014.PubMed/NCBI View Article : Google Scholar

7 

Manabe T, Fujikura Y, Mizukami K, Akatsu H and Kudo K: Pneumonia-associated death in patients with dementia: A systematic review and meta-analysis. PLoS One. 14(e0213825)2019.PubMed/NCBI View Article : Google Scholar

8 

Izcovich A, Ragusa MA, Tortosa F, Marzio MA, Agnoletti C, Bengolea A, Ceirano A, Espinosa F, Saavedra E, Sanguine V, et al: Prognostic factors for severity and mortality in patients infected with COVID-19: A systematic review. PLoS One. 15(e0241955)2020.PubMed/NCBI View Article : Google Scholar

9 

Secnik J, Eriksdotter M, Xu H and Annetorp M: SweGeroCOVID Project. Rytarowski A, Johnell K, Hägg S and Religa D: Dementia and psychotropic medications are associated with significantly higher mortality in geriatric patients hospitalized with COVID-19: data from the StockholmGeroCovid project. Alzheimers Res Ther. 15(5)2023.PubMed/NCBI View Article : Google Scholar

10 

Kostev K, Gessler N, Wohlmuth P, Arnold D, Bein B, Bohlken J, Herrlinger K, Jacob L, Koyanagi A, Nowak L, et al: Is dementia associated with COVID-19 mortality? A multicenter retrospective cohort study conducted in 50 hospitals in Germany. J Alzheimers Dis. 91:719–726. 2023.PubMed/NCBI View Article : Google Scholar

11 

Hugo J and Ganguli M: Dementia and cognitive impairment: Epidemiology, diagnosis, and treatment. Clin Geriatr Med. 30:421–442. 2014.PubMed/NCBI View Article : Google Scholar

12 

Vrillon A, Mhanna E, Aveneau C, Lebozec M, Grosset L, Nankam D, Albuquerque F, Feroldi RR, Maakaroun B, Pissareva I, et al: COVID-19 in adults with dementia: Clinical features and risk factors of mortality-a clinical cohort study on 125 patients. Alzheimers Res Ther. 13(77)2021.PubMed/NCBI View Article : Google Scholar

13 

Richardson S, Hirsch JS, Narasimhan M, Crawford JM, McGinn T and Davidson KW: the Northwell COVID-19 Research Consortium. Barnaby DP, Becker LB, Chelico JD, et al: Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York city area. JAMA. 32:2052–2059. 2020.PubMed/NCBI View Article : Google Scholar

14 

Hariyanto TI, Putri C, Arisa J, Situmeang RFV and Kurniawan A: Dementia and outcomes from coronavirus disease 2019 (COVID-19) pneumonia: A systematic review and meta-analysis. Arch Gerontol Geriatr. 93(104299)2021.PubMed/NCBI View Article : Google Scholar

15 

Roig-Marín N and Roig-Rico P: Elderly people with dementia admitted for COVID-19: How different are they? Exp Aging Res. 48:177–190. 2022.PubMed/NCBI View Article : Google Scholar

16 

Chen S, Cardinal RN and Auckland K: EpiCov Database. Gräf S, O'Brien JT and Underwood BR: Risk factors for longer-term mortality in discharged patients with dementia and SARS-CoV-2 infection: A matched case-control study. J Alzheimers Dis. 92:295–309. 2023.PubMed/NCBI View Article : Google Scholar

17 

Georgakopoulou VE, Papalexis P, Sanos C, Bitsani A, Garmpi A, Damaskos C, Garmpis N, Gkoufa A, Chlapoutakis S, Sklapani P, et al: Asymptomatic SARS-CoV-2 infection in an unvaccinated 97-year-old woman: A case report. Biomed Rep. 15(107)2021.PubMed/NCBI View Article : Google Scholar

18 

Georgakopoulou VE, Basoulis D, Voutsinas PM, Makrodimitri S, Samara S, Triantafyllou M, Eliadi I, Karamanakos G, Papageorgiou CV, Anastasopoulou A, et al: Factors predicting poor outcomes of patients treated with tocilizumab for COVID-19-associated pneumonia: A retrospective study. Exp Ther Med. 24(724)2022.PubMed/NCBI View Article : Google Scholar

19 

Kokkoris S, Gkoufa A, Maneta E, Doumas G, Mizi E, Georgakopoulou VE, Sigala I, Dima E, Papachatzakis I, Ntaidou TK, et al: Older adults with severe coronavirus disease 2019 admitted to intensive care unit: Prevalence, characteristics and risk factors for mortality. Minerva Anestesiol. 88:803–814. 2022.PubMed/NCBI View Article : Google Scholar

20 

Gkoufa A, Maneta E, Ntoumas GN, Georgakopoulou VE, Mantelou A, Kokkoris S and Routsi C: Elderly adults with COVID-19 admitted to intensive care unit: A narrative review. World J Crit Care Med. 10:278–289. 2021.PubMed/NCBI View Article : Google Scholar

21 

Griffin JB, Haddix M, Danza P, Fisher R, Koo TH, Traub E, Gounder P, Jarashow C and Balter S: SARS-CoV-2 infections and hospitalizations among persons aged ≥16 years, by vaccination status-Los Angeles County, California, May 1-July 25, 2021. MMWR Morb Mortal Wkly Rep. 70:1170–1176. 2021.PubMed/NCBI View Article : Google Scholar

22 

Ellis RJ, Moffatt CR, Aaron LT, Beaverson G, Chaw K, Curtis C, Freeman-Lamb R, Judd D, Khatry K, Li YS, et al: Factors associated with hospitalisations and deaths of residential aged care residents with COVID-19 during the Omicron (BA.1) wave in Queensland. Med J Aust. 218:174–179. 2023.PubMed/NCBI View Article : Google Scholar

23 

Gomes D, Beyerlein A, Katz K, Hoelscher G, Nennstiel U, Liebl B, Überla K and von Kries R: Is the BNT162b2 COVID-19 vaccine effective in elderly populations? Results from population data from Bavaria, Germany. PLoS One. 16(e0259370)2021.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Georgakopoulou VE, Gkoufa A, Tsakanikas A, Makrodimitri S, Karamanakos G, Basoulis D, Voutsinas PM, Eliadi I, Bougea A, Spandidos DA, Spandidos DA, et al: Predictors of COVID‑19‑associated mortality among hospitalized elderly patients with dementia. Exp Ther Med 26: 395, 2023.
APA
Georgakopoulou, V.E., Gkoufa, A., Tsakanikas, A., Makrodimitri, S., Karamanakos, G., Basoulis, D. ... Sipsas, N.V. (2023). Predictors of COVID‑19‑associated mortality among hospitalized elderly patients with dementia. Experimental and Therapeutic Medicine, 26, 395. https://doi.org/10.3892/etm.2023.12094
MLA
Georgakopoulou, V. E., Gkoufa, A., Tsakanikas, A., Makrodimitri, S., Karamanakos, G., Basoulis, D., Voutsinas, P. M., Eliadi, I., Bougea, A., Spandidos, D. A., Angelopoulou, E., Steiropoulos, P., Sipsas, N. V."Predictors of COVID‑19‑associated mortality among hospitalized elderly patients with dementia". Experimental and Therapeutic Medicine 26.2 (2023): 395.
Chicago
Georgakopoulou, V. E., Gkoufa, A., Tsakanikas, A., Makrodimitri, S., Karamanakos, G., Basoulis, D., Voutsinas, P. M., Eliadi, I., Bougea, A., Spandidos, D. A., Angelopoulou, E., Steiropoulos, P., Sipsas, N. V."Predictors of COVID‑19‑associated mortality among hospitalized elderly patients with dementia". Experimental and Therapeutic Medicine 26, no. 2 (2023): 395. https://doi.org/10.3892/etm.2023.12094
Copy and paste a formatted citation
x
Spandidos Publications style
Georgakopoulou VE, Gkoufa A, Tsakanikas A, Makrodimitri S, Karamanakos G, Basoulis D, Voutsinas PM, Eliadi I, Bougea A, Spandidos DA, Spandidos DA, et al: Predictors of COVID‑19‑associated mortality among hospitalized elderly patients with dementia. Exp Ther Med 26: 395, 2023.
APA
Georgakopoulou, V.E., Gkoufa, A., Tsakanikas, A., Makrodimitri, S., Karamanakos, G., Basoulis, D. ... Sipsas, N.V. (2023). Predictors of COVID‑19‑associated mortality among hospitalized elderly patients with dementia. Experimental and Therapeutic Medicine, 26, 395. https://doi.org/10.3892/etm.2023.12094
MLA
Georgakopoulou, V. E., Gkoufa, A., Tsakanikas, A., Makrodimitri, S., Karamanakos, G., Basoulis, D., Voutsinas, P. M., Eliadi, I., Bougea, A., Spandidos, D. A., Angelopoulou, E., Steiropoulos, P., Sipsas, N. V."Predictors of COVID‑19‑associated mortality among hospitalized elderly patients with dementia". Experimental and Therapeutic Medicine 26.2 (2023): 395.
Chicago
Georgakopoulou, V. E., Gkoufa, A., Tsakanikas, A., Makrodimitri, S., Karamanakos, G., Basoulis, D., Voutsinas, P. M., Eliadi, I., Bougea, A., Spandidos, D. A., Angelopoulou, E., Steiropoulos, P., Sipsas, N. V."Predictors of COVID‑19‑associated mortality among hospitalized elderly patients with dementia". Experimental and Therapeutic Medicine 26, no. 2 (2023): 395. https://doi.org/10.3892/etm.2023.12094
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