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Microascus cirrosus SZ 2021: A potentially new genotype of Microascus cirrosus, which can cause fatal pulmonary infection in patients with acute leukemia following haplo‑HSCT

  • Authors:
    • Jianjun Cheng
    • Daxiong Zeng
    • Ting Zhang
    • Lu Zhang
    • Xiu Han
    • Peng Zhou
    • Lin Wang
    • Jun He
    • Qingzhen Han
  • View Affiliations / Copyright

    Affiliations: Center of Clinical Laboratory, Dushu Lake Hospital Affiliated to Soochow University, Soochow University, Suzhou, Jiangsu 215000, P.R. China, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, Jiangsu 215006, P.R. China
    Copyright: © Cheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 404
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    Published online on: July 7, 2023
       https://doi.org/10.3892/etm.2023.12103
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Abstract

Uncommon Microascus cirrosus (M. cirrosus) species have been reported to cause an increasing number of subcutaneous and invasive fungal infections worldwide; since the first human infection was reported in 1992, seven cases have been reported in PubMed. The present study reports a novel genotype named M. cirrosus SZ 2021 isolated from a patient undergoing hematopoietic stem cell transplantation, who exhibited extensive drug resistance and suffered a fatal pulmonary infection. This isolated M. cirrosus was cultured and determined by morphological observation, multi‑locus sequence typing, matrix‑assisted laser desorption and ionization time‑of‑flight mass spectrometry, and whole genome sequencing by next‑generation sequencing. The whole nucleotide sequence (32.61 Mb) has been uploaded in the NCBI database (PRJNA835605). In addition, M. cirrosus SZ 2021 was not sensitive to the commonly used antifungal drugs, including fluconazole, amphotericin B, 5‑flucytosine and caspofungin. The current literature on human infections by M. cirrosus was reviewed to closely define the comprehensive clinical characteristics and etiological identification. In brief, the present study identified a new M. cirrosus and summarized the clinical characteristics of fungal pneumonia by M. cirrosus species. Complete laboratory identification methods from morphology to gene sequencing were also established for an improved etiological identification and further investigation into the real prevalence of invasive pneumonia by M. cirrosus.
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Copy and paste a formatted citation
Spandidos Publications style
Cheng J, Zeng D, Zhang T, Zhang L, Han X, Zhou P, Wang L, He J and Han Q: <em>Microascus cirrosus</em> SZ 2021: A potentially new genotype of <em>Microascus cirrosus</em>, which can cause fatal pulmonary infection in patients with acute leukemia following haplo‑HSCT. Exp Ther Med 26: 404, 2023.
APA
Cheng, J., Zeng, D., Zhang, T., Zhang, L., Han, X., Zhou, P. ... Han, Q. (2023). <em>Microascus cirrosus</em> SZ 2021: A potentially new genotype of <em>Microascus cirrosus</em>, which can cause fatal pulmonary infection in patients with acute leukemia following haplo‑HSCT. Experimental and Therapeutic Medicine, 26, 404. https://doi.org/10.3892/etm.2023.12103
MLA
Cheng, J., Zeng, D., Zhang, T., Zhang, L., Han, X., Zhou, P., Wang, L., He, J., Han, Q."<em>Microascus cirrosus</em> SZ 2021: A potentially new genotype of <em>Microascus cirrosus</em>, which can cause fatal pulmonary infection in patients with acute leukemia following haplo‑HSCT". Experimental and Therapeutic Medicine 26.2 (2023): 404.
Chicago
Cheng, J., Zeng, D., Zhang, T., Zhang, L., Han, X., Zhou, P., Wang, L., He, J., Han, Q."<em>Microascus cirrosus</em> SZ 2021: A potentially new genotype of <em>Microascus cirrosus</em>, which can cause fatal pulmonary infection in patients with acute leukemia following haplo‑HSCT". Experimental and Therapeutic Medicine 26, no. 2 (2023): 404. https://doi.org/10.3892/etm.2023.12103
Copy and paste a formatted citation
x
Spandidos Publications style
Cheng J, Zeng D, Zhang T, Zhang L, Han X, Zhou P, Wang L, He J and Han Q: <em>Microascus cirrosus</em> SZ 2021: A potentially new genotype of <em>Microascus cirrosus</em>, which can cause fatal pulmonary infection in patients with acute leukemia following haplo‑HSCT. Exp Ther Med 26: 404, 2023.
APA
Cheng, J., Zeng, D., Zhang, T., Zhang, L., Han, X., Zhou, P. ... Han, Q. (2023). <em>Microascus cirrosus</em> SZ 2021: A potentially new genotype of <em>Microascus cirrosus</em>, which can cause fatal pulmonary infection in patients with acute leukemia following haplo‑HSCT. Experimental and Therapeutic Medicine, 26, 404. https://doi.org/10.3892/etm.2023.12103
MLA
Cheng, J., Zeng, D., Zhang, T., Zhang, L., Han, X., Zhou, P., Wang, L., He, J., Han, Q."<em>Microascus cirrosus</em> SZ 2021: A potentially new genotype of <em>Microascus cirrosus</em>, which can cause fatal pulmonary infection in patients with acute leukemia following haplo‑HSCT". Experimental and Therapeutic Medicine 26.2 (2023): 404.
Chicago
Cheng, J., Zeng, D., Zhang, T., Zhang, L., Han, X., Zhou, P., Wang, L., He, J., Han, Q."<em>Microascus cirrosus</em> SZ 2021: A potentially new genotype of <em>Microascus cirrosus</em>, which can cause fatal pulmonary infection in patients with acute leukemia following haplo‑HSCT". Experimental and Therapeutic Medicine 26, no. 2 (2023): 404. https://doi.org/10.3892/etm.2023.12103
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