Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
August-2023 Volume 26 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2023 Volume 26 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Ethyl acetate extract of Gastrodia elata protects Caenorhabditis elegans from oxidative stress and amyloid β peptide toxicity

  • Authors:
    • Xiongfei Shi
    • Xingzhi Yu
    • Liping Yang
    • Xiaohua Duan
  • View Affiliations / Copyright

    Affiliations: Yunnan Key Laboratory of Dai and Yi Medicines, Yunnan University of Chinese Medicine, Kunming, Yunnan 650500, P.R. China
    Copyright: © Shi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 405
    |
    Published online on: July 7, 2023
       https://doi.org/10.3892/etm.2023.12104
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Gastrodia elata Blume is a traditional Chinese medicine with a long history, which has numerous pharmacological activities, such as anti‑inflammation, anti‑oxidation and protection of nerves. The present study investigated the regulatory effect of ethyl acetate extract of Gastrodia elata (EEGE) on the β‑amyloid (Aβ) toxicity of Caenorhabditis elegans (C. elegans). First, the main components of EEGE were analyzed using high‑performance liquid chromatography, and the total phenols, total flavonoids and total antioxidant capacity of EEGE were determined. Next, the regulation effect of EEGE on Aβ‑induced toxicity of C. elegans was evaluated through experiments on nematode paralysis, lifespan, oxidative and heat stress, locomotor ability, reproductive ability, reactive oxygen species (ROS) level, Aβ aggregation test, malondialdehyde (MDA) level, catalase (CAT) activity and superoxide dismutase (SOD) activity. Finally, the mechanism of EEGE was elucidated using RNA sequencing (RNA‑Seq) and the expression levels of related genes were verified using quantitative PCR. The present study revealed that the main components of EEGE included phosphorylated (p)‑hydroxybenzyl alcohol, p‑hydroxybenzaldehyde and 4,4'‑dihydroxydiphenylmethane, possessing strong in vitro free radical scavenging and reducing abilities. In addition, after the intervention of EEGE, the paralysis of nematodes could be delayed, the survival time of the nematodes was prolonged, the survival rate of the nematodes under stress (high temperature and oxidation) conditions was improved, the activity capacity and reproductive capacity of the nematodes were improved, the activities of SOD and CAT were improved and the levels of ROS and MDA were reduced. Notably, EEGE directly inhibited Aβ plaque aggregation in nematodes. RNA‑Seq analysis showed that EEGE regulated metabolism and longevity‑related genes, and these genes were regulated by the insulin/IGF‑1 signaling (IIS) pathway. Therefore, the present study hypothesized that the regulatory mechanism of EEGE was significantly related to the IIS pathway. The present research results demonstrated that the protective effect of EEGE on transgenic C. elegans was to reduce Aβ protein aggregation, improve the in vivo antioxidant level, effectively remove free radicals and to regulate the expression of genes related to IIS pathway, thereby reducing Aβ‑induced toxicity and delaying nematode paralysis.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Lane CA, Hardy J and Schott JM: Alzheimer's disease. Eur J Neurol. 25:59–70. 2018.PubMed/NCBI View Article : Google Scholar

2 

De Strooper B and Karran E: The cellular phase of Alzheimer's disease. Cell. 164:603–615. 2016.PubMed/NCBI View Article : Google Scholar

3 

Mohsenzadegan M and Mirshafiey A: The immunopathogenic role of reactive oxygen species in Alzheimer disease. Iran J Allergy Asthma Immunol. 11:203–216. 2012.PubMed/NCBI

4 

Alafuzoff I, Pikkarainen M, Arzberger T, Thal DR, Al-Sarraj S, Bell J, Bodi I, Budka H, Capetillo-Zarate E, Ferrer I, et al: Inter-laboratory comparison of neuropathological assessments of beta-amyloid protein: A study of the BrainNet Europe consortium. Acta Neuropathol. 115:533–546. 2008.PubMed/NCBI View Article : Google Scholar

5 

Zhang X, Kang X, Du L, Zhang L, Huang Y, Wang J, Wang S, Chang Y, Liu Y and Zhao Y: Tanshinone IIA loaded chitosan nanoparticles decrease toxicity of β-amyloid peptide in a Caenorhabditis elegans model of Alzheimer's disease. Free Radical BiolMed. 193:81–94. 2022.PubMed/NCBI View Article : Google Scholar

6 

Song X, Sun Y, Wang Z, Su Y, Wang Y and Wang X: Exendin-4 alleviates β-Amyloid peptide toxicity via DAF-16 in a Caenorhabditis elegans model of Alzheimer's disease. Front Aging Neurosci. 14(955113)2022.PubMed/NCBI View Article : Google Scholar

7 

Du F, Zhao H, Yao M, Yang Y, Jiao J and Li C: Deer antler extracts reduce amyloid-beta toxicity in a Caenorhabditis elegans model of Alzheimer's disease. J Ethnopharmacol. 285(114850)2022.PubMed/NCBI View Article : Google Scholar

8 

Zhi D, Yang W, Yue J, Xu S, Ma W, Zhao C, Wang X and Wang D: HSF-1 mediated combined ginsenosides ameliorating Alzheimer's disease like symptoms in Caernorhabditis elegans. Nutr Neurosci. 25:2136–2148. 2022.PubMed/NCBI View Article : Google Scholar

9 

Anand R, Gill KD and Mahdi AA: Therapeutics of Alzheimer's disease: Past, present and future. Neuropharmacology. 76 Pt A:27–50. 2014.PubMed/NCBI View Article : Google Scholar

10 

Sangha JS, Sun X, Wally OS, Zhang K, Ji X, Wang Z, Wang Y, Zidichouski J, Prithiviraj B and Zhang J: Liuwei Dihuang (LWDH), a traditional Chinese medicinal formula, protects against β-amyloid toxicity in transgenic Caenorhabditis elegans. PLoS One. 7(e43990)2012.PubMed/NCBI View Article : Google Scholar

11 

Li Y, Guan S, Liu C, Chen X, Zhu Y, Xie Y, Wang J, Ji X, Li L, Li Z, et al: Neuroprotective effects of Coptis Chinensis Franch polysaccharide on amyloid-beta (Aβ)-induced toxicity in a transgenic Caenorhabditis elegans model of Alzheimer's disease (AD). Int J Biol Macromol. 113:991–995. 2018.PubMed/NCBI View Article : Google Scholar

12 

Ding Y, Bao X, Lao L, Ling Y, Wang Q and Xu S: p-Hydroxybenzyl alcohol prevents memory deficits by increasing neurotrophic factors and decreasing inflammatory factors in a mice model of Alzheimer's disease. J Alzheimers Dis. 67:1007–1019. 2019.PubMed/NCBI View Article : Google Scholar

13 

He F, Duan X, Dai R, Wang W, Yang C and Lin Q: Protective effects of ethyl acetate extraction from Gastrodia elata blume on blood-brain barrier in focal cerebral ischemia reperfusion. Afr J Tradit Complement Altern Med. 13:199–209. 2016.PubMed/NCBI View Article : Google Scholar

14 

Huang Q, Zhang C, Qu S, Dong S, Ma Q, Hao Y, Liu Z, Wang S, Zhao H and Shi Y: Chinese herbal extracts exert neuroprotective effect in alzheimer's disease mouse through the dopaminergic synapse/apoptosis signaling pathway. Front Pharmacol. 13(817213)2022.PubMed/NCBI View Article : Google Scholar

15 

Heese K: Gastrodia elata Blume (Tianma): Hope for brain aging and dementia. Evid Based Complement Alternat Med. 2020(8870148)2020.PubMed/NCBI View Article : Google Scholar

16 

Mishra M, Huang J, Lee YY, Chua DSK, Lin X, Hu JM and Heese K: Gastrodia elata modulates amyloid precursor protein cleavage and cognitive functions in mice. Biosci Trends. 5:129–138. 2011.PubMed/NCBI View Article : Google Scholar

17 

Chen XY, Liao DC, Sun ML, Cui XH and Wang HB: Essential oil of acorus tatarinowii schott ameliorates Aβ-induced toxicity in caenorhabditis elegans through an autophagy pathway. Oxid Med Cell Longev. 2020(3515609)2020.PubMed/NCBI View Article : Google Scholar

18 

Lublin AL and Link CD: Alzheimer's disease drug discovery: In vivo screening using Caenorhabditis elegans as a model for β-amyloid peptide-induced toxicity. Drug Discov Today Technol. 10:e115–e119. 2013.PubMed/NCBI View Article : Google Scholar

19 

Dai R, Wang T, Si X, Jia Y, Wang L, Yuan Y, Lin Q and Yang C: Vasodilatory effects and underlying mechanisms of the ethyl acetate extracts from Gastrodia elata. Can J Physiol Pharmacol. 95:564–571. 2017.PubMed/NCBI View Article : Google Scholar

20 

Romero-Márquez JM, Navarro-Hortal MD, Jiménez-Trigo V, Vera-Ramírez L, Forbes-Hernández TJ, Esteban-Muñoz A, Giampieri F, Bullón P, Battino M, Sánchez-González C and Quiles JL: An oleuropein rich-olive (Olea europaea L.) leaf extract reduces β-amyloid and tau proteotoxicity through regulation of oxidative- and heat shock-stress responses in Caenorhabditis elegans. Food Chem Toxicol. 162(112914)2022.PubMed/NCBI View Article : Google Scholar

21 

Navarro-Hortal MD, Romero-Márquez JM, Esteban-Muñoz A, Sánchez-González C, Rivas-García L, Llopis J, Cianciosi D, Giampieri F, Sumalla-Cano S, Battino M and Quiles JL: Strawberry (Fragaria × ananassa cv. Romina) methanolic extract attenuates Alzheimer's beta amyloid production and oxidative stress by SKN-1/NRF and DAF-16/FOXO mediated mechanisms in C. elegans. Food Chem. 372(131272)2022.PubMed/NCBI View Article : Google Scholar

22 

Romero-Márquez JM, Navarro-Hortal MD, Jiménez-Trigo V, Muñoz-Ollero P, Forbes-Hernández TY, Esteban-Muñoz A, Giampieri F, Noya ID, Bullón P, Vera-Ramírez L, et al: An olive-derived extract 20% Rich in hydroxytyrosol prevents β-amyloid aggregation and oxidative stress, two features of Alzheimer disease, via SKN-1/NRF2 and HSP-16.2 in Caenorhabditis elegans. Antioxidants (Basel). 11(629)2022.PubMed/NCBI View Article : Google Scholar

23 

Qadir A, Aqil M, Ali A, Ahmad FJ, Ahmad S, Arif M and Khan N: GC-MS analysis of the methanolic extracts of Smilax China and Salix alba and their antioxidant activity. Turk J Chem. 44:352–363. 2020.PubMed/NCBI View Article : Google Scholar

24 

Re R, Pellegrini N, Proteggente A, Pannala A, Yang M and Rice-Evans C: Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radic Biol Med. 26:1231–1237. 1999.PubMed/NCBI View Article : Google Scholar

25 

DanQing L, YuJie G, ChengPeng Z, HongZhi D, Yi H, BiSheng H and Yan C: N-butanol extract of Hedyotis diffusa protects transgenic Caenorhabditis elegans from Aβ-induced toxicity. Phytother Res. 35:1048–1061. 2021.PubMed/NCBI View Article : Google Scholar

26 

Meng F, Li J, Rao Y, Wang W and Fu Y: Gengnianchun extends the lifespan of caenorhabditis elegans via the Insulin/IGF-1 signalling pathway. Oxid Med Cell Longev. 2018(4740739)2018.PubMed/NCBI View Article : Google Scholar

27 

Dilberger B, Baumanns S, Schmitt F, Schmiedl T, Hardt M, Wenzel U and Eckert GP: Mitochondrial oxidative stress impairs energy metabolism and reduces stress resistance and longevity of C. elegans. Oxid Med Cell Longev. 2019(6840540)2019.PubMed/NCBI View Article : Google Scholar

28 

Zhi D, Wang D, Yang W, Duan Z, Zhu S, Dong J, Wang N, Wang N, Fei D, Zhang Z, et al: Dianxianning improved amyloid β-induced pathological characteristics partially through DAF-2/DAF-16 insulin like pathway in transgenic C. elegans. Sci Rep. 7(11408)2017.PubMed/NCBI View Article : Google Scholar

29 

Wang X, Yi K and Zhao Y: Fucoidan inhibits amyloid-β-induced toxicity in transgenic Caenorhabditis elegans by reducing the accumulation of amyloid-β and decreasing the production of reactive oxygen species. Food Funct. 9:552–560. 2018.PubMed/NCBI View Article : Google Scholar

30 

Ito K and Murphy D: Application of ggplot2 to pharmacometric graphics. CPT Pharmacometrics Syst Pharmacol. 2(e79)2013.PubMed/NCBI View Article : Google Scholar

31 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

32 

Markesbery WR: Oxidative stress hypothesis in Alzheimer's disease. Free Radic Biol Med. 23:134–147. 1997.PubMed/NCBI View Article : Google Scholar

33 

Chiang PK, Lam MA and Luo Y: The many faces of amyloid beta in Alzheimer's disease. Curr Mol Med. 8:580–584. 2008.PubMed/NCBI View Article : Google Scholar

34 

Huang GB, Zhao T, Muna SS, Jin HM, Park JL, Jo KS, Lee BH, Chae SW, Kim SY, Park SH, et al: Therapeutic potential of Gastrodia elata Blume for the treatment of Alzheimer's disease. Neural Regen Res. 8:1061–1070. 2013.PubMed/NCBI View Article : Google Scholar

35 

Link CD: Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans. Proc Natl Acad Sci USA. 92:9368–9372. 1995.PubMed/NCBI View Article : Google Scholar

36 

Fay DS, Fluet A, Johnson CJ and Link CD: In vivo aggregation of beta-amyloid peptide variants. J Neurochem. 71:1616–1625. 1998.PubMed/NCBI View Article : Google Scholar

37 

Zhu S, Li H, Dong J, Yang W, Liu T, Wang Y, Wang X, Wang M and Zhi D: Rose essential oil delayed Alzheimer's disease-like symptoms by SKN-1 pathway in C. elegans. J Agric Food Chem. 65:8855–8865. 2017.PubMed/NCBI View Article : Google Scholar

38 

Pagano G, Rengo G, Pasqualetti G, Femminella GD, Monzani F, Ferrara N and Tagliati M: Cholinesterase inhibitors for Parkinson's disease: A systematic review and meta-analysis. J Neurol Neurosurg Psychiatry. 86:767–773. 2015.PubMed/NCBI View Article : Google Scholar

39 

Zhang Y, Li H, Jin S, Lu Y, Peng Y, Zhao L and Wang X: Cannabidiol protects against Alzheimer's disease in C. elegans via ROS scavenging activity of its phenolic hydroxyl groups. Eur J Pharmacol. 919(174829)2022.PubMed/NCBI View Article : Google Scholar

40 

Song E, Chung H, Shim E, Jeong JK, Han BK, Choi HJ and Hwang J: Gastrodia elata blume extract modulates antioxidant activity and ultraviolet a-irradiated skin aging in human dermal fibroblast cells. J Med Food. 19:1057–1064. 2016.PubMed/NCBI View Article : Google Scholar

41 

Liu Y, Lu YY, Huang L, Shi L, Zheng ZY, Chen JN, Qu Y, Xiao HT, Luo HR and Wu GS: Para-Hydroxybenzyl alcohol delays the progression of neurodegenerative diseases in models of caenorhabditis elegans through activating multiple cellular protective pathways. Oxid Med Cell Longev. 2022(8986287)2022.PubMed/NCBI View Article : Google Scholar

42 

Xin L, Yamujala R, Wang Y, Wang H, Wu WH, Lawton MA, Long C and Di R: Acetylcholineestarase-inhibiting alkaloids from Lycoris radiata delay paralysis of amyloid beta-expressing transgenic C. elegans CL4176. PLoS One. 8(e63874)2013.PubMed/NCBI View Article : Google Scholar

43 

Takahashi A, Watanabe T, Fujita T, Hasegawa T, Saito M and Suganuma M: Green tea aroma fraction reduces β-amyloid peptide-induced toxicity in Caenorhabditis elegans transfected with human β-amyloid minigene. Biosci Biotechnol Biochem. 78:1206–1211. 2014.PubMed/NCBI View Article : Google Scholar

44 

Yang J, Huang XB, Wan QL, Ding AJ, Yang ZL, Qiu MH, Sun HY, Qi SH and Luo HR: Otophylloside B protects against Aβ toxicity in caenorhabditis elegans models of Alzheimer's disease. Nat Prod Bioprospect. 7:207–214. 2017.PubMed/NCBI View Article : Google Scholar

45 

Pandey S, Phulara SC, Mishra SK, Bajpai R, Kumar A, Niranjan A, Lehri A, Upreti DK and Chauhan PS: Betula utilis extract prolongs life expectancy, protects against amyloid-β toxicity and reduces Alpha Synuclien in Caenorhabditis elegans via DAF-16 and SKN-1. Comp Biochem Physiol Toxicol Pharmacol. 228(108647)2020.PubMed/NCBI View Article : Google Scholar

46 

Yin JA, Gao G, Liu XJ, Hao ZQ, Li K, Kang XL, Li H, Shan YH, Hu WL, Li HP and Cai SQ: Genetic variation in glia-neuron signalling modulates ageing rate. Nature. 551:198–203. 2017.PubMed/NCBI View Article : Google Scholar

47 

Yue Y, Shen P, Chang AL, Qi W, Kim KH, Kim D and Park Y: trans-Trismethoxy resveratrol decreased fat accumulation dependent on fat-6 and fat-7 in Caenorhabditis elegans. Food Funct. 10:4966–4974. 2019.PubMed/NCBI View Article : Google Scholar

48 

Jia W, Su Q, Cheng Q, Peng Q, Qiao A, Luo X, Zhang J and Wang Y: Neuroprotective effects of palmatine via the enhancement of antioxidant defense and small heat shock protein expression in Aβ-transgenic caenorhabditis elegans. Oxid Med Cell Longe. 2021(9966223)2021.PubMed/NCBI View Article : Google Scholar

49 

Mendler M, Riedinger C, Schlotterer A, Volk N, Fleming T, Herzig S, Nawroth PP and Morcos M: Reduction in ins-7 gene expression in non-neuronal cells of high glucose exposed Caenorhabditis elegans protects from reactive metabolites, preserves neuronal structure and head motility, and prolongs lifespan. J Diabetes Complications. 31:304–310. 2017.PubMed/NCBI View Article : Google Scholar

50 

Murphy CT, McCarroll SA, Bargmann CI, Fraser A, Kamath RS, Ahringer J, Li H and Kenyon C: Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature. 424:277–283. 2003.PubMed/NCBI View Article : Google Scholar

51 

Lin C, Zhang X, Zhuang C, Lin Y, Cao Y and Chen Y: Healthspan improvements in caenorhabditis elegans with traditional chinese herbal tea. Oxid Med Cell Longev. 2020(4057841)2020.PubMed/NCBI View Article : Google Scholar

52 

Yang ZZ, Yu YT, Lin HR, Liao DC, Cui XH and Wang HB: Lonicera japonica extends lifespan and healthspan in Caenorhabditis elegans. Free Radic Biol Med. 129:310–322. 2018.PubMed/NCBI View Article : Google Scholar

53 

Brunet A: Aging and the control of the insulin-FOXO signaling pathway. Med Sci (Paris). 28:316–320. 2012.PubMed/NCBI View Article : Google Scholar : (In French).

54 

Liu T, Hua Z, Han P, Zhao Y, Zhou J, Jin Y, Li X, Huang L and Yuan Y: Mycorrhizosphere bacteria, rahnella sp. HPDA25, promotes the growth of armillaria gallica and its parasitic host gastrodia elata. Front Microbiol. 13(842893)2022.PubMed/NCBI View Article : Google Scholar

55 

Hu Y, Li C and Shen W: Gastrodin alleviates memory deficits and reduces neuropathology in a mouse model of Alzheimer's disease. Neuropathology. 34:370–377. 2014.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Shi X, Yu X, Yang L and Duan X: Ethyl acetate extract of <em>Gastrodia elata</em> protects <em>Caenorhabditis elegans</em> from oxidative stress and amyloid β peptide toxicity. Exp Ther Med 26: 405, 2023.
APA
Shi, X., Yu, X., Yang, L., & Duan, X. (2023). Ethyl acetate extract of <em>Gastrodia elata</em> protects <em>Caenorhabditis elegans</em> from oxidative stress and amyloid β peptide toxicity. Experimental and Therapeutic Medicine, 26, 405. https://doi.org/10.3892/etm.2023.12104
MLA
Shi, X., Yu, X., Yang, L., Duan, X."Ethyl acetate extract of <em>Gastrodia elata</em> protects <em>Caenorhabditis elegans</em> from oxidative stress and amyloid β peptide toxicity". Experimental and Therapeutic Medicine 26.2 (2023): 405.
Chicago
Shi, X., Yu, X., Yang, L., Duan, X."Ethyl acetate extract of <em>Gastrodia elata</em> protects <em>Caenorhabditis elegans</em> from oxidative stress and amyloid β peptide toxicity". Experimental and Therapeutic Medicine 26, no. 2 (2023): 405. https://doi.org/10.3892/etm.2023.12104
Copy and paste a formatted citation
x
Spandidos Publications style
Shi X, Yu X, Yang L and Duan X: Ethyl acetate extract of <em>Gastrodia elata</em> protects <em>Caenorhabditis elegans</em> from oxidative stress and amyloid β peptide toxicity. Exp Ther Med 26: 405, 2023.
APA
Shi, X., Yu, X., Yang, L., & Duan, X. (2023). Ethyl acetate extract of <em>Gastrodia elata</em> protects <em>Caenorhabditis elegans</em> from oxidative stress and amyloid β peptide toxicity. Experimental and Therapeutic Medicine, 26, 405. https://doi.org/10.3892/etm.2023.12104
MLA
Shi, X., Yu, X., Yang, L., Duan, X."Ethyl acetate extract of <em>Gastrodia elata</em> protects <em>Caenorhabditis elegans</em> from oxidative stress and amyloid β peptide toxicity". Experimental and Therapeutic Medicine 26.2 (2023): 405.
Chicago
Shi, X., Yu, X., Yang, L., Duan, X."Ethyl acetate extract of <em>Gastrodia elata</em> protects <em>Caenorhabditis elegans</em> from oxidative stress and amyloid β peptide toxicity". Experimental and Therapeutic Medicine 26, no. 2 (2023): 405. https://doi.org/10.3892/etm.2023.12104
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team