Open Access

Advances in targeted therapy and immunotherapy for melanoma (Review)

  • Authors:
    • Ziyao Qin
    • Mei Zheng
  • View Affiliations

  • Published online on: July 13, 2023     https://doi.org/10.3892/etm.2023.12115
  • Article Number: 416
  • Copyright: © Qin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Melanoma is the most aggressive and deadly type of skin cancer and is known for its poor prognosis as soon as metastasis occurs. Since 2011, new and effective therapies for metastatic melanoma have emerged, with US Food and Drug Administration approval of multiple targeted agents, such as V‑Raf murine sarcoma viral oncogene homolog B1/mitogen‑activated protein kinase kinase inhibitors and multiple immunotherapy agents, such as cytotoxic T lymphocyte‑associated protein 4 and anti‑programmed cell death protein 1/ligand 1 blockade. Based on insight into the respective advantages of the above two strategies, the present article provided a review of clinical trials of the application of targeted therapy and immunotherapy, as well as novel approaches of their combinations for the treatment of metastatic melanoma in recent years, with a focus on upcoming initiatives to improve the efficacy of these treatment approaches for metastatic melanoma.
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September-2023
Volume 26 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Qin Z and Qin Z: Advances in targeted therapy and immunotherapy for melanoma (Review). Exp Ther Med 26: 416, 2023
APA
Qin, Z., & Qin, Z. (2023). Advances in targeted therapy and immunotherapy for melanoma (Review). Experimental and Therapeutic Medicine, 26, 416. https://doi.org/10.3892/etm.2023.12115
MLA
Qin, Z., Zheng, M."Advances in targeted therapy and immunotherapy for melanoma (Review)". Experimental and Therapeutic Medicine 26.3 (2023): 416.
Chicago
Qin, Z., Zheng, M."Advances in targeted therapy and immunotherapy for melanoma (Review)". Experimental and Therapeutic Medicine 26, no. 3 (2023): 416. https://doi.org/10.3892/etm.2023.12115