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Online dynamic nomogram for predicting pain recurrence after microvascular decompression in trigeminal neuralgia

  • Authors:
    • Hongliang Wang
    • Sai Li
    • Zhiwei Wang
    • Dejun Wu
    • Zhifei Guo
    • Bing Zhao
    • Jinghai Wan
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230000, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 431
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    Published online on: July 21, 2023
       https://doi.org/10.3892/etm.2023.12130
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Abstract

Trigeminal neuralgia (TN) is one of the most common causes of facial pain. Microvascular decompression (MVD) is the first‑choice surgical treatment. The present study aimed to develop a novel practical assessment system based on preoperative clinical and imaging factors for clinicians to predict the likelihood of pain recurrence following MVD in TN. A total of 56 patients with primary unilateral TN who underwent MVD were retrospectively analyzed. Patients were followed up to observe pain recurrence 1 year after MVD. An online dynamic nomogram was constructed for predicting the probability of pain recurrence after MVD in patients with TN based on multivariate logistic model. The concordance index (C‑index) and receiver operating characteristic (ROC) were used to measure model discrimination. Bootstrap resampling was used for internal validation of the model and calibration curve was constructed. Decision curve analysis (DCA) was used to assess clinical applicability. Factors such as numeric rating scale (to score pain degree of patients with TN), response to neuroanalgesic drugs and neurovascular contact on magnetic resonance imaging were independent risk factors affecting the pain recurrence rate (all P<0.05).C‑index was 0.973 (95%CI, 0.938‑1.000) and the area under the ROC was 0.973 (95%CI, 0.938‑1.000). Calibration curve with a 1,000 bootstrap resampling showed a good fit between dynamic nomogram prediction and actual observations. The DCA showed that at a threshold probability between 0 and 100%, this model can achieve a greater net benefit than if all patients had surgery or none had surgery. In conclusion, this online dynamic nomogram reliably predicted risk of pain recurrence in patients with TN following MVD.
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1 

Cruccu G, Di Stefano G and Truini A: Trigeminal neuralgia. N Engl J Med. 383:754–762. 2020.PubMed/NCBI View Article : Google Scholar

2 

Cruccu G, Gronseth G, Alksne J, Argoff C, Brainin M, Burchiel K, Nurmikko T and Zakrzewska JM: American Academy of Neurology Society and European Federation of Neurological Society. AAN-EFNS guidelines on trigeminal neuralgia management. Eur J Neurol. 15:1013–1028. 2008.PubMed/NCBI View Article : Google Scholar

3 

Barker FG II, Jannetta PJ, Bissonette DJ, Larkins MV and Jho HD: The long-term outcome of microvascular decompression for trigeminal neuralgia. N Engl J Med. 334:1077–1083. 1996.PubMed/NCBI View Article : Google Scholar

4 

Zheng JH, Sun K, Zhang HT, Xie YJ, Wang-Yang LX, Chen HY and Wang C: A study on the recurrence rate of trigeminal neuralgia after MVD and the related factors. J Neurol Surg B Skull Base. 81:572–578. 2020.PubMed/NCBI View Article : Google Scholar

5 

Lee SH, Levy EI, Scarrow AM, Kassam A and Jannetta PJ: Recurrent trigeminal neuralgia attribuTable to veins after microvascular decompression. Neurosurgery. 46:356–361; discussion 361-362. 2000.PubMed/NCBI View Article : Google Scholar

6 

Meybodi AT, Habibi Z, Miri M and Tabatabaie SA: Microvascular decompression for trigeminal neuralgia using the ‘Stitched Sling Retraction’ technique in recurrent cases after previous microvascular decompression. Acta Neurochir (Wien). 156:1181–1187; discussion 1187. 2014.PubMed/NCBI View Article : Google Scholar

7 

Hardaway FA, Gustafsson HC, Holste K, Burchiel KJ and Raslan AM: A novel scoring system as a preoperative predictor for pain-free survival after microsurgery for trigeminal neuralgia. J Neurosurg. 1–8. 2019.PubMed/NCBI View Article : Google Scholar : (Online ahead of print).

8 

Panczykowski DM, Jani RH, Hughes MA and Sekula RF: Development and evaluation of a preoperative trigeminal neuralgia scoring system to predict long-term outcome following microvascular decompression. Neurosurgery. 87:71–79. 2020.PubMed/NCBI View Article : Google Scholar

9 

Katusic S, Beard CM, Bergstralh E and Kurland LT: Incidence and clinical features of trigeminal neuralgia, Rochester, Minnesota, 1945-1984. Ann Neurol. 27:89–95. 1990.PubMed/NCBI View Article : Google Scholar

10 

Zhang WB, Min LZ, Tao BB, Sun QY, Li ST and Wang XQ: Prognosis comparison of different branches of trigeminal neuralgia. World Neurosurg. 133:e1–e5. 2020.PubMed/NCBI View Article : Google Scholar

11 

Poshataev VK, Konovalov AN and Shimanskiy VN: [Surgical management of venous compression causing trigeminal neuralgia]. Zh Vopr Neirokhir Im N N Burdenko. 81:48–55. 2017.PubMed/NCBI View Article : Google Scholar : (In Russian).

12 

Kumar K, Das KK, Singh S, Khatri D, Deora H, Singh J, Bhaisora K, Srivastava AK, Jaiswal AK and Behari S: Vascular offenders in trigeminal neuralgia: A unified classification and assessment of the outcome of microvascular decompression. World Neurosurg. 127:e366–e375. 2019.PubMed/NCBI View Article : Google Scholar

13 

Liu J, Wu G, Jiang Y, Li L, Wang D and Liu R: Relationship between arterial blood pressure during trigeminal nerve combing and surgical outcome in patients with trigeminal neuralgia. World Neurosurg. 137:e98–e105. 2020.PubMed/NCBI View Article : Google Scholar

14 

Zakrzewska JM, Wu N, Lee JYK, Werneburg B, Hoffman D and Liu Y: Characterizing treatment utilization patterns for trigeminal neuralgia in the United States. Clin J Pain. 34:691–699. 2018.PubMed/NCBI View Article : Google Scholar

15 

Eller JL, Raslan AM and Burchiel KJ: Trigeminal neuralgia: Definition and classification. Neurosurg Focus. 18(E3)2005.PubMed/NCBI View Article : Google Scholar

16 

Maarbjerg S, Wolfram F, Gozalov A, Olesen J and Bendtsen L: Significance of neurovascular contact in classical trigeminal neuralgia. Brain. 138:311–319. 2015.PubMed/NCBI View Article : Google Scholar

17 

Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition. Cephalalgia. 38:1–211. 2018.PubMed/NCBI View Article : Google Scholar

18 

Bendtsen L, Zakrzewska JM, Abbott J, Braschinsky M, Di Stefano G, Donnet A, Eide PK, Leal PRL, Maarbjerg S, May A, et al: European academy of neurology guideline on trigeminal neuralgia. Eur J Neurol. 26:831–849. 2019.PubMed/NCBI View Article : Google Scholar

19 

Scholz J, Finnerup NB, Attal N, Aziz Q, Baron R, Bennett MI, Benoliel R, Cohen M, Cruccu G, Davis KD, et al: The IASP classification of chronic pain for ICD-11: Chronic neuropathic pain. Pain. 160:53–59. 2019.PubMed/NCBI View Article : Google Scholar

20 

Leal PR, Hermier M, Souza MA, Cristino-Filho G, Froment JC and Sindou M: Visualization of vascular compression of the trigeminal nerve with high-resolution 3T MRI: A prospective study comparing preoperative imaging analysis to surgical findings in 40 consecutive patients who underwent microvascular decompression for trigeminal neuralgia. Neurosurgery. 69:15–25; discussion 26. 2011.PubMed/NCBI View Article : Google Scholar

21 

Sandhu SK and Lee JY: Measurement of trigeminal neuralgia pain: Penn facial pain scale. Neurosurg Clin N Am. 27:327–336. 2016.PubMed/NCBI View Article : Google Scholar

22 

Ishaque AH, Xie H, Danyluk H, Wheatley BM, Broad R, Kong L and Sankar T: Comparison of prognostic scoring systems to predict durable pain relief after microvascular decompression for trigeminal neuralgia. World Neurosurg. 157:e432–e440. 2022.PubMed/NCBI View Article : Google Scholar

23 

Farrar JT, Young JP Jr, LaMoreaux L, Werth JL and Poole MR: Clinical importance of changes in chronic pain intensity measured on an 11-point numerical pain rating scale. Pain. 94:149–158. 2001.PubMed/NCBI View Article : Google Scholar

24 

Hawker GA, Mian S, Kendzerska T and French M: Measures of adult pain: Visual Analog Scale for Pain (VAS Pain), Numeric Rating Scale for Pain (NRS Pain), McGill Pain Questionnaire (MPQ), Short-Form McGill Pain Questionnaire (SF-MPQ), Chronic Pain Grade Scale (CPGS), Short Form-36 Bodily Pain Scale (SF-36 BPS), and measure of Intermittent and Constant Osteoarthritis Pain (ICOAP). Arthritis Care Res (Hoboken). 63 (Suppl 11):S240–S252. 2011.PubMed/NCBI View Article : Google Scholar

25 

Holste K, Chan AY, Rolston JD and Englot DJ: Pain outcomes following microvascular decompression for drug-resistant trigeminal neuralgia: A systematic review and meta-analysis. Neurosurgery. 86:182–190. 2020.PubMed/NCBI View Article : Google Scholar

26 

Chen Q, Yi DI, Perez JNJ, Liu M, Chang SD, Barad MJ, Lim M and Qian X: The molecular basis and pathophysiology of trigeminal neuralgia. Int J Mol Sci. 23(3604)2022.PubMed/NCBI View Article : Google Scholar

27 

Smith CA, Paskhover B and Mammis A: Molecular mechanisms of trigeminal neuralgia: A systematic review. Clin Neurol Neurosurg. 200(106397)2021.PubMed/NCBI View Article : Google Scholar

28 

Araya EI, Claudino RF, Piovesan EJ and Chichorro JG: Trigeminal neuralgia: Basic and clinical aspects. Curr Neuropharmacol. 18:109–119. 2020.PubMed/NCBI View Article : Google Scholar

29 

Yang CC, Lee MH, Yang JT, Chen KT, Huang WC, Tsai PJ, Kao CH, Liao CW and Lin MH: Percutaneous radiofrequency trigeminal rhizotomy benefits in patients with refractory trigeminal neuralgia. Medicine (Baltimore). 101(e29543)2022.PubMed/NCBI View Article : Google Scholar

30 

Chen M, Li Z, Yan Z, Ge S, Zhang Y, Yang H, Zhao L, Liu L, Zhang X, Cai Y and Qu Y: Predicting neurological deterioration after moderate traumatic brain injury: Development and validation of a prediction model based on data collected on admission. J Neurotrauma. 39:371–378. 2022.PubMed/NCBI View Article : Google Scholar

31 

Chen Z, Zhong M, Xu Z, Ye Q, Xie W, Gao S, Chen L, Qiu L, Jiang J, Wu H, et al: Development and validation of a nomogram based on geriatric nutritional risk index to predict surgical site infection among gynecologic oncology patients. Front Nutr. 9(864761)2022.PubMed/NCBI View Article : Google Scholar

32 

Guo X, Liu Y, Liu LJ, Li J, Zhao L, Jin XR, Yan W, Lin BQ, Shi S, Li ZY, et al: Development and validation of survival nomograms in colorectal cancer patients with synchronous liver metastases underwent simultaneous surgical treatment of primary and metastatic lesions. Am J Cancer Res. 11:2654–2669. 2021.PubMed/NCBI

33 

Theodosopoulos PV, Marco E, Applebury C, Lamborn KR and Wilson CB: Predictive model for pain recurrence after posterior fossa surgery for trigeminal neuralgia. Arch Neurol. 59:1297–1302. 2002.PubMed/NCBI View Article : Google Scholar

34 

Reinard K, Nerenz DR, Basheer A, Tahir R, Jelsema T, Schultz L, Malik G, Air EL and Schwalb JM: Racial disparities in the diagnosis and management of trigeminal neuralgia. J Neurosurg. 126:368–374. 2017.PubMed/NCBI View Article : Google Scholar

35 

Chang B, Zhu W and Li S: Effects of depression and anxiety on microvascular decompression outcome for trigeminal neuralgia patients. World Neurosurg. 128:e556–e561. 2019.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Wang H, Li S, Wang Z, Wu D, Guo Z, Zhao B and Wan J: Online dynamic nomogram for predicting pain recurrence after microvascular decompression in trigeminal neuralgia. Exp Ther Med 26: 431, 2023.
APA
Wang, H., Li, S., Wang, Z., Wu, D., Guo, Z., Zhao, B., & Wan, J. (2023). Online dynamic nomogram for predicting pain recurrence after microvascular decompression in trigeminal neuralgia. Experimental and Therapeutic Medicine, 26, 431. https://doi.org/10.3892/etm.2023.12130
MLA
Wang, H., Li, S., Wang, Z., Wu, D., Guo, Z., Zhao, B., Wan, J."Online dynamic nomogram for predicting pain recurrence after microvascular decompression in trigeminal neuralgia". Experimental and Therapeutic Medicine 26.3 (2023): 431.
Chicago
Wang, H., Li, S., Wang, Z., Wu, D., Guo, Z., Zhao, B., Wan, J."Online dynamic nomogram for predicting pain recurrence after microvascular decompression in trigeminal neuralgia". Experimental and Therapeutic Medicine 26, no. 3 (2023): 431. https://doi.org/10.3892/etm.2023.12130
Copy and paste a formatted citation
x
Spandidos Publications style
Wang H, Li S, Wang Z, Wu D, Guo Z, Zhao B and Wan J: Online dynamic nomogram for predicting pain recurrence after microvascular decompression in trigeminal neuralgia. Exp Ther Med 26: 431, 2023.
APA
Wang, H., Li, S., Wang, Z., Wu, D., Guo, Z., Zhao, B., & Wan, J. (2023). Online dynamic nomogram for predicting pain recurrence after microvascular decompression in trigeminal neuralgia. Experimental and Therapeutic Medicine, 26, 431. https://doi.org/10.3892/etm.2023.12130
MLA
Wang, H., Li, S., Wang, Z., Wu, D., Guo, Z., Zhao, B., Wan, J."Online dynamic nomogram for predicting pain recurrence after microvascular decompression in trigeminal neuralgia". Experimental and Therapeutic Medicine 26.3 (2023): 431.
Chicago
Wang, H., Li, S., Wang, Z., Wu, D., Guo, Z., Zhao, B., Wan, J."Online dynamic nomogram for predicting pain recurrence after microvascular decompression in trigeminal neuralgia". Experimental and Therapeutic Medicine 26, no. 3 (2023): 431. https://doi.org/10.3892/etm.2023.12130
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