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Predictors of negative outcomes in hospitalized patients with SARS‑CoV‑2 pneumonia: A retrospective study

  • Authors:
    • Alexandra-Maria Cristea
    • Dragos-Cosmin Zaharia
    • Daniela Jipa-Duna
    • Stefan Dumitrache-Rujinski
    • Oana Andreea Parliteanu
    • Alexandru Miron Bogdan
    • Claudia Lucia Toma

  • View Affiliations

  • Published online on: July 31, 2023     https://doi.org/10.3892/etm.2023.12137
  • Article Number: 437

  • Copyright: © Cristea et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The coronavirus disease 2019 (COVID‑19) pandemic posed a serious threat to human health worldwide after the first case was identified in December 2019. Specific therapeutic options for COVID‑19 are lacking; thus, the treatment of patients infected with severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) is complex in clinical practice. Despite the development of treatment options and methods to limit the spread of SARS‑CoV‑2, certain patients experience critical illness and numerous deaths have occurred. Notably, treatment of this disease is complex due to the evolution of viral mutations and variants with different rates of infection. Moreover, specific patient characteristics may be associated with rapid disease progression and poor outcomes. Thus, the present study aimed to identify the specific characteristics of patients who developed poor outcomes, including clinical manifestations, blood samples (blood cell count and coagulation tests) at hospital admission and comorbidities. The present study included a total of 1,813 patients hospitalized with pneumonia and SARS‑CoV‑2 infection, and mortality rates associated with each patient characteristic were calculated. The characteristics associated with the highest risk of mortality were as follows: Age >90 years (OR, 105; 95% CI, 17.70‑2,023.00); oxygen saturation at the time of hospital admission <89% in room air (OR, 14.3; 95% CI, 7.54‑30.7), admission to the Intensive Care Unit (OR, 39.4; 95% CI, 27.7‑57.0); and a neutrophil/lymphocyte ratio of 8.76‑54.2 (OR, 14; 95% CI, 7.62‑29.0). Treatment of patients with SARS‑CoV‑2 pneumonia represents a challenge for the healthcare system, but there are a number of predictors for poor patient outcomes that could be identified at the time of hospital admission.
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September-2023
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Spandidos Publications style
Cristea A, Zaharia D, Jipa-Duna D, Dumitrache-Rujinski S, Parliteanu OA, Bogdan AM and Toma CL: Predictors of negative outcomes in hospitalized patients with SARS‑CoV‑2 pneumonia: A retrospective study. Exp Ther Med 26: 437, 2023
APA
Cristea, A., Zaharia, D., Jipa-Duna, D., Dumitrache-Rujinski, S., Parliteanu, O.A., Bogdan, A.M., & Toma, C.L. (2023). Predictors of negative outcomes in hospitalized patients with SARS‑CoV‑2 pneumonia: A retrospective study. Experimental and Therapeutic Medicine, 26, 437. https://doi.org/10.3892/etm.2023.12137
MLA
Cristea, A., Zaharia, D., Jipa-Duna, D., Dumitrache-Rujinski, S., Parliteanu, O. A., Bogdan, A. M., Toma, C. L."Predictors of negative outcomes in hospitalized patients with SARS‑CoV‑2 pneumonia: A retrospective study". Experimental and Therapeutic Medicine 26.3 (2023): 437.
Chicago
Cristea, A., Zaharia, D., Jipa-Duna, D., Dumitrache-Rujinski, S., Parliteanu, O. A., Bogdan, A. M., Toma, C. L."Predictors of negative outcomes in hospitalized patients with SARS‑CoV‑2 pneumonia: A retrospective study". Experimental and Therapeutic Medicine 26, no. 3 (2023): 437. https://doi.org/10.3892/etm.2023.12137