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FIB‑4 index and serum α‑fetoprotein are useful predictors of hepatocellular carcinoma occurrence in hepatitis B patients with nucleos(t)ide analogs therapy

  • Authors:
    • Akifumi Kuwano
    • Masayuki Miyazaki
    • Masayoshi Yada
    • Kosuke Tanaka
    • Yuta Koga
    • Akihide Masumoto
    • Kenta Motomura
  • View Affiliations / Copyright

    Affiliations: Department of Hepatology, Aso Iizuka Hospital, Iizuka, Fukuoka 820‑8505, Japan
    Copyright: © Kuwano et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 441
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    Published online on: August 1, 2023
       https://doi.org/10.3892/etm.2023.12140
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Abstract

Current antiviral therapies cannot achieve eradication of hepatitis B virus (HBV) and can reduce but not eliminate the risk of hepatocellular carcinoma (HCC) in patients with chronic HBV infection. The present study aimed to identify the risk factors for HCC development by analyzing nucleoside analogue (NA)‑treated patients as a retrospective cohort using fibrosis‑4 index (FIB‑4 index) as a non‑invasive fibrosis marker. A total of 260 patients with HBV receiving NAs without a history of HCC between January 2001 and January 2021 were included in the present study. The incidence of HCC in patients with HBV during NA therapy and the factors contributing to HCC occurrence were identified using clinical characteristics and blood test results. Among the 260 patients, 40 patients (15.4%) developed HCC. Univariate and multivariate analysis showed that age [hazard ratio (HR), 1.03; P=0.045], male sex (HR, 3.14; P<0.01) and FIB‑4 index at 6 months after NA treatment <1.95 (HR, 4.35; P<0.01) correlated with the incidence of HCC. The cumulative incidence of HCC in patients with FIB‑4 index at 6 months after NA treatment >1.95 was significantly higher compared with that in patients with FIB‑4 index ≤1.95 (P<0.01). Multivariate analysis in patients in which serum α‑fetoprotein (AFP) level at 6 months after NA treatment was measured showed that FIB‑4 index >1.95 (HR, 8.27; P=0.014) and serum AFP level >4 ng/ml (HR, 4.26; P=0.033) contributed to HCC occurrence. FIB‑4 index at 6 months after NA treatment and serum AFP levels at 6 months after NA treatment were predictors for the development of HCC in patients with HBV during NA treatment. Further study of hepatocarcinogenesis during NA with a longer follow‑up period and larger numbers of participants is required.
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1 

Rumgay H, Ferlay J, de Martel C, Georges D, Ibrahim AS, Zheng R, Wei W, Lemmens VEPP and Soerjomataram I: Global, regional and national burden of primary liver cancer by subtype. Eur J Cancer. 161:108–118. 2022.PubMed/NCBI View Article : Google Scholar

2 

Trépo C, Chan HL and Lok A: Hepatitis B virus infection. Lancet. 384:2053–2063. 2014.PubMed/NCBI View Article : Google Scholar

3 

Global Burden of Disease Cancer Collaboration. Fitzmaurice C, Allen C, Barber RM, Barregard L, Bhutta ZA, Brenner H, Dicker DJ, Chimed-Orchir O, Dandona R, et al: Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 32 cancer groups, 1990 to 2015: A systematic analysis for the global burden of disease study. JAMA Oncol. 3:524–548. 2017.PubMed/NCBI View Article : Google Scholar

4 

El-Serag HB: Epidemiology of viral hepatitis and hepatocellular carcinoma. Gastroenterology. 142:1264–1273.e1. 2012.PubMed/NCBI View Article : Google Scholar

5 

Tong S and Revill P: Overview of hepatitis B viral replication and genetic variability. J Hepatol. 64 (1 Suppl):S4–S16. 2016.PubMed/NCBI View Article : Google Scholar

6 

European Association for the Study of the Liver. Electronic address: simpleeasloffice@easloffice.eu; European Association for the Study of the Liver. EASL 2017 clinical practice guidelines on the management of hepatitis B virus infection. J Hepatol. 67:370–398. 2017.PubMed/NCBI View Article : Google Scholar

7 

Terrault NA, Lok ASF, McMahon BJ, Chang KM, Hwang JP, Jonas MM, Brown RS Jr, Bzowej NH and Wong JB: Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance. Hepatology. 67:1560–1599. 2018.PubMed/NCBI View Article : Google Scholar

8 

Marcellin P, Gane E, Buti M, Afdhal N, Sievert W, Jacobson IM, Washington MK, Germanidis G, Flaherty JF, Aguilar Schall R, et al: Regression of cirrhosis during treatment with tenofovir disoproxil fumarate for chronic hepatitis B: A 5-year open-label follow-up study. Lancet. 381:468–475. 2013.PubMed/NCBI View Article : Google Scholar

9 

Hosaka T, Suzuki F, Kobayashi M, Seko Y, Kawamura Y, Sezaki H, Akuta N, Suzuki Y, Saitoh S, Arase Y, et al: Long-term entecavir treatment reduces hepatocellular carcinoma incidence in patients with hepatitis B virus infection. Hepatology. 58:98–107. 2013.PubMed/NCBI View Article : Google Scholar

10 

Nguyen MH, Yang HI, Le A, Henry L, Nguyen N, Lee MH, Zhang J, Wong C, Wong C and Trinh H: Reduced Incidence of Hepatocellular Carcinoma in Cirrhotic and Noncirrhotic Patients With Chronic Hepatitis B Treated With Tenofovir-A Propensity Score-Matched Study. J Infect Dis. 219:10–18. 2019.PubMed/NCBI View Article : Google Scholar

11 

Kumada T, Toyoda H, Tada T, Kiriyama S, Tanikawa M, Hisanaga Y, Kanamori A, Niinomi T, Yasuda S, Andou Y, et al: Effect of nucleos(t)ide analogue therapy on hepatocarcinogenesis in chronic hepatitis B patients: A propensity score analysis. J Hepatol. 58:427–433. 2013.PubMed/NCBI View Article : Google Scholar

12 

Papatheodoridis GV, Chan HL, Hansen BE, Janssen HL and Lampertico P: Risk of hepatocellular carcinoma in chronic hepatitis B: Assessment and modification with current antiviral therapy. J Hepatol. 62:956–967. 2015.PubMed/NCBI View Article : Google Scholar

13 

Lampertico P, Maini M and Papatheodoridis G: Optimal management of hepatitis B virus infection-EASL special conference. J Hepatol. 63:1238–1253. 2015.PubMed/NCBI View Article : Google Scholar

14 

Papatheodoridis G, Dalekos G, Sypsa V, Yurdaydin C, Buti M, Goulis J, Calleja JL, Chi H, Manolakopoulos S, Mangia G, et al: PAGE-B predicts the risk of developing hepatocellular carcinoma in Caucasians with chronic hepatitis B on 5-year antiviral therapy. J Hepatol. 64:800–806. 2016.PubMed/NCBI View Article : Google Scholar

15 

Wong VWS and Janssen HLA: Can we use HCC risk scores to individualize surveillance in chronic hepatitis B infection? J Hepatol. 63:722–732. 2015.PubMed/NCBI View Article : Google Scholar

16 

Marrero JA, Fontana RJ, Fu S, Conjeevaram HS, Su GL and Lok AS: Alcohol, tobacco and obesity are synergistic risk factors for hepatocellular carcinoma. J Hepatol. 42:218–224. 2005.PubMed/NCBI View Article : Google Scholar

17 

Tada T, Kumada T, Toyoda H, Tsuji K, Hiraoka A and Tanaka J: Impact of FIB-4 index on hepatocellular carcinoma incidence during nucleos(t)ide analogue therapy in patients with chronic hepatitis B: An analysis using time-dependent receiver operating characteristic. J Gastroenterol Hepatol. 32:451–458. 2017.PubMed/NCBI View Article : Google Scholar

18 

Tseng TC, Choi J, Nguyen MH, Peng CY, Siakavellas S, Papatheodoridis G, Wang CC, Lim YS, Lai HC, Trinh HN, et al: One-year fibrosis-4 index helps identify minimal HCC risk in non-cirrhotic chronic hepatitis B patients with antiviral treatment. Hepatol Int. 15:105–113. 2021.PubMed/NCBI View Article : Google Scholar

19 

Yang HI, Yuen MF, Chan HL, Han KH, Chen PJ, Kim DY, Ahn SH, Chen CJ, Wong VW and Seto WK: REACH-B Working Group. Risk estimation for hepatocellular carcinoma in chronic hepatitis B (REACH-B): Development and validation of a predictive score. Lancet Oncol. 12:568–574. 2011.PubMed/NCBI View Article : Google Scholar

20 

Wong VW, Chan SL, Mo F, Chan TC, Loong HH, Wong GL, Lui YY, Chan AT, Sung JJ, Yeo W, et al: Clinical scoring system to predict hepatocellular carcinoma in chronic hepatitis B carriers. J Clin Oncol. 28:1660–1665. 2010.PubMed/NCBI View Article : Google Scholar

21 

Yuen MF, Tanaka Y, Fong DY, Fung J, Wong DK, Yuen JC, But DY, Chan AO, Wong BC, Mizokami M and Lai CL: Independent risk factors and predictive score for the development of hepatocellular carcinoma in chronic hepatitis B. J Hepatol. 50:80–88. 2009.PubMed/NCBI View Article : Google Scholar

22 

Vallet-Pichard A, Mallet V, Nalpas B, Verkarre V, Nalpas A, Dhalluin-Venier V, Fontaine H and Pol S: FIB-4: An inexpensive and accurate marker of fibrosis in HCV infection. Comparison with liver biopsy and fibrotest. Hepatology. 46:32–36. 2007.PubMed/NCBI View Article : Google Scholar

23 

Drafting Committee for Hepatitis Management Guidelines, the Japan Society of Hepatology. Japan society of hepatology guidelines for the management of hepatitis B virus infection: 2019 Update. Hepatol Res. 50:892–923. 2020.PubMed/NCBI View Article : Google Scholar

24 

Kobashi H, Miyake Y, Ikeda F, Yasunaka T, Nishino K, Moriya A, Kubota J, Nakamura S, Takaki A, Nouso K, et al: Long-term outcome and hepatocellular carcinoma development in chronic hepatitis B or cirrhosis patients after nucleoside analog treatment with entecavir or lamivudine. Hepatol Res. 41:405–416. 2011.PubMed/NCBI View Article : Google Scholar

25 

Köklü S, Tuna Y, Gülşen MT, Demir M, Köksal AŞ, Koçkar MC, Aygün C, Coban S, Ozdil K, Ataseven H, et al: Long-term efficacy and safety of lamivudine, entecavir, and tenofovir for treatment of hepatitis B virus-related cirrhosis. Clin Gastroenterol Hepatol. 11:88–94. 2013.PubMed/NCBI View Article : Google Scholar

26 

Tacke F and Kroy DC: Treatment for hepatitis B in patients with drug resistance. Ann Transl Med. 4(334)2016.PubMed/NCBI View Article : Google Scholar

27 

Papatheodoridis GV, Lampertico P, Manolakopoulos S and Lok A: Incidence of hepatocellular carcinoma in chronic hepatitis B patients receiving nucleos(t)ide therapy: A systematic review. J Hepatol. 53:348–356. 2010.PubMed/NCBI View Article : Google Scholar

28 

Schafer DF and Sorrell MF: Hepatocellular carcinoma. Lancet. 353:1253–1257. 1999.PubMed/NCBI View Article : Google Scholar

29 

Okuda K: Hepatocellular carcinoma. J Hepatol. 32 (1 Suppl):S225–S237. 2000.PubMed/NCBI View Article : Google Scholar

30 

Kim JH, Kim JW, Seo JW, Choe WH and Kwon SY: Noninvasive tests for fibrosis predict 5-year mortality and hepatocellular carcinoma in patients with chronic hepatitis B. J Clin Gastroenterol. 50:882–888. 2016.PubMed/NCBI View Article : Google Scholar

31 

Suh B, Park S, Shin DW, Yun JM, Yang HK, Yu SJ, Shin CI, Kim JS, Ahn E, Lee H, et al: High liver fibrosis index FIB-4 is highly predictive of hepatocellular carcinoma in chronic hepatitis B carriers. Hepatology. 61:1261–1268. 2015.PubMed/NCBI View Article : Google Scholar

32 

Cho JY, Paik YH, Sohn W, Cho HC, Gwak GY, Choi MS, Lee JH, Koh KC, Paik SW and Yoo BC: Patients with chronic hepatitis B treated with oral antiviral therapy retain a higher risk for HCC compared with patients with inactive stage disease. Gut. 63:1943–1950. 2014.PubMed/NCBI View Article : Google Scholar

33 

Zoutendijk R, Reijnders JG, Zoulim F, Brown A, Mutimer DJ, Deterding K, Hofmann WP, Petersen J, Fasano M, Buti M, et al: Virological response to entecavir is associated with a better clinical outcome in chronic hepatitis B patients with cirrhosis. Gut. 62:760–765. 2013.PubMed/NCBI View Article : Google Scholar

34 

Chen CJ, Yang HI, Su J, Jen CL, You SL, Lu SN, Huang GT and Iloeje UH: REVEAL-HBV Study Group. Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level. JAMA. 295:65–73. 2006.PubMed/NCBI View Article : Google Scholar

35 

Chen G, Lin W, Shen F, Iloeje UH, London WT and Evans AA: Past HBV viral load as predictor of mortality and morbidity from HCC and chronic liver disease in a prospective study. Am J Gastroenterol. 101:1797–1803. 2006.PubMed/NCBI View Article : Google Scholar

36 

European Association for the Study of the Liver. Electronic address: simpleeasloffice@easloffice.eu; European Association for the Study of the Liver. EASL clinical practice guidelines: Management of hepatocellular carcinoma. J Hepatol. 69:182–236. 2018.PubMed/NCBI View Article : Google Scholar

37 

Oze T, Hiramatsu N, Yakushijin T, Miyazaki M, Yamada A, Oshita M, Hagiwara H, Mita E, Ito T, Fukui H, et al: Post-treatment levels of α-fetoprotein predict incidence of hepatocellular carcinoma after interferon therapy. Clin Gastroenterol Hepatol. 12:1186–1195. 2014.PubMed/NCBI View Article : Google Scholar

38 

Tada T, Kumada T, Toyoda H, Kiriyama S, Tanikawa M, Hisanaga Y, Kanamori A, Kitabatake S, Yama T and Tanaka J: Post-treatment levels of α-fetoprotein predict long-term hepatocellular carcinoma development after sustained virological response in patients with hepatitis C. Hepatol Res. 47:1021–1031. 2017.PubMed/NCBI View Article : Google Scholar

39 

Kuwano A, Yada M, Nagasawa S, Tanaka K, Morita Y, Masumoto A and Motomura K: Serum α-fetoprotein level at treatment completion is a useful predictor of hepatocellular carcinoma occurrence more than one year after hepatitis C virus eradication by direct-acting antiviral treatment. J Viral Hepat. 29:35–42. 2022.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Kuwano A, Miyazaki M, Yada M, Tanaka K, Koga Y, Masumoto A and Motomura K: FIB‑4 index and serum α‑fetoprotein are useful predictors of hepatocellular carcinoma occurrence in hepatitis B patients with nucleos(t)ide analogs therapy. Exp Ther Med 26: 441, 2023.
APA
Kuwano, A., Miyazaki, M., Yada, M., Tanaka, K., Koga, Y., Masumoto, A., & Motomura, K. (2023). FIB‑4 index and serum α‑fetoprotein are useful predictors of hepatocellular carcinoma occurrence in hepatitis B patients with nucleos(t)ide analogs therapy. Experimental and Therapeutic Medicine, 26, 441. https://doi.org/10.3892/etm.2023.12140
MLA
Kuwano, A., Miyazaki, M., Yada, M., Tanaka, K., Koga, Y., Masumoto, A., Motomura, K."FIB‑4 index and serum α‑fetoprotein are useful predictors of hepatocellular carcinoma occurrence in hepatitis B patients with nucleos(t)ide analogs therapy". Experimental and Therapeutic Medicine 26.3 (2023): 441.
Chicago
Kuwano, A., Miyazaki, M., Yada, M., Tanaka, K., Koga, Y., Masumoto, A., Motomura, K."FIB‑4 index and serum α‑fetoprotein are useful predictors of hepatocellular carcinoma occurrence in hepatitis B patients with nucleos(t)ide analogs therapy". Experimental and Therapeutic Medicine 26, no. 3 (2023): 441. https://doi.org/10.3892/etm.2023.12140
Copy and paste a formatted citation
x
Spandidos Publications style
Kuwano A, Miyazaki M, Yada M, Tanaka K, Koga Y, Masumoto A and Motomura K: FIB‑4 index and serum α‑fetoprotein are useful predictors of hepatocellular carcinoma occurrence in hepatitis B patients with nucleos(t)ide analogs therapy. Exp Ther Med 26: 441, 2023.
APA
Kuwano, A., Miyazaki, M., Yada, M., Tanaka, K., Koga, Y., Masumoto, A., & Motomura, K. (2023). FIB‑4 index and serum α‑fetoprotein are useful predictors of hepatocellular carcinoma occurrence in hepatitis B patients with nucleos(t)ide analogs therapy. Experimental and Therapeutic Medicine, 26, 441. https://doi.org/10.3892/etm.2023.12140
MLA
Kuwano, A., Miyazaki, M., Yada, M., Tanaka, K., Koga, Y., Masumoto, A., Motomura, K."FIB‑4 index and serum α‑fetoprotein are useful predictors of hepatocellular carcinoma occurrence in hepatitis B patients with nucleos(t)ide analogs therapy". Experimental and Therapeutic Medicine 26.3 (2023): 441.
Chicago
Kuwano, A., Miyazaki, M., Yada, M., Tanaka, K., Koga, Y., Masumoto, A., Motomura, K."FIB‑4 index and serum α‑fetoprotein are useful predictors of hepatocellular carcinoma occurrence in hepatitis B patients with nucleos(t)ide analogs therapy". Experimental and Therapeutic Medicine 26, no. 3 (2023): 441. https://doi.org/10.3892/etm.2023.12140
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