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A multimodal MRI study of functional and structural changes in concomitant exotropia

  • Authors:
    • Rui Hao
    • Yang Wang
    • Kailei Wang
    • Ang Wei
    • Wei Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Pediatric Ophthalmology and Strabismus, Tianjin Eye Hospital, Clinical College of Ophthalmology of Tianjin Medical University, Nankai University Affiliated Eye Hospital, Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin Eye Institute, Tianjin 300020, P.R. China, Department of Radiology, Tianjin Medical University General Hospital, Tianjin Key Laboratory of Functional Imaging, Tianjin 300052, P.R. China, Department of Pediatric Ophthalmology and Strabismus, Tianjin Eye Hospital, Clinical College of Ophthalmology of Tianjin Medical University, Nankai University Affiliated Eye Hospital, Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin Eye Institute, Tianjin 300020, P.R. China, Department of Ophthalmology, Tianjin Hospital of Integrated Traditional Chinese and Western Medicine, Nankai Hospital, Tianjin 300102, P.R. China
    Copyright: © Hao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 442
    |
    Published online on: August 1, 2023
       https://doi.org/10.3892/etm.2023.12141
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Abstract

The present prospective study aimed to investigate the structural and functional changes in patients with concomitant exotropia using multimodal MRI. A total of 11 adult patients with concomitant exotropia (5 males and 6 females) and 11 healthy adult individuals (5 males and 6 females) were recruited and examined using multimodal MRI techniques. Near and distance exotropia deviation angles were measured. The structrual changes were evaluated using the gray matter volume. Functional reorganization was assessed using the amplitude of low‑frequency fluctuation, regional homogeneity and resting‑state functional connectivity (FC) on MRI. No significant differences could be found in terms of sex, age or body mass index between the two groups. However, the near and distance exotropia angles were significantly higer in the concomitant exotropia group compared with those in the normal control group (P<0.001). Compared with those in normal individuals, the bilateral thalamus, right middle temporal gyrus (MTG) and right cuneus had significantly reduced gray matter volumes in the concomitant exotropia group (false discovery rate corrected, P<0.05). Reduced FC was found between the bilateral thalamus and the bilateral precuneus, between the right MTG and the right medial superior frontal gyrus in addition to the right precuneus, and between the right cuneus and the right primary sensorimotor cortex (P<0.05, Gaussian random‑field corrected) in the concomitant exotropia group compared with that in the normal individuals. In conclusion, the present study indicated that structural and functional reorganization occurs in specific brain regions of patients with concomitant exotropia. These reorganized areas appeared to mainly involve the subcortical structures and related cortices that process visual information.
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Copy and paste a formatted citation
Spandidos Publications style
Hao R, Wang Y, Wang K, Wei A and Zhang W: A multimodal MRI study of functional and structural changes in concomitant exotropia. Exp Ther Med 26: 442, 2023.
APA
Hao, R., Wang, Y., Wang, K., Wei, A., & Zhang, W. (2023). A multimodal MRI study of functional and structural changes in concomitant exotropia. Experimental and Therapeutic Medicine, 26, 442. https://doi.org/10.3892/etm.2023.12141
MLA
Hao, R., Wang, Y., Wang, K., Wei, A., Zhang, W."A multimodal MRI study of functional and structural changes in concomitant exotropia". Experimental and Therapeutic Medicine 26.3 (2023): 442.
Chicago
Hao, R., Wang, Y., Wang, K., Wei, A., Zhang, W."A multimodal MRI study of functional and structural changes in concomitant exotropia". Experimental and Therapeutic Medicine 26, no. 3 (2023): 442. https://doi.org/10.3892/etm.2023.12141
Copy and paste a formatted citation
x
Spandidos Publications style
Hao R, Wang Y, Wang K, Wei A and Zhang W: A multimodal MRI study of functional and structural changes in concomitant exotropia. Exp Ther Med 26: 442, 2023.
APA
Hao, R., Wang, Y., Wang, K., Wei, A., & Zhang, W. (2023). A multimodal MRI study of functional and structural changes in concomitant exotropia. Experimental and Therapeutic Medicine, 26, 442. https://doi.org/10.3892/etm.2023.12141
MLA
Hao, R., Wang, Y., Wang, K., Wei, A., Zhang, W."A multimodal MRI study of functional and structural changes in concomitant exotropia". Experimental and Therapeutic Medicine 26.3 (2023): 442.
Chicago
Hao, R., Wang, Y., Wang, K., Wei, A., Zhang, W."A multimodal MRI study of functional and structural changes in concomitant exotropia". Experimental and Therapeutic Medicine 26, no. 3 (2023): 442. https://doi.org/10.3892/etm.2023.12141
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