|
1
|
Soria Lopez JA, González HM and Léger GC:
Alzheimer's disease. Handb Clin Neurol. 167:231–255.
2019.PubMed/NCBI View Article : Google Scholar
|
|
2
|
Tiwari S, Atluri V, Kaushik A, Yndart A
and Nair M: Alzheimer's disease: Pathogenesis, diagnostics, and
therapeutics. Int J Nanomedicine. 14:5541–5554. 2019.PubMed/NCBI View Article : Google Scholar
|
|
3
|
Ayers D and Scerri C: Non-coding RNA
influences in dementia. Noncoding RNA Res. 3:188–194.
2018.PubMed/NCBI View Article : Google Scholar
|
|
4
|
Panza F, Lozupone M, Logroscino G and
Imbimbo BP: A critical appraisal of amyloid-β-targeting therapies
for Alzheimer disease. Nat Rev Neurol. 15:73–88. 2019.PubMed/NCBI View Article : Google Scholar
|
|
5
|
Gao Y and Tan L, Yu JT and Tan L: Tau in
Alzheimer's disease: Mechanisms and therapeutic strategies. Curr
Alzheimer Res. 15:283–300. 2018.PubMed/NCBI View Article : Google Scholar
|
|
6
|
Fernández-Calle R, Konings SC,
Frontiñán-Rubio J, García-Revilla J, Camprubí-Ferrer L, Svensson M,
Martinson I, Boza-Serrano A, Venero JL, Nielsen HM, et al: APOE in
the bullseye of neurodegenerative diseases: Impact of the APOE
genotype in Alzheimer's disease pathology and brain diseases. Mol
Neurodegener. 17(62)2022.PubMed/NCBI View Article : Google Scholar
|
|
7
|
Honjo K, Black SE and Verhoeff NPLG:
Alzheimer's disease, cerebrovascular disease, and the β-amyloid
cascade. Can J Neurol Sci. 39:712–728. 2012.PubMed/NCBI View Article : Google Scholar
|
|
8
|
Sharma K: Cholinesterase inhibitors as
Alzheimer's therapeutics (review). Mol Med Rep. 20:1479–1487.
2019.PubMed/NCBI View Article : Google Scholar
|
|
9
|
Hynd MR, Scott HL and Dodd PR:
Glutamate-mediated excitotoxicity and neurodegeneration in
Alzheimer's disease. Neurochem Int. 45:583–595. 2004.PubMed/NCBI View Article : Google Scholar
|
|
10
|
Sun MK: Roles of neural regeneration in
memory pharmacology. Neural Regen Res. 13:406–407. 2018.PubMed/NCBI View Article : Google Scholar
|
|
11
|
Altman J and Das GD: Autoradiographic and
histological evidence of postnatal hippocampal neurogenesis in
rats. J Comp Neurol. 124:319–335. 1965.PubMed/NCBI View Article : Google Scholar
|
|
12
|
von Bohlen Und Halbach O:
Immunohistological markers for staging neurogenesis in adult
hippocampus. Cell Tissue Res. 329:409–420. 2007.PubMed/NCBI View Article : Google Scholar
|
|
13
|
Low VF, Faull RL, Bennet L, Gunn AJ and
Curtis MA: Neurogenesis and progenitor cell distribution in the
subgranular zone and subventricular zone of the adult sheep brain.
Neuroscience. 244:173–187. 2013.PubMed/NCBI View Article : Google Scholar
|
|
14
|
Gould E, Reeves AJ, Graziano MS and Gross
CG: Neurogenesis in the neocortex of adult primates. Science.
286:548–552. 1999.PubMed/NCBI View Article : Google Scholar
|
|
15
|
Farzanehfar P: Comparative review of adult
midbrain and striatum neurogenesis with classical neurogenesis.
Neurosci Res. 134:1–9. 2018.PubMed/NCBI View Article : Google Scholar
|
|
16
|
Tobin MK, Musaraca K, Disouky A, Shetti A,
Bheri A, Honer WG, Kim N, Dawe RJ, Bennett DA, Arfanakis K and
Lazarov O: Human hippocampal neurogenesis persists in aged adults
and Alzheimer's disease patients. Cell Stem Cell. 24:974–982.e3.
2019.PubMed/NCBI View Article : Google Scholar
|
|
17
|
Scheff SW, Price DA, Schmitt FA and Mufson
EJ: Hippocampal synaptic loss in early Alzheimer's disease and mild
cognitive impairment. Neurobiol Aging. 27:1372–1384.
2006.PubMed/NCBI View Article : Google Scholar
|
|
18
|
Wang YJ, Gong WG, Ren QG and Zhang ZJ:
Escitalopram alleviates Alzheimer's disease-type tau pathologies in
the aged P301L tau transgenic mice. J Alzheimers Dis. 77:807–819.
2020.PubMed/NCBI View Article : Google Scholar
|
|
19
|
Zhang L, Qin Z, Sharmin F, Lin W, Ricke
KM, Zasloff MA, Stewart AFR and Chen HH: Tyrosine phosphatase PTP1B
impairs presynaptic NMDA receptor-mediated plasticity in a mouse
model of Alzheimer's disease. Neurobiol Dis.
156(105402)2021.PubMed/NCBI View Article : Google Scholar
|
|
20
|
Yang XB, Zu HB, Zhao YF and Yao K:
Agomelatine prevents amyloid plaque deposition, tau
phosphorylation, and neuroinflammation in APP/PS1 mice. Front Aging
Neurosci. 13(766410)2022.PubMed/NCBI View Article : Google Scholar
|
|
21
|
Duan S, Guan X, Lin R, Liu X, Yan Y, Lin
R, Zhang T, Chen X, Huang J, Sun X, et al: Silibinin inhibits
acetylcholinesterase activity and amyloid β peptide aggregation: A
dual-target drug for the treatment of Alzheimer's disease.
Neurobiol Aging. 36:1792–1807. 2015.PubMed/NCBI View Article : Google Scholar
|
|
22
|
He Z, Li X, Wang Z, Tu S, Feng J, Du X, Ni
J, Li N and Liu Q: Esculentoside A alleviates cognitive deficits
and amyloid pathology through peroxisome proliferator-activated
receptor γ-dependent mechanism in an Alzheimer's disease model.
Phytomedicine. 98(153956)2022.PubMed/NCBI View Article : Google Scholar : (Epub ahead of
print).
|
|
23
|
Wang C, Zheng D, Weng F, Jin Y and He L:
Sodium butyrate ameliorates the cognitive impairment of Alzheimer's
disease by regulating the metabolism of astrocytes.
Psychopharmacology (Berl). 239:215–227. 2022.PubMed/NCBI View Article : Google Scholar
|
|
24
|
Zhang HA, Yuan CX, Liu KF, Yang QF, Zhao
J, Li H, Yang QH, Song D, Quan ZZ and Qing H: Neural stem cell
transplantation alleviates functional cognitive deficits in a mouse
model of tauopathy. Neural Regen Res. 17:152–162. 2022.PubMed/NCBI View Article : Google Scholar
|
|
25
|
Lilja AM, Malmsten L, Röjdner J, Voytenko
L, Verkhratsky A, Ögren SO, Nordberg A and Marutle A: Neural stem
cell transplant-induced effect on neurogenesis and cognition in
Alzheimer Tg2576 mice is inhibited by concomitant treatment with
amyloid-lowering or cholinergic α7 nicotinic receptor drugs. Neural
Plast. 2015(370432)2015.PubMed/NCBI View Article : Google Scholar
|
|
26
|
Li W, Kong LH, Wang H, Shen F, Wang YW,
Zhou H and Sun GJ: High-frequency electroacupuncture evidently
reinforces hippocampal synaptic transmission in Alzheimer's disease
rats. Neural Regen Res. 11:801–806. 2016.PubMed/NCBI View Article : Google Scholar
|
|
27
|
Riolo G, Ricci C, De Angelis N, Marzocchi
C, Guerrera G, Borsellino G, Giannini F and Battistini S: BDNF and
pro-BDNF in amyotrophic lateral sclerosis: A new perspective for
biomarkers of neurodegeneration. Brain Sci. 12(617)2022.PubMed/NCBI View Article : Google Scholar
|
|
28
|
Levey AI, Qiu D, Zhao L, Hu WT, Duong DM,
Higginbotham L, Dammer EB, Seyfried NT, Wingo TS, Hales CM, et al:
A phase II study repurposing atomoxetine for neuroprotection in
mild cognitive impairment. Brain. 145:1924–1938. 2022.PubMed/NCBI View Article : Google Scholar
|
|
29
|
Zoladz JA, Majerczak J, Zeligowska E,
Mencel J, Jaskolski A, Jaskolska A and Marusiak J:
Moderate-intensity interval training increases serum brain-derived
neurotrophic factor level and decreases inflammation in Parkinson's
disease patients. J Physiol Pharmacol. 65:441–448. 2014.PubMed/NCBI
|
|
30
|
Eyileten C, Sharif L, Wicik Z, Jakubik D,
Jarosz-Popek J, Soplinska A, Postula M, Czlonkowska A,
Kaplon-Cieslicka A and Mirowska-Guzel D: The relation of the
brain-derived neurotrophic factor with MicroRNAs in
neurodegenerative diseases and ischemic stroke. Mol Neurobiol.
58:329–347. 2021.PubMed/NCBI View Article : Google Scholar
|
|
31
|
Ball S, Marangell LB, Lipsius S and
Russell JM: Brain-derived neurotrophic factor in generalized
anxiety disorder: results from a duloxetine clinical trial. Prog
Neuropsychopharmacol Biol Psychiatry. 43:217–221. 2013.PubMed/NCBI View Article : Google Scholar
|
|
32
|
Shekari A and Fahnestock M: Retrograde
axonal transport of BDNF and proNGF diminishes with age in basal
forebrain cholinergic neurons. Neurobiol Aging. 84:131–140.
2019.PubMed/NCBI View Article : Google Scholar
|
|
33
|
Thoenen H, Zafra F, Hengerer B and
Lindholm D: The synthesis of nerve growth factor and brain-derived
neurotrophic factor in hippocampal and cortical neurons is
regulated by specific transmitter systems. Ann N Y Acad Sci.
640:86–90. 1991.PubMed/NCBI View Article : Google Scholar
|
|
34
|
Nagahara AH, Merrill DA, Coppola G,
Tsukada S, Schroeder BE, Shaked GM, Wang L, Blesch A, Kim A, Conner
JM, et al: Neuroprotective effects of brain-derived neurotrophic
factor in rodent and primate models of Alzheimer's disease. Nat
Med. 15:331–337. 2009.PubMed/NCBI View Article : Google Scholar
|
|
35
|
Arora S, Kanekiyo T and Singh J:
Functionalized nanoparticles for brain targeted BDNF gene therapy
to rescue Alzheimer's disease pathology in transgenic mouse model.
Int J Biol Macromol. 208:901–911. 2022.PubMed/NCBI View Article : Google Scholar
|
|
36
|
Beeri MS and Sonnen J: Brain BDNF
expression as a biomarker for cognitive reserve against Alzheimer
disease progression. Neurology. 86:702–703. 2016.PubMed/NCBI View Article : Google Scholar
|
|
37
|
Dong BE, Chen H and Sakata K: BDNF
deficiency and enriched environment treatment affect
neurotransmitter gene expression differently across ages. J
Neurochem. 154:41–55. 2020.PubMed/NCBI View Article : Google Scholar
|
|
38
|
Paraskevopoulou F, Herman MA and Rosenmund
C: Glutamatergic innervation onto striatal neurons potentiates
GABAergic synaptic output. J Neurosci. 39:4448–4460.
2019.PubMed/NCBI View Article : Google Scholar
|
|
39
|
Miyazaki S, Oikawa H, Takekoshi H,
Hoshizaki M, Ogata M and Fujikawa T: Anxiolytic effects of
acanthopanax senticosus HARMS occur via regulation of autonomic
function and activate hippocampal BDNF-TrkB signaling. Molecules.
24(132)2018.PubMed/NCBI View Article : Google Scholar
|
|
40
|
Li Y, Xiang L, Wang C, Song Y, Miao J and
Miao M: Protection against acute cerebral ischemia/reperfusion
injury by leonuri herba total alkali via modulation of
BDNF-TrKB-PI3K/Akt signaling pathway in rats. Biomed Pharmacother.
133(111021)2021.PubMed/NCBI View Article : Google Scholar
|
|
41
|
Yamaguchi A, Tamatani M, Matsuzaki H,
Namikawa K, Kiyama H, Vitek MP, Mitsuda N and Tohyama M: Akt
activation protects hippocampal neurons from apoptosis by
inhibiting transcriptional activity of p53. J Biol Chem.
276:5256–5264. 2001.PubMed/NCBI View Article : Google Scholar
|
|
42
|
Chimenti MS, Sunzini F, Fiorucci L, Botti
E, Fonti GL, Conigliaro P, Triggianese P, Costa L, Caso F, Giunta
A, et al: Potential role of cytochrome c and tryptase in psoriasis
and psoriatic arthritis pathogenesis: Focus on resistance to
apoptosis and oxidative stress. Front Immunol.
9(2363)2018.PubMed/NCBI View Article : Google Scholar
|
|
43
|
Zhou LJ, Mo YB, Bu X, Wang JJ, Bai J,
Zhang JW, Cheng AB, Ma JH, Wang YW and Xie YX: Erinacine
facilitates the opening of the mitochondrial permeability
transition pore through the inhibition of the PI3K/Akt/GSK-3β
signaling pathway in human hepatocellular carcinoma. Cell Physiol
Biochem. 50:851–867. 2018.PubMed/NCBI View Article : Google Scholar
|
|
44
|
Jiang T, Wang XQ, Ding C and Du XL:
Genistein attenuates isoflurane-induced neurotoxicity and improves
impaired spatial learning and memory by regulating cAMP/CREB and
BDNF-TrkB-PI3K/Akt signaling. Korean J Physiol Pharmacol.
21:579–589. 2017.PubMed/NCBI View Article : Google Scholar
|
|
45
|
Merkouris S, Barde YA, Binley KE, Allen
ND, Stepanov AV, Wu NC, Grande G, Lin CW, Li M, Nan X, et al: Fully
human agonist antibodies to TrkB using autocrine cell-based
selection from a combinatorial antibody library. Proc Natl Acad Sci
USA. 115:E7023–E7032. 2018.PubMed/NCBI View Article : Google Scholar
|
|
46
|
Tacke C, DiStefano PS, Lindsay RM,
Metzdorf K, Zagrebelsky M and Korte M: Actions of the TrkB agonist
antibody ZEB85 in regulating the architecture and synaptic
plasticity in hippocampal neurons. Front Mol Neurosci.
15(945348)2022.PubMed/NCBI View Article : Google Scholar
|
|
47
|
Chen C, Wang Z, Zhang Z, Liu X, Kang SS,
Zhang Y and Ye K: The prodrug of 7,8-dihydroxyflavone development
and therapeutic efficacy for treating Alzheimer's disease. Proc
Natl Acad Sci USA. 115:578–583. 2018.PubMed/NCBI View Article : Google Scholar
|
|
48
|
Fan CH, Lin CW, Huang HJ, Lee-Chen GJ, Sun
YC, Lin W, Chen CM, Chang KH, Su MT and Hsieh-Li HM: LMDS-1, a
potential TrkB receptor agonist provides a safe and neurotrophic
effect for early-phase Alzheimer's disease. Psychopharmacology
(Berl). 237:3173–3190. 2020.PubMed/NCBI View Article : Google Scholar
|
|
49
|
Tuszynski MH, Yang JH, Barba D, U HS,
Bakay RA, Pay MM, Masliah E, Conner JM, Kobalka P, Roy S and
Nagahara AH: Nerve growth factor gene therapy: Activation of
neuronal responses in Alzheimer disease. JAMA Neurol. 72:1139–1147.
2015.PubMed/NCBI View Article : Google Scholar
|
|
50
|
Rocco ML, Soligo M, Manni L and Aloe L:
Nerve growth factor: Early studies and recent clinical trials. Curr
Neuropharmacol. 16:1455–1465. 2018.PubMed/NCBI View Article : Google Scholar
|
|
51
|
Ding XW, Li R, Geetha T, Tao YX and Babu
JR: Nerve growth factor in metabolic complications and Alzheimer's
disease: Physiology and therapeutic potential. Biochim Biophys Acta
Mol Basis Dis. 1866(165858)2020.PubMed/NCBI View Article : Google Scholar
|
|
52
|
Tiveron C, Fasulo L, Capsoni S, Malerba F,
Marinelli S, Paoletti F, Piccinin S, Scardigli R, Amato G, Brandi
R, et al: ProNGF\NGF imbalance triggers learning and memory
deficits, neurodegeneration and spontaneous epileptic-like
discharges in transgenic mice. Cell Death Differ. 20:1017–1030.
2013.PubMed/NCBI View Article : Google Scholar
|
|
53
|
Mitra S, Behbahani H and Eriksdotter M:
Innovative therapy for Alzheimer's disease-with focus on
biodelivery of NGF. Front Neurosci. 13(38)2019.PubMed/NCBI View Article : Google Scholar
|
|
54
|
Ruberti F, Capsoni S, Comparini A, Di
Daniel E, Franzot J, Gonfloni S, Rossi G, Berardi N and Cattaneo A:
Phenotypic knockout of nerve growth factor in adult transgenic mice
reveals severe deficits in basal forebrain cholinergic neurons,
cell death in the spleen, and skeletal muscle dystrophy. J
Neurosci. 20:2589–2601. 2000.PubMed/NCBI View Article : Google Scholar
|
|
55
|
Soligo M, Albini M, Bertoli FL, Marzano V,
Protto V, Bracci-Laudiero L, Minnone G, De Benedetti F, Chiaretti
A, Mantuano E and Manni L: Different responses of PC12 cells to
different pro-nerve growth factor protein variants. Neurochem Int.
129(104498)2019.PubMed/NCBI View Article : Google Scholar
|
|
56
|
Isaev NK, Stelmashook EV and Genrikhs EE:
Role of nerve growth factor in plasticity of forebrain cholinergic
neurons. Biochemistry (Mosc). 82:291–300. 2017.PubMed/NCBI View Article : Google Scholar
|
|
57
|
Delivanoglou N, Boziki M, Theotokis P,
Kesidou E, Touloumi O, Dafi N, Nousiopoulou E, Lagoudaki R,
Grigoriadis N, Charalampopoulos I and Simeonidou C: Spatio-temporal
expression profile of NGF and the two-receptor system, TrkA and
p75NTR, in experimental autoimmune encephalomyelitis. J
Neuroinflammation. 17(41)2020.PubMed/NCBI View Article : Google Scholar
|
|
58
|
Yan T, Zhang Z and Li D: NGF receptors and
PI3K/AKT pathway involved in glucose fluctuation-induced damage to
neurons and α-lipoic acid treatment. BMC Neurosci.
21(38)2020.PubMed/NCBI View Article : Google Scholar
|
|
59
|
Ioannou MS and Fahnestock M: ProNGF, but
not NGF, switches from neurotrophic to apoptotic activity in
response to reductions in TrkA receptor levels. Int J Mol Sci.
18(599)2017.PubMed/NCBI View Article : Google Scholar
|
|
60
|
Karami A, Eyjolfsdottir H, Vijayaraghavan
S, Lind G, Almqvist P, Kadir A, Linderoth B, Andreasen N, Blennow
K, Wall A, et al: Changes in CSF cholinergic biomarkers in response
to cell therapy with NGF in patients with Alzheimer's disease.
Alzheimers Dement. 11:1316–1328. 2015.PubMed/NCBI View Article : Google Scholar
|
|
61
|
Pakzaban P and Chiocca EA: Nerve growth
factor protects against herpes simplex virus type 1 neurotoxicity
in the rat striatum. Neuroreport. 5:993–996. 1994.PubMed/NCBI View Article : Google Scholar
|
|
62
|
De Rosa R, Garcia AA, Braschi C, Capsoni
S, Maffei L, Berardi N and Cattaneo A: Intranasal administration of
nerve growth factor (NGF) rescues recognition memory deficits in
AD11 anti-NGF transgenic mice. Proc Natl Acad Sci USA.
102:3811–3816. 2005.PubMed/NCBI View Article : Google Scholar
|
|
63
|
Lambiase A, Pagani L, Di Fausto V, Sposato
V, Coassin M, Bonini S and Aloe L: Nerve growth factor eye drop
administrated on the ocular surface of rodents affects the nucleus
basalis and septum: Biochemical and structural evidence. Brain Res.
1127:45–51. 2007.PubMed/NCBI View Article : Google Scholar
|
|
64
|
Hohsfield LA, Geley S, Reindl M and Humpel
C: The generation of NGF-secreting primary rat monocytes: A
comparison of different transfer methods. J Immunol Methods.
391:112–124. 2013.PubMed/NCBI View Article : Google Scholar
|
|
65
|
Eriksdotter M, Navarro-Oviedo M, Mitra S,
Wahlberg L, Linderoth B, Tjernberg LO and Behbahani H:
Cerebrospinal fluid from Alzheimer patients affects cell-mediated
nerve growth factor production and cell survival in vitro. Exp Cell
Res. 371:175–184. 2018.PubMed/NCBI View Article : Google Scholar
|
|
66
|
Moyano P, Flores A, Garcia J, García JM,
Anadon MJ, Frejo MT, Sola E, Pelayo A and Del Pino J: Bisphenol A
single and repeated treatment increases HDAC2, leading to
cholinergic neurotransmission dysfunction and SN56 cholinergic
apoptotic cell death through AChE variants overexpression and
NGF/TrkA/P75NTR signaling disruption. Food Chem Toxicol.
157(112614)2021.PubMed/NCBI View Article : Google Scholar
|
|
67
|
Eyjolfsdottir H, Eriksdotter M, Linderoth
B, Lind G, Juliusson B, Kusk P, Almkvist O, Andreasen N, Blennow K,
Ferreira D, et al: Targeted delivery of nerve growth factor to the
cholinergic basal forebrain of Alzheimer's disease patients:
Application of a second-generation encapsulated cell biodelivery
device. Alzheimers Res Ther. 8(30)2016.PubMed/NCBI View Article : Google Scholar
|
|
68
|
Amaral LD, Santos NAGD, Sisti FM, Del Bel
E and Santos ACD: The antibiotic doxycycline mimics the NGF
signaling in PC12 cells: A relevant mechanism for neuroprotection.
Chem Biol Interact. 341(109454)2021.PubMed/NCBI View Article : Google Scholar
|
|
69
|
James ML, Belichenko NP, Shuhendler AJ,
Hoehne A, Andrews LE, Condon C, Nguyen TV, Reiser V, Jones P, Trigg
W, et al: [18F]GE-180 PET detects reduced microglia activation
after LM11A-31 therapy in a mouse model of Alzheimer's disease.
Theranostics. 7:1422–1436. 2017.PubMed/NCBI View Article : Google Scholar
|
|
70
|
Bartus RT, Dean RL III, Beer B and Lippa
AS: The cholinergic hypothesis of geriatric memory dysfunction.
Science. 217:408–414. 1982.PubMed/NCBI View Article : Google Scholar
|
|
71
|
Moss DE: Improving anti-neurodegenerative
benefits of acetylcholinesterase inhibitors in Alzheimer's disease:
Are irreversible inhibitors the future? Int J Mol Sci.
21(3438)2020.PubMed/NCBI View Article : Google Scholar
|
|
72
|
Korabecny J, Spilovska K, Mezeiova E,
Benek O, Juza R, Kaping D and Soukup O: A systematic review on
donepezil-based derivatives as potential cholinesterase inhibitors
for Alzheimer's disease. Curr Med Chem. 26:5625–5648.
2019.PubMed/NCBI View Article : Google Scholar
|
|
73
|
Parsons CG, Danysz W, Dekundy A and Pulte
I: Memantine and cholinesterase inhibitors: Complementary
mechanisms in the treatment of Alzheimer's disease. Neurotox Res.
24:358–369. 2013.PubMed/NCBI View Article : Google Scholar
|
|
74
|
Liang J, Li J, Jia R, Wang Y, Wu R, Zhang
H, Hang L and Xu Y: Identification of the optimal cognitive drugs
among Alzheimer's disease: A Bayesian meta-analytic review. Clin
Interv Aging. 13:2061–2073. 2018.PubMed/NCBI View Article : Google Scholar
|
|
75
|
Aguglia E, Onor ML, Saina M and Maso E: An
open-label, comparative study of rivastigmine, donepezil and
galantamine in a real-world setting. Curr Med Res Opin.
20:1747–1752. 2004.PubMed/NCBI View Article : Google Scholar
|
|
76
|
Nordberg A, Darreh-Shori T, Peskind E,
Soininen H, Mousavi M, Eagle G and Lane R: Different cholinesterase
inhibitor effects on CSF cholinesterases in Alzheimer patients.
Curr Alzheimer Res. 6:4–14. 2009.PubMed/NCBI View Article : Google Scholar
|
|
77
|
Joshi S and Kapur J: N-methyl-D-aspartic
acid receptor activation downregulates expression of δ
subunit-containing GABAA receptors in cultured hippocampal neurons.
Mol Pharmacol. 84:1–11. 2013.PubMed/NCBI View Article : Google Scholar
|
|
78
|
Shih CC, Chen PY, Chen MF and Lee TJF:
Differential blockade by huperzine A and donepezil of sympathetic
nicotinic acetylcholine receptor-mediated nitrergic neurogenic
dilations in porcine basilar arteries. Eur J Pharmacol.
868(172851)2020.PubMed/NCBI View Article : Google Scholar
|
|
79
|
Ito T, Inden M, Ueda T, Asaka Y, Kurita H
and Hozumi I: The neuroprotective effects of activated alpha7
nicotinic acetylcholine receptor against mutant copper-zinc
superoxide dismutase 1-mediated toxicity. Sci Rep.
10(22157)2020.PubMed/NCBI View Article : Google Scholar
|
|
80
|
Noh MY, Koh SH, Kim Y, Kim HY, Cho GW and
Kim SH: Neuroprotective effects of donepezil through inhibition of
GSK-3 activity in amyloid-beta-induced neuronal cell death. J
Neurochem. 108:1116–1125. 2009.PubMed/NCBI View Article : Google Scholar
|
|
81
|
Kihara T, Shimohama S, Sawada H, Honda K,
Nakamizo T, Shibasaki H, Kume T and Akaike A: alpha 7 nicotinic
receptor transduces signals to phosphatidylinositol 3-kinase to
block A beta-amyloid-induced neurotoxicity. J Biol Chem.
276:13541–13546. 2001.PubMed/NCBI View Article : Google Scholar
|
|
82
|
Makitani K, Nakagawa S, Izumi Y, Akaike A
and Kume T: Inhibitory effect of donepezil on bradykinin-induced
increase in the intracellular calcium concentration in cultured
cortical astrocytes. J Pharmacol Sci. 134:37–44. 2017.PubMed/NCBI View Article : Google Scholar
|
|
83
|
Arias E, Gallego-Sandin S, Villarroya M,
García AG and López MG: Unequal neuroprotection afforded by the
acetylcholinesterase inhibitors galantamine, donepezil, and
rivastigmine in SH-SY5Y neuroblastoma cells: Role of nicotinic
receptors. J Pharmacol Exp Ther. 315:1346–1353. 2005.PubMed/NCBI View Article : Google Scholar
|
|
84
|
Zhao S, Zhang X and Li H: Beyond histone
acetylation-writing and erasing histone acylations. Curr Opin
Struct Biol. 53:169–177. 2018.PubMed/NCBI View Article : Google Scholar
|
|
85
|
Ganai SA, Ramadoss M and Mahadevan V:
Histone deacetylase (HDAC) inhibitors-emerging roles in neuronal
memory, learning, synaptic plasticity and neural regeneration. Curr
Neuropharmacol. 14:55–71. 2016.PubMed/NCBI View Article : Google Scholar
|
|
86
|
Fuller NO, Pirone A, Lynch BA, Hewitt MC,
Quinton MS, McKee TD and Ivarsson M: CoREST complex-selective
histone deacetylase inhibitors show prosynaptic effects and an
improved safety profile to enable treatment of synaptopathies. ACS
Chem Neurosci. 10:1729–1743. 2019.PubMed/NCBI View Article : Google Scholar
|
|
87
|
Xu K, Dai XL, Huang HC and Jiang ZF:
Targeting HDACs: A promising therapy for Alzheimer's disease. Oxid
Med Cell Longev. 2011(143269)2011.PubMed/NCBI View Article : Google Scholar
|
|
88
|
Kumar V, Kundu S, Singh A and Singh S:
Understanding the role of histone deacetylase and their inhibitors
in neurodegenerative disorders: Current targets and future
perspective. Curr Neuropharmacol. 20:158–178. 2022.PubMed/NCBI View Article : Google Scholar
|
|
89
|
Guan JS, Haggarty SJ, Giacometti E,
Dannenberg JH, Joseph N, Gao J, Nieland TJ, Zhou Y, Wang X,
Mazitschek R, et al: HDAC2 negatively regulates memory formation
and synaptic plasticity. Nature. 459:55–60. 2009.PubMed/NCBI View Article : Google Scholar
|
|
90
|
Janczura KJ, Volmar CH, Sartor GC, Rao SJ,
Ricciardi NR, Lambert G, Brothers SP and Wahlestedt C: Inhibition
of HDAC3 reverses Alzheimer's disease-related pathologies in vitro
and in the 3xTg-AD mouse model. Proc Natl Acad Sci USA.
115:E11148–E11157. 2018.PubMed/NCBI View Article : Google Scholar
|
|
91
|
Chen YA, Lu CH, Ke CC, Chiu SJ, Chang CW,
Yang BH, Gelovani JG and Liu RS: Evaluation of class IIa histone
deacetylases expression and in vivo epigenetic imaging in a
transgenic mouse model of Alzheimer's disease. Int J Mol Sci.
22(8633)2021.PubMed/NCBI View Article : Google Scholar
|
|
92
|
Li Y, Sang S, Ren W, Pei Y, Bian Y, Chen Y
and Sun H: Inhibition of histone deacetylase 6 (HDAC6) as a
therapeutic strategy for Alzheimer's disease: A review (2010-2020).
Eur J Med Chem. 226(113874)2021.PubMed/NCBI View Article : Google Scholar
|
|
93
|
Cuadrado-Tejedor M, Garcia-Barroso C,
Sánchez-Arias JA, Rabal O, Pérez-González M, Mederos S, Ugarte A,
Franco R, Segura V, Perea G, et al: A first-in-class small-molecule
that acts as a dual inhibitor of HDAC and PDE5 and that rescues
hippocampal synaptic impairment in Alzheimer's disease mice.
Neuropsychopharmacology. 42:524–539. 2017.PubMed/NCBI View Article : Google Scholar
|
|
94
|
Rabal O, Sánchez-Arias JA,
Cuadrado-Tejedor M, de Miguel I, Pérez-González M, García-Barroso
C, Ugarte A, Estella-Hermoso de Mendoza A, Sáez E, Espelosin M, et
al: Design, synthesis, biological evaluation and in vivo testing of
dual phosphodiesterase 5 (PDE5) and histone deacetylase 6
(HDAC6)-selective inhibitors for the treatment of Alzheimer's
disease. Eur J Med Chem. 150:506–524. 2018.PubMed/NCBI View Article : Google Scholar
|
|
95
|
Koch G, Martorana A and Caltagirone C:
Transcranial magnetic stimulation: Emerging biomarkers and novel
therapeutics in Alzheimer's disease. Neurosci Lett.
719(134355)2020.PubMed/NCBI View Article : Google Scholar
|
|
96
|
Bursali C, Özkan FÜ, Kaysin MY, Dortcan N,
Aktas I and Külcü DG: Effectiveness of repetitive transcranial
magnetic stimulation in patients with failed back surgery syndrome:
A double-blind randomized placebo-controlled study. Pain Physician.
24:E23–E30. 2021.PubMed/NCBI
|
|
97
|
Minzenberg MJ and Leuchter AF: The effect
of psychotropic drugs on cortical excitability and plasticity
measured with transcranial magnetic stimulation: Implications for
psychiatric treatment. J Affect Disord. 253:126–140.
2019.PubMed/NCBI View Article : Google Scholar
|
|
98
|
Zhao J, Li Z, Cong Y, Zhang J, Tan M,
Zhang H, Geng N, Li M, Yu W and Shan P: Repetitive transcranial
magnetic stimulation improves cognitive function of Alzheimer's
disease patients. Oncotarget. 8:33864–33871. 2017.PubMed/NCBI View Article : Google Scholar
|
|
99
|
Sabbagh M, Sadowsky C, Tousi B, Agronin
ME, Alva G, Armon C, Bernick C, Keegan AP, Karantzoulis S, Baror E,
et al: Effects of a combined transcranial magnetic stimulation
(TMS) and cognitive training intervention in patients with
Alzheimer's disease. Alzheimers Dement. 16:641–650. 2020.PubMed/NCBI View Article : Google Scholar
|
|
100
|
Saitoh Y, Hosomi K, Mano T, Takeya Y,
Tagami S, Mori N, Matsugi A, Jono Y, Harada H, Yamada T and Miyake
A: Randomized, sham-controlled, clinical trial of repetitive
transcranial magnetic stimulation for patients with Alzheimer's
dementia in Japan. Front Aging Neurosci. 14(993306)2022.PubMed/NCBI View Article : Google Scholar
|
|
101
|
Ahmed MA, Darwish ES, Khedr EM, El Serogy
YM and Ali AM: Effects of low versus high frequencies of repetitive
transcranial magnetic stimulation on cognitive function and
cortical excitability in Alzheimer's dementia. J Neurol. 259:83–92.
2012.PubMed/NCBI View Article : Google Scholar
|
|
102
|
Trojano L, Conson M, Maffei R and Grossi
D: Categorical and coordinate spatial processing in the imagery
domain investigated by rTMS. Neuropsychologia. 44:1569–1574.
2006.PubMed/NCBI View Article : Google Scholar
|
|
103
|
Turriziani P, Smirni D, Zappalà G, Mangano
GR, Oliveri M and Cipolotti L: Enhancing memory performance with
rTMS in healthy subjects and individuals with mild cognitive
Impairment: The role of the right dorsolateral prefrontal cortex.
Front Hum Neurosci. 6(62)2012.PubMed/NCBI View Article : Google Scholar
|
|
104
|
Sanches C, Levy R, Benisty S, Volpe-Gillot
L, Habert MO, Kas A, Ströer S, Pyatigorskaya N, Kaglik A, Bourbon
A, et al: Testing the therapeutic effects of transcranial direct
current stimulation (tDCS) in semantic dementia: A double blind,
sham controlled, randomized clinical trial. Trials.
20(632)2019.PubMed/NCBI View Article : Google Scholar
|
|
105
|
Bunai T, Hirosawa T, Kikuchi M, Fukai M,
Yokokura M, Ito S, Takata Y, Terada T and Ouchi Y: tDCS-induced
modulation of GABA concentration and dopamine release in the human
brain: A combination study of magnetic resonance spectroscopy and
positron emission tomography. Brain Stimul. 14:154–160.
2021.PubMed/NCBI View Article : Google Scholar
|
|
106
|
Lefebvre S and Liew SL: Anatomical
parameters of tDCS to modulate the motor system after stroke: A
review. Front Neurol. 8(29)2017.PubMed/NCBI View Article : Google Scholar
|
|
107
|
Boggio PS, Ferrucci R, Mameli F, Martins
D, Martins O, Vergari M, Tadini L, Scarpini E, Fregni F and Priori
A: Prolonged visual memory enhancement after direct current
stimulation in Alzheimer's disease. Brain Stimul. 5:223–230.
2012.PubMed/NCBI View Article : Google Scholar
|
|
108
|
Batsikadze G, Moliadze V, Paulus W, Kuo MF
and Nitsche MA: Partially non-linear stimulation
intensity-dependent effects of direct current stimulation on motor
cortex excitability in humans. J Physiol. 591:1987–2000.
2013.PubMed/NCBI View Article : Google Scholar
|
|
109
|
Woods AJ, Antal A, Bikson M, Boggio PS,
Brunoni AR, Celnik P, Cohen LG, Fregni F, Herrmann CS, Kappenman
ES, et al: A technical guide to tDCS, and related non-invasive
brain stimulation tools. Clin Neurophysiol. 127:1031–1048.
2016.PubMed/NCBI View Article : Google Scholar
|
|
110
|
Iaccarino HF, Singer AC, Martorell AJ,
Rudenko A, Gao F, Gillingham TZ, Mathys H, Seo J, Kritskiy O,
Abdurrob F, et al: Gamma frequency entrainment attenuates amyloid
load and modifies microglia. Nature. 540:230–235. 2016.PubMed/NCBI View Article : Google Scholar
|
|
111
|
Bradford A, Barlow A and Chazot PL:
Probing the differential effects of infrared light sources IR1072
and IR880 on human lymphocytes: Evidence of selective
cytoprotection by IR1072. J Photochem Photobiol B. 81:9–14.
2005.PubMed/NCBI View Article : Google Scholar
|
|
112
|
Grillo SL, Duggett NA, Ennaceur A and
Chazot PL: Non-invasive infra-red therapy (1072 nm) reduces
β-amyloid protein levels in the brain of an Alzheimer's disease
mouse model, TASTPM. J Photochem Photobiol B. 123:13–22.
2013.PubMed/NCBI View Article : Google Scholar
|
|
113
|
Wang M, Cao J, Amakye WK, Gong C, Li Q and
Ren J: Mid infrared light treatment attenuates cognitive decline
and alters the gut microbiota community in APP/PS1 mouse model.
Biochem Biophys Res Commun. 523:60–65. 2020.PubMed/NCBI View Article : Google Scholar
|
|
114
|
Huang N, Yao D, Jiang W, Wei C, Li M, Li
W, Mu H, Gao M, Ma Z, Lyu J and Tong Z: Safety and efficacy of
630-nm red light on cognitive function in older adults with mild to
moderate Alzheimer's disease: Protocol for a randomized controlled
study. Front Aging Neurosci. 12(143)2020.PubMed/NCBI View Article : Google Scholar
|
|
115
|
Figueiro MG and Leggett S: Intermittent
light exposures in humans: A case for dual entrainment in the
treatment of Alzheimer's disease. Front Neurol.
12(625698)2021.PubMed/NCBI View Article : Google Scholar
|
|
116
|
Ying Y and Wang JZ: Illuminating neural
circuits in Alzheimer's disease. Neurosci Bull. 37:1203–1217.
2021.PubMed/NCBI View Article : Google Scholar
|
|
117
|
Ourednik J, Ourednik V, Lynch WP,
Schachner M and Snyder EY: Neural stem cells display an inherent
mechanism for rescuing dysfunctional neurons. Nat Biotechnol.
20:1103–1110. 2002.PubMed/NCBI View
Article : Google Scholar
|
|
118
|
Alessandrini M, Preynat-Seauve O, De Bruin
K and Pepper MS: Stem cell therapy for neurological disorders. S
Afr Med J. 109:70–77. 2019.PubMed/NCBI View Article : Google Scholar
|
|
119
|
Kang JM, Yeon BK, Cho SJ and Suh YH: Stem
cell therapy for Alzheimer's disease: A review of recent clinical
trials. J Alzheimers Dis. 54:879–889. 2016.PubMed/NCBI View Article : Google Scholar
|
|
120
|
Zhang B, Yan W, Zhu Y, Yang W, Le W, Chen
B, Zhu R and Cheng L: Nanomaterials in neural-stem-cell-mediated
regenerative medicine: Imaging and treatment of neurological
diseases. Adv Mater. 30(e1705694)2018.PubMed/NCBI View Article : Google Scholar
|
|
121
|
Shu H, Guo Z, Chen X, Qi S, Xiong X, Xia
S, Huang Q, Lan L, Gong J, Huang S, Yang B, et al: Intracerebral
transplantation of neural stem cells restores manganese-induced
cognitive deficits in mice. Aging Dis. 12:371–385. 2021.PubMed/NCBI View Article : Google Scholar
|
|
122
|
Csobonyeiova M, Polak S, Zamborsky R and
Danisovic L: Recent progress in the regeneration of spinal cord
injuries by induced pluripotent stem cells. Int J Mol Sci.
20(3838)2019.PubMed/NCBI View Article : Google Scholar
|
|
123
|
Banda E and Grabel L: Directed
differentiation of human embryonic stem cells into neural
progenitors. Methods Mol Biol. 1307:289–298. 2016.PubMed/NCBI View Article : Google Scholar
|
|
124
|
Shahbazi E, Mirakhori F, Ezzatizadeh V and
Baharvand H: Reprogramming of somatic cells to induced neural stem
cells. Methods. 133:21–28. 2018.PubMed/NCBI View Article : Google Scholar
|
|
125
|
Daadi MM: Generation of neural stem cells
from induced pluripotent stem cells. Methods Mol Biol. 1919:1–7.
2019.PubMed/NCBI View Article : Google Scholar
|
|
126
|
Matsui T, Akamatsu W, Nakamura M and Okano
H: Regeneration of the damaged central nervous system through
reprogramming technology: Basic concepts and potential application
for cell replacement therapy. Exp Neurol. 260:12–18.
2014.PubMed/NCBI View Article : Google Scholar
|
|
127
|
Zhang L, Dong ZF and Zhang JY:
Immunomodulatory role of mesenchymal stem cells in Alzheimer's
disease. Life Sci. 246(117405)2020.PubMed/NCBI View Article : Google Scholar
|
|
128
|
Yip S, Aboody KS, Burns M, Imitola J,
Boockvar JA, Allport J, Park KI, Teng YD, Lachyankar M, McIntosh T,
et al: Neural stem cell biology may be well suited for improving
brain tumor therapies. Cancer J. 9:189–204. 2003.PubMed/NCBI View Article : Google Scholar
|
|
129
|
Park KI: Transplantation of neural stem
cells: Cellular & gene therapy for hypoxic-ischemic brain
injury. Yonsei Med J. 41:825–835. 2000.PubMed/NCBI View Article : Google Scholar
|
|
130
|
Zhao L, Liu JW, Kan BH, Shi HY, Yang LP
and Liu XY: Acupuncture accelerates neural regeneration and
synaptophysin production after neural stem cells transplantation in
mice. World J Stem Cells. 12:1576–1590. 2020.PubMed/NCBI View Article : Google Scholar
|
|
131
|
De Feo D, Merlini A, Laterza C and Martino
G: Neural stem cell transplantation in central nervous system
disorders: From cell replacement to neuroprotection. Curr Opin
Neurol. 25:322–333. 2012.PubMed/NCBI View Article : Google Scholar
|
|
132
|
Yu JH, Seo JH, Lee JY, Lee MY and Cho SR:
Induction of Neurorestoration From Endogenous Stem Cells. Cell
Transplant. 25:863–882. 2016.PubMed/NCBI View Article : Google Scholar
|
|
133
|
Wu K, Zhang R, Lu Y, Wen L, Li Y, Duan R,
Yao Y and Jia Y: Lin28B regulates the fate of grafted mesenchymal
stem cells and enhances their protective effects against
Alzheimer's disease by upregulating IGF-2. J Cell Physiol.
234:21860–21876. 2019.PubMed/NCBI View Article : Google Scholar
|
|
134
|
Sun B, Taing A, Liu H, Nie G, Wang J, Fang
Y, Liu L, Xue Y, Shi J, Liao YP, et al: Nerve growth
factor-conjugated mesoporous silica nanoparticles promote
neuron-like PC12 cell proliferation and neurite growth. J Nanosci
Nanotechnol. 16:2390–2393. 2016.PubMed/NCBI View Article : Google Scholar
|
|
135
|
Mili B, Das K, Kumar A, Saxena AC, Singh
P, Ghosh S and Bag S: Preparation of NGF encapsulated chitosan
nanoparticles and its evaluation on neuronal differentiation
potentiality of canine mesenchymal stem cells. J Mater Sci Mater
Med. 29(4)2017.PubMed/NCBI View Article : Google Scholar
|
|
136
|
Mortazavi Y, Sheikhsaran F, Khamisipour
GK, Soleimani M, Teimuri A and Shokri S: The evaluation of nerve
growth factor over expression on neural lineage specific genes in
human mesenchymal stem cells. Cell J. 18:189–196. 2016.PubMed/NCBI View Article : Google Scholar
|
|
137
|
Lee HJ, Lim IJ, Park SW, Kim YB, Ko Y and
Kim SU: Human neural stem cells genetically modified to express
human nerve growth factor (NGF) gene restore cognition in the mouse
with ibotenic acid-induced cognitive dysfunction. Cell Transplant.
21:2487–2496. 2012.PubMed/NCBI View Article : Google Scholar
|
|
138
|
Ma Y, Li C, Huang Y, Wang Y, Xia X and
Zheng JC: Exosomes released from neural progenitor cells and
induced neural progenitor cells regulate neurogenesis through
miR-21a. Cell Commun Signal. 17(96)2019.PubMed/NCBI View Article : Google Scholar
|
|
139
|
Zhang R, Mao W, Niu L, Bao W, Wang Y, Wang
Y, Zhu Y, Yang Z, Chen J, Dong J, et al: NSC-derived exosomes
enhance therapeutic effects of NSC transplantation on cerebral
ischemia in mice. Elife. 12(e84493)2023.PubMed/NCBI View Article : Google Scholar
|
|
140
|
Ma Y, Wang K, Pan J, Fan Z, Tian C, Deng
X, Ma K, Xia X, Huang Y and Zheng JC: Induced neural progenitor
cells abundantly secrete extracellular vesicles and promote the
proliferation of neural progenitors via extracellular
signal-regulated kinase pathways. Neurobiol Dis. 124:322–334.
2019.PubMed/NCBI View Article : Google Scholar
|
|
141
|
Zhang J, Li S, Li L, Li M, Guo C, Yao J
and Mi S: Exosome and exosomal microRNA: Trafficking, sorting, and
function. Genomics Proteomics Bioinformatics. 13:17–24.
2015.PubMed/NCBI View Article : Google Scholar
|
|
142
|
Xin H, Wang F, Li Y, Lu QE, Cheung WL,
Zhang Y, Zhang ZG and Chopp M: Secondary release of exosomes from
astrocytes contributes to the increase in neural plasticity and
improvement of functional recovery after stroke in rats treated
with exosomes harvested from MicroRNA 133b-overexpressing
multipotent mesenchymal stromal cells. Cell Transplant. 26:243–257.
2017.PubMed/NCBI View Article : Google Scholar
|
|
143
|
Gan C and Ouyang F: Exosomes released from
bone-marrow stem cells ameliorate hippocampal neuronal injury
through transferring miR-455-3p. J Stroke Cerebrovasc Dis.
31(106142)2022.PubMed/NCBI View Article : Google Scholar
|
|
144
|
Li D, Zhang P, Yao X, Li H, Shen H, Li X,
Wu J and Lu X: Exosomes derived from miR-133b-modified mesenchymal
stem cells promote recovery after spinal cord injury. Front
Neurosci. 12(845)2018.PubMed/NCBI View Article : Google Scholar
|
|
145
|
Takata T, Nonaka W, Iwama H, Kobara H,
Deguchi K, Masugata H, Touge T, Miyamoto O, Nakamura T, Itano T and
Masaki T: Light exercise without lactate elevation induces ischemic
tolerance through the modulation of microRNA in the gerbil
hippocampus. Brain Res. 1732(146710)2020.PubMed/NCBI View Article : Google Scholar
|
|
146
|
Zhu Q, Zhang N, Hu N, Jiang R, Lu H, Xuan
A, Long D and Chen Y: Neural stem cell transplantation improves
learning and memory by protecting cholinergic neurons and restoring
synaptic impairment in an amyloid precursor protein/presenilin 1
transgenic mouse model of Alzheimer's disease. Mol Med Rep.
21:1172–1180. 2020.PubMed/NCBI View Article : Google Scholar
|
|
147
|
Kim HJ, Seo SW, Chang JW, Lee JI, Kim CH,
Chin J, Choi SJ, Kwon H, Yun HJ, Lee JM, et al: Stereotactic brain
injection of human umbilical cord blood mesenchymal stem cells in
patients with Alzheimer's disease dementia: A phase 1 clinical
trial. Alzheimers Dement (N Y). 1:95–102. 2015.PubMed/NCBI View Article : Google Scholar
|
|
148
|
Gauthier S, Rosa-Neto P, Morais JA and
Webster C: World Alzheimer Report, 2021: Journey through the
diagnosis of dementia. Alzheimer's Disease International. 2021.
|