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Efficacy of apatinib combined with temozolomide in the treatment of recurrent high‑grade glioma: A meta‑analysis

  • Authors:
    • Guanglie Li
    • Xiwei Xu
    • Jianqi Cui
    • Fan Zhang
    • Siyang Wang
  • View Affiliations / Copyright

    Affiliations: Department of Head and Neck Oncology, The Fifth Affiliated Hospital of Sun Yat‑sen University, Zhuhai, Guangdong 519000, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 452
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    Published online on: August 3, 2023
       https://doi.org/10.3892/etm.2023.12151
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Abstract

Recurrent high‑grade glioma is a refractory disease, and its prognosis is poor. Although the treatment of apatinib combined with temozolomide provides improved efficacy and is able to prolong survival, this conclusion has been based on small samples. In order to clarify this treatment's efficacy, a meta‑analysis was performed in the present study. Different databases were screened and finally, 10 studies were included, comprising 357 patients with recurrent high‑grade gliomas. The efficacy and prognosis were analyzed using Stata software. The results indicated that the overall objective response rate (ORR) and disease control rate (DCR) of apatinib combined with temozolomide were 0.36 (95% CI, 0.26‑0.46) and 0.86 (95% CI, 0.82‑0.89), respectively. Subgroup analysis indicated that the overall ORR was 0.43 (95% CI, 0.29‑0.57) and 0.26 (95% CI, 0.14‑0.38), and the DCR was 0.89 (95% CI, 0.85‑0.93) and 0.76 (95% CI, 0.69‑0.84) in the treatment of apatinib with temozolomide dose‑dense group and the conventional‑dose group (5/28 regimen), respectively. Further prognostic analysis indicated that the median overall survival of patients with high‑grade glioma treated with apatinib combined with temozolomide was 8.21 months (95% CI, 7.20‑9.22 months) and the median progression‑free survival was 5.45 months (95% CI, 4.53‑6.37). Analysis of the publication bias of the effect size revealed that there was bias in the DCR, while no bias was found in the remaining effect size (ORR, median overall survival and median progression‑free survival). After correction by the trim‑and‑fill method, bias was indicated to have no significant impact on the results. In conclusion, apatinib combined with temozolomide has the effect that, compared with traditional Bevacizumab treatment, it can improve the efficacy in the treatment of recurrent high‑grade glioma and improve prognosis. When combining with dose‑dense temozolomide, the effect may be better than that of the conventional 5/28 regimen.
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Copy and paste a formatted citation
Spandidos Publications style
Li G, Xu X, Cui J, Zhang F and Wang S: Efficacy of apatinib combined with temozolomide in the treatment of recurrent high‑grade glioma: A meta‑analysis. Exp Ther Med 26: 452, 2023.
APA
Li, G., Xu, X., Cui, J., Zhang, F., & Wang, S. (2023). Efficacy of apatinib combined with temozolomide in the treatment of recurrent high‑grade glioma: A meta‑analysis. Experimental and Therapeutic Medicine, 26, 452. https://doi.org/10.3892/etm.2023.12151
MLA
Li, G., Xu, X., Cui, J., Zhang, F., Wang, S."Efficacy of apatinib combined with temozolomide in the treatment of recurrent high‑grade glioma: A meta‑analysis". Experimental and Therapeutic Medicine 26.3 (2023): 452.
Chicago
Li, G., Xu, X., Cui, J., Zhang, F., Wang, S."Efficacy of apatinib combined with temozolomide in the treatment of recurrent high‑grade glioma: A meta‑analysis". Experimental and Therapeutic Medicine 26, no. 3 (2023): 452. https://doi.org/10.3892/etm.2023.12151
Copy and paste a formatted citation
x
Spandidos Publications style
Li G, Xu X, Cui J, Zhang F and Wang S: Efficacy of apatinib combined with temozolomide in the treatment of recurrent high‑grade glioma: A meta‑analysis. Exp Ther Med 26: 452, 2023.
APA
Li, G., Xu, X., Cui, J., Zhang, F., & Wang, S. (2023). Efficacy of apatinib combined with temozolomide in the treatment of recurrent high‑grade glioma: A meta‑analysis. Experimental and Therapeutic Medicine, 26, 452. https://doi.org/10.3892/etm.2023.12151
MLA
Li, G., Xu, X., Cui, J., Zhang, F., Wang, S."Efficacy of apatinib combined with temozolomide in the treatment of recurrent high‑grade glioma: A meta‑analysis". Experimental and Therapeutic Medicine 26.3 (2023): 452.
Chicago
Li, G., Xu, X., Cui, J., Zhang, F., Wang, S."Efficacy of apatinib combined with temozolomide in the treatment of recurrent high‑grade glioma: A meta‑analysis". Experimental and Therapeutic Medicine 26, no. 3 (2023): 452. https://doi.org/10.3892/etm.2023.12151
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