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A successfully cured case of cytomegalovirus multiple organ infection after hematopoietic stem cell transplantation: A case report

  • Authors:
    • Qiqi Li
    • Quan Liang
    • Rongmei Meng
    • Qingqiao Xie
    • Yingzhen Zhang
    • Changjin Wei
    • Yunjie Wei
    • Kaiye He
    • Meihua Li
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Autonomous Region 530021, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 454
    |
    Published online on: August 4, 2023
       https://doi.org/10.3892/etm.2023.12153
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Abstract

Cytomegalovirus (CMV) infection is one of the most common infectious complications following hematopoietic stem cell transplantation (HSCT); however, cases involving multiple organs at the same time are rare. The present study describes a case of CMV pneumonia combined with CMV DNAemia and CMV cystitis after HSCT. A 33‑year‑old male patient with acute myeloid leukemia was treated with HSCT. The first month after HSCT, the patient developed a cough and shortness of breath. At 2 months post‑HSCT, the patient developed hematuria. The CMV DNA levels in the blood and urine were elevated; bronchoalveolar lavage fluid (BALF) was also positive for CMV DNA. Heterotypic cells exhibiting a large nuclear morphology were observed in the BALF and bronchial brushes. Recurrent and progressive ground‑glass opacities were evident on chest computed tomography. The patient was diagnosed with CMV pneumonia complicated by CMV DNAemia and CMV cystitis, and was treated with a combination of ganciclovir and foscarnet, along with immunoglobulin therapy. The patient was cured and discharged. It was determined that the CMV DNA in the blood was inconsistent with that in the BALF, which delayed the early diagnosis of CMV pneumonia. The association between T‑cell immune function and the therapeutic efficacy for CMV multi‑organ infection following HSCT is known to be significant. Moreover, the timely administration of ganciclovir and foscarnet in combination with immunoglobulin therapy demonstrated favorable clinical outcomes.
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Copy and paste a formatted citation
Spandidos Publications style
Li Q, Liang Q, Meng R, Xie Q, Zhang Y, Wei C, Wei Y, He K and Li M: A successfully cured case of cytomegalovirus multiple organ infection after hematopoietic stem cell transplantation: A case report. Exp Ther Med 26: 454, 2023.
APA
Li, Q., Liang, Q., Meng, R., Xie, Q., Zhang, Y., Wei, C. ... Li, M. (2023). A successfully cured case of cytomegalovirus multiple organ infection after hematopoietic stem cell transplantation: A case report. Experimental and Therapeutic Medicine, 26, 454. https://doi.org/10.3892/etm.2023.12153
MLA
Li, Q., Liang, Q., Meng, R., Xie, Q., Zhang, Y., Wei, C., Wei, Y., He, K., Li, M."A successfully cured case of cytomegalovirus multiple organ infection after hematopoietic stem cell transplantation: A case report". Experimental and Therapeutic Medicine 26.3 (2023): 454.
Chicago
Li, Q., Liang, Q., Meng, R., Xie, Q., Zhang, Y., Wei, C., Wei, Y., He, K., Li, M."A successfully cured case of cytomegalovirus multiple organ infection after hematopoietic stem cell transplantation: A case report". Experimental and Therapeutic Medicine 26, no. 3 (2023): 454. https://doi.org/10.3892/etm.2023.12153
Copy and paste a formatted citation
x
Spandidos Publications style
Li Q, Liang Q, Meng R, Xie Q, Zhang Y, Wei C, Wei Y, He K and Li M: A successfully cured case of cytomegalovirus multiple organ infection after hematopoietic stem cell transplantation: A case report. Exp Ther Med 26: 454, 2023.
APA
Li, Q., Liang, Q., Meng, R., Xie, Q., Zhang, Y., Wei, C. ... Li, M. (2023). A successfully cured case of cytomegalovirus multiple organ infection after hematopoietic stem cell transplantation: A case report. Experimental and Therapeutic Medicine, 26, 454. https://doi.org/10.3892/etm.2023.12153
MLA
Li, Q., Liang, Q., Meng, R., Xie, Q., Zhang, Y., Wei, C., Wei, Y., He, K., Li, M."A successfully cured case of cytomegalovirus multiple organ infection after hematopoietic stem cell transplantation: A case report". Experimental and Therapeutic Medicine 26.3 (2023): 454.
Chicago
Li, Q., Liang, Q., Meng, R., Xie, Q., Zhang, Y., Wei, C., Wei, Y., He, K., Li, M."A successfully cured case of cytomegalovirus multiple organ infection after hematopoietic stem cell transplantation: A case report". Experimental and Therapeutic Medicine 26, no. 3 (2023): 454. https://doi.org/10.3892/etm.2023.12153
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